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A bi-annual update on the activities of UMIP, the University’s intellectual property management and commercialisation company

UMIPNEWS Issue 5, June 2011

UMIP APPOINTS EMERGO GROUP AS REGULATOR-IN-RESIDENCE UMIP has appointed Emergo Group, a leading medical device consultancy, as Regulator-in-Residence. Emergo Group will provide regulatory support in relation to the development and commercialisation of University research projects related to medical devices and diagnostics. The University of Manchester has an extensive track record in biomedical innovation and over the past 18 months, Emergo Group has been involved in providing regulatory input for a number of projects connected to UMIP, and in one case has provided a formal regulatory opinion concerning an in-vitro diagnostic test kit intended to screen women at risk of developing cervical cancer.

Richard Love, Emergo Group senior consultant

Emergo Group senior consultant, Richard Love, will provide regulatory input via quarterly clinics with UMIP’s biomedical staff. Input would include medical device identification and classification as well as the

key Regulatory and Quality Management System (QMS) requirements in primary markets such as the EU, USA, Canada and Australia. Richard commented: “We are delighted to be associated with UMIP and this collaboration presents an exciting opportunity for Emergo Group. We look forward to working with UMIP staff and to providing key regulatory support and guidance as these early-stage device and IVD projects evolve into commercial enterprises. More than 90% of our clients are small to medium size companies so we understand their needs and challenges very well.”

Dr Rich Ferrie, Head of UMIP Biomedica, said that he was delighted that Emergo Group had agreed to accept the appointment. “We are very much looking forward to working with Richard and the Emergo Group team. Their extensive expertise will add significant value in shaping the regulatory landscape for our early-stage device and diagnostics technologies and will offer us a clearer vision of the requirements to take our technologies and products to market.” For more information about Emergo, visit www.emergogroup.com

UMIC TO MERGE WITH UMIP UMIC, the University’s business incubation services provider, will be merging with its sister company, UMIP, with effect from the 1st August 2011. A new company will be formed to house a corporate services division which will support UMIC’s and UMIP’s business units with services such as finance, legal and HR as well as sales, marketing and promotion.

This company will be called The University of Manchester I3 (I-cubed) which reflects the entrepreneurial spirit of UMIC’s and UMIP’s activities: Inspire/Invent/Innovate. Both the UMIC and UMIP brands will remain, with UMIC continuing to provide worldclass business incubation facilities for University spin-out companies, with added emphasis on its role as a true Innovation Centre, and UMIP to provide

intellectual property commercialisation activities on behalf of the University. Since the creation of the ‘new’ University in 2004, both UMIC and UMIP have worked side by side to ensure the seamless transition of academic innovation from idea to marketplace either via spin-out creation or licence to third parties and have established a well-regarded international reputation for University innovation.

Core Technology Facility... part of the Innovation Centre

UMIP - REPUTATION AND VALUE THROUGH INTELLECTUAL PROPERTY®


INTELLECTUAL PROPERTY RESOURCE An intranet resource for: > Understanding IP > IP Commercialisation > IP in Research and Consultancy

www.manchester.ac.uk/ipresource

> IP & Academic Materials

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UMIP PREMIER FUND UPDATE... OUR SEED FUND RUNNING SINCE MARCH 2008 The companies in our portfolio, excepting one company that has fully exited, are still going strong and are making good commercial progress. All of them are recent start-up companies commercialising rich IP and many now have customers. Customers are the best form of finance any company can secure and are the ultimate validation of the utility of the science. Among the currently most promising companies in the portfolio is Arvia, a spin-out from the School of Chemical Engineering. Arvia has destroyed its first batch of radioactive oil at Magnox's Trawsfynydd Power Station. Radioactive oil waste is currently impossible to treat in volume and can only be stored at present. Bioxydyn (spin-out from the School of Medicine) has also secured a contract with a major pharmaceutical company for lung MRI imaging services to support clinical trials. As these companies gain momentum their teams and operations need to expand to service increasing customer interest. Often this expansion is required in advance of substantial sales revenue and as a consequence these young companies require significant sums of further investment. In most cases the UPF will collaborate with other investment groups to syndicate the necessary investment required to fund the companies properly, in the region of several million pounds per company. Securing this additional investment in the current

economic climate is very tricky and is probably the major challenge for the UPF in 2011. Early indications are positive but I don’t want to say anything more at this time for the risk of tempting fate… In addition, the UPF has also supported 17 Proof-of-Principle (PoP) projects in three years since the fund launch. These projects are essential for the development of a commercial plan around University IP and can be used to support commercially relevant technical work in the University as well as non-technical activities supporting business development. The UPF is open for business for additional new PoP projects and if you have an idea please contact UMIP.

www.theupf.com Mark Rahn Investment Manager MTI Partners (Managers of the UMIP Premier Fund)

MEET YOUR UMIP FRONTLINE CONTACTS UMIP’s Commercialisation Executives are your first point of call for any questions you may have should you have an idea or observation and are wondering if it has potential value. Our Commercialisation Executives are faculty specific:

For Technology and Humanities: Dr Pushkar Wadke, EPS T: 0161 306 8832 E: pushkar.wadke@umip.com Dr Lorna Farnsworth, EPS T: 0161 306 8813 E: lorna.farnsworth@umip.com Dr Mugdha Joshi, EPS T: 0161 306 8513 E: mugdha.joshi@umip.com

For Life Sciences and Medical & Human Sciences: Dr Arnaud Garçon, FLS/MHS T: 0161 603 7757 E: arnaud.garcon@umip.com Dr Edward Maughfling, MHS T: 0161 606 7213 E: edward.maughfling@umip.com Dr Gill Shuttleworth, FLS T: 0161 603 7738 E: gillian.shuttleworth@umip.com

Daniel Syder, Humanities T: 0161 306 8512 E: daniel.syder@umip.com

If you are working on research that you think has commercial potential, we would be pleased to hear from you.


LATEST LICENSING & SPIN-OUT NEWS BIOXYDYN - ADVANCED MEDICAL IMAGING BiOxyDyn’s technology centres on an unique, non-invasive magnetic imaging (MRI) tool which has the potential to considerably improve the treatment of lung conditions such as chronic obstructive pulmonary disease (COPD), asthma, cystic fibrosis and emphasema as well as aiding cancer specialists and neuroscientists.

Prof. Geoff Parker

BiOxyDyn was spun out of the Imaging Sciences Research Group, School of Cancer and Enabling Sciences within the Faculty of Medical and Human Sciences in 2010 and is based on research undertaken by Professor Geoff Parker and his research group. The spin-out has received commercialisation support and advice from UMIP and both Proof-of-Principle and additional funding from The UMIP Premier Fund (UPF).

COPD is the world’s 3rd biggest killer but Bioxydyn’s diagnostic imaging technologies have the potential to change the way in which lung disease is diagnosed and monitored by providing non-invasive regional assessments of lung ventilation/perfusion ratio (V/Q) and measures of changes in pulmonary vascular function. Bioxydyn is also developing powerful MRI based oncology tools for quantifying tumour oxygenation and oxygen metabolism. By providing unique non-invasive characterisation of the oxygenation status of tumours

its technologies will aid therapeutic decision making and provide additional information for assessing the response of tumours to intervention.

Imaging Institute, has been named by the Institute of Public Policy Research as one of 50 'Northern Lights' in recognition of his work with BiOxyDyn.

Commenting on the potential for this new technology Professor Geoff Parker, Bioxydyn Director said: “There currently simply isn't an inexpensive or practical 3D lung imaging technique available that can capture the structure and function of the lung, so we feel we've got something the market will want quickly. Lung diseases and disorders are so commonplace, with COPD affecting 80M people and causing 3M deaths world-wide each year.” He continues: “We've some exciting interest from major pharmaceutical players, so the race is on to develop our products and engage with the market to bring this to a commercial reality as soon as possible.”

In 2010 BiOxyDyn was named as Startup of the Year at the Northwest Biomedical Awards.

Professor Geoff Parker who is also Director of The University of Manchester’s Biomedical

www.bioxydyn.com

VRGS - SOFTWARE FOR GEOLOGICAL APPLICATIONS is specifically designed for geological applications. VRGS is a Windows based application, which allows the manipulation, interpretation and analysis of LiDAR data in a way that is meaningful to a geologist. Though initially developed to solve Oil and Gas production issues, the software is now being developed to address the needs of geologists in other non petroleum sectors such as geo-conservation.

UMIP has assisted Dr Dave Hodgetts from the Basin Studies and Petroleum Geoscience Group within The School of Earth, Atmospheric and Environmental Sciences, to license his latest processing software for PCs, which enables the interpretation of geological outcrops. Dr Hodgetts' research group has developed a novel means of 3D interpretation and mapping

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geological structures, using light detection and range technology (LiDAR). The resulting data is of great importance in the Petroleum industry to help understand and improve production from hydrocarbon reservoirs.

A LiDAR scanner collects up to 12,000 points of data in a second, creating a 3D image of a structure such as a cave, cliff or rock formation. This data is then collated and analysed by the unique software which Dr Hodgetts has created. It is capable of analysing the results at a far greater level of detail than has previously been possible.

At the centre of Dr Hodgetts’ research is the development of software called Virtual Reality Geological Studio (VRGS) which

Commenting on the successful licencing of the technology, Dr Hodgetts said: “The scanning technology itself is not especially

novel but the means of analysing the data certainly is and we have received interest around the world from other universities, geo-conservationalists and petroleum companies. It can provide a complete picture of a structure in intricate detail which is invaluable for hydrocarbon production, drilling and mining.” The software has already been licensed to universities in the UK and Spain, and a further licence is being finalised in Scandinavia. These techniques are being applied in several projects, ranging from modeling of Miocene deposits in Sinai, mapping Triassic fluvial sediments in Morocco and Canada as well as the improved analysis and archiving of dinosaur track ways in Spain. The technology was shown recently on National Geographic's Dino Autopsy programme, and on Channel 4 as The Dinosaur Mummy.

Remember to discuss possible IP protection before you publish. Contact your UMIP Commercialisation Executive first.


UMIP/MIMIT DESIGNER-IN-RESIDENCE – ONE YEAR ON…

By David Maddison, Maddison Ltd

the one certainty I now have is that every project will be looking for very different inputs and experience from myself. Perhaps I had expected that the common skills such as, development planning, user interface and proof-of-principle experience would form common threads in my conversations with different research groups. Rather excitingly this has not proved to be the case and unexpected interventions such as introducing potential funding partners and Maddison clients from the corporate world have formed part of my input. I never really knew what to expect when appointed as Designer-in-Residence for UMIP and MIMIT (Manchester: Integrating Medicine and Innovative Technology). It is now a year since the start of this programme and probably what has excited me the most about this role is the breadth of technologies that both their teams are dealing with. I have had some fascinating meetings with different groups working on amazing science and

We have recently initiated a series of lunchtime discussions on subjects of interest to UMIP and MIMIT. The first of these was by Mike Addison, Section Head R&D at Procter & Gamble who talked about their open innovation programme and the engagement process. Although P&G’s areas of activity are perhaps not mainstream for Manchester, I think the principles of engaging with corporate companies was well received and we are planning more to follow.

So far only two of the projects we have worked on are available for discussion due to the obvious confidential nature of most projects. Firstly, Dr Paul Malone’s very clever device to help steady and position the arm and wrist during MRI scans. We have worked with Paul and Dr Arnaud Garçon, UMIP’s commercialisation executive for FLS and MHS, to bring the design

up to a manufacturing specification and provide costings and visualisations for licensing discussions. Another, and perhaps in some ways more challenging, project has been working with MIMIT on solutions to various problems associated with colostomy. This work is still ongoing but has produced some exciting possibilities.

Imaging jig for upper limb

DARE TO BE DIFFERENT Social Enterprise we have been working towards, it is the recognition for STORM® and its contribution to the community that is the greatest reward.”

In late 2010, Dr Gill Green, MD of STORM® , scooped a ‘Dare to be Different’ Award from the HE Social Entrepreneurship Awards programme from UnLtd and the Higher Education Funding Council for England (HEFCE). UnLtd is a charity which supports social entrepreneurs by providing a complete package of funding and support, to help these individuals make their ideas a reality. Gill was awarded £15,000 and will also receive business support and mentorship from UnLtd for a year. The money will help towards the start up of STORM® as a community interest company (CIC). Gill comments: “We are delighted to have been successful. This is a prestigious award and we were up against stiff competition. Although the money will help us to set up the

STORM®’s training packages help frontline staff in health and social care spot the signs of suicidal tendencies and selfinjury. The training packages are used across a range of adult and children’s services including primary care, A&E departments, third sector services and schools. A new Higher Education package, which consists of two products: Occupational Health (for OH staff) and Higher Education (for staff working with students) is currently being piloted. The University will be one of the first customers. The STORM® model has been embraced by UK governments as part of their suicide prevention strategies. Attempting to reduce the suicide rate is important; the World Health Organisation estimates that one person will die by suicide every 40 seconds worldwide. To date there has been little skills training in suicide prevention provided to

healthcare profesisonals in the UK whose interventions could make the difference between life and death. Gill explains: “In my work as a clinician and now as a researcher, I have seen a real gap in the market and a need for flexible skills-based training packages in suicide prevention. Training is key if we are to have a responsive workforce that can positively and effectively help people in distress and thinking of ending their lives.” STORM® continues to evolve through ongoing research, with customer feedback helping to improve the product and to identify additional markets. Explains Gill: “Through a process of continual customer feedback we discovered that there was a further need for a training product that deals with self injury, therefore we have addressed this with the production of an additional STORM® product dealing specifically with this issue.”

Dr Gill Green

Dr Martin Henery, HEFCE Social Enterprise Ambassador for the University felt that Gill’s success in gaining one of the coveted UnLtd HEFCE awards was fully deserved given both the strength of the business case and the value of their social mission. In fact the University has enjoyed above average success with another 5 student run social enterprises accessing a further £20k in awards from UnLtd. Martin commented: “These awards just reflect the strong desire and abilities of both students and staff from this University to create sustainable solutions to some of the bigger social problems that currently face us.” For more information about STORM® visit their new website at www.stormskillstraining.com

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Download the following guides and booklets from www.umip.com

A Guide to UMIP Case Studies of Licensing Case Studies of Spin-outs

5 Years of UMIP IP & Confidentiality

Spin-out Companies

Licensing

Consulting IP Workbook Academic Materials and Publishing

Research Contracts Hard copies available from: sarah.harris@umip.com

PROOF OF PRINCIPLE FUNDING CASE STUDY:

AN INTERVIEW WITH DR BILL CROWTHER We have received really helpful and strategic advice from Geoff and UMIP which has certainly focused our thinking. UMIP quickly secured the IP on our technology and put forward an external expert who has really challenged our thinking and introduced us to potential new markets.” We met with Dr Bill Crowther from the School of Mechanical Aerospace and Civil Engineering to find out more about how UMIP Proof-of-Principle funding has helped him to exploit the commercial potential of the innovative miniature pump technology his team is developing. Bill began developing the technology, with the aerospace industry in mind, for producing small air jets to control the flow over wings. However, with help and advice from UMIP, the same principle is now being developed as a general technology for pumping both liquids and gases for non aerospace applications. Bill explains: “Our research group had been working closely with Airbus and BAE Systems to develop flow control actuators. It wasn't until we started working with our commercial mentor, Geoff Butcher, whose background cuts across the engineering sector that we realised there was also a huge potential for wider application, such as in pumping liquids for various medical applications. UMIP introduced us to Geoff who has assessed the technology and its potential for commercial applications and has encouraged us to explore other uses which we would otherwise not have considered.

Bill continues: “The market for pumps such as this is extremely diverse so we know there are lots of potential uses in sectors such as biomedical, gas sensing and electronics and we are working on getting the appropriate prototypes made. The funding we have received from the UMIP Proof-of-Principle Fund has been invaluable and will enable us to get to the stage where we can cost out the production. Now we are in the position to test out the mathematical model and to discover what companies’ requirements are so we can refine it to meet their needs. I would certainly urge others to seek the advice of UMIP sooner rather than later, as they can really help you explore commercial opportunities of your research work early on. Ultimately, if there is commercial potential, you can get going in the right direction at the beginning of the project, which saves a great deal of time further down the line.” Please see our IP Awareness Resource at www.manchester.ac.uk/ipresource for a valuable insight into the types of IP which can be used to protect novel ideas/inventions along with a series of guides and booklets which you may find useful.

UMIP PROOF-OF-PRINCIPLE (PoP) INVESTMENT SCHEME One of the significant added value aspects in technology transfer which attracts seed funders and licensees is Proof-of-Principle investment funding. To add value, UMIP manages, for the University, a ‘Proof-of-Principle’ account for projects with good potential. We encourage you to find out more and make an application. Applications are reviewed throughout the year. To find out more, please contact your UMIP commercialisation executive listed on the second page of this newsletter. To illustrate the diversity of projects awarded since October 2010, please see below: Dr Suresh Victor (School of Biomedicine) and Prof Patrick Gaydecki (School of Electrical and Electronic Engineering) Software for the automatic analysis of brain electrical activity in premature newborn babies > Licensing PoP awarded January 2011 Prof. Mark Boyett & Dr. Halina Dobrzynski (School of Biomedicine, Faculty of Medical and Human Sciences) and Prof. Henggui Zhang (School of Physics & Astronomy, Faculty of Engineering and Physical Sciences). Mathematical model of the human heart >Licensing PoP awarded February 2011 Dr Alan Brisdon - School of Chemistry, Faculty of Engineering and Physical Sciences, Prof Konstantin Novoselov - School of Physics,

Faculty of Engineering and Physical Sciences Fluorographene and 2D Fluropolymers >Spin-out / Licensing PoP awarded March 2011 Dr. Ian Kinloch, Prof. Robert Young - School of Materials, Faculty of Engineering and Physical Sciences, Prof Robert Dryfe, Prof Michael Turner - School of Chemistry, Faculty of Engineering and Physical Sciences Scalable Routes For Graphene Production > Spin-out / Licensing PoP awarded March 2011 Professor Jian Lu - School of Physics and Astronomy, Faculty of Engineering and Physical Sciences Thermo-responsive cell culture surfaces > Licensing PoP awarded October 2010 Drs Clare O’Donnell and Hema Radhakrishnan - Eye and Vision Science Centre, Faculty of Life Sciences Method of processing eye aberration measurements for keratoconic lens manufacture > Licensing PoP awarded January 2011 Dr Curtis Dobson - Faculty of Life Sciences MicroSensor > Spinout PoP awarded April 2011 Dr. Chris Rose - School of Cancer and Enabling Sciences, Faculty of Medical and Human Sciences Sparse Parametric Imaging > Licensing PoP awarded November 2010

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NORTH WEST CLEAN TECH COMPANY NUCLEAR PIONEERS In January, North West based water and waste treatment specialists Arvia Technology Ltd, and Nuclear operators Magnox Ltd, scooped a prestigious Rushlight clean technology award at one of the UK and Ireland’s premier environmental events.

Arvia Technology and Magnox Ltd scoop major environmental award

The companies jointly walked away with the coveted Rushlight Clean Environment Award, in recognition of their partnership in developing the Arvia Titan, a new and highly innovative

solution for the treatment of radioactive oil waste. Retrieving and processing this type of waste material is a major challenge, as part of decommissioning and cleaningup the UK’s nuclear legacy. Arvia Technology, a spin-out from The University of Manchester which started life as a Proof-of-Principle investment, developed new low carbon, waste and chemical free technology for the treatment of

water and waste water. However, innovative collaboration with nuclear specialists Magnox Ltd revealed a new and high-value, sustainable solution.

www.arviatechnology.com

GOVERNMENT VISITS TO UMIC AND UMIP companies associated with UMIC and UMIP. Mr Lewis has since written to say he plans to visit again and assist the University in developing its entrepreneurial networks.

science. Universities, small local businesses, global companies and financiers all need to be able to work together to cross fertilise ideas, enable innovation and growth. I hope UMIP can continue to work with all stakeholders in this way.”

Alan Lewis, CBE and Clive Rowland, UMIP CEO

In January this year, Chi Onwurah, the Shadow Minister for Innovation & Science (Business, Innovation and Skills Team) and MP for Newcastle Upon Tyne Central, visited.

Since our last issue of UMIP News, UMIC and UMIP have received three government visits. On Wednesday 20th April, Alan Lewis CBE, the Conservatives’ Vice Chairman for Business Relations visited to discover how universities are working with businesses to generate growth for the UK economy. He was particularly interested in meeting a selection

Having discussed education, innovation and enterprise with Professor Rod Coombs and Clive Rowland, CEO of UMIP, Ms Onwurah commented: “Innovation is the engine of growth and progress. I was impressed by the work UMIP is doing to commercialise innovation and help us keep our place at the forefront of world

Dr Cable was given a tour of the world-class business incubation resources in the Core Technology Facility. During the tour, Dr Cable discovered how the University identifies and supports innovative research commercialisation potential, nurtures and develops spin-out companies and licenses technology.

additional promotional literature, producing posters for display, promoting competitions and also arranging events for UMIP to attend.

UMIP itself and the University. It has helped me gain a better understanding of the company and also the range of other roles and tasks.”

Our online Intellectual Property Resource is proving to be popular with staff. Since we have been using innovative ways of promoting it campus-wide, we have seen a notable increase in visitors.”

It is evident that Sarah is full of enthusiasm, stating: “After 11 years, I still gain a great sense of achievement from my role and it has been fantastic to watch the development over the years. I am particularly looking forward to developments in UMI3.”

of spin-out companies from the University and local entrepreneurs to gain a clearer understanding of the issues which affect them in today’s economic climate. Welcomed by Professor Rod Coombs, Deputy President, and Peter Fell, Director of Regional and Economic Affairs, Alan Lewis took part in a roundtable discussion with 6 start-up

In October last year, The Rt Hon Vince Cable, Secretary of State for Business, Innovation and Skills, visited UMIC.

BEHIND THE SCENES Having been with the company for 11 years, Sarah has experience working in a variety of roles and took up her current position upon returning from maternity leave 5 years ago.

In this column, we will be taking a look behind the scenes to meet some of our UMIP support staff. Sarah Harris is Marketing Assistant with the Corporate Communications, PR and Media Team.

“A lot of my time is spent working with our marketing manager, Allan Prits, in increasing the awareness of UMIP throughout the University. One of my main remits is to discover ways of getting our message across to the many research groups by distributing our Researchers’ Guides,

Sarah added: “I enjoy how my role enables me to interact with a variety of people, both within

STOP PRESS... Arago Technology voted the UK’s most promising spin-out by business magazine, Real Business

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UMIP Newsletter June 2011