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Portfolio David Goodsell

Key for Excitatory and Inhibitory Synapses

7. NSF protein separates the SNARE proteins after fusion.

1. Transporters pump glutamate or GABA into vesicles.

8. Voltage-dependent calcium channels trigger release of neurotransmitters.

2. Synapsin holds vesicles in storage. 3. Scaffolding proteins guide vesicles to the surface. 4. CaMKII (Calmodulin-dependent protein kinase II) regulates the action of many proteins. 5. SNARE proteins will fuse vesicles with the membrane. 6. SNARE complexes have docked the vesicle in the inhibitory painting, and fused the vesicle with the membrane in the excitatory painting.

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9. Neurexin and Neuroligin connect the two cells across the synapse. 10a. AMPAR (glutamate receptor), b. NMDAR (glutamate receptor), and c. GABA receptors bind to neurotransmitters and allow ions to enter the receiving cell. 11. Postsynaptic density proteins form a scaffold to support the receiving cell. 12. Actin filaments are part of the cytoskeleton.

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