The use of Nunc cell factory technology for large~scalecell c u l t ~ r eand viral ~ vaccine production offers a variety of adv~ntages. he^ utilized ~ r o p e r l ythe ~ storage space com~aredto units ~ e ~ ~less i r than e half the i n c ~ b a t i nand T-flask or roller bottle system. There is also a reduced possi~ilityfor conta~inance connected co~rectly~ the units are a closed sy$tem and do riot ~ e ~ u i ~ n t ~ ~ i n a tite ~ can , be closures or openings. If a unit is found to b unit is processed in a ed easily from the remainder of the batch. An f r ~ ~ t i oofr i the time required to process the 40 x 150 c d T-flasks that it r e ~ l ~ c e ~ icati~~ the s units can be re-used, m ~ ~ the i nactivity ~ e~tremely wever, the fact that the cell factory cannot be observed micro~ ~ o ~ i c amay l l y be the only d ~ a w b a cThis ~ . tech~icald i ~ c u l t ycan be o v e ~ ~ o by pre~aringa single plate unit in con~unctionwith the ~ u l t i ~ l acell t e factory, carefully e ~ a ~ i nthe i ~single g plate, the operator can determi~ethe growth pattern and cell m ~ ~ ~ ~ o l ~ ~ ~ .
u b o ~ t i ~ quality al of the raw ~ a t ~ r i a may l s be detrim he most obvious co ~ ~ e ~calf~ and o a~d un l ~appear ,~ to suppor
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