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GENOME DUPLICATION Melvin L. DePamphilis and Stephen D. Bell

Genome Duplication provides a comprehensive and readable overview of the underlying principles that govern genome duplication in all forms of life, from the simplest cell to the most complex multicellular organism. Genome Duplication provides advanced undergraduate and graduate students in biological sciences and medicine with a highly readable, insightful, and authoritative textbook.   Using examples from the three domains of life – bacteria, archaea, and eukarya – Genome Duplication shows how all living organisms store their genome as DNA and how they all use the same evolutionary-conserved mechanism to duplicate it: semi-conservative DNA replication by the replication fork. The text shows how the replication fork determines where organisms begin genome duplication, how they produce a complete copy of their genome each time a cell divides, and how they link genome duplication to cell division.   Genome Duplication explains how mistakes in genome duplication are associated with genetic disorders and cancer, and how understanding genome duplication, its regulation, and how the mechanisms differ between different forms of life, is critical to the understanding and treatment of human disease. Garland Science • October 2010 464 pages • 185 illustrations Paperback: 978-0-415-44206-0 • £49.00

THE AUTHORS Melvin L. DePamphilis is Section Chief of the Senior Biomedical Research Service, National Institute of Child Health and Human Development, Bethesda, Maryland, USA. Stephen D. Bell is Professor of Microbiology at the Sir William Dunn School of Pathology, University of Oxford, UK. The Stephen D. Bell Lab is studying the molecular biology of the archaea.

Key Features • The book is based on experimental evidence, using selected model organisms. • DNA Replication is integrated with other cellular events such as the cell cycle and cell division. • The entire subject is broken down into a series of simple concepts that are summarized in tables and figures. • 3D structures for proteins, DNA and protein-DNA complexes are provided. • Each chapter ends with a summary of the major points.

Contents 1. Genomes 2. Three Domains of Life 3. Replication Forks 4. Replication Proteins: leading-strand synthesis 5. Replication Proteins: lagging-strand synthesis 6. Termination 7. Chromatin Assembly, Cohesion, and Modification 8. Replicons 9. Replication Origins 10. Origin Paradigms 11. Initiation 12. Cell Cycles 13. Checkpoints 14. Human Disease 15. Evolution of Cellular Replication Machines

Praise for Genome Duplication “The writers find a perfect balance between the level of detail and the clarity of the subject for readers from various levels.” Dr Rob de Bruin, University College, London, UK

Sample chapters and the complete set of figures from the book in JPEG format are available at

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Genome Duplication