__MAIN_TEXT__
feature-image

Page 1

Efficacy of a MULTICOMPONENT MYCOTOXIN detoxifying agent on concurrent exposure to ZEARALENONE and T-2 TOXIN in weaned pigs Jog Raj, 1Marko Vasiljević, 2PanagiotisTassis, 1Hunor Farkaš and 3KlausMänner

1

PATENT CO, DOO., Serbia School of Veterinary Medicine, Aristotle University of Thessaloniki, Greece 3 Institute of Animal Nutrition, Freie Universität Berlin, Germany Livestock Science, 242, 104295. doi: 10.1016/j.livsci.2020.104295 1 2

1


OBJECTIVE The aim of this in vivo study was to evaluate the efficacy of a novel multicomponent mycotoxin detoxifying agent as a mineral premix consisting of modified zeolite, Bacillus spp., yeast cell wall and silymarin (MMDA; Patent Co, Misicevo, Serbia) administered through feed in weaned pigs in feed to adsorb mycotoxins zearalenone (ZEN) and T-2.

MATERIALS & METHODS The multicomponent mycotoxin detoxifying

Group G1 served as control group that received feed

agent (MMDA; Patent Co, Misicevo, Serbia)

without any mycotoxins or MMDA.

evaluated consisted of: Group G2 received feed with spiked corn and wheat Modified zeolite

reaching contamination levels of 0.35 mg ZEN/kg and 0.5 mg T2/kg feed.

Bacillus spp.

Group G3 received contaminated feed (similar

Yeast cell wall

contamination levels with G2 group) with the addition of 1 g MMDA/kg.

Sylmarin In total, 112 post-weaning barrows

Group G4 received contaminated feed (similar

and gilts (Danbred x Pietrain) from the

contamination levels with G2 group) with the addition

25th day of age (day 0 of the trial) until

of 3 g MMDA/kg.

the 66th day of age (end of trial) were allocated in four trial groups. Each group consisted of 28 pigs placed in seven pens (replicates) with four animals in each pen.

Growth performance (body weight, average daily gain, feed conversion ratio), as well as hematological and serum biochemical parameters, fecal scoring, gross pathology, and mycotoxins

G1

G2

Mycotoxins MMDA

0.35 mg ZEN/kg feed 0.5 mg T2/kg feed MMDA

G3

G4

0.35 mg ZEN/kg feed 0.5 mg T2/kg feed 1 g MMDA/kg

0.35 mg ZEN/kg feed 0.5 mg T2/kg feed 3 g MMDA/kg

residue levels in liver, spleen, kidneys and muscle tissue were assessed.

2


RESULTS

Results suggested that inclusion of MMDA in trial diets induced dosedependent reduction of genital organ relative weight (ovaries, cornu uteri and vagina-vestibule) and vulva size, which had been increased due to ZEN ingestion in G2 group. Additionally, in both groups that received MMDA, significantly reduced residue levels of ZEN in liver and kidney samples were observed, in comparison with G2 group. A significant reduction of the residue levels of T-2/HT-2 toxins was also observed in kidney samples of MMDA-fed groups when compared with G2 group.

Taken together, MMDA added to diets containing ZEN and T-2 toxin has a dosedependent affinity for ZEN and, to a lower extent, for T2 toxin, whereas its beneficial effects seem to be greater at inclusion levels of 3 g MMDA/kg feed.

3

Profile for agrinews

Efficacy of a multicomponent mycotoxin detoxifying agent on weaned pigs  

Efficacy of a multicomponent mycotoxin detoxifying agent on weaned pigs  

Recommendations could not be loaded

Recommendations could not be loaded

Recommendations could not be loaded

Recommendations could not be loaded