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05/05/2011

Content • Neuropharmacology • Pharmacology of inflammation

Pharmacology Review

• More neuropharmacology

Created by Sebastian Leuschner ©

Precursor

Pharmacology of Inflammation Enzyme

G-protein coupled receptor

Precursor -> Neurotransmitter

Phospholipase A2

Vesicle Ca2+ dependent Exocytosis

Ligand-gated ion channel

Arachidonic Acid

Voltage gated Na+ channel

Enzymatic breakdown

Cyclo-oxygenase (COX)

Lipoxygenase (LO)

Na+

Re-uptake transporter

Leukotrienes

Prostanoids Modulator

PGE2 PGI2

PGF2α

LTA4, LTB4, LTC4, LTD4...

TxA2

Enzyme Breakdown products

Epilepsy • Generalised seizures – Tonic-clonic – Myoclonic (only generalised seizure w/o LOC) – Absence – Atonic / clonic

• Partial seizures – Effects depend on brain regions involved

Depression • Monoamine theory of depression – Depression due to reduced levels of monoamine neurotransmitters – Drug treatments aimed at increasing these

• Other theories: – Hippocampal volume loss – Reduced levels of brain-derived neurotrophic factor (BDNF)

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05/05/2011

Schizophrenia • Dopamine theory – Excess of dopamine causes symptoms of schizophrenia – Drug treatment block dopaminergic transmission

• Other theories

Questions?

– Glutamate theory (low levels of NMDA receptors)

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Stage 2 Pharmacology Presentation  

• Generalised seizures • Monoamine theory of depression • Partial seizures • Other theories: –Effects depend on brain regions involved Leuko...

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