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TJ Robertson Chief Operating Officer TIME MEDICAL Systems September 15, 2010

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A brief introduction

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Professor Q.Y. Ma, PhD Founder, Chairman & CEO

Founded on core technology developed in the USA at Columbia University’s Translational Research Lab. and later validated & refined at Harvard Medical School and Hong Kong University

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Our USA USA--based Team of Clinical Advisors

Professor William Bradley, M.D., PhD Chairman of Radiology UCSD Medical Center University of California, San Diego

Professor Ferenc Jolesz, M.D. Director of the MRI Division Brigham & Women’s Hospital Harvard Medical School

Prof. Bradley has authored more than 160 articles and 17 books on Radiology & MRI.

Prof. Jolesz has published over 300 articles and book chapters on Surgery, Computer Science, Neurology, Neurosurgery, Radiology and MRI.

He is one of the world’s foremost authorities in MRI & Radiology - and has provided 3 decades of critical leadership across clinical, technical, research and policy-making initiatives.

He is widely recognized for his pioneering innovations in Radiology and MRI Research. 4


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Our ChinaChina-based Partners

Taizhou, Jiangsu May 31, 2010 TIME MEDICAL SYSTEMS proudly hosts Mr. Li Yuan Chao, Chairman of the Organization Department of the Chinese Communist Party & former Secretary General of Jiangsu province. He is a strong supporter of China Medical City

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Our Facilities

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R&D Facility Hong Kong HK Science Park

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R&D Facility Singapore Int’l Business Park

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R&D Facility Shanghai Zhangjiang Hi--tech Park Hi

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R&D Facility San Diego UCSD Medical Center

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Production Facility Taizhou China Medical City

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A brief history

MRI Innovations

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Magnetic Fields (B0) Higher B0 = higher SNR The trend of using higher field strengths to improve SNR is coming to an end, driven mainly by the need for cost-containment and regulatory constraints placed on clinical MRI < 4T.

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Radio Frequency (RF) Coils

In spite of RF Array Coil improvements,

copper RF coils are the dominant source of noise in the MR image. HTS materials are now considered the best solution for improving SNR.

Phantom image comparison: (a) signal intensity plot and (b) corresponding cropped images Room temperature copper Cooled copper HTS coil

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High Temperature Superconductors (HTS)

TIME MEDICAL SYSTEMS brings HTS RF Technology to the MRI market. On June 1, 2010 Professor Ma and his team received Patent approval for the development of the 1st

“INTEGRATED SUPERCONDUCTOR MR IMAGING SYSTEM” According to Prof. Ma “This marks the beginning of the SUPER MRI era!”

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High Temperature Superconductors (HTS) TIME MEDICAL SYSTEMS brings HTS RF Technology to the MRI market. On June 1, 2010 Professor Ma and his team received Patent approval for the development of the 1st

“INTEGRATED SUPERCONDUCTOR MR IMAGING SYSTEM” According to Prof. Ma “This marks the beginning of the SUPER MRI era!”

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The beginning of a new era:

HTS MRI

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Hybrid the HTS System 18


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Hybrid MONA the HTS System

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The HTS breakthrough led to the new era of low-cost, high-performance MRI scanners. Hybrid PICA (whole body) and Hybrid MONA (dedicated orthopedic) MRI scanners are the first MRI scanners to take advantage of HTS RF Coil Technology. Operating in conventional or HTS mode, the Hybrid PICA and Hybrid MONA MRI scanners enable a full range of clinical applications, with competitive IQ and scan time.

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The news of HTS is getting out. And the recognition is coming in. On June 24, 2010 Professor Ma and his team accepted the award for 2010 Medical Imaging Product Innovation of the Year!

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A brief summary

MRI Markets, Opportunities & Trends 22


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Global MRI Market and TM opportunity  

2,000 MRI systems sold annually / USD $5 Billion annual market Global MRI forecast in Mio. USD

16% annual growth rate 9000

22,000 MRI systems installed globally

8000 7000 6000

 

30 MRI units per 1M population (USA/Japan) 1.5 MRI units per 1M population (China)

5000 4000 3000 2000 1000 0

2008 2009 2010 2011 2012 2013 2014 2015

< 1 MRI unit per 1M population (Developing markets)

Approximate Customer Realized Price in Developed Markets  $3M - Ultra High-field (3T)  $1.5M - High-field (1.5T)  $500K - Low-field (0.35T)

(in USD)


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Value!

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Performance!

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Innovation!

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Lowest cost of ownership

Value

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Equipment Lease

Service Contract

Revenue per patient

$ / month

$ / month

$ / patient

Breakeven

< x Patient per day (y days / week)

Lowest break-even fixed costs in the MR industry! Based on xyz market figures

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TIME MEDICAL SYSTEMS Fixed costs

Equipment Lease

Service Contract

Revenue per patient

USD $8,800 / month

USD $4,100 / month

USD $360

Breakeven

< 2 Patient per day (6 days / week)

Lowest break-even fixed costs in the MR industry! Based on Hong Kong market figures

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Hardware, Software & Clinical Applications

Performance

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MONA / PICA Specs: Brains and Muscle Magnet

Gradients

RF Coils

• • • • •

0.2T / 0.35T Vertical Field, Open 30 cm / 42cm opening 5,500 kg / 17,000 kg Auto Shimming

Pulse Sequences

• SE, GE, FSE, FLAIR, STIR, IR-FSE, Single Shot , 2D/3D TOF MRA • Single, multi-slice, radial, 3D volume

• 25 mT/m / 33 mT/m (Amplitude) • 50 T/m/s / 90T/m/s (Slew Rate) • 0.5 ms / 0.37 ms (Rise Time)

• CP: Head, C-Spine, Shoulder, Knee, Extremity, Wrist/Hand, Foot /Ankle – For both MONA & PICA • CP: Breast, Flex Body (3 sizes) – For PICA only • Multi-Array L/S Spine

Imaging Parameters

• FOV: 5cm – 42 cm • TR: 6 ms – 18 sec • TE: 4 ms (minimum) • Slice Thickness: 2D 2mm (min) • Slice Thickness: 3D 0.25m (min)

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Easy-to-Operate Graphic User Interface

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Efficient Siting

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Site Planning Support

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A brief look at the proof

MRI Images

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TIME MEDICAL SYSTEMS HTS Head Coil

Quad Head Array Coil

Quad C-Spine Array Coil

Quad Body Array Coil HTS Wrist Coil

HTS Helmholtz Coil

Large FOV Spine Coil Quad Shoulder Array Coil

Quad Knee Array Coil

Quad Wrist Array Coil

HTS Knee Coil Quad Ankle Array Coil

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Patient Comfort + Fast Scan Times =

MRI for All…

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Hybrid MONA and PICAâ&#x20AC;&#x2122;s Open-design offers patient comfort and fast acquisition times. This ensures that scans are successfully completed on the most challenging patients. Especially important for children, elderly & sedated patients, as well as those suffering from claustrophobia.

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Patient Comfort

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Fast Acquisition Times The 20 minute BRAIN MRI Scan

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Non--obsolescence through HTS Non

Innovation

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Copper RF coils remain the dominant source of noise in MR image. HTS RF Coils overcome this problem! 45


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Phantom image comparison: (a) signal intensity plot and (b) corresponding cropped images Room temperature copper Cooled copper HTS coil

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A brief comparison

HTS Results

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HTS

0.35T vs.

Copper HTS Coil Technology

HTS Coil

Copper Coil

SNR = 192

SNR = 57

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HTS

0.2T vs.

Copper HTS Coil Technology

HTS Coil

Copper Coil

SNR = 51

SNR = 25

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HTS vs. Cu RF Coil at 2T

HTS Coil Technology

HTS coil

Cu surface coil

Cu volume coil

2T Rat Brain in-vivo images using HTS surface coil. The SNR ratio for is 8:4:1 respectively

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High Resolution InIn-Vivo MR Microscopy 1. LN / out Tubes

2. Vacuum Port

3. DC connector

4. Seal Screws

Rat brain images obtained in vivo with an HTS coil at 2.0T 25 Âľm resolution Images courtesy of the NIH Center for In vivo Microscopy at Duke University

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HTS White Paper The Hybrid MRI systems can be run in the traditional, or HTS modeâ&#x20AC;Ś

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HTS Poster from ISMRM 2010

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HTS: Peer Review Journal Articles 55


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Hybrid MONA & Hybrid PICA bring a new dimension to MR Imaging.

HTS Technology make high performance MRI available to all.

TIME MEDICAL SYSTEMS Vision Beyond Imagination.

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3 mm slice thickness

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3 mm slice thickness

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Thank You.

This information is furnished without warranty, representation, or license of any kind, except that it is accurate to the best of Time Medicalâ&#x20AC;&#x2122;s knowledge or obtained from sources believed to be accurate. Time Medical does not assume any legal responsibility for use or reliance upon same. Customers are encouraged to conduct their own evaluation. Before using any product, read the product manuals and labels. For products/features under development the information is provided to assist you. Until Time Medical releases this product for general sale, Time Medical reserves the right to alter prices, specifications, features, capabilities, function, manufacturing release dates, and even general availability of the product at any time.

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