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Multiwave PRO Microwave Reaction System for Synthesis ::: Excellence in Microwave Synthesis

Multiwave PRO Challenging technology Anton Paar has been working in the field of microwave technology for more than three decades. Using high-quality materials and innovative solutions, Anton Paar defines the standard for toplevel instruments. The Multiwave PRO platform serves two groups: professionals in synthetic chemistry and trace analysis. This brochure focuses on the use of Multiwave PRO as a microwave reaction system for parallel synthesis. One for all Do you need a small instrument for method development or a large instrument for the multigram scale? Now there is no need to choose: Multiwave PRO serves both. You can upgrade the system to cover different scales at any time by just adding rotors. Save ressources by reducing reaction times Whenever time equals money, microwave synthesis is the method of choice. Parallel synthesis with Multiwave PRO saves processing time in any scale. The combination of sealed vessel technology with reaction conditions beyond the boiling point of the applied solvent significantly reduces the reaction time. Get in touch with your microwave synthesis system Multiwave PRO has an on-board PC which provides an intuitive and multilingual state-of–theart software solution. Its large color touchscreen enables convenient operation and is easy to read from a distance. The standard Ethernet connection allows network printing of in-situ generated experiment reports. Data storage on an USB device is also supported. Close to you For the entire working life of your Multiwave PRO, specialists from Anton Paar are at your service. With subsidiaries and sales partners worldwide, you are close to an experienced team which speaks your language and provides application support and training.

Excellence in Microwave Synthesis Variety of configurations With its diverse rotor types Multiwave PRO serves all scales from milligram to multigram synthesis in chemical laboratories. For your special needs in parallel synthesis we offer a family of high-throughput rotors in plate format together with well-established scale-up rotors.

➤ Reaction screening with a new dimension

The microtiter plates are made from silicon carbide and sealable. With this equipment you can process up to 192 high-temperature and high-pressure reactions at a time.

➤ Parallel optimization in different solvents

Rotor configurations utilizing silicon carbide allow the use of different solvents in the same experiment. With Multiwave PRO you can generate libraries with up to 96 members under utmost temperature homogeneity.

➤ Scale up at optimized conditions

Multiwave PRO masters the liter scale with 16 parallel multigram reactions using the identical protocols from previous reaction screening and optimization steps.

➤ Unrivaled special applications

Up to 8 multigram reactions can be performed simultaneously utilizing gaseous reagents or even applying near-critical water conditions.

Reaction Screening & Method Optimization ➤ High-throughput rotors for method development

Applications related to drug development, proteomics, forensics and similar research areas predominantly deal with small quantities. A range of small-scale high-throughput rotors for Multiwave PRO perfectly match the requirements of microwave-assisted parallel method development.

➤ High reproducibility with silicon carbide

Using silicon carbide plates ensures the utmost temperature homogeneity in plate format. This significantly increases the reproducibility of chemical reactions. With these systems any solvent can be employed as consistent microwave absorptivity is ensured by the SiC plates.

➤ Plate chemistry at high temperatures and pressures

An aluminum sealing mechanism for the microtiter plates allows you to perform plate chemistry at elevated temperatures and pressures. This means the same microwave conditions can be applied for subsequent scaling up from the initial idea to gramscale synthesis.

➤ Easy and efficient library generation

Your optimized procedures for valuable scaffolds or intermediates can be directly performed in the entry model, Rotor 64MG5. This economical configuration enables seamless preparation of up to 64 derivatives in one go. Focused product libraries can be quickly prepared in parallel in a single experiment employing identical reaction conditions for all building block combinations.

A Quicker Route to Your Results Microwave irradiation is a modern tool for synthesis applications. The route it provides to your results is 4 quick 4 precise 4 economical When applying microwave technology, you do not need to change your usual procedures. Simply continue your chemistry but heat more effectively with microwaves. Your routine tools remain: 4 common microtiter plate processing, 4 standard HPLC/GC vials, 4 any typical organic solvents. There is no need for reoptimization with microwaveabsorbing solvents or for product transfer to analyzer vials. The plate format fits any standard analytic autosampler.











Reaction container

6x8 SiC microtiter plate

HPLC/GC vials in 5x4 SiC plate

Glass vials in 6x4 SiC plate

Glass vials in PTFE holder

Reaction control Operation volume

0.02 mL to 0.3 mL

0.1 mL to 1.5 mL

Operation parameters Max. design pressure Typical applications

Remote IR control of 16 positions

Remote IR control of each SiC plate

0.3 mL to 3.0 mL

200 째C @ 20 bar (290 psi) 55 bar (800 psi) Reaction screening, combinatorial chemistry

33 bar (480 psi) Method development, proteomics, forensics

Parallel optimization, library generation

Library generation

Large-scale & Highperformance Synthesis ➤ Scale-up rotors for large-scale parallel synthesis

The large-scale rotors for Multiwave PRO meet the requirements of multigram applications and highperformance synthesis. The vessels used for largescale synthesis are modular and interchangeable, using the same vessel caps and liners. Opening and sealing Multiwave PRO’s rotors, vessels and sensors is quick and simple - just use your hands. This toolfree handling is unique to Anton Paar and simplifies this frequently repeated work step.

Precisely tooled fluoropolymer liners and seals allow the processing of various chemical reactions in solution and in solid phase. Thick-walled quartz vessels are available which withstand extreme conditions up to 300 °C and 80 bar. These are suitable even for near-critical water chemistry.

➤ Precise reaction control

An immersing temperature probe in a reference vessel combined with infrared sensors monitoring the external vessel temperature provide utmost accuracy in the control of reaction conditions. An additional hydraulic pressure system simultaneously monitors the pressure in all vessels of Rotor 8N. The sensors are already installed and ready for use. For convenient handling, the sensors transfer data to the Multiwave PRO controller wirelessly, so you do not need to connect cables before loading the rotor.

➤ Safe and smooth operation

Multiwave PRO’s high overpressure tolerance provides trouble-free operation even under extreme conditions. To ensure a safe working environment, pressure is released and noxious vapors are exhausted automatically before you open the rotor.

Efficient Scale-up ➤ Direct scalability up to the multigram range

All methods developed in the high-throughput rotors can be directly transferred to the scale-up rotors. With a capacity of about 15 g per vessel a productivity of approximately 200 g product per run can be achieved.

➤ Scale-up with low-absorbing solvents

To enable scale-up of methods utilizing low-absorbing solvents Multiwave PRO uses passive-heating elements made from silicon carbide. Adding these to the vessels enables efficient heating of mixtures containing non-polar solvents.

➤ Create a gas atmosphere in each vessel

Rotor No. of vessels Reaction control Liner material






8 One reference vessel with immersing temperature probe Remote IR control in all positions


50 mL

Operation parameters

200 °C @ 20 bar (290 psi) 60 bar (870 psi)




Typical applications


One reference vessel with immersing temperature probe and pressure sensor Remote IR control in 16 positions

Pressure jacket

Max. design pressure

An ingeniously simple gas loading system enables you to create a reactive or inert gas atmosphere individually in each vessel. Pressures up to 20 bar can be applied prior to reactions for safe and effective syntheses with sensitive substrates and gaseous reagents.

n/a Ceramic


100 mL 240 °C @ 40 bar (580 psi) 115 bar (1670 psi)

Multigram library generation, parallel scale-up, synthesis of key intermediates, nanomaterials

80 mL 260 °C @ 60 bar (870 psi)

300 °C @ 80 bar (1160 psi)

140 bar (2000 psi) Pre-pressurized reactions, nanomaterials

Near-critical water chemistry, nanomaterials

Fotos: Croce & Wir

Anton Paar速 GmbH Anton-Paar-Str. 20 A-8054 Graz Austria - Europe Tel: +43 (0)316 257-0 Fax: +43 (0)316 257-257 E-mail: Web:

Instruments for: Density & concentration measurement Rheometry & viscometry Sample preparation Microwave synthesis Colloid science X-ray structure analysis Refractometry Polarimetry High-precision temperature measurement

Specifications subject to change without notice. 04/12 D19IP004EN-A

Anton-Paar - Multiwave Pro_Synthesis  

Apresentação do sistema de microndas Multiwave Pro da Anton-Paar.

Anton-Paar - Multiwave Pro_Synthesis  

Apresentação do sistema de microndas Multiwave Pro da Anton-Paar.