POLYMER THERAPEUTICS REFERENT SCIENTISTS Dott.ssa Cristina Lenardi: Department of Molecular Science Applied to Biosystems, UniversitĂ degli Studi di Milano (firstname.lastname@example.org) Dott. Federico Martello: Fondazione Filarete (email@example.com)
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INTRODUCTION The Polymer Therapeutics Platform is equipped for chemical synthesis or modifications of organic compounds. In particular, the platform possesses the capability of producing and characterizing a number of tailor-made polymeric substances or performing chemical modification of natural polymers. The expertise of the platform includes synthesis and characterization of a number of polymers for biomedical applications, such as polyurethanes (PU), poly(2hydroxyethylmethacrylate) (PHEMA), poly(N-isopropylacrylamide) (PNIPAAM), polyvinylpirrolidone (PVP), poly(lactic-co-glycolic) acid (PLGA), poly(amidoamine)s (PAA). The physico-chemical properties of all these polymers can be adjusted by introducing chemical functionalities in the polymer backbone or by controlling the polymer molecular weight and the branching degree. Many polymers can also be obtained in a reticulated and insoluble form (i.e. hydrogels).
SERVICE FEES SERVICE
FULL FEE (1)(2)
Polyamides (e.g. nylon 6; 6,6; 6,10) (per gram)
Polyacrylates (e.g. PMMA, PHEMA, PNIPAAM, polyacryloylmorpholine) (per gram)
Polyesters (e.g. PET) (per gram)
Silicones (e.g. PDMS) (per gram)
Polyamidoamines (per gram)
(1) All prices do not include VAT (2) Minimum price: price changes with amount ordered, chemical modifications, etc
PLATFORM CAPABILITIES The following services can be activated under specific request: Assays and chemical analyses (e.g. HPLC, acid-base titrations, UV-Visible spectroscopy, Infrared spectroscopy ATR-FTIR). Identification of active ingredients and organic impurities in the materials. Separation, identification and quantification of each constituent in an unknown material (HPLC, titration, UV-Vis, IR, Nuclear Magnetic Resonance). Analysis of chemical structure by Size Exclusion Chromatography/HPLC, UV-Vis, ATR-FTIR. Analysis of thermal properties by Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA). Analysis of mechanical properties by Rheometry and Dynamic Mechanical Analysis (DMA). Degradation behaviour of the material under different environmental conditions (stove, SEC, UV-Vis, ATR-FTIR). Biological tests involving the use of cell lines, primary cells, bacteria and fungi can be performed in collaboration with other Platforms of Fondazione Filarete. Moreover, in vivo biological tests can be performed. The Polymer Therapeutics Platform offers also advices to research group and companies for improvement and optimization of polymer synthesis and production process, with emphasis on applications in the biomedical field.
EXAMPLES OF ONGOING PROJECTS Synthesis of biocompatible and biodegradable hydrogels as scaffolds for tissue regeneration. An interpenetrating polymer network (IPN) with polymer such as PEG, PHEMA, PLGA is used to produce three dimensional scaffolds that induce primary cell growth and proliferation in vivo. Synthesis of tailor-made biocompatible, biodegradable and pH-responsive polymers for drug delivery applications. Different series of functionalized polyamidoamines are synthesized and loaded with several bioactive molecules. These formulations are able to release the loaded molecules in the external environment under specific stimuli (i.e. pH variation).