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Georgia Health Sciences Research Community






New Extramural Grant Awards Recent High-Impact Publications Warrior Care Gordon Conference Featured Researcher Ga. Bio Life Sciences: a, b Wong to Discuss Research Institutional Review Board Updates Augusta State University a, b, c







Young Research Faculty Speakers Scheduled Office of Clinical Investigative Services Training Laboratory Animal Services Division of Sponsored Programs Administration Technology Transfer & Economic Development Conflict of Interest







S U M M E R Contact information:

RESEARCH Impact is published quarterly for the GHSU Research Community by the Office of the Senior Vice President for Research. • Dr. Mark Hamrick—Senior

Vice President for Research, and Professor, Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics (mhamrick@

• Publications Director—Christine Hurley Deriso (

• Editor/Designers—Patricia Johnson

( and Tricia Perea (

• Photographers—Patricia Johnson, Phil Jones, Ga. Tech, UCLA , Innoventure, University of Memphis and U.S. Army

Links: Submissions:

Please send news and updates for future editions to Dr. Mark Hamrick, (mhamrick@georgiahealth. edu).

New Extramural Grant Awards

� � � �

Lin Mei, Ph.D.

Jay Hegde, Ph.D.

Lin Mei, Ph.D.; Director; Institute of Molecular Medicine and Genetics, “Mechanisms of Neuregulin 1 Protection of Excitatory Neurons in Stroke Models,” National Institutes of Health / DHHS. Javier Stern, Ph.D., M.D.; Professor; Department of Physiology, “Central Neuronal-Glial Mechanisms and Neurohumoral Activation in Hypertension,” National Heart, Lung and Blood Institute / NIH / DHHS.

Phillip J. Buckhaults, Ph.D.; Associate Professor; Cancer Research Center, “A Genetic Model for Early-Onset Breast and Colon Cancer in African Americans,” National Cancer Institute / NIH / DHHS. Shuang Huang, Ph.D.; Professor; Department of Biochemistry & Molecular Biology, “Combat ing Lung Cancer Metastasis by Raising Intracellular cAMP Concentration,” US Army Medical Research Acquisition Activity / DOD.

� Jay Hegde, Ph.D.; Assistant Professor; Department of Ophthalmology, “Neural Mechanisms of Camouflage-Breaking Under Natural Viewing Conditions: High-Resolution Electroencepha longraphical (EEG) Measurements of Brain Activity,” Army Research Office. �

Analia Loria, Ph.D.; Assistant Research Scientist; MCG – Experimental Medicine, “Early Life Stress and Chronic Control of Blood Pressure,” National Heart, Lung, & Blood Institute / NIH / DHHS.

Recent High-Impact Publications �

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL. Immunol Rev. 2012 Sep;249(1):135-57. Impact Factor = 11.1

Translocations Disrupting PHF21A in the Potocki-Shaffer-Syndrome Region Are Associated with Intellectual Disability and Craniofacial Anomalies. Kim HG, Kim HT, Leach NT, Lan F, Ullmann R, Silahtaroglu A, Kurth I, Nowka A, Seong IS, Shen Y, Talkowski ME, Ruderfer D, Lee JH, Glotzbach C, Ha K, Kjaergaard S, Levin AV, Romeike BF, Kleefstra T, Bartsch O, Elsea SH, Jabs EW, Macdonald ME, Harris DJ, Quade BJ, Ropers HH, Shaffer LG, Kutsche K, Layman LC, Tommerup N, Kalscheuer VM, Shi Y, Morton CC, Kim CH, Gusella JF. Am J Hum Genet. 2012 Jul 13;91(1):56-72. Impact Factor=10.6

Phil Jones

Patricia Johnson Phil Jones

Distinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation. Wu H, Lu Y, Shen C, Patel N, Gan L, Xiong WC, Mei L. Neuron. 2012 Jul 12;75(1):94-107. Impact Factor = 14.7

Patricia Johnson

Warrior Care Symposium Slated Oct. 29

the Army’s Vice Chief of Staff. He received the Henry M. Jackson Foundation’s 2011 Hero of Military Medicine Award for assisting soldiers with traumatic brain injury and post-traumatic stress.  He has also served as Senior Military Assistant to the Secretary of Defense and Commander of the Multi-National Corps in Iraq, among other positions.  The deadline to register for the

symposium is Oct. 1. To register or view the full program, visit http:// warriorcare/index.html

“Eliminating the stigma associated with seeking treatment for the invisible wounds of war.”

 Retired U.S. Army Gen. Peter W. Chiarelli and Lt. Gen. David Fridovich will be the featured keynote speakers at the second annual symposium on Research Advances in Warrior Care Oct. 29 at Augusta’s Kroc Center.  “The symposium is sponsored by One Mind for Research (http://1mind4research. org), an independent, non-profit organization uniting health care providers, researchers, academicians and industry leaders on a global scale to cure brain disorders.”  The organization was founded by U.S. Rep. Patrick Kennedy and mental health advocate Garen Staglin. Chiarelli, Chief Executive Officer of One Mind for Research, recently served as

Gordon Conference Draws Nobel Laureates

 A neurobiology conference chaired by Dr. Lin Mei, Professor and Director of the GHSU Institute of Molecular

Medicine and Genetics, drew more 170

neuroscientists worldwide, including

two Nobel Laureates and many members of the National Academy of Science.  “The 2012 Gordon Research

Conference on Molecular and Cellular Neurobiology, held in Hong Kong June 17-22 at picturesque Hong Kong University of Science and Technology, featured updates in areas including neuronal polarity, circuitry assembly and

function, plasticity, molecular basis of behavior, regenerative neuroscience and brain disorders.” Attendance was so highly coveted that many applications had to be turned down due to capacity.  The meeting, which has stimulated interdisciplinary and international collaboration, enabled junior scientists, graduate students and postdoctoral fellows to present their work, exchange ideas and explore career options with neuroscience leaders in both formal and informal settings. Twelve junior investigators were among the conference’s 36 speakers. Ryan Bates, a GHSU Ph.D. student, chaired the conference.

Featured Researcher Dr. Julia Brittain

Background: Brittain joined GHSU in 2012 as Associate Profes-

sor of Cellular Biology & Anatomy and the Vascular Biology Center. She completed graduate training in pharmacology and a postdoctoral fellowship at the School of Medicine at the University of North Carolina-Chapel Hill School of Medicine, then joined the UNC faculty as a K12 Scholar. The scholarship funded two additional years of training in clinical research.

Research Focus: Brittain studies red blood cell adhesion and

pathology in sickle cell disease. Her lab investigates how blood cells interact with and influence each other. She seeks to learn how this interaction contributes to declining pulmonary and renal function in sickle cell disease. She also wants to understand how red blood cells in various disease states acquire the ability to adhere to the vessel wall, promoting coagulation activation and inflammation. Research in her lab involves clinical trials, direct study with patient samples and models of human disease in mice.


Brittain has an R01 from the National Institute of Diabetes and Digestive and Kidney Diseases to study how chronic kidney failure and hemodialysis affects red blood cell-induced coagulation and blood clotting. She also holds an R21 to investigate a novel mechanism of red blood cell-mediated coagulation activation in sickle cell disease. She serves on the World Journal of Hematology editorial board.

Goals: “I would like to see more of a relationship between basic

researchers and clinicians at GHSU. It is at this interface of expertise where novel therapies and the ability to implement them truly come to light for our patients.�

GeorgiaBio Life Sciences Summit to Feature Extensive GHSU Participation

“More than 70 experts will explore trends and issues in therapeutics, diagnostics and vaccines; medical technology and devices; the changing landscape of pharma; and exciting new science.”

 The summit has become a premier bioscience conference in the Southeast, hosting nearly 1,000 executives, scientists and public policy officials statewide and beyond. It is the one day a year that unites academia, industry and government to showcase Georgia’s innovation in areas including basic research, manufacturing, the environment and the health and well-being of both people and animals.


 The deadline to submit abstracts

is Aug. 31. For more information, including registration and abstract submission, visit

Phil Jones

 The 2012 Georgia Life Sciences Summit, “Innovation for Global Health,” will be held Oct. 3 at the Georgia International Convention Center in Atlanta.

GeorgiaBio Life Sciences

phil jones

Patricia Johnson

Summit to Feature Extensive GHSU Participation


N O T E S :

 GHSU will play several key roles in this year’s   summit. “Mark Hamrick, Senior Vice

President for Research, will co-chair the Program Committee with Brian Adams of Arbor Pharmaceuticals.” Dr. Chris McKinney, Associate Vice President of Technology Transfer & Economic Development, will moderate the session, “The Next Generation of Georgia’s Life Sciences Companies.”

 Panelists will include Dr. Daniel White, President and CEO of Clearside Biomedical; Dr. James W. Lillard Jr., Associate Dean for Research Affairs at the Morehouse School of Medicine; Dr. Kevin Schultz of Pathens Inc.; and Dr. Richard A. McIndoe, GHSU Vice President of Operations and Information Technology, Jinfiniti Biosciences LLC, Center of Innovation for Life Sciences.

 The summit is hosted by Georgia Bio, a nonprofit association whose members include bioscience companies, universities, medical centers and other business groups. Alex Gorsky, CEO of Johnson & Johnson, and Julie Kim, Global Franchise Head of Biotherapeutics for Baxter International, will deliver keynote addresses.

Dr. Wong to Discuss Research

 Dr. David Wong, Associate Dean of Research and Professor of Oral Biology and Medicine at the UCLA School of Dentistry, will discuss “Impactful Oral, Dental and Craniofacial Research” at the Sept. 27 Vice Presidents’ Research Exchange. The lecture will begin at noon in room 1222 of the Health Sciences Building. The GHSU and Augusta State University communities are invited to the lecture, which is sponsored by the GHSU College of Dental Medicine, Cancer Center and Center for Biotechnology and Genomic Medicine.  Wong began his career at the Harvard School of Dental Medicine, heading the Division of Oral Pathology from 1992 to 2001. In 2002, he joined the UCLA School of Dentistry as Professor and Director of the Dental Research Institute. He was named Chair of the Division of Oral Biology and Medicine in 2003, one of the six academic divisions in the UCLA School of Dentistry.  His research into the genomic and proteomic molecular determinants of head and neck cancer has been continuously funded by the National

Institute of Dental and Craniofacial Research and the National Cancer Institute for 18 years. He currently has NIDCR funding to create the UCLA Collaborative Oral Fluid Diagnostic Research Center (developing nano-technology-based microsensors to diagnose oral cancer and oral pathogens through saliva) and the Human Salivary Proteome Project (deciphering the entire catalogue of proteins in human saliva).  Wong is intimately involved with the research training and career development of dentist-scientists and oral health researchers. He was the program director of the Harvard Institutional Dentist Scientist Program from 1994 to 2001. He has trained over 40 dentist-scientists and graduate students. He is also the Program Director of the recently funded “UCLA Fundamental Clinical Research Training Program,” a five-year comprehensive research-training program funded by the NIDCR. Wong chairs the NIDCR Special Grant Review Committee.

Patricia Johnson


Oral, Dental, Craniofacial Research

Institutional Review Board Updates 窶サhe Human Assurance Committee Policy for the Continuing Review has

been revised and condensed. Visit

policies/ Continuing%20Review06%2021%2012.pdf New IRB One-Time Fee Policy Effective September 1, 2012,

窶アll industry-sponsored studies with a budget of at least $10,000 will be

charged a one-time Institutional Review Board fee of $4,000 for non-oncology studies and $4,500 for oncology studies. For more information, contact Angela Randazzo at or 706-721-9346.





Foundation or MCG Research Institute-sponsored studies industry-sponsored studies with budgets less than $10,000 and academic studies government-sponsored studies (including National Institutes of Health)

investigator-initiated studies without pharmaceutical or device company support

Augusta State University Research Activities

Jake Reed


 ASU student Jake Reed spent six weeks this summer pursuing virology

research in Belgium. The Belgium research built on Reed’s work last year in the lab of Dr. Chad Stephens seeking to synthesize potential drug inhibitors for Human Herpes Virus-6, which causes roseola and may contribute to other diseases, including multiple sclerosis, epilepsy, chronic fatigue

He has prepared several new compounds for testing against HHV-6, as well as other viruses. syndrome and some cancers.

 The Belgium research took place at the Rega Institute for Medical Research in Leuven, Belgium. Reed worked in the laboratory of Dr. Lieve Naesens, a virologist who evaluated the antiviral activity of compounds developed in the ASU lab. Naesens and a colleague recently submitted a joint patent application. Reed also worked with the influenza A virus in Naesens’ lab. He has begun his

Reed’s research and trip to Belgium were funded by the ASU Center for Undergraduate Research and Scholarship, the ASU Foundation, the HHV-6 Foundation and the Rega Institute for Medical Research.

Patricia Johnson

thesis based on his research both at ASU and in Belgium.

Augusta State University Research Activities Continued...


 Dr. Trinanjan Datta, Assistant Professor of Physics,

recently discussed his research at the 2012 Gordon Research Conference and Seminar on Correlated Electron Systems. The conference was held in June at Mount Holyoke College.  Datta discussed Effects of Magnetic Field, Anisotropy, and Biquadratic Interactions in Type-IIA fcc Antiferromagnets Studied by Linear Spin-Wave Theory. The results of this work are published in the February 2012 issue of Physical Review B. The published work predicts not only

the effect of external magnetic field and anisotropy in three-dimensional quantum FCC magnets, but also the neutron scattering spectra and structure factor for MnO and CoO. Such theoretical predictions on magnetic compounds

guide material scientists to fabricate novel magnetic devices for modern technological purposes.  Datta also visited Sun Yat-Sen University in Guangzhou, China this summer on an invited collaborative research trip. He collaborated with Dr. Daoxin Yao and undergraduate research student Zewei Chen on a theoretical project related to spin conductivity in magnetic materials. Datta also presented an invited talk on frustrated magnetism at Sun Yat-Sen University.

A /

Dr. Kathleen Searles in the Department of Political Science is a co-author of “Predicting Presidential Appearances During Midterm Elections” in American Political Research.

Dr. Richard Topolski in the Department of Psychology is

participating in a $300,000 Army Research Institute study called

“Innovative Methods for Capturing and Transferring Detection Expertise.” The researchers are also using a database of 8,880 patients to identify factors related to breast cancer outcomes.

Augusta State University Research Activities Continued...


Dr. Michael B. Bishku in the Department of History, Anthropology & Philosophy, published “Ethiopia and Israel: A Long-term Relationship on the Periphery of the Arab and Muslim Worlds,” in Les relations de l’Ethiopie avec les nations étrangères:

histoires humaines et diplomatiques (des origines à nos jours), ed. Lukian Prijac (Berlin: LIT Verlag, 2012). He also presented “Is it an Arab Spring or Business as Usual? What it Means for the U.S. and the Region,” to the 513th Military Intelligence Brigade at Fort Gordon in April.

Young Research Faculty Roundtable Scheduled Sept. 27


Patricia Johnson



A GHSU-ASU young research faculty roundtable will be held at the Enterprise Mill Fat Man’s facility Sept. 27 from 5:30-7:30 p.m. All ages are welcome. The event promises to build on the success of last year’s inaugural event in uniting research faculty from both institutions in an informal, collegial setting as consolidation nears.

Speakers Scheduled ASU Science/Math Series

The following speakers are scheduled for this fall’s ASU Science and Math Seminar Series, sponsored by the Savannah River Scholars Program. All seminars will be held at Science Hall W-1002 at 1 p.m. For more information, visit

Phil Jones

Sept. 14 Dr. Magnani

Oct. 12 Yang

Nov. 9 Curtis

Sept. 14 Dr. M. Beatrice Magnani Center for Earthquake Research and Information University of Memphis

“The New Madrid Earthquakes Two Hundred Years Later: What Have We Learned About Earthquakes at the Center of Tectonic Plates?” Oct. 12 Zhiyong Yang Brain and Behavior Discovery Institute GHSU

“Computational Principles of Natural Vision”

Nov. 9 Jennifer Curtis Department of Physics Georgia Institute of Technology

“Nanopatterning Light and Molecules for Single-Cell Studies“

Office of Clinical Investigative Services 窶サhe Translational Research Unit is now available for clinical trials requiring

inpatient facilities. Located on the eighth floor of Georgia Health Sciences Medical Center, the

unit offers space and services for clinical research participants. They and their family members have the convenience of receiving study services in setting customized to meet their needs. For more information about the unit, a collaborative effort of the Office of Clinical Investigative Services and the Georgia Health Sciences Health System, call 706-721-6247 or visit

Casey Stallings, an Office Specialist, provides administrative support to

the Office of Human Research Protection and the Institutional Review Board and assists GHSU research team members.

Phil Jones

the Human Assurance Committee and oversees amendments and continuing reviews.


Rebecca Miller, an IRB Specialist, provides administrative support to

t h

ogy/ hematology, conducts audits, serves as a resource to coordinators and investigators, assists with training and education, and reviews reportable events.


Sandra White, a full-time clinical trials auditor with a focus on oncol-




Email for details.

eIRB Training

Sept. 4 9-11 a.m. Room 2134, Pavilion III


Lunch and Learn

Topic: “Quality Control for the eIRB System: Developing More Efficient Navigation” Sept. 14 11 a.m. Room 2109, Interdisciplinary Research Building

Topic: “PowerTrials: Pre-Screening Tool” Sept. 21 1 p.m. Room 4080, Georgia Health Sciences Medical Center

New Research Team Member Orientation

eIRB Training

Oct. 9 9-11 a.m. Room 2134, Pavilion III

Investigator University

Oct. 5 9 a.m. to noon Room 3302, Pavilion III

Coordinator University 101

Oct. 22-24 8:30 a.m. to 12:30 p.m. Room 2109, Interdisciplinary Research Building To register, visit MCStrategies at Registration deadline: Sept. 14

Register your department for this two-hour course for principal investigators and sub-investigators. Continuing education credits available.

Office of Laboratory Animal Services The office has submitted a “Developing and Improving Institutional Animal Resources” (G20) application to replace the cage rack washer in the Research and Education Building and to purchase additional HEPA-filtered procedure stations to help mitigate allergens and cross-contamination. The �

office is consulting with Charles River Laboratories to minimize risks of rodent pathogen exposures and enhance the sentinel health surveillance program. Also, GHSU core labs are being assessed as possible resources for diagnostic needs to improve efficiency and decrease costs. �

The U.S. Department of Agriculture visited the office recently, citing only four

deficiencies, all of which have been corrected.

The office now uses disposable caging to maintain husbandry activities outside the vivarium, some ABSL2 areas and chemical hazard areas.

This will help minimize pathogens entering the animal facility from satellite areas via cage wash; decrease staff exposure to the hazards, including potential allergens; decrease labor costs associated with autoclaving and cage wash; and improve containment and disposal of hazardous materials.

Patricia Johnson

Division of Sponsored Programs Administration

The division requires three full business days to review complete research proposals. This review assures federal agencies and other sponsors that GHSU is aware

of the scope of the work in the proposal, that adequate resources are available to complete the project, that the budget has been reviewed and approved, that GHSU has resources to meet cost-share or other financial commitments, that compliance protocols and assurances are in place and that intellectual property is protected.

Division of Sponsored Programs Administration E - S P R O U T T O R O U T E P R O P O S A L S Risks associated with last-minute submissions include missing the sponsor deadline, having proposals returned for lack of compliance with program specifications and having to withdraw the proposal due to errors.   

Funding agencies know when proposals are submitted and are becoming increasingly concerned that research institutions are not allowing adequate time to properly review them. Auditors also note patterns of when proposals are submitted to ensure that universities follow their own review policies and procedures. Perhaps most importantly, note that proposals prepared well in advance are funded at a higher rate than those prepared at the last minute.

The National Institutes of Health Loan Repayment Program will accept new and renewed applications Sept. 1 through Nov. 15. The program aims to ease the �

debt burden clinical scientists may have incurred during professional/graduate school and residency training. Criteria include a demonstrated commitment to a research career and having a debt-to-salary ratio of at least 20 percent. Contact Sarah White,, or Sheree Wright,, for other criteria or more information.

� Have you noticed? This box on our homepage ( html) is intended to generate your feedback. You can alert us to problems, ask questions or post comments, including those about pre- and post-awards. Posts are confidential unless you want a response, in which case we request your name and email address. Your input is welcomed and valued. � We recommend reading “Reforming Regulation of Research Universities,” an article in the summer 2011 edition of Issues in Science and Technology. The article highlights the increasing costs of regulatory burdens associated with federally sponsored research. The authors makes recommendations regarding effort reporting, human subject and animal research, export regulation, conflicts of interest, hazardous materials and financial reporting.

Office of Technology Transfer & Economic Development �

Recent federal legislation has dramatically overhauled the U.S. patent system. The Ameri-

ca Invents Act, signed into law last fall, changes the “first to invent” system to a “first to file” approach typical of most other countries. Priority goes not to who in-

vented first, but who filed first for a patent. The change takes effect March 16, 2013. We are well-prepared for the changes, but don’t hesitate to contact Chris McKinney at 706-721-4062 for more information. We also recommend attending Dr. Charles Vorndran’s Oct. 24 lunch-and-learn presentation on the topic. Lunch is provided. To register or for more information, contact Sandra Jackson at sanjackson@ or 706-721-0153.

The Georgia Research Alliance has awarded Dr. Lin Mei a Phase I VentureLab grant to explore commercialization of Erbin, a protein that regulates ErbB4/Her2 stability, for breast cancer treatment. The alliance has also awarded Dr.

Phil Jones

Olivier Rixe, Professor in the GHSU Cancer Center, and Sisene Oncology Inc. a $100,000 Phase 2 VentureLab grant. Sisene Oncology is a spinoff of Sisene Biotech (France), and is moving into GHSU’s biobusiness incubator. The goal for 2013 is to complete preclinical studies to file an Investigational New Drug request for a Phase I clinical trial in solid tumors.

Office of Technology Transfer & Economic Development Drs. Chris McKinney and Carl Clark were among the 15,000 attendees at BIO (, the world’s largest biotech partnering and trade show, in Boston in June.

is an innovation conference and trade show that has been hugely successful in the Greenville, S.C., region for nearly a decade. The goal is to have a similar major event in Augusta, enabling participants to pitch innovations, learn about area resources and network with colleagues. Stay tuned for details!


Dr. Chris McKinney is working with the Savannah River National Laboratory to bring InnoVenture to the Augusta area in 2013. InnoVenture ( �


Participants visited with investors, biotech/ pharma firms and others engaged in fostering high-tech innovation and commercialization. McKinney has also recently discussed GHSU’s economic impact, express licensing and prototyping capabilities in venues including the “Buzz on Biz” radio program and meetings of the Southeast Technology Transfer Directors, the Future Industries and the Global Center for Medical Innovation.

Conflict of Interest

Patricia Johnson

The Georgia Health Sciences enterprise recently adopted a single comprehensive conflict-of-interest policy in response to a U.S. Department of Health and Human Services ruling that went into effect Aug. 24. The ruling, an overhaul of the 1995 Public Health Service conflict-of-interest policy, serves to: �

Expand the amount of information that must be disclosed

Require an annual disclosure of outside activities and interests (which

Lower the threshold of significant financial interest and broaden its scope to include all of an investigator’s responsibilities on behalf of the institution

Shift the burden of determining the relationship between a significant financial interest and an institution’s research

must be updated throughout the year)

Conflict of Interest  The revisions require investigators to complete conflict-of-interest training before beginning Public

Health Service-funded research, disclose all significant financial interests before submitting a proposal to the Public Health Service, update their disclosure at least annually during the period covered by the grant or within 30 days of identifying or acquiring a new significant financial interest and disclosing reimbursed or sponsored travel paid by an entity on behalf of the investigator.

(Travel sponsored by or reimbursed by the federal government, U.S. institutions of higher learning and their affiliated research institutes, medical centers or academic teaching hospitals are excluded.) Also, the monetary threshold for a significant financial interest was lowered to $5,000.  Representatives from Compliance and Enterprise Risk Management, Legal Affairs and the Division of Sponsored Program Administration and others have been working to ensure enterprise compliance with the new regulations. Procedural changes that implement the new policy will be announced soon.

  For more information, contact Sarah White ( or 1-3087) or

Patricia Johnson

Sheree Wright ( or 1-6480). To read the new Georgia Health Sciences conflict-of-interest policy, visit http://www.georgiahealth. edu/SPA/Final%20Enterprise%20COI%20Policy%208-14-12.pdf



F E E D B A C K :


Georgia Health Sciences Research Community

Research Impact Summer 2012  

Georgia Health Sciences Research Community