FifthReport Report Fifth of the Fifth Report ofof thethe National Transplant Registry 2008 National Transplant Registry 2008 National Transplant Registry 2008
BLOOD BLOOD AND AND MARROW MARROW TRANSPLANTATION TRANSPLANTATION
1.0TRANSPLANT INTRODUCTION 1.3 PRACTICES Haematopoietic Stem Cell8% Transplantation (HSCT) activity in Malaysia continued to Second grafts constituted of the 181 transplants performed. The majority of the increase at a steady pace which was reflected in the increased number of transplants grafts were allogeneic (64%). The commonest stem cell source was peripheral blood performed year on which year. This 5th annual to provide an and accurate stem cells (PBSC) formed 84% ofreport HSCTattempts done. Bone marrow cord record blood of the total number of HSCT performed in 2008. Overall access to HSCT remained stem cells contributed 11% and 5% to the total, respectively. low at 6 per million population. The donors for the 115 allogeneic HSCT were HLA-identical sibling donors in 102 1.1 STOCK AND13FLOW cases. There were unrelated donors who were 1-antigen mismatched in 7 cases and 2-antigen mismatched in 6 cases. The unrelated donor transplantations used cord In 2008 of 181forHSCT were The performed. new centres namely Hospital blood for a8 total and PBSC 5 patients. recourseTwo to unrelated donors remained low and compared Hospital Universiti Malaysia startedKong autologous HSCT atPulau 11% Pinang in Malaysia with Japan,Sains Singapore and Hong where 40-60% making totalunrelated of 12 transplant of HSCTaused donors. centres operating in Malaysia. The Adult Transplant team which operated in Hospital Kuala Lumpur shifted to Hospital Ampang in December has performed the by most number of HSCT in 2008 contributing 31% Table 1.3.1:2006, Distribution of Patients Graft Number, 1987-2008 Year of the total national1988 transplant1989 activity. 1990 1987 1991 1992 1993 1994 Graft number
No.
%
No.
8
100
6 1987
%
No.
%
No.
19 1989 86
4 1990
%
No.
%
No.
%
No.
%
No.
18 1995
95199624
Table 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2008 1Year 2New
0 transplant
3patients
Deaths TOTAL
0
8
100
Lost to follow-
up Year
0
0
0
0
2
0
0
1
Alive at 31 Graft DecemberNo. number
%
1
97
6
16 0
1995 st
29
8
100 1988
1 100 1996
7
5
22 6 100
0 12
9
22 0
No.
%
No.
%
28
100
31
94
1
3
1 94
Year 1998 1999 2 1 3 0 0 New transplant 62 3 0 0 490 0 patients TOTAL 30 100 28 100 Deaths 17 16 Lost to follow0 2004 0 Year 2003 up st Graft Alive at 31 No. % 167 No. % 213 number December
2000
33
31
91992 75 1993 19
1
20
3
0
0
0
12
65
1 100
0
1997
28
5
80 1991
1998
27
No. 47
2
12
0 38
25
21
0 100
0
%
No.
%
96
61
98
2
1
2
2001
2002
3
1081
114 2
0128 0
100
4749
100
62
1
0 2005
0
No. 276 %
No. 337
34
2003 56
100
0
0 2007
% 417
No. 489 %
2006
2
10
1
5
0
0
0
25
0
9 21 0
1999
57
19
90 1994
No. 91
0
0
0
87
100
117
%
No.
97
103
95
113
5
5
1
136 0
0 149 0
1400
148 0
5294
100
3
61
108
42
2008 0
No. 577
% 664
2007
100
0 Total No. 758
%857
125
98
135
98
125
98
123
97
121
98
156
92
1395
96
2
3
2
3
2
2
2
2
2
2
2
13
8
48
4
3
0
0
0
0
0
0
1
1
0
0
0
0
4
0
128
100
138
100
127
100
126
100
123
100
169
100
1447
100
Note: Missing in graft number = 71 patients (5%)
7 21
135
% 99
2008 1
181 0
100 50 114 71
0
1
TOTAL
0
No.
2006
0
15 100
2002
%
2005
0
4
100 11 25
2001
96 1997
33
0
1917
2004 3
1
28
5 100 2000
67
30
%
0 967