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TO PURCHASE THIS BOOK CALL (credit cards) +44 (0) 1235 400524 INTERNET www.garlandscience.com

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Physical Biology of the Cell ISBN

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“One of the clear messages of the book is that at least some aspects of Biology can be made quantitative. In this sense, I like the idea to present systematically orders of magnitude and the fact that the authors show explicitly experimental results that can be compared quantitatively to the theoretical models presented. This is the classical approach of physicists but many of my biology colleagues do not work this way. In this sense, I think that this book could play a very important role. The book is also well structured with a rigorous outline, a short overview at the beginning of each chapter and a summary of the main points at the end of each chapter.” —Jean-François Joanny, Institut Curie “I enjoyed reading [Physical Biology of the Cell] tremendously and greatly benefited from it. I loved playing with the simple but very useful estimates spread throughout this book and, most importantly, it made me more optimistic about the role of physics in biology.” —Yitzak Rabin, Bar-Ilan University

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THE AUTHORS

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ROB PHILLIPS is in the Department of Applied Physics at the California Institute of Technology. He received a Ph.D. in physics from Washington University in St. Louis.

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JANE KONDEV is in the Department of Physics and the Graduate Program in Quantitative Biology at Brandeis University. He attended the Mathematical High School in Belgrade, Serbia, received his Physics B.S. degree from the University of Belgrade, and his Ph.D. from Cornell University.

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JULIE THERIOT is in the Department of Biochemistry and the Department of Microbiology and Immunology at the Stanford University School of Medicine. She received concurrent B.S. degrees in Physics and Biology from the Massachusetts Institute of Technology, and a Ph.D. in Cell Biology from the University of California at San Francisco.

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GARL0838 A B C

For more information on this title and other titles from Garland Science, please visit: http://www.garlandscience.com/gs_textbooks.asp

ISBN: 978-0-418-22923-1

Book cover photo by Matthew Footer

Breaking New Ground in Biophysics


PBC A4 Lft GARL0838

28/10/08

16:54

Page 2

CONTENTS To download a detailed table of contents and sample chapters, please visit: http://www.garlandscience.com/gs_textbooks.asp

Yes please send me a copy of:

hysical Biology of the Cell is a biophysics textbook that explores how the basic tools and insights of physics and mathematics can illuminate the study of molecular and cell biology. Drawing on key examples and seminal experiments from cell biology, the book demonstrates how quantitative models can help refine our understanding of existing biological data and also be used to make useful predictions. The book blends traditional models in cell biology with the quantitative approach typical in physics, in order to introduce the reader to both the possibilities and boundaries of the emerging field of physical biology. While teaching physical model building in cell biology through a practical, case-study approach, the text explores how quantitative modeling can be used to build a more profound, intuitive understanding of cell biology.

Part I: The Facts of Life Chapter 1 Chapter 2 Chapter 3 Chapter 4

Chapter 5 Chapter Chapter Chapter Chapter Chapter

6 7 8 9 10

Chapter 11

A practical introduction to physical model building in cell biology: for both students and scientists in physics, biology, or biochemistry! Explores how and why quantitative models can enrich and refine an intuitive understanding of experimental approaches in cell biology. Over 550 illustrations and micrographs merge the visual style of traditional molecular and cellular biology texts with the quantitative approaches of physics. Special sections are integrated throughout the chapters to help build an intuitive understanding of the mathematics and experiments: (1) Estimates; (2) Experiments Behind the Facts; (3) Math Behind the Models; (4) Tricks Behind the Math. The end-of-chapter questions challenge the reader to extend the knowledge gained in the chapter to new data or additional situations. A comprehensive solutions manual will be available for instructors.

Physical Biology of the Cell 978-0-8153-4163-5

li. rium E. co the bacte tents of n co r la cu .2 Mole Figure 2

Mechanical and Chemical Equilibrium in the Living Cell Entropy Rules! Two-State Systems: From Ion Channels to Cooperative Binding Random Walks and the Structure of Macromolecules Electrostatics for Salty Solutions Beam Theory: Architecture for Cells and Skeletons Biological Membranes: Life in Two Dimensions

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Part III: Life in Motion Chapter 12 Chapter 13 Chapter 14

Chapter 16 Chapter 17

Why: Biology By the Numbers What and Where: Construction Plans for Cells and Organisms When: Stopwatches at Many Scales Who: “Bless the Little Beasties”

Part II: Life at Rest

Chapter 15

KEY FEATURES

INSPECTION COPY REQUESTS

Physical Biology of the Cell

The Mathematics of Water A Statistical View of Biological Dynamics Life in Crowded and Disordered Environments Rate Equations and Dynamics in the Cell Dynamics of Molecular Motors Biological Electricity and the Hodgkin-Huxley Model

Part IV: The Meaning of Life Chapter 18 Chapter 19 Chapter 20

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COUNTY

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EMAIL

SIGNATURE

Figure 1 9.3 associated 7 Schematic repre sentation energies (“ of possib capable o le configu f either b states and weigh ts rations an inding to intramole d a soluble ”) for a signaling cular loop protein th ligand or . at is forming a compet ing

Sequences, Specificity and Evolution Network Organization in Space and Time Whither Physical Biology?

DATE

This paperback title is available for 60 days inspection for lecturers considering adopting the books. If you adopt the book and expect 10 or more students to buy a copy, you may keep the book free of charge if you complete and return a comments form. We will then expect your bookshop to order at least 12 copies of the title. Otherwise you must pay the full price of the book/s or return them in mint condition. Please note that inspection copies are not sent out before the month of publication and are sent out at our discretion.

Rob Phillips California Institute of Technology

FAX +44 (0) 20 7017 6711

Jane Kondev Brandeis University

Julie Theriot Stanford University School of Medicine December 2008 8-1/2 x 11 • 800pp 550 illustrations • 25 tables Paperback • 978-0-8153-4163-5 £50.00

INSTRUCTOR AND STUDENT RESOURCES

INTERNET www.garlandscience.com

The following supplements are available for instructors and students: • PowerPoint® slides of the figures & micrographs • “Hints for the reader” for some of the more difficult problems • Supplementary data sets • Supplementary videos • Solutions Manual for all end-of-chapter problems

EMAIL felicity.dibben@tandf.co.uk

With the exception of the Solutions Manual, these resources are available on the book’s Website, which can be accessed at www.garlandscience.com. The Solutions Manual, which is available only to qualified instructors, may be requested via e-mail from science@garland.com.

(sales enquiries only, please do not include card details in your email. To order online please visit www.garlandscience.com)

POST

- Return this form to:

Felicity Dibben Garland Science Marketing FREEPOST SN926 2 Park Square, Milton Park, Abingdon, OX14 4BR (only affix stamp if posting from outside UK)


PBC A4 Lft GARL0838

28/10/08

16:54

Page 2

CONTENTS To download a detailed table of contents and sample chapters, please visit: http://www.garlandscience.com/gs_textbooks.asp

Yes please send me a copy of:

hysical Biology of the Cell is a biophysics textbook that explores how the basic tools and insights of physics and mathematics can illuminate the study of molecular and cell biology. Drawing on key examples and seminal experiments from cell biology, the book demonstrates how quantitative models can help refine our understanding of existing biological data and also be used to make useful predictions. The book blends traditional models in cell biology with the quantitative approach typical in physics, in order to introduce the reader to both the possibilities and boundaries of the emerging field of physical biology. While teaching physical model building in cell biology through a practical, case-study approach, the text explores how quantitative modeling can be used to build a more profound, intuitive understanding of cell biology.

Part I: The Facts of Life Chapter 1 Chapter 2 Chapter 3 Chapter 4

Chapter 5 Chapter Chapter Chapter Chapter Chapter

6 7 8 9 10

Chapter 11

A practical introduction to physical model building in cell biology: for both students and scientists in physics, biology, or biochemistry! Explores how and why quantitative models can enrich and refine an intuitive understanding of experimental approaches in cell biology. Over 550 illustrations and micrographs merge the visual style of traditional molecular and cellular biology texts with the quantitative approaches of physics. Special sections are integrated throughout the chapters to help build an intuitive understanding of the mathematics and experiments: (1) Estimates; (2) Experiments Behind the Facts; (3) Math Behind the Models; (4) Tricks Behind the Math. The end-of-chapter questions challenge the reader to extend the knowledge gained in the chapter to new data or additional situations. A comprehensive solutions manual will be available for instructors.

Physical Biology of the Cell 978-0-8153-4163-5

li. rium E. co the bacte tents of n co r la cu .2 Mole Figure 2

Mechanical and Chemical Equilibrium in the Living Cell Entropy Rules! Two-State Systems: From Ion Channels to Cooperative Binding Random Walks and the Structure of Macromolecules Electrostatics for Salty Solutions Beam Theory: Architecture for Cells and Skeletons Biological Membranes: Life in Two Dimensions

PERSONAL DETAILS

(PLEASE USE CAPS)

SURNAME

FIRST NAME

DEPARTMENT

INSTITUTION

VAT NUMBER (EU member States)

ADDRESS

Part III: Life in Motion Chapter 12 Chapter 13 Chapter 14

Chapter 16 Chapter 17

Why: Biology By the Numbers What and Where: Construction Plans for Cells and Organisms When: Stopwatches at Many Scales Who: “Bless the Little Beasties”

Part II: Life at Rest

Chapter 15

KEY FEATURES

INSPECTION COPY REQUESTS

Physical Biology of the Cell

The Mathematics of Water A Statistical View of Biological Dynamics Life in Crowded and Disordered Environments Rate Equations and Dynamics in the Cell Dynamics of Molecular Motors Biological Electricity and the Hodgkin-Huxley Model

Part IV: The Meaning of Life Chapter 18 Chapter 19 Chapter 20

TOWN

COUNTY

POSTCODE

COUNTRY

TELEPHONE

EMAIL

SIGNATURE

Figure 1 9.3 associated 7 Schematic repre sentation energies (“ of possib capable o le configu f either b states and weigh ts rations an inding to intramole d a soluble ”) for a signaling cular loop protein th ligand or . at is forming a compet ing

Sequences, Specificity and Evolution Network Organization in Space and Time Whither Physical Biology?

DATE

This paperback title is available for 60 days inspection for lecturers considering adopting the books. If you adopt the book and expect 10 or more students to buy a copy, you may keep the book free of charge if you complete and return a comments form. We will then expect your bookshop to order at least 12 copies of the title. Otherwise you must pay the full price of the book/s or return them in mint condition. Please note that inspection copies are not sent out before the month of publication and are sent out at our discretion.

Rob Phillips California Institute of Technology

FAX +44 (0) 20 7017 6711

Jane Kondev Brandeis University

Julie Theriot Stanford University School of Medicine December 2008 8-1/2 x 11 • 800pp 550 illustrations • 25 tables Paperback • 978-0-8153-4163-5 £50.00

INSTRUCTOR AND STUDENT RESOURCES

INTERNET www.garlandscience.com

The following supplements are available for instructors and students: • PowerPoint® slides of the figures & micrographs • “Hints for the reader” for some of the more difficult problems • Supplementary data sets • Supplementary videos • Solutions Manual for all end-of-chapter problems

EMAIL felicity.dibben@tandf.co.uk

With the exception of the Solutions Manual, these resources are available on the book’s Website, which can be accessed at www.garlandscience.com. The Solutions Manual, which is available only to qualified instructors, may be requested via e-mail from science@garland.com.

(sales enquiries only, please do not include card details in your email. To order online please visit www.garlandscience.com)

POST

- Return this form to:

Felicity Dibben Garland Science Marketing FREEPOST SN926 2 Park Square, Milton Park, Abingdon, OX14 4BR (only affix stamp if posting from outside UK)


PBC A4 Lft GARL0838

28/10/08

16:53

Page 1

TO PURCHASE THIS BOOK CALL (credit cards) +44 (0) 1235 400524 INTERNET www.garlandscience.com

POST

- Return this form to:

Felicity Dibben Taylor & Francis Group FREEPOST SN926 2 Park Square, Milton Park, Abingdon, OX14 4BR (only affix stamp if posting from outside UK) TITLE

QTY

Physical Biology of the Cell ISBN

PRICE PER BOOK (£)

Pb: 978-0-8153-4163-5

£50.00

PERSONAL DETAILS

“One of the clear messages of the book is that at least some aspects of Biology can be made quantitative. In this sense, I like the idea to present systematically orders of magnitude and the fact that the authors show explicitly experimental results that can be compared quantitatively to the theoretical models presented. This is the classical approach of physicists but many of my biology colleagues do not work this way. In this sense, I think that this book could play a very important role. The book is also well structured with a rigorous outline, a short overview at the beginning of each chapter and a summary of the main points at the end of each chapter.” —Jean-François Joanny, Institut Curie “I enjoyed reading [Physical Biology of the Cell] tremendously and greatly benefited from it. I loved playing with the simple but very useful estimates spread throughout this book and, most importantly, it made me more optimistic about the role of physics in biology.” —Yitzak Rabin, Bar-Ilan University

(PLEASE USE CAPS)

SURNAME

THE AUTHORS

FIRST NAME

DEPARTMENT

ROB PHILLIPS is in the Department of Applied Physics at the California Institute of Technology. He received a Ph.D. in physics from Washington University in St. Louis.

INSTITUTION

VAT NUMBER (EU member States)

ADDRESS

TOWN

COUNTY

POSTCODE

COUNTRY

JANE KONDEV is in the Department of Physics and the Graduate Program in Quantitative Biology at Brandeis University. He attended the Mathematical High School in Belgrade, Serbia, received his Physics B.S. degree from the University of Belgrade, and his Ph.D. from Cornell University.

TELEPHONE

EMAIL

SIGNATURE

DATE

JULIE THERIOT is in the Department of Biochemistry and the Department of Microbiology and Immunology at the Stanford University School of Medicine. She received concurrent B.S. degrees in Physics and Biology from the Massachusetts Institute of Technology, and a Ph.D. in Cell Biology from the University of California at San Francisco.

SELECT PAYMENT METHOD (please tick or fill appropriate boxes & select card type)

PLEASE SEND ME A PRE-PAYMENT INVOICE (my ref number)

CHEQUE payable to Taylor & Francis £ CREDIT CARD (NB Select card type)

MASTERCARD

VISA

AMEX

SWITCH

ISSUE NUMBER (Only applies if paying by Switch)

EXPIRY DATE

SECURITY NUMBER Last 3 digits of security number on back of card

GARL0838 A B C

For more information on this title and other titles from Garland Science, please visit: http://www.garlandscience.com/gs_textbooks.asp

ISBN: 978-0-418-22923-1

Book cover photo by Matthew Footer

Breaking New Ground in Biophysics

Physical Biology of the Cell  
Physical Biology of the Cell  

Physical Biology of the Cell is a biophysics textbook that explores how the basic tools and insights of physics and mathematics can illumina...

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