More than a mycotoxin binder… Anta®Ferm MT FlavoMax
by Monika Korzekwa, Dr Eckel
ycotoxin contamination of feed stuff often involves multiple toxins affecting various aspects of animal health, gut integrity, and animal performance. This is mainly caused by the detrimental effects mycotoxins have on the immune system, the gut barrier or the oxidative status of the animals. Effects that can be seen are, for instance, enlarged or shrunken organs as well as inflamed tissues. Binding components efficacy is essential to prevent the maximum of toxins from entering the digestive tract. But as mycotoxins and their metabolites are so numerous with different chemical structures (polarity, size, conformation, etc), no binder is able to bind efficiently all categories of mycotoxins. In addition to special care to prevent the growth of moulds, detoxification measures, reduction of gastrointestinal absorption with mycotoxin binders, there is a need for prevention of the mycotoxin-induced toxic effects once the toxin is ingested. Nutritional approaches, such as supplementation of nutrients, food components, or additives with protective effects against mycotoxin toxicity are gaining interest. In response, Dr Eckel has developed a new generation of mycotoxin binder to face the challenges of modern animal production.
Comprehensive solution fights 4 main toxicity mechanisms
Anta®Ferm MT FlavoMax is a comprehensive solution that targets the 4 main toxicity mechanisms to prevent the harmful effects of a wide range of mycotoxins. Anta®Ferm MT FlavoMax impacts directly on the toxins (binding components) and on the animal, activating its own natural defences (fig 1): • Binding of mycotoxins • Reduction of oxidative stress • Protection of the gut barrier function including antiinflammatory effects along the digestive tract • Modulation of the immune system
Binding of mycotoxins
Anta®Ferm MT Flavomax includes a proven combination of selected mineral clays and yeast cell walls, showing an excellent binding efficacy of different mycotoxins (Lohölter et al. 2013). The selected mineral clays bind mycotoxins in their interlayers by a process called chemisorption. Yeast cell walls are composed of complex polymers of β-(1,3)/(1,6) glucan, mannan- oligosaccharide (MOS) and chitin. MOS is located on the surface of the cell wall and plays an important role in binding mycotoxins and improving the micro-environment of the animal’s digestive tract. The efficacy of glucomannan-containing yeast products as mycotoxin absorbents in feed has been investigated in several studies on animals. As a mycotoxin binder, yeast cell walls have numerous characteristics including: Binding mycotoxins, especially zearalenone (ZEN); unaffected by the pH of the gastrointestinal tract; without changing nutritional value (regarding mineral and vitamin) in feed; no residue in animal.
Reduction of oxidative stress.
Some mycotoxins (ie, OTA, FB1, AFB1, DON, and T2) have been known to produce damages by increasing oxidative stress. The animal has to detoxify mycotoxins, which is called xenobiotic metabolisation. During this detoxification process, free radicals are produced that increase levels of oxidative stress resulting in DNA damage, lipid peroxidation and 54 | January 2016 - Milling and Grain