P63 Gene Mutation â€“ Three Syndromes, Complications And Surgery
Cleft associated with p63-gene - The ULTIMATE Clinical pearls To achieve the ultimate result various aspects have to be considered. Ignoring one or more of these aspects will lead to suboptimal aesthetic and functional results. 1. Clefts associated with the p63-gene are part of rare syndromes with a 0.3% prevalence. The three most common syndromes diagnosed with the p63-gene show the following distribution ratio: AEC 23.1% : RHS 7.7% : EEC 69.2%. 2. The ectodermal component associated with the three syndromes, seems to have a negative effect on the postoperative wound healing of nasal, vestibular and palatal mucosa, as well as on the development of skeletal midfacial region. 3. As partial hypo- and adontia often do occur in these syndromes, best possible dental rehabilitation becomes a major challenge for the orthodontist and prosthodontist. 4. In patients with a p63-gene abnormality, the treatment and follow-up should take place in a multidisciplinary setting to ensure the most favourable treatment outcome. Nevertheless, both primary cleft and future secondary surgical repairs of upcoming defects in these patients remain challenges for surgeons and allied specialties.
Book: Cleft Ultimate Treatment -- Oro-facial and Cranio-maxillo-facial Deformities (Second Edition) Authors: Dr. Kurt Butow and Dr. Roger Z...