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BIOLEX® MB40

Neutralising mycotoxins Bild by Dr Jan Frericks, Leiber GmbH, Germany

E

NEUTRALIZING MYCOTOXINS - BIOLEX® MB40 WITH KEY FUNCTIONS INSIDE THE GUT using synthetic buffer solution and porcine gastrointestinal juice. nvironmental toxins not only affect the

(%)

54 | September 2015 - Milling and Grain

In the 2nd phase of the trial, the University of Vienna has tested the adsorption capacity of various toxin binders and

Under these between the and their effi ning approx. good adsorp and also the Furthermore, ZEA was pro (Fig. 3).

Fig.3: Binding anorgan

100 x

80 60 (%)

(%)

Initially, 10 milligrams (mg) of a toxin binder or Biolex®MB40 health and performance of livestock Environmental toxins not onlydegree, affect they the health and performance livestock a substantial degree, and 0.2 mgofZEA were to added to a standard citrate buffer (5 ml) to amay substantial also pose but they also pose aarisk risk to tohuman humanhealth. health.Mycotoxins Mycotoxins in particular canvalue enterofthe food chain1 through aniwith a pH three. Figure shows that the binding capacity mal feed and foodstuffs and have high the riskfood potential. thean world these fungal are ever-present agricultural incubation period toxins of 24 hours in synthetic in buffer is, on in particular canaenter chain All overafter one hand, relatively low, and that, on the other hand, there through animal feed and foodstuffs products depending on the respective crop type, weather conditions, producer region and the storage conditions.isThe hardly any furthermore difference between the various toxinsubstances binders(OTA) and(zeoyeast andthe have a hightoxins risk potential. All It was proven that anorganic negative impacts of primary Deoxynivalenol (DON), Zearalenone (ZEA), Aflatoxin B1 and Ochratoxin are products. over the world these fungal toxins are lite/bentonite) haveextent a rather ZEA adsorption capacity well researched and documented. However, it remains largely unknown to what thelow interactions between these It was furthermore that an-organic substances products under these conditions. mycotoxins and theever-present numerous in lessagricultural well-researched environmental toxins pose a proven risk to animal health. Under these(zeolite/ circumbentonite) have a rather low ZEA adsorption capacity under these depending on the respective crop type, weather conditions, stances, one would expect to see increased susceptibility to infections, diminished immune system efficiency and an increThis type of testing therefore seems unsuitable to evaluate conditions. producer region and the storage conditions. ased risk of autoimmune diseases even at very low concentrations.the Especially breeder animals are at risk Furthermore, in the long term. performance of mycotoxin binders. it can This type of testing therefore seems unsuitable to evaluate The negative impacts of the primary toxins Deoxynivalenol be assumed that simple adsorbents also bind other essen(DON), Zearalenone (ZEA), Aflatoxin B1 and Ochratoxin tial nutrients without promoting the detoxification process (OTA) are well researched and documented. However, it remains Fig.1: capacity of toxin binders and Biolex® MB40 Merely binding mycotoxins simply in theAdsorption gut. largely unknown to what extent the interactions between these in synthetic buffer solution for ZEA (%) isn‘t enough mycotoxins and the numerous less well-researched environmental 100 Activating the gut and strengthening heating nor preserving during processing statoxinsNeither pose a risk to animal health. Under these the circumstances, 80 the intestinal barrier ges can render accumulated fungaltotoxins harmless. one would expect to seethe increased susceptibility infections, 60 Biolex® MB40 is a cell wall product made from brewers‘ Once immune the available breeding, cultivation diminished systemmeasures efficiencyinand an increased risk of and 40 yeast Saccharomyces cerevisiae with a high content of autoimmune diseases even at very low concentrations. Breeder harvesting leading up to the production of compound animannans and β-glucans. For one, these two specific subsanimals especially are at risk in the long term. 20 mal feed have been exhausted, there is a prevailing opinitances have a high adsorption capacity; on the other hand, on that mycotoxin binders can protect the animal from da0 many studies have proven the immunomodulating properMerely binding mycotoxins is not Bentonite To TToxin xin TTo Toxin xin TToxin To xin MOS Biolex® maging effects by bindingsimply the toxins. Theenough proof of efficacy binder 1 binder 2 binder 3 (molasses) MB40 ties of 1.3-1.6-β-glucans. Prebiotic characteristics of these Neither heatingdocumented nor preservingusing duringantheinprocessing stages test, is usually vitro adsorption MOS+glucan mannan oligosaccharides (MOS)toxin canbinding also promote the stacan render the accumulated fungal toxins harmless. Once the meaning, in a test tube rather than in the animal itself. In bilization of the gut by supporting an intact microflora. available measures breeding, cultivation and harvesting doing so, it isinasserted that fixation with a toxin binder aloleading up to the production of compound animal feed have been ne is sufficient to render the respective mycotoxin harmInitially, 10 mg of a toxin binder or Biolex® MB40 and Fig.2: Adsorption of ZEA to toxin binders and Biolex® MB40 in exhausted, there is a prevailing opinion that mycotoxin binders less. However, the detoxification process is much more 0.2 mggastrointestinal ZEA were added topiglets a standard citrate buffer (5 ml) juice of depending on the mannan can protect the animal from damaging effects by binding the and value glucanof content (%) 1 shows that the binding capacomplex, and it doesn‘t happen in the feed but in the gut with a pH 3. Figure toxins. of the animal. city80after an incubation period of 24 hours in synthetic The proof of efficacy is usually documented using an in vitro 70 buffer is, on one hand, relatively low, and that, on the other adsorption meaning,conducted in a test tube than in the In antest, experiment at rather the University ofanimal Vienna in 60 hand, 50 there is hardly any difference between the various itself. Austria In doing(Fruhauf so, it is asserted that fixation with a toxintobinder et al., 2012), it was examined what ex40 binders and yeast products. toxin alone tent is sufficient to render the respective mycotoxin harmless. various commercial toxin binders and yeast cell wall 30 However, the detoxification process is much more complex, and products can absorb Zearalenone (ZEA). The experiments 20 it doesn’t in the using feed but in the gut of thesolution animal. and porci10 werehappen conducted synthetic buffer In anne experiment conducted 0 gastrointestinal juice.at the University of Vienna in Bentonite Toxin Toxin Toxin MOS Biolex® Austria (Fruhauf et al., 2012), it was examined to what extent binder 1 binder 2 binder 3 (molasses) MB40 various commercial toxin binders and yeast cell wall products toxin binding MOS+glucan can absorb Zearalenone (ZEA). The experiments were conducted

40 20 0

bentonit 1

However, the be sufficient therefore rath damaging at proving the b in Biolex® M on the intest “tight junction epithelial cel fluids from th ned. Due to much more

Sep 2015 - Milling and Grain magazine  

The September 2015 edition of Milling and Grain magazine

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