Revealing How Steroids Work GRIP1 Required
Inez Rogatsky, PhD, and her lab discovered that without GRIP1, glucocorticoids (GC) fail to control inflammation. The team found that without GRIP1, the GC receptors on macrophages fail to repress NFkB activity. Transcription is “on”, pro-inflammatory cytokines keep being produced. Until now, the key molecular mechanisms of how GC stop inflamation had not been known.
Inez Rogatsky, PhD, HSS Associate Scientist
The Role of Transcriptional Coregulator Glucocorticoid hormone Receptor Interacting Protein-1 (GRIP1) in the Anti-inflammatory Actions of Glucocorticoids (GC)
Published in PNAS, July, 2012 Full Details now on HSS.edu
HSS Authors: Yurii Chinenov, PhD Rebecca Gupte Jana Dobrovolna, PhD Jamie R. Flammer, PhD Bill Liu Francesco E. Michelassi Inez Rogatsky, PhD next study
Learn more about the HSS Rheumatology Research Studies presented at the 2012 ACR Meeting.