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Datasheet of Ara-G
Description: Ara-G (9-β-D-Arabinofuranosyl guanine) is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic. Ara-G is converted by cellular kinases to the active 5'-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis. The cellular accumulation of Ara-GTP is indicative of the clinical response to treatment with nelarabine, the prodrug. The differential accumulation and consequent selective cytotoxicity of Ara-G in T cells has been postulated to be due to the higher accumulation and slower elimination of ara-GTP in these cells. Nelarabine was developed because of poor water solubility of Ara-G, but Ara-G is DMSO-soluble. Nelarabine is approved in the United States for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).
Chemical Information Catalog
DC8888
Purity of current batch:
>98%
Molecular Weight (MW)
283.24
Molecular Formula
C10H13N5O5
CAS No.
38819-10-2
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.