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Innovator: Dr Ali Fathi Innovation: TrimphDent

While completing his PhD at the University of Sydney in 2014, Dr Ali Fathi invented an injectable class of scaffolds that is able to regenerate bone, cartilage and connective tissue. Together with Terence Abrams, he founded Trimph in 2015 and established a production facility in 2016. Their first product, TrimphDent, has been developed in collaboration with A/Prof Dax Calder. TrimphDent is a polymer solution that is injected at the base of an extraction socket. It instantly forms an elastic that mixes with blood to stabilise the clot. The scaffold complements the natural healing process by providing an optimised environment for cellular regeneration, vascular ingrowth and bone regeneration. What’s more, within three months TrimphDent is resorbed into the body, leaving healthy tissue at the site. “Application of TrimphDent in fresh extraction sockets is simple and easy to use in clinical practice,” says Dr Fathi. “Unlike all other bone substitute materials, it is delivered as a liquid and forms an elastic matrix at the site. TrimphDent requires no specialised preparation, socket packing or additional surgical expertise.” Since its incorporation in August 2015, Trimph has secured more than $5.2 million in both private and public source. Their sterile facility is located in the Sydney suburb of Alexandria and is a key strategic asset for IP protection, quality control and early access to the Australian market. Recently, Trimph secured $1 million from the NSW Health Medical Device Fund to complete TrimphDent’s clinical trial. Trimph has also secured nearly $1.4 million from the Entrepreneurs’ Accelerating Commercialisation Programme to position the company for initial sales of TrimphDent. Dr Fathi has also used his technology in the creation of TrimphGlue, an elastic scaffold that is easily applied to bone defects, and TrimphGel, an injectable gel that uses the heat of the body to form a regenerative scaffold for soft tissue repair. “Our products are unique due to four key elements—they are injectable, temperature responsive, regenerative and resorbable,” says Dr Fathi.

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Bite December 2018  

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