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Dr. Hargreaves is an established international star with outstanding reputations as both a basic scientist and a clinician-scientist. He has brought great credit to the UT Health Science Center and continues to generate outstanding discoveries that literally offer the potential to change the face of health care. Dr. Hargreaves holds the President’s Council Chair in Dental Research and most recently was named the USAA Foundation President’s Distinguished University Chair in Neurosciences. As the first holder of the neurosciences chair, he will help retain and recruit international leaders and foster interdisciplinary discovery in neuroscience research, a field that spans all five schools and multiple scientific disciplines at the Health Science Center. Since his arrival at the Health Science Center in 1997, Dr. Hargreaves has served as a principal or co-principal investigator on more than $40 million in National Institutes of Health grants, which include a MERIT award and seven R01 grants. He also serves as a co-principal investigator of the Clinical and Translational Science Award and a co-director of the T32 COSTAR training grant and the D.D.S./Ph.D. training track. Throughout his distinguished career, Dr. Hargreaves has served as a role model and mentor to countless students and post-doctoral fellows. Many of his former trainees have gone on to become faculty members at prominent universities across the country including at the UT Health Science Center. Dr. Hargreaves has played a major role in recruiting top scientists to the university who have gained international recognition for pain and wound healing research in the Dental School. One of his earliest contributions was the “Hargreaves Apparatus,” which measures response to infrared heat stimulus and is now a standard method in pain research. In 2009, Dr. Hargreaves and his lab reported the discovery of a family of endogenous capsaicin-like substances derived from linoleic acid.

The oxidized linoleic acid metabolites (OLAMs) potently activate the body’s major pain receptor, TRPV1, thereby contributing to the development of inflammatory pain. He and his team discovered how to block these capsaicin-like molecules and created a new class of nonaddictive painkillers. Dr. Hargreaves was funded by the Department of Defense for his research on the role of OLAMs in burn pain in wounded warriors. This is simply an outstanding example of translational research ranging from the bench to clinical studies in patients suffering from intense pain conditions. Dr. Hargreaves has since expanded his research to utilize stem cell and tissue engineering methods for improved dental care. He and his research group developed a novel method for determining pharmacological regulation of human nociceptive neurons by superfusion of dental pulp. This method has led to the discovery of peripheral genderspecific differences in peripheral pain mechanisms. He is a fellow of both the American College of Dentists and the International College of Dentists; a diplomate of the American Board of Endodontists; and a member of the Board of Directors of the American Association of Endodontists. He has also served as editor-in-chief of the Journal of Endodontics and has published nearly 200 peerreviewed papers in top-tier journals such as the Proceedings of the National Academy of Sciences, Nature, the Journal of Biological Chemistry and the Journal of Clinical Investigation. In turn, this has generated more than 7,600 lifetime citations. Dr. Hargreaves’ extensive recognition by scientists who cite his work, his development of a major pain testing method used around the world, and the impact of the recent discovery of endogenous TRPV1 antagonists, portray a senior scientist who continues to make landmark discoveries that generate high impact on his field. William W. Dodge, D.D.S., dean ad interim, Dental School

UT Health Science Center Presidential Awards 2013  

Recipients of the UT Health Science Center Presidential Awards 2013, represent exceptional achievement in their fields.

UT Health Science Center Presidential Awards 2013  

Recipients of the UT Health Science Center Presidential Awards 2013, represent exceptional achievement in their fields.