When applying zits medicine, cover your entire face instead of just addressing visible problem areas. You could have a pimple underneath your skin that is waiting to rear it’s ugly head! You need to apply the medication to your forehead, too. Change your pillowcase everyday to help with zits. Consider the following. Also, think of how you turn and roll onto this each night. You can avoid the dirt and grime that accumulates by having a washed, fresh pillowcase to lay your head on each night.