CATALOGUE OF PARTNERING EVENT PROFILES
noncoding RNAs and epigenetic modifications (DNA methylation of CpG motifs) integrate various input signals (infection, inflammation, stress, metabolism, nutrition) which are ultimately recorded and imprinted into the epigenome. Identifying specific protein interactions and signaling functions in relation to epigenetic marks in in different in vitro/ in vivo cell models, representative for cancer, cardiovascular or neuroimmunological disease, is an absolute requirement for translational approaches aiming at identifying small inhibitor molecules (for example derived from medicinal plants) for preventive or therapeutic applications.
PROJECT Research project
Description of project
Expertise offered
Requested partner expertise
Optimised delivery of Ayurvedic functional food for improved cardiometabolic health and reduced cardiovascular risk Cardiometabolic disease includes a wide range of risk factors leading to vascular damage. Cardiovascular disease remains to be among the foremost causes of deaths worldwide and statistics about this condition is quite alarming. Despite steadily improving patient care,cardiovascular disease continues to grow to epidemic proportions, with the continued prevalence of a variety of risk factors including dyslipidemia, diabetes, obesity, hyperhomocysteinemia and arterial damage. Nutrition, i.e. our daily diet, is a major life style factor, greatly impacting on cardiometabolic disease. Today, there is growing interest in the composition of manufactured foods and the role that reformulation can play in making our diets healthier. Ayurveda, one of the ancient systems of health care of Indian origin, requires rediscovery in light of our current knowledge of allopathic (modern) medicine for the therapeutic and preventive purpose. Roughly translated into "Knowledge of life", it is based on the use of natural herbs and herb products for therapeutic measures depending on synergistic health beneficial effects of all compounds present in a given formulation. Ayurvedic extracts are used in several indigenous preparations (food supplements, tonics, drugs) for maintaining health as well as treatment of several disease conditions, including cardiometabolic disease. CARDIYURVEDA, aims at:(1) identifying synergistic cardioprotective formulations of Ayurvedic bioactives with turmeric and their metabolites; (2) investigating key parameters of bioavailability upon gastrointestinal simulation towards surrogate markers of cardiovascular function in vitro/vivo; (3) developing innovative, functional, and nutritionally responsible food matricesfor optimised dietary delivery of Ayurvedic formulations; (4) demonstrating cardiovascular benefits and safety of Ayurvedic food products (5) exchanging know-how between India (ayurveda) and Europe (allopathy) through a dedicated training programme Molecular Cell Biology, Epigenetics, Chromatin Biology, Gene Expression, Kinase signaling, NFkappaB, Hormone receptor biology, Herbal Compound purification, inflammation, cancer, cardiovascular disease Ayurvedic medicine - Ayurvedic herbs - Herbal formulations
PROFILE The Netherlands
Lia van der Hoek c.m.vanderhoek@amc.uva.nl Associate professor
Areas of activity
Respiratory viruses, virus discovery, coronavirus, parvovirus, HIV-1, RSV, parechoviruses, influenzavirus
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