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Monday, September 17, 2012 • Volume 14, Issue 36

New Research Publication Habib AS. Do we really understand what constitutes an acupuncture point? European Journal of Pain 2012;16(9):1207-8. Xu ZZ, Berta T, Ji RR. Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. J Neuroimmune Pharmacol. 2012 Aug 10. [Epub ahead of print] Chen MJ, Kress B, Han X, Moll K, Peng W, Ji RR, Nedergaard M. Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Glia. 2012 Nov;60(11):1660-70. Epub 2012 Aug 1.

News sistance from Dr. Will Thompson in the Institute for Genome Sciences and Policy (IGSP) who will perform quantitative LC-MS/MS-based SUMO and ubiquitin prote-omics analyses. Small ubiquitin-like modifier (SUMO) conjugation modulates all major cellular pathways, including those associated with gene expression and genome stability, protein quality control, proteasomal degradation of proteins and DNA damage repair. Transient cerebral is-chemia massively activates SUMO conjugation, resulting in a dramatic rise in levels of SU-MO2/3-conjugated proteins. Cell culture studies suggest that the post-ischemic activation of SUMO2/3 conjugation is a protective stress response. However, the role of SUMO conjugation in the fate of post-ischemic neurons in the intact brain and the mechanisms and pathways that link SUMO conjugation to restoration of function impaired by transient ischemia are not known. Without this knowledge it is

Anesthesiology Excellence On August 31, 2012, Ru-Rong Ji, Anesthesiology Professor of Duke University, was invited to give a plenary lecture for the 14th World Congress on Pain in Milan, Italy. The title of his lecture was: “Glia and Pain”.

New Research Grant Awards Ru-Rong Ji, PhD, of the Sensory Plasticity Laboratory in Division of Basic Sciences, received a new 5-year $1,954,875 NIH Research Grant (R01) from the National Institute of Dental and Craniofacial Research (NIDCR) for his research project entitled “Hemichannels, astrocytic release, and neuropathic pain”. Pain conditions are a major health problem in the US and lead to medical morbidity and a reduced quality of life for millions of Americans. Chronic neuropathic pain conditions are especially difficult to treat. A largely unaddressed challenge is how the transition from acute pain to chronic neuropathic pain occurs and how to prevent and reverse this transition in patients. Spinal cord synaptic plasticity and long-term potentiation (LTP) have been strongly implicated in chronic neuropathic pain development. Accumulating evidence also points to an important role of glial cells in the pathogenesis of neuropathic pain. Astrocytes are the most abundant cell type in the CNS and maintain the homeostasis of the CNS. It is well established that astrocytic hemichannels such as connexin-43 (Cx43) constitute an important pathway for gliotransmitter release. Although Cx43 was typically thought to regulate gap junction communication between astrocytes, this function could be switched to paracrine signaling via ATP and glutamate release under injury conditions. Our central hypothesis is hemichannels-mediated gliotransmitter release after nerve injury contributes to transition from acute pain to chronic neuropathic pain by modulating spinal cord synaptic plasticity and LTP.

highly unlikely that the SUMO conjugation pathway can be manipu-lated for therapeutic purposes. Our long-term goal is to understand how to manipulate the SUMO conjugation pathway for preventive and therapeutic purposes. The objective of this particular application is to elucidate the role of individual SUMO paralogues in the recovery of neurons from ischemic stress and to identify the mechanisms and pathways involved. During the past 25 years, our laboratory has been interested in understanding the mechanisms linking stress responses to the fate of cells exposed to stress conditions with focus on cerebral ischemia/stroke, a Story continues on page 3.

Wulf Paschen, PhD, Professor of Anesthesiology in the Division of Basic Sciences, received a 5-year $1,717,190 NIH Research Grant (R01) from the National Institute of Neurological Disor-ders and Stroke (NINDS) for his research project entitled “Role of SUMO Conjugation in Ische-mia: Significance, Mechanisms, and Pathways”.

Department of Anesthesiology Research Conference

The project was funded in the first round of submission. Working with Dr. Paschen on the project are Co-Investigators Drs. Wei Yang (right) and Huaxin Sheng (left) from the Department of Anesthesiology, with as-

Upcoming: Nov. 12, Dec. 10, Jan 14, Feb. 11, March 11, April 8, May-No Research Conference, June 10

http://anesthesiology.duke.edu

Monday, October 8, 2012 | 5-6 pm | 5685-HAFS

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This Month in the Department of Anesthesiology September 2012 MONDAY

TUESDAY

17 7:15-8:00 am, RM203-Pain Clinic MRC Pain Conference 2:30-3:30 pm, VAMC VA Echocardiography Conference 5-6:30 pm, 5685-HAFS Executive Team Meeting

WEDNESDAY

THURSDAY

FRIDAY

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5-6 pm, 5685-HAFS CT Conference: “Challenges in Animal Cardiorespiratory Physiology” - Anne Cherry, MD

7:00 am, 2002DN Grand Rounds: “Chairman’s Grand Rounds” - Mark F. Newman, MD

7:15-8:00 am, RM203-Pain Clinic MRC Pain Journal Club

5-6 pm, 2001DN CA-1 Resident Lectures: “Pulmonary Gas Exchange and Oxygen Transport” - Richard Moon, MD

4:30 pm, 5685-HAFS Advanced Resident Lecture: “Pediatric Anesthesia for Subspecialty Surgery” - Wads Ames, MD

5-6 pm, 6686-HAFS GVTCCM Conference: “Colloids and Acute Kidney Injury: What Does the Literature Say?” - Meredith Miller, MD, CA-2

12-1 p.m., 2003DN Critical Care Grand Rounds Cancelled 4-5 pm, 5680A-HAFS Pediatric Conference 5-6 pm, 7683-HAFS Fellow Seminar Series: “Presentation of Fellow Clinical Projects” - Critical Care Medicine

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7:15-8:00 am, RM203-Pain Clinic MRC Pain Conference

5-6 pm, 5685-HAFS CT Conference

2:30-3:30 pm, VAMC VA Echocardiography Conference

5-6 pm, 2001DN CA-1 Resident Lectures: “Why Do People Breathe or Stop Breathing? Control of Ventilation and the Anesthesiologist” - Richard Moon, MD

7:00 am, 2001DN Grand Rounds: “From Random Observation to Essential Cerebral Physiology” - Lingzhong Meng, MD

7:15-8:00 am, RM203-Pain Clinic MRC Pain Journal Club

5-6 pm, 6686-HAFS GVTCCM Conference: “Anesthetic Management: Liver Transplantation and Porphyria” - Haley DiGiacomo, MD, CA2

4:30 pm, 5685-HAFS Advanced Resident Lecture: “Pediatric Pharmacology” - Eddie Jooste, MD

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12-1 p.m., 2003DN Critical Care Grand Rounds: “MICU M&M” - Dr. Nidhi Huff 4-5 pm, 5680A-HAFS Pediatric Conference 5-6 pm, 5685-HAFS Fellow Seminar Series: “How to Prepare for the Orals” - Catherine Kuhn, MD

IRB Deadline October 1, 2012

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7:15-8:00 am, RM203-Pain Clinic MRC Pain Conference

5-6 pm, 5685-HAFS CT Conference

7:00 am, 2001DN Grand Rounds

2:30-3:30 pm, VAMC VA Echocardiography Conference

5-6 pm, 2001DN CA-1 Resident Lectures

4:30 pm, 5685-HAFS Advanced Resident Lecture

7:15-8:00 am, RM203-Pain Clinic MRC Pain Journal Club

5-6 pm, 6686-HAFS GVTCCM Conference IRB Deadline

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12-1 p.m., 2003DN Critical Care Grand Rounds 4-5 pm, 5680A-HAFS Pediatric Conference 5-6 pm, 5685-HAFS Fellow Seminar Series: “Presentation of Fellow Clinical Projects” - Obstetrics, Neurosurgical, Regional & Ambulatory

Upcoming: 2012 Duke Anesthesiology Alumni Reception: Sunday, October 14, 2012 | Washington, DC 2012 ASA: October 13-17, 2012 | Washington, DC 2012 Duke Anesthesiology Holiday Party: Saturday, December 1, 2012 | Cotton Room at Golden Belt | Downtown Durham, NC 2013 Duke Anesthesiology Resident Graduation: June 22, 2013 | Hope Valley Country Club | Durham, NC

http://anesthesiology.duke.edu

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ANESTHESIOLOGY NEWS Story continued from page 1. pathological state of high clinical significance. Since transient cerebral is-chemia/stroke triggers a long-lasting suppression of protein synthesis, we have focused on post-translational protein modifications. SUMO conjugation is believed to play key roles in the physiology and pathology of cells because it modulates all major cellular pathways. The com-plexity of processes modulated by SUMO conjugation is a challenge because the tools needed to investigate the role of SUMO conjugation in pathological states have not been available. In-deed, the knowledge that SUMO conjugation is mechanistically linked to key pathways that are essential for cellular integrity, including gene expression and genome stability, protein quality control, proteasomal degradation of proteins, and DNA damage repair is based almost entirely on cell culture studies, many of which were performed on yeast cells. When the tools to investi-gate the role of SUMO conjugation in pathological states are at hand, we will have a unique opportunity to open a new dimension in SUMO research and advance from cell culture models to intact organs.

Comings and Goings Please welcome Jennifer Parsons, Nurse Practitioner to the department. Jennifer started working with the Pain Management Division today, Monday, September 17, 2012. If you haven’t already, check out our new alumni database at:

http://anesalumni.duhs.duke.edu/alumni

Leaving the department soon? Let’s keep in touch! Please contact Tiffany Nickel at tiffany.nickel@duke.edu with your new mailing and email address prior to your departure so that we can add you to our database!

The project is highly innovative, because it uses, for the first time, SUMO3-/-, conditional SU-MO2-/- and SUMO2-/-SUMO3-/- mice, and SUMO transgenic animals that conditionally express tagged SUMO paralogues. These mouse models were developed and are in the process of be-ing developed in our laboratory and will allow us to elucidate the significance of SUMO conjuga-tion in post-ischemic brains. This will also be the first study to identify proteins that are SUMO- or ubiquitin-conjugated after ischemia, the first in vivo study to investigate the crosstalk between the SUMO and ubiquitin conjugation pathways, and the first comprehensive in vivo analysis of the protein-protein interaction networks, biological processes, and canonical pathways that link mechanistically SUMO conjugation to the fate and function of cells exposed to stress conditions. Brain ischemia, brain tumor, and brain ageing/degenerative diseases have a common denomi-nator that defines the fate of cells – stress response pathways. Various stress response path-ways that make cells more resistant to damage induced by ischemia are also activated in cells in a solid tumor and help these cells to survive unfavorable environmental conditions, while ageing is believed to be associated with decreased capacity of cells to respond to stress. Our over-arching goal for future studies is to uncover the mechanisms that define the role of the SUMO conjugation pathway in these three closely related pathological states that have become re-search priorities as our population ages. In addition to ischemia, the SUMO conjugation is asso-ciated with various human diseases including, cancer, diabetes, degenerative diseases, arthritis, and heart failure. Our findings from the planned studies will therefore contribute to a better understanding of the mechanisms that link SUMO conjugation to these disorders.

Dream Campaign Fiscal Year 2012 Goal The DREAM Innovation Grant (DIG) supports innovative high-risk, and potentially high-reward investigations to accelerate anesthesia and pain management research. Our goal is to raise $90,000, which will allow us to fund three $30K DIG recipients in 2013. The winners of this grant will be announced in October 2012. Total raised to date: $73,371.00. To make a gift, please visit: http://blueprint.duhs.duke.edu/

http://anesthesiology.duke.edu

Save The Date! Department of Anesthesiology Annual Holiday Party Saturday, D ecembe r 1, The Cott 7-1 2012 on R oom 1 pm Downto a w t n Du rham Golden ,N B elt C

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ANESTHESIOLOGY NEWS Upcoming CME Activities 7th Annual Winter Anesthesia and Critical Care Review March 3-8, 2013 | Canyons Resort | Park City, UT For more information, contact Kathy Long: kathy.long@duke.edu.

6th Annual Emerging Technologies in the OR and Great Fluid Debate June 10-14, 2013 Disney’s Grand Floridian Resort & Spa | Lake Buena Vista, FL For more information, email Katherine Siler: siler006@mc.duke.edu.

16th Annual Cardiothoracic Update and TEE Board Review

Classifieds Go to Carolina Beach in the off-season. Enjoy this 6 bedroom home with its own walkway to the ocean. Amenities can be seen on the realtor’s website, but the rates are much lower for friends and coworkers at $250/weekend night and $200/weekday night. Please contact allison.ross@duke.edu if interested. http://www.bluewaterrealtyinc.com/vacation/ rental/PropertyDisplay.aspx?PropertyId=110& WebCode=featured&ReturnPath=/vrmgr/search/WebGroupList.aspx

June 20-23, 2013 The Westin Hilton Head Island Resort and Spa | Hilton Head Island, SC For more information, contact Jaime C. Cooke: jca24@notes.duke.edu.

Preceptorships Ultrasound Guided Regional Anesthesia Preceptorship Course

2012-2013 Dates Available | Duke University Medical Center, Durham, NC For more information, email Katherine Siler: siler006@dm.duke.edu. Participants in the Duke Preceptorship will spend three days in the regional block area, operating rooms and on the floor with post surgery patients observing ultrasound guided single shot nerve blocks and catheter techniques in a wide variety of clinical scenarios.

Visiting Preceptorship in Intraoperative Transesophageal Echocardiography

2012-2013 Dates Available | Duke University Medical Center, Durham, NC For more information, email Jaime C. Cooke: jca24@notes.duke.edu. Participants in the Duke Intraoperative TEE Preceptorship spend one three-day session in the cardiac operating suites, observing techniques of intraoperative TEE and interpretation of images.

For more information and to register, visit http://anesthesiology.duke.edu

http://anesthesiology.duke.edu

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