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Datasheet of Sofosbuvir

Description: PSI-7977(Sofosbuvir) is an investigational nucleotide analog currently in Phase 2 For treatment of chronic HCV infection. PSI-7851 is a mixture of two similar molecules, PSI-7976 and PSI-7977, which exist in PSI-7851 as isomers of each other. Once inside a liver cell, both molecules are rapidly converted to the same active triphosphate. Given the ability to more easily manufacture PSI-7977, and potentially advantageous in vitro characteristics, PSI-7977 was selected For further clinical development. Antiviral agents.Sofosbuvir ( Formerly PSI-7977 or GS-7977) is a drug For the treatment and cure of hepatitis C. It was discovered at Pharmasset and then acquired For development by Gilead Sciences. Sofosbuvir is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate. Sofosbuvir is a nucleotide analogue inhibitor of the hepatitis C virus (HCV) polymerase. The HCV polymerase or NS5B protein is a RNA-dependent RNA polymerase critical For the viral cycle. Sofosbuvir is being studied in combination with pegylated interferon and ribavirin, with ribavirin alone, and with other direct-acting antiviral agents. It has shown excellent clinical efficacy when used either with pegylated interferon/ribavirin or in interferon-free combinations. In particular, combinations of sofosbuvir with NS5A inhibitors, such as daclatasvir or GS-5885, have shown sustained virological response rates of up to 100% in people infected with HCV. Data from the ELECTRON trial showed that a dual interferon-free regimen of sofosbuvir plus ribavirin produced a 24-week post-treatment sustained virological response (SVR24) rate of 100% For previously untreated patients with HCV genotypes 2 or 3. Data presented at the 20th Conference on Retroviruses and Opportunistic Infections in March 2013 showed that a triple regimen of sofosbuvir, ledipasvir, and ribavirin produced a 12-week post-treatment sustained virological response (SVR12) rate of 100% For both treatment-naive patients and prior non-responders with HCV genotype 1.Gilead has developed a sofosbuvir + ledipasvir co Formulation that is being tested with and without ribavirin \Chemical

Information

Catalog

DC6308

Purity of current batch:

>98%

Molecular Weight (MW)

529.45

Molecular Formula

C22H29FN3O9P

CAS No.

1190307-88-0

Solubility (25°C)

DMSO

Storage

Store at -20°C (desiccating conditions).


Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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