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The Immune System, Third Edition is designed for use in immunology courses for undergraduate, medical, dental, and pharmacy students. This class-tested and proven textbook synthesizes the established facts of immunology into a comprehensible, coherent, and up-to-date account of how the human immune system works and the effect it has on the health and survival of individuals and populations, making generous use of medical examples to illustrate points. The reader-friendly text, full-color illustrations, and section and chapter summaries make the book accessible and easily understandable to students. The Third Edition is a major revision and includes two new chapters: Innate Immunity (Chapter 2) and Principles of Adaptive Immunity (Chapter 3). Former Chapter 12 has been divided into three chapters: vaccination (Chapter 14), transplantation (Chapter 15), and cancer (Chapter 16). The number of end-of-chapter questions has been expanded and now include essay, multiple choice, and case study questions with answers provided at the end of the book. The Immune System is adapted from Immunobiology by Janeway, Travers, and Walport.



Completely updated throughout.

Chapter 2: Innate Immunity. Presents expanded coverage of innate immunity before discussion of adaptive immunity. Aspects of innate immunity such as Toll-like receptors, defensins, and C-reactive protein are explored.

Presents immunolo with a central focu to combat human d

Each chapter make to illustrate points

Chapter 3: Principles of Adaptive Immunity. Covers the cellular and genetic principles underlying adaptive immunity.

Seamless integratio and clinical facets o

Separate chapters now devoted to vaccination (Chapter 14), transplantation (Chapter 15), and cancer (Chapter 16).

The crucial role of dendritic cells in initiating the primary adaptive immune response is emphasized throughout.

The use of immunotherapies developed from humanized monoclonal antibodies as preferred treatments for certain diseases are discussed in several chapters.

An outstanding ful drawings, microgra program, using dist designed to enhanc principles presented the reader with exc

End-of-chapter que Questions consist o Detailed answers to back of the book.

End-of-section and a broad overview o students to review what they have rea

The end-of-chapter questions have been significantly revised and now include essay, multiple choice, and case study questions.

Question Bank for instructors to accompany The Immune System, Third Edition. Includes over 500 questions organized by book chapter and designed for quiz and examination purposes.

ABOUT THE AUTHOR Peter Parham is a Professor in the Departments of Structural Biology, and Microbiology and Immunology, at Stanford University.

Garland Science 608pp: 513 illust Paperback: 978-0

CONTENTS To download a detailed table of contents and sample chapters, please visit: 1.

Elements of the Immune System and their Roles in Defense



Innate Immunity

10. The Body’s Defenses Against Infection


Principles of Adaptive Immunity

11. Failures of the Body’s Defenses


Antibody Structure and the Generation of B-Cell Diversity

12. Over-reactions of the Immune System


Antigen Recognition by T Lymphocytes

13. Disruption of Healthy Tissue by the Immune Response


The Development of B Lymphocytes

14. Vaccination to Prevent Infectious Disease


The Development of T Lymphocytes

15. Transplantation of Tissues and Organs


T Cell-Mediated Immunity

16. Cancer and Its Interaction with the Immune System

Immunity Mediated by B Cells and Antibodies

TEACHING SUPPLEMENTS The Art of The Immune System, Third Edition


ogy from the human perspective s on how the immune system works disease. s frequent use of medical examples and principles.

on of the molecular, cellular, genetic of immunology.

l color art program including line aphs and photographs. The art tinct and consistent iconography, is ce and extend the concepts and d in the text without overwhelming cessive detail.

estions throughout the book. of a mix of basic and clinical science. o all questions are provided in the

end-of-chapter summaries provide of material presented allowing and assess their understanding of ad.

March 2009: trations 0-8153-4146-8: £41.00

ISBN: 978-0-8153-4429-2

The Art of The Immune System, Third Edition CD-ROM contains the figures from the book for presentation purposes. The figures are available in both PowerPoint® and JPEG formats. Available to instructors upon adoption.

Question Bank The Question Bank features over 500 essay and multiple choice questions and includes detailed answers to all questions. Prepared by Sheryl L. Fuller-Espie, Cabrini College, USA, the questions are organized by book chapter and designed for instructors to use for quiz and examination purposes. They measure knowledge of essential concepts and help students link basic science to medical and research applications.

Lecture Outlines Lecture outlines from the book’s concept heads are available in PowerPoint® format.

Case Studies in Immunology, Fifth Edition ISBN: 978-0-8153-4145-1 • Paperback • 2007 • 328pp • 238 illustrations

Case Studies in Immunology, by Raif Geha and Fred Rosen, reviews major topics of immunology as background to a selection of real clinical cases that serve to reinforce and extend the basic science. This new edition illustrates the importance of an understanding of immunology in diagnosis and therapy. This book can be used as a clinical companion together with The Immune System, Third Edition. A correlation guide matching relevant sections of the two books is packaged with every copy of The Immune System, Third Edition.

Garland Science Classwire™ All of the book figures in PowerPoint and JPEG formats, as well as the Question Bank and Lecture Outlines, are available to qualified instructors online at the Garland Science Classwire Web site. Garland Science Classwire offers access to other instructional resources from all of the Garland Science textbooks, and provides free online course management tools. For additional information, please visit or e-mail

(Classwire is a trademark of Chalkfree, Inc.)

The Immune System, Third Edition