How JAK Inhibitors Stop Inflammation in Rheumatoid Arthritis
Lionel B. Ivashkiv MD Associate Chief Scientific Officer
It has not been completely understood exactly how JAK inhibitors suppress inflammation in RA. Now, an HSS study of two JAK inhibitors (tofacitinib and ruxolitinib) has revealed key mocleular mechanisms. The drugs are able to suppress macrophage activation and attenuate tumor necrosis factor (TNF) responses. Cytokine/chemokine production is diminished.
Regulation of Inflammatory Responses in Tumor Necrosis Factor-activated and RA Synovial Macrophages by Janus Kinase Inhibitors
Published in Arthritis & Rheumatism, (epub in advance of print) August, 2012. Authors
the 20 years or so I have been studyingHSS: Anna Yarilina MD, PhD The research team also found that Kai Xu inhibitors partially interfered with ulation ofJAKinflammation, this seems to be Chunhin Chan factor NF-KB, blocking the Lionel B. Ivashkiv MD the mosttranscription potent inhibitory mechanism expression of genes that encode proFull details on HSS.edu cytokines. we haveinflammatory ever seen.
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– Lionel Ivashkiv, MD, Associate Chief Scientific Officer,