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8 Renal & Urology News 

october 2013

News in Brief

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Short Takes Exercise May Counter Diet-Related ED

occlusion had significantly smaller in-

Aerobic exercise training could be a

by ischemia. The decrease in plasma

practical means of preventing erectile

glutamate levels was associated

dysfunction (ED) brought on by a

with a significant 12.1% reduction in

Western diet, Christopher J. Wingard,

the volume of cerebral infarct, José

PhD, and colleagues at East Carolina

Sánchez-Prieto, PhD, of Universidad

University in Greenville, N.C., reported

Complutense in Madrid, and col-

online in the American Journal of Phys-

leagues reported online in The Journal

iology: Regulatory, Integrative, and

of Clinical Investigation.

creases in plasma glutamate induced

Comparative Physiology. In rats fed of saturated fat, omega-6 polyunsatu-

New Penile Cancer Guidelines Issued

rated fatty acids, and added sugar

Partial or total penectomy with a nega-

for 12 weeks, those that ran on a

tive surgical margin remains the gold

treadmill five days a week maintained

standard in managing invasive penile

erectile function, as measured by elec-

cancer, but less invasive options that

trical stimulation of the anesthetized

may improve quality of life are being

animals’ cavernosal nerve. Other rats

considered based on tumor stage

fed the same diet without exercising

and grade, according to new clinical

exhibited ED.

practice guidelines from the National

a Western diet containing high levels

Comprehensive Cancer Network and

Peritoneal Dialysis May Reduce Stroke Damage

published in the Journal of the Na-

Peritoneal dialysis (PD) may lower

(2013;11:659-662). Alternatives

glutamate levels released into the

include topical treatment with either

brain during ischemic stroke, minimiz-

imiquimod 5% or 5-fluorouracil cream,

ing tissue damage, according to study

or wide local excision with circumci-

involving rats. Rats administered PD

sion. Laser therapy and complete

2.5 hours after being subjected to

glansectomy are also appropriate in

permanent middle cerebral artery

specific circumstances.

tional Comprehensive Cancer Network

Newborn Circumcision in the U.S. Nationally, during the 32-year period from 1979 through 2010, the ­percentage of male newborns circumcised during their birth hospitalization decreased 10% overall. This percentage peaked in 1981 and dropped to its lowest level in 2007. 80 70 60 50 40











30 20 10 0

Source: CDC/National Center for Health Statistics, National Hospital Discharge Survey, 1979-2010.

RUN1013_NIB.indd 8

Cell Phone Allows Patients to Self-Test Albumin Level A

smartphone-based automated albumin-testing tool that weighs approximately one-third of a pound can determine urinary albumin levels and transmit results all within about five minutes. A digital sensing platform installed on the camera unit of a smartphone captures images of fluorescent assays confined within disposable test tubes, Aydogan Ozcan, PhD, and colleagues at the University of California Los Angeles explained in the Royal Society of Chemistry journal Lab on a Chip. It automatically analyzes them for sensitive and specific detection of urinary albumin using a battery-powered laser diode that probes the test-tube sample, interacts with the control tube, and collects the fluorescent emission. The phone camera captures the images of the fluorescent tubes and processes them within one second through an application running on the phone. The technology could be useful for early diagnosis of kidney disease or for monitoring chronically ill patients, particularly those with diabetes, hypertension, and/or cardiovascular diseases.

Combined High-Dosage Drugs Shown to Ease Resistant OAB E

lderly patients with overactive bladder (OAB) that does not respond sufficiently to dose-escalated antimuscarinic monotherapy may benefit from combined high-dosage antimuscarinics, researchers reported online in the UroToday International Journal. They studied 81 OAB patients older than 65 years who previously received double-dose antimuscarinic monotherapy with trospium. After at least six months of such treatment with no or short-lived symptom improvement, patients were treated with two antimuscarinics. Significant improvements were seen at a six-week follow-up, with the average number of daily incontinence events declining from six to two, average maximum bladder capacity increasing from 177 to 356 mL, average reflex volume rising from 149 to 284 mL, and average detrusor compliance improving from 16 to 37 mL/cm H 2O. Side effects were comparable to those of normal-dosed antimuscarinics.

Biomarker Found to Predict AKI in Emergency Patients A

prospective cohort study has shown plasma neutrophil gelatinase-associated lipocalin (NGAL) to be an accurate biomarker for predicting acute kidney injury (AKI) in patients admitted from the emergency department (ED). As Prasad Devarajan, MD, and colleagues described in the Clinical Journal of the American Society of Nephrology, 21% of 616 patients admitted to a hospital from the ED were classified as having AKI. Compared with other patients, this group had the highest median levels of plasma NGAL (146 to 174 ng/mL at various time points), which increased with AKI severity (207 to 244 ng/mL). The discriminative ability of plasma NGAL improved with higher grades of severity. The test distinguished AKI from normal function and transient azotemia, and could classify patients into low-, moderate-, and high-risk AKI. n

9/24/13 10:41 AM

Renal & Urology News October 2013 Issue  

Clinical news for nephrologists and urologists.

Renal & Urology News October 2013 Issue  

Clinical news for nephrologists and urologists.