What we build is knowledge. It is knowledge that informs the ways that patients and doctors talk to each other and think through the options for care. It helps policymakers to make sense of potential benefits and harms posed by emerging technologies. It is a trusted resource for journalists writ- ing about complex and controversial topics, such as synthetic biology, the increased prescribing of psychiatric drugs to children, and genetics research. It enriches scholarship in the sciences and the humanities. It is knowledge about ethical issues in medicine, the life sciences, and the environment.