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E Z H2 基因在宫颈癌中的表达及其意义 方 静 1 薛 艳 1 周党侠2 苟文丽1 西安交通大 学医学院:1. 第一附属医院妇产科,陕西西安7 1 00 6 1 2. 病理系,陕西西安71 006 1

摘要:目的  研究E ZH2  ( en ha nce r  of  z est e  ho mol og  2 ,E ZH2 )基因在宫颈癌组织中的表达及其意义。方法   采用 RT-PC R方法检测2 0例正常宫颈组织和60例宫颈癌组织中EZ H2 mR NA的表达情况,并结合临床资料分析其与宫 颈癌各临床病理特征的相关性。结果  E ZH2 m RNA在宫颈癌组织中的表达高于正常宫颈组织(0.8 6±0 .1 7vs . 0.0 6士0 .02 ,P<0. 01 ),E ZH 2  mRN A表达与患者年龄及肿瘤大小无明显相关性( P>0. 05 ),而与肿瘤细胞分化、临床 分期、浸润深度及淋巴结转移密切相关( P<0. 05 )。结论   EZ H2 基因表达增强与宫颈癌恶性生长及不良预后有关。

宫颈癌;EZH 2;基因表达;RT-P CR R737.33

16 7 1- 8 25 9 (2 0 1 1 ) 0 6 - 0 75 8 - 0 3

Expression of EZH2 gene in cervical cancer and its sig nific ance

FANG Jing XUE Yan ZHOU Dang-xia GOU Wen-li

2 011 -0 1-1 8

201 1- 04- 18

方静(1 9 7 2 - ), 女(汉族) ,主治医师,博 士. 研究方向 :妇科肿瘤. E -m a i l :   f a n g j in g 8 8 9 9 3 @   1 2 6 .  c o m

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3讨   论

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EZH2基因在宫颈癌中的表达及其意义 作者: 作者单位:

方静, 薛艳, 周党侠, 苟文丽, FANG Jing, XUE Yan, ZHOU Dang-xia, GOU Wen-li 方静,薛艳,苟文丽,FANG Jing,XUE Yan,GOU Wen-li(西安交通大学医学院第一附属医院妇产科,陕西西 安,710061), 周党侠,ZHOU Dang-xia(西安交通大学医学院病理系,陕西西安,710061)

刊名:

西安交通大学学报(医学版) Journal of Xi'an Jiaotong University(Medical Sciences) 2011,32(6)

英文刊名: 年,卷(期):

参考文献(16条) 1.HE LR;LIU MZ;LI BK High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy[外文期刊] 2010(01) 2.SASAKI M;IKEDA H;ITATSU K The overexpression of polycomb group proteins Bmil and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma[外文期刊] 2008(08) 3.VAN LEENDERS GJ;DUKERS D;HESSELS D Polycomb-group oncogenes EZH2,BMI1,and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features[外文期刊] 2007(02) 4.MATSUKAWA Y;SEMBA S;KATO H Expression of the enhancer of homolog 2 is correlated with poor prognosis in human gastric cancer[外文期刊] 2006(06) 5.CHOI JH;SONG YS;YOON JS Enhancer of zeste homolog 2 expression is associated with tumor cell proliferation and metastasis in gastric cancer[外文期刊] 2010(03) 6.连丽娟 林巧稚妇科肿瘤学 2008 7.SARAMAKI OR;TAMMELA TL;MARTIKAINEN PM The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer[外文期刊] 2006(07) 8.KIENLE D;KATZENBERGER T;OTT G Quantitative gene expression deregulation in mantle-cell lymphoma:correlation with clinical and biologic factors[外文期刊] 2007(19) 9.ARISAN S;BUYUKTUNCER ED;PALAVAN-UNSAL N Increased expression of EZH2,a polycomb group protein,in bladder carcinoma[外文期刊] 2005(03) 10.LA TULIPPE E;SATAGOPAN J;SMITH A Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease[外文期刊] 2002(15) 11.SIMON JA;LANGE CA Roles of the EZH2 histonc methyltransferase in cancer cpigenetics[外文期刊] 2008(1-2) 12.RAAPHORST FM;MEIJER CJ;FIERET E Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene 2003(06) 13.TONINI T;BAGELLA L;ANDRILLI G EZH2 reduces the ability of HDACl-dependent pRb/pl30 transcriptional repression of cyclin A[外文期刊] 2004(28) 14.李海波;王禾;武国军 EZH2基因在肾透明细胞癌中的表达及其意义[期刊论文]-西安交通大学学报(医学版) 2009(02) 15.HILLIER LW;FULTON RS;FULTON LA The DNA sequence of human chromosome 7[外文期刊] 2003(6945) 16.CARDOSO C;TIMSIT S;VILLARD L Specific interaction between the XNP/ART-X gene product and the SET domain of the human EZH2 protein[外文期刊] 1998(04)

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EZH2基因在宫颈癌中的表达及其意义