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DANIEL J. ISAACMAN, M.D., FAAP PRESIDENT, CLINICAL PHARMA SOLUTIONS PROFESSOR OF PEDIATRICS, DREXEL UNIVERSITY SCHOOL OF MEDICINE 1271 Peterman Lane | Ambler, PA 19002

EDUCATION B.S., University of Pennsylvania (Biological Basis of Behavior and Natural Sciences) 1976-1980 M.D., University of Pennsylvania 1980-1984

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS 1984-1985

Internship in Pediatrics: Children's Hospital of Northern California, Oakland, CA

1985-1987

Residency in Pediatrics: Children's Hospital of Philadelphia, PA

1987-1989

Fellowship, Pediatric Emergency Medicine, Children’s Hospital of Pittsburgh, PA

FACULTY APPOINTMENTS 1989-1990

Assistant Professor of Pediatrics, Department of Pediatrics, Medical College of Wisconsin

1990-1994

Assistant Professor of Pediatrics, Department of Pediatrics, University of Pittsburgh School of Medicine

1994-1995

Associate Professor of Pediatrics, Department of Pediatrics, University of Pittsburgh School of Medicine

1995-1999

Associate Professor of Pediatrics, Department of Pediatrics, Eastern Virginia

1999-2004

Medical

School

Professor of Pediatrics, Department of Pediatrics, Eastern Virginia Medical School

2005-2013

Professor of Pediatrics, University of Pennsylvania School of Medicine

2013-Present

Professor of Clinical Pediatrics, Drexel University School of Medicine


PROFESSIONAL / HOSPITAL POSITIONS 1989-1990

Attending physician – Children’s Hospital of Wisconsin

1990-1994

Attending physician – Children’s Hospital of Pittsburgh

1995-2003

Medical Director Emergency Services – Children’s Hospital of The King’s

Daughters 1995-2004

Division Director, Pediatric Emergency Medicine – Children’s Hospital of The King’s Daughters Director, Sedation Service – Children’s Hospital of The King’s Daughters

2004-2010

Attending Physician – Emergency Department, Children’s Hospital of Philadelphia

2004-2010

Director/Senior Director, Vaccines, Global Medical Affairs, Wyeth Vaccines

2010-2013

Director, Vaccines, Vaccines Clinical Research, Merck Research Laboratories

2011-2013

Attending Physician, Pediatric Medical Associates, Norriton, PA.

2013-Present

Attending Physician, Emergency Department, St. Christopher’s Hospital for Children, Philadelphia, PA.

2013-2014

Vice President, Clinical Development, Infacare Corporation, Trevose, PA.

CURRENT JOB RESPONSIBILITIES 2014-Present

President, Clinical Pharma Solutions Independent consulting firm specializing in all aspects of clinical drug development with an emphasis on pediatric drug development, lifecycle management and medical affairs activities.

2013-Present

Professor of Pediatrics, Drexel University School of Medicine and Attending Physician Emergency Department, St. Christopher’s Hospital for Children Responsible for patient care, resident and student education, and training of subspecialty fellows.


INDUSTRY EXPERIENCE 2004-2010

Director/Senior Director Vaccines, Global Medical Affairs, Wyeth Vaccines -

Core member of Prevnar and Prevnar 13 Global Brand Teams.

-

Responsible for the development of the lifecycle strategy for Prevnar 13

-

Served as medical monitor for numerous Phase 4 studies worldwide.

-

Inaugurated the "rapid response" team charged with timely review and critique of all key literature related to Wyeth Vaccines. Reviews/critiques distributed to Wyeth/Pfizer Vaccine medical personnel worldwide.

-

Interim medical lead of the adult PCV13 program.

-

Planned and orchestrated two advisory boards each year,

-

Evaluated Investigator Originated Proposals for potential funding.

-

Completed regulatory requests including clinical overviews/expert report.

-

Provided marketing support including key opinion leader and advocate interaction.

-

2010-2013

Conducted promotional review of advertising material

Director, Vaccine Clinical Research, Merck Research Laboratories -

Clinical lead - pneumococcal conjugate vaccine candidate, responsible for authoring of the clinical development plan including protocol development for all phase III studies, basis for licensure, and planned indications at licensure. Assumed role while program was beginning phase II and served as medical monitor for the phase II trial while authoring the development plan.

-

Clinical lead – C. Difficile vaccine candidate. Responsible for orchestrating all of the early phase clinical development of this vaccine, including constructing the early development plan, the target product profile, and the basis for licensure of this vaccine candidate. Developed phase I, II and III protocol outlines for the candidate vaccine.

-

Program lead – pneumovax program. Responsible for coordinating all phase IV activity and label optimization activity for this marketed product.


INDUSTRY EXPERIENCE (CONT) 2013-Present Senior Partner, Transcrip Partners, Inc. (Transcrip-partners.com) -

International medical consulting firm providing expertise in development and market positioning strategies for early molecules as well as tailored support in due diligence, drug development, medical affairs, pharmacovigilance, regulatory and medical writing during pre and postapproval.

2013-2014

Vice President, Clinical Development, Infacare Corporation -

Responsible for the clinical development of all pre-marketed products for the company. Charged with planning and orchestrating the clinical development plan for all products in development as well as providing the medical expertise to articulate the health care proposition offered by products in development.

PROFESSIONAL LICENSES Licensure (Number/State): #53074/Virginia 035622E/Pennsylvania Board Certification:

Specialty: Pediatrics

1988

Sub-Specialty: Pediatric Emergency Medicine 1992, 1999,2006 Other Certification/Licensure:

Advanced Trauma Life Support (ATLS)

1987,1991,1995

Instructor, Pediatric Advanced Life Support (PALS)

1989-2008

PALS certified

2009-present

Advanced Cardiac Life Support

2006,2008,2010

MEMBERSHIP IN NATIONAL PROFESSIONAL AND SCIENTIFIC SOCIETIES Member, American Academy of Pediatrics, Section on Emergency Medicine. 1988-present. Fellow, American Academy of Pediatrics. 1989-present. Member, American Academy of Pediatrics, Section on Emergency Medicine. Subcommittee on Pediatric Emergency Medicine Fellowship Curriculum. 1994. Member, Program Committee. American Academy of Pediatrics Annual Meeting, Section on Emergency Medicine. 1994. Co-Chairman, Subcommittee for Emergency Medicine Resident Trainees Curriculum. American Academy

of Pediatrics, Section on Emergency Medicine. 1995.


MEMBERSHIP IN NATIONAL PROFESSIONAL AND SCIENTIFIC SOCIETIES (CONT) Member, Program Committee. American Academy of Pediatrics Annual Meeting, Section on Emergency Medicine. 1995. Member, Collaborative Research Committee. American Academy of Pediatrics Section on Emergency Medicine. 1995-2004. Member, Executive Committee. American Academy of Pediatrics, Section on Emergency Medicine. 1996-2006. Member, Society for Pediatric Research. 1998-2004. Member, Strategic Planning Committee, Ambulatory Pediatric Association. 1999. Chair, Executive Committee. American Academy of Pediatrics Section on Emergency Medicine. 2002-2004 Member, Emergency Medical Services for Children (EMSC) Coordinating Committee 2001-2003 Member, Virginia College of Emergency Physicians Health Finance/Reimbursement Committee. 2002-2004 Member, Advanced Pediatric Life Support, Joint Task Force of the American Academy of Pediatrics and the American College of Emergency Physicians 2002-2004

NATIONAL SCIENTIFIC COMMITTEES Reviewer, Canadian Institutes of Health Research. 2002, 2003 Abstract Reviewer, American Pediatric Society/Society for Pediatric Research Scientific Session. 1998-2006. Member, Program Committee; American Academy of Pediatrics Annual Meeting, Scientific Session on Emergency Pediatrics. 1996. 1997-2001 Chairman, Scientific Program Committee, American Academy of Pediatrics, Section on Emergency Medicine

LOCAL SCIENTIFIC COMMITTEES Member – Institutional Review Board – Eastern Virginia Medical School 2000-2002 Chair, Clinical Research Review Committee, Children’s Hospital of The King’s Daughters, 2002-2004

EDITORIAL POSITIONS Member, Editorial Board; Pediatrics. 1992-2000 Member, Editorial Board, Pediatric Emergency and Acute Care. 1997-2002 Member, Senior Editorial Board, Pediatric Emergency and Acute Care. 2002-2009. Member, Editorial Board, Clinical Pediatric Emergency Medicine. 1999-present.


EDITORIAL POSITIONS (CONT) Member, Editorial Board, Pediatric Emergency Pocketbook, 3rd Edition 1998, 4th Edition 2003 Member, Editorial Board , APLS The Pediatric Emergency Medicine Resource, Fourth Edition. Sudbury, Massachusetts: Jones and Bartlett Publishers. 2004 Section Co-Editor, Controversies in Pediatric Emergency Medicine, Pediatric Emergency Care. 2001-04. Associate Editor, Schwartz Textbook of Emergency Medicine. 4th Edition, 1999 Reviewer, Pediatrics 1992-present Reviewer, Yearbook of Pediatrics, Mosby. 2002 Edition. Reviewer, Annals of Emergency Medicine. 2003-Present. Reviewer, Journal of Pediatrics, 1998 – present Reviewer, Archives of Pediatric and Adolescent Medicine, 1999 – present Reviewer, Academic Emergency Medicine – 2005-present

LECTURES BY INVITATION Rapid detection of bacteremia in children. Pediatric Grand Rounds. Eastern Virginia Medical School, Norfolk, Virginia. January 7, 1999. The unknown poison. Annual Meeting of the Pediatric Section of the Puerto Rico Medical Association, San Juan, Puerto Rico. February 13, 1999. Altered mental status. Annual Meeting of the Pediatric Section of the Puerto Rico Medical Association, San Juan, Puerto Rico. February 13, 1999. Neonatal fever. Annual Meeting of the Pediatric Section of the Puerto Rico Medical Association, San Juan, Puerto Rico. February 14, 1999. Panel Discussion: Academic Careers – Strategies for Success. PEM Fellows Conference, Los Angeles, CA. April 11, 1999. Breakfast Roundtable: Clinical Research. PEM Fellows Conference, Los Angeles, CA. April 12, 1999. Moderator, Scientific Plenary Session. Pediatric Academic Societies’ Annual Meeting, San Francisco, CA. May 4, 1999 Foley C, Isaacman D, Zaritsky A. Evidence-based Medicine. APA Workshop, Pediatric Academic Societies’ Annual Meeting, San Francisco, CA. May 5, 1999. Fever in the First Three Years of Life: A Sensible Approach. Suncoast Pediatric Conference, St. Petersburg, FL. June 25, 1999. Visual Diagnosis. Suncoast Pediatric Conference, St. Petersburg, CA. June 26, 1999.


LECTURES BY INVITATION (CONT) Jones ME, Davis P, Veligeti H, Isaacman DJ. Practice pattern of emergency physicians and pediatric emergency medicine physicians managing fever without source in young children. Platform presentation. Southern Soc. for Pediatric Research Meeting. New Orleans, LA. March 17, 2000. Breakfast Roundtable: Career Development. PEM Fellows Conference, Baltimore, MD. March 25, 2000. Reviewer, Paper Presentation Session. PEM Fellows Conference, Baltimore, MD. March 25, 2000. Isaacman DJ, Kaminer K, Veligeti H, Jones M. Davis P, Mason J. Comparative practice pattern of emergency physicians and pediatric emergency medicine physicians managing fever without source in young children. Poster presentation. Pediatric Academic Societies’ Annual Meeting, Boston, MA. May 14, 2000. Isaacman DJ, Veligheti H, Jones M, Davis P. Practice patterns of pediatric emergency physicians managing fever without source in infants 0 to 3 months of age. Poster presentation. Pediatric Academic Societies’ Annual Meeting, Boston, MA. May 14, 2000. Doobinin KA, Maniktala A, Isaacman DJ. Clinical Utility of Serum Electrolytes in the Emergency Department Management of Dehydrated Children. Poster presentation. Pediatric Academic Societies’ Annual Meeting, Boston, MA. May 14, 2000. Three-Hour workshop: Evidence-Based Medicine. Pediatric Academic Societies’ Annual Meeting, Boston, MA. May 16, 2000. Sweating it Out: Fever and Bacteremia. The Confidence of Knowing: Emergency Pediatrics and Acute Cardiology, Philippine Pediatric Association Annual Meeting, Manila, Philippines. October 18, 2000. What’s New with PALS? The Confidence of Knowing: Emergency Pediatrics and Acute Cardiology, Philippine Pediatric Association Annual Meeting, Manila, Philippines. October 18, 2000. Apparent Life Threatening Events: Pediatric Grand Rounds. Maryview Medical Center. Portsmouth, VA. November 3, 2000. Apparent Life Threatening Events: Family Medicine Resident Rounds. Renaissance Pediatrics. Virginia Beach, VA. January 17, 2001. Time Management. Breakfast Roundtable. 8th Annual National Pediatric Emergency Medicine Fellowship Conference, Marina Del Ray, CA. March 2001. Career Development, Breakfast Roundtable. 8th Annual National Pediatric Emergency Medicine Fellowship Conference. Marina Del Ray, CA. March 2001. Faculty Moderator: Abstract Presentation Session. 8th Annual National Pediatric Emergency Medicine Fellowship Conference. Marina Del Ray, CA. March 2001.


LECTURES BY INVITATION (CONT) New Pediatric Advanced Life Support Guidelines. 22nd Postgraduate Course, Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines January 23, 2002 Non-traumatic Orthopedic Emergencies in Children. 22nd Postgraduate Course, Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines January 23, 2002 Dental Emergencies in Children. 22nd Postgraduate Course, Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines, January 24, 2002 Emergency Pediatrics: Past, Present and Future. 12th Dr. Florencio N. Quintos Memorial Lecture, Quezon City, Philippines. January 25, 2002. Fever in the Young Child. Philippine Pediatric Society, Cebu Chapter, Cebu City, Philippines. January 26, 2002. Pediatric Emergency Medicine: Past, Present & Future. Pediatric Grand Rounds, Eastern Virginia Medical School. Norfolk, VA. April 4, 2002. Career Development. PEM Fellow’s Conference, Dallas, TX. April 2002. Isaacman DJ, Lawson L. Utility of the Serum C-Reactive Protein (CRP) for Detection of Occult Bacterial Infection in Children. Pediatric Academic Societies’ Meeting, Baltimore MD. May 4, 2002. Isaacman DJ, Burke BL. Utility of the Serum C-Reactive Protein (CRP) for Detection of Occult Bacterial Infection in Children. Poster presentation. Pediatric Academic Societies’ Annual Meeting, Baltimore, MD, May 4, 2002. Wadsworth MR, McGowan JL, Burke B, Isaacman DJ. A Time Flow Study in a Pediatric Emergency Department: Identifying Opportunities for Process Improvement. Poster presentation. Pediatric Academic Societies’ Annual Meeting, Baltimore, MD. May 4, 2002. Pruitt CW, Keriwala RD, Isaacman DJ, Doobinin KA. Injury Prevention Knowledge of Parents in a Pediatric Emergency Department. Poster presentation. Pediatric Academic Societies’ Annual Meeting, Baltimore, MD. May 4, 2002. The Occult Bacteremia Controversy. Special Interest Group Presentation. Pediatric Academic Societies’ Annual Meeting. Baltimore, MD. May 5, 2002. Isaacman DJ, Burke BL. Utility of the Serum C-Reactive Protein (CRP) for Detection of Occult Bacterial Infection in Children. Oral presentation. APHA Annual Meeting, Philadelphia, PA. November 13, 2002 Acute Life Threatening Events – AAP PREP:EM Board Review Course. Toronto, Ontario, August 2004 Orthopedic Emergencies -

AAP PREP:EM Board Review Course. Toronto, Ontario, August 2004


LECTURES BY INVITATION (CONT) Neurologic Emergencies - AAP PREP:EM Board Review Course. Toronto, Ontario,. August 2004 Neurologic Emergencies in Children. 5th Annual Pediatric Emergency Medicine Update, Norfolk, VA. April 10, 2003. So you want to be an ED Director. Breakfast Roundtable, PEM National Leadership Conference, Albuquerque, NM. August 2003. APLS Instructor: Neurologic Emergencies. AAP National Conference and Exhibition. New Orleans, LA. November 2003. Hematologic Emergencies – AAP PREP:EM Board Review Course. Montreal, Quebec. August 2004 Orthopedic Emergencies -

AAP PREP:EM Board Review Course. Montreal, Quebec. August 2004

Neurologic Emergencies - AAP PREP:EM Board Review Course. Montreal, Quebec. August 2004 Fever in the Age of Prevnar: ACEP Pediatric Emergency Medicine Assembly. Washington, D.C. April 10, 2005 Indirect Effects Associate with Pneumococcal 7-valent Conjugate Vaccine. 5th Annual International Pneumococcal and Pneumococcal Disease Symposium, Alice Springs Australia, April 6, 2006 Career Directions for Pediatric Emergency Medicine Physicians. American Academy of Pediatrics National Conference and Exhibition. San Francisco, CA. October 21, 2007

BIBLIOGRAPHY / MANUSCRIPTS Isaacman DJ. Otitic hydrocephalus: an uncommon complication of a common condition. Ann

Emerg Med 1989 Jun 6;18:684-687. Isaacman DJ, Karasic RB. Lack of effect of changing needles on contamination of blood cultures.

Pediatr Infect Dis J 1990;9:274-278. Isaacman DJ. Pediatric emergency medicine-current standards of care: results of a national survey.

Ann Emerg Med 1990 May 5;19:527-531. Isaacman DJ, Karasic RB. Utility of collecting blood cultures through newly inserted intravenous catheters. Pediatr Infect Dis J 1990;9(11):815-818. Li MI, Isaacman DJ. Ideal standards for pediatric EDs [letter]. Ann Emerg Med 1990 Dec 12;19:1473. Bonadio WA, Lehrmann ML, Hennes H, Smith D, Ruffing R, Melzer-Lange M, Lye P, Isaacman DJ. Relationship of temperature pattern and serious bacterial infections in infants 4 to 8 weeks old 24 to 48 hours after antibiotic treatment. Ann Emerg Med 1991 Sep;20(9):1006-1008.


BIBLIOGRAPHY / MANUSCRIPTS (CONT) Isaacman DJ, Verdile V, Kohen F, Verdile LA. Pediatric telephone advice: results of a mock scenario.

Pediatrics 1992 Jan;89:35-39. Isaacman DJ, Bell LM. The wheezer that wasn't. Pediatr Emerg Care 1992;8(2):107-109. Crain EF, Li M, Rodewald L, Hodge D, Avner J, Isaacman DJ. The role of the emergency department in primary care. Pediatr Emerg Care 1992;8(2):98-104. Isaacman DJ, Purvis KP, Gyuro J, Anderson Y, Smith D. Standardized instructions: Do they improve communication of discharge information from the emergency department? Pediatrics 1992;89:1204-1207. Isaacman DJ, Davis HW. Pediatric emergency medicine: state of the art. Pediatrics 1993 Mar 3;91(3):587-590. Bonadio WA, Hennes H, Smith D, Melzer-Lange M, Lye D, Isaacman DJ. Reliability of observation variables in distinguishing infectious outcome of febrile young infants. Pediatr Infect Dis J 1993;12(2):111-114. Avner J, Isaacman D, Seidel J, Selbst S, Quan L. Telephone advice in the pediatric emergency department. Pediatr Emerg Care 1993;9(5):300-306. Isaacman DJ. Telephone fees: are they worth it? J Clin Ethics 1993;4(3):271-273. Isaacman DJ, Scarfone RJ, Kost SI, et al. Utility of routine laboratory testing for detecting intraabdominal injury in the pediatric trauma patient. Pediatrics 1993;92:691-694. Rosenberg N, Barnett T, Isaacman DJ, Walkley E. To file or not to file. Pediatr Emerg Care 1994 Apr;10(2):113-116. Isaacman DJ, Rogers KD. Practice guidelines for management of infants and children with fever without source [letter]. Pediatrics 1994;93:346-347. Zhang Y, Isaacman DJ, Wadowsky RM, Rydquist-White J, Post JC, Ehrlich GD. Detection of S.

pneumoniae in whole blood by PCR. J Clin Microbiol 1995 Mar;33(3):596-601. Isaacman DJ, Zhang Y, Rydquist-White J, Wadowsky R, Post JC, Ehrlich GD. Identification of a patient with S. pneumoniae bacteremia and meningitis by the polymerase chain reaction.

Molecular and Cellular Probes 1995 Jun;9(3):157-160. Training Emergency Medicine Residents in Pediatric Emergency Medicine (TERIPEM) Committee, Section on Emergency Medicine, American Academy of Pediatrics. Modification of the pediatric emergency medicine fellowship curriculum statement for emergency medicine resident graduates (EMRGs). Pediatr Emerg Care 1995;11(2):142-149. Isaacman DJ, Karasic RB, Reynolds EA, Kost SI. Effect of number of blood cultures and volume of blood on detection of bacteremia in children. J Pediatr 1996 Feb;128(2):190-195.


BIBLIOGRAPHY / MANUSCRIPTS (CONT) Isaacman DJ, Reynolds EA. Effect of a research nurse on patient enrollment in a clinical study.

Pediatr Emerg Care 1996;12(5):340-342. Zempsky WT, Isaacman DJ, Sullivan KM. Child restraint device use in patients leaving a children’s hospital. Arch Pediatr Adolesc Med 1996 Dec;150:1284-1287. Isaacman DJ, Khine H, Losek JD. A simple intervention for improving telephone contact of patients discharged from the emergency department. Ped Emerg Care 1997;13(4):256-258. Isaacman DJ. Strategies for improving the detection of bacteremia in children. Inf Dis Clin Prac 1998;7(1):28-31. Isaacman DJ, Zhang Y, Reynolds EA, Ehrlich GD. Accuracy of a polymerase chain reaction-based assay for detection of pneumococcal bacteremia in children. Pediatrics 1998 May;101(5):813-816. Isaacman DJ. The Occult Bacteremia Controversy. Clin Pediatr Emerg Med.2000; 1:109-116. Decker M, Isaacman DJ. A common cause of altered mental status occurring at an uncommon age: case report and review of the literature. Pediatric Emergency Care 2000;16:94-96.. Isaacman DJ, Shults J, Gross TK, Davis PH, Harper M. Predictors of Bacteremia in Febrile Children 3 to 36 Months of Age.

Pediatrics 2000:106;977-.982.

Isaacman DJ, Kaminer K, Veligeti H, Jones M, Davis P, Mason JD. Comparative Practice Patterns of Emergency Medicine Physicians and Pediatric Emergency Medicine Physicians Managing Fever in Young Children. Pediatrics 2001 August;108(2):354-358. Isaacman DJ, Burke B. Utility of serum C-reactive protein for the diagnosis of occult bacterial infection in children. Arch Pediatr Adolesc Med 2002;156:905-909. Kelly CP., Isaacman DJ. Group B Streptococcal Retropharyngeal Cellulitis in a Young Infant: A Case Report and Review of the literature.

J Emerg Med 2002:23;179-182.

Isaacman DJ. Review Article. Approach to the Febrile Child in the Post-Pneumococcal Era. Posted on June 2002 on Pediatric Emergency Medicine Database (Pem-Database.Org). Isaacman DJ, Poirier MP, Loiselle JM, Poirier MP, Schutzman S. Closed head injury in children. Controversies in pediatric emergency medicine. Pediatr Emerg Care 2002;18:48-52. Isaacman DJ, Poirier MP, Harper M, Neuman M, Trainor J, Bell LM. Infectious diseases. Controversies in pediatric emergency medicine. Pediatr Emerg Care 2002;18:125-129. Isaacman DJ, Poirier MP, Baxter AL, Bechtel K, Pierce MC. Abuse or not abuse. That is the question. Controversies in pediatric emergency medicine. Pediatr Emerg Care. 2002;18:203-208. Doobinin KA, Heidt PE, Gross TK, Isaacman DJ. Nonurgent pediatric emergency department visits: Care-seeking behavior and parental knowledge of insurance. Pediatr Emerg Care 2003;19(1):10-4.


BIBLIOGRAPHY / MANUSCRIPTS (CONT) Poirier MP, MD, Isaacman DJ, Causey AL, Gonzalez del-Rey JA, Mason JD. Boundaries of the emergency department. Controversies in pediatric emergency medicine. Pediatr Emerg Care. 2003;19:41-43. Isaacman DJ, Poirier MP, Hegenbarth M, Lillis KA, Scarfone R. Ventriculoperitoneal shunt management. Controversies in pediatric emergency medicine. Pediatr Emerg Care. 2003;19:119125. Isaacman DJ, Poirier MP, Bothner J, Fitzmaurice L, Khan, N. Medical director dilemmas. Controversies in pediatric emergency medicine. Pediatr Emerg Care. 2003;19:198-202. Poirier MP, Isaacman DJ, Nichols MH, Pomerantz WJ, Givens TG. Who Is the Boss? Controversies in pediatric emergency medicine. Pediatr Emerg Care 2003;19:277-281. Isaacman DJ, Poirier MP, Chande VT, Hampers L, Gochman RF. Coaxing the consultant. Controversies in pediatric emergency medicine. Pediatr Emerg Care. 2003;5:373-377. Isaacman DJ, Poirier MP, Connors JM, Macias CG. Steele DW. The fellowship of the future. Pediatr

Emerg Care 2004;20:244-250. Poirier MP, Isaacman DJ, Barber JW, While N, Luria J. Pediatric trauma: “A horse of a different color� Pediatr Emerg Care 2004;20: 412-418 Poirier MP, Isaacman DJ, Strait RT, Counselman FL, Foster RL. Pain and sedation. Pediatr Emerge Care 2004; 20:57-62. Baxter A, Welch JC, Burke BL, Isaacman, DJ. Pain, position, and stylet styles: infant lumbar puncture practices of pediatric emergency attending physicians. Pediatr Emerg Care. 2004 Dec;20(12):81620 Baxter A, Fisher G, Burke B, Goldblatt D, Isaacman DJ, and Lawson L. Local anesthetic and stylet styles: Factors associated with resident lumbar puncture success.

Pediatrics 2006;117:876-881

Huang C, Poirier MP, Cantwell J, Ermis P, Isaacman DJ. The prudent layperson definition of an emergency medical condition. Clin Pediatr 2006; 45:149-55. Butterfoss FD, Major D, Clarke S, Cardena RA, Isaacman DJ, Mason JD, Clements D. What providers from general emergency departments say about implementing a pediatric asthma pathway.

Clin Pediatr 2006;45:325-33.

Isaacman DJ, Fletcher M, Fritzell B, Schranz J. Indirect effects associated with widespread vaccination with heptavalent pneumococcal conjugate vaccine. Vaccine, 2007; 25:2420-7 Black S, France EK, Isaacman D et al. Surveillance for invasive pneumococcal disease during 20002005 in a population of children who received 7-valent pneumococcal conjugate vaccine. Pediatr

Infect Dis J 2007; 26:771-7.


BIBLIOGRAPHY / MANUSCRIPTS (CONT) Isaacman D, Strutton D, Kalpas E et al. The Impact of indirect protection on the cost-effectiveness of pneumococcal conjugate vaccine. Clinical Therapeutics 2008;30:1-18 Isaacman, DJ, McIntosh ED, Reinert RR. Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines.

Int J

Infect Dis. 2010 Mar;14(3):e197-209. Epub 2009 Aug 22. Benavides JA, Ovalle O, Salvador G, , Gray S, Isaacman D , Rodgers G, Epidemiology of Invasive Pneumococcal disease in children in Colombia, Vaccine, 2012 in press

BIOGRAPHY ABSTRACTS Sacks L, Isaacman, DJ, Frishman G, Delivoria M. Relative effect of blood oxygen transport characteristics on optimal oxygen delivery to the tissues. Pediatr Res 1981;15:587A. Isaacman DJ, Karasic RB. The effect of changing needles on blood culture contamination rate.

Pediatr Emerg Care 1988;4(4):293A. Isaacman DJ. Pediatric emergency medicine - where are we now? Pediatr Emerg Care 1988 Dec;4:296A. Isaacman DJ, Karasic RB. Are two blood cultures better than one? Pediatr Emerg Care 1989;5(4):283A.

Child 1990 Apr;144:429A. Isaacman DJ, Verdile V, Kohen F, Verdile LA. Emergency department pediatric telephone advice.

Am J Dis Isaacman DJ, Purvis KP, Smith DS, et al. Do pre-specified instructions improve communication of discharge information? Pediatr Emerg Care 1990;6(3):227A. Isaacman DJ, Karasic RB, Davis HW. Pediatric emergency medicine--state of the art. Am J Dis Child 1991 Apr;145:409A. Isaacman DJ, Scarfone RJ, Kost SI. Utility of routine laboratory testing in the pediatric trauma patient. Am J Dis Child 1992 Apr;146:488A. Bonadio WA, Hennes H, Smith D, Ruffing R, Melzer-Lange M, Lye P, Isaacman DJ. Efficacy of the young infant observation scale (YIOS) in correlating clinical appearance (CA) with infectious outcome in febrile young infants. Am J Dis Child 1992 Apr;146:481-482A.


BIOGRAPHY ABSTRACTS (CONT) Isaacman DJ, Scarfone RJ, Kost SI. Utility of routine laboratory testing in the pediatric trauma patient. Ann Emerg Med 1992 May;21(5):592A. Isaacman DJ, Wadowsky RM, Post JC, Karasic RB, Hamilton PJ, Libert TA, Ehrlich GD. Utility of the polymerase chain reaction for detecting S. pneumoniae in blood. Pediatr Emerg Care 1991;8:305306A. Karasic RB, Isaacman DJ, Kost SI, Reynolds EA. Collecting two blood cultures and a larger volume of blood improves detection of bacteremia in children. Arch Pediatr Adolesc Med 1994;148:42. Isaacman DJ, Zhang Y, Wald ER, Wadowsky RM, Ehrlich GD. A sensitive and specific assay utilizing the polymerase chain reaction for the detection of S. pneumoniae in blood. Pediatr Res 1994;35(4 Pt 2):182A. Isaacman DJ, Reynolds EA. Effect of a research nurse on patient enrollment in a clinical study.

Arch Pediatr Adolesc Med 1994;148:66. Isaacman DJ, Zhang Y, Wadowsky R, Wald ER, Reynolds EA, Ehrlich GD. Evaluation of a polymerase chain reaction (PCR) -based assay for the detection of pneumococcal bacteremia in children.

Pediatr Emerg Care 1995;11:325A. Zempsky WT, Isaacman DJ, Sipp N. Child restraint device compliance in patients leaving a children’s hospital. Arch Pediatr Adolesc Med 1995; 149:5A. Khine H, Isaacman DJ, Losek JD. A simple intervention to improve telephone contact of patients discharged from an emergency department. Arch Pediatr Adolesc Med 1995; 149:53-54A. Gross TK, Isaacman DJ, Lakkis H. Clinical predictors of bacteremia in children 3-36 months of age.

J Inv Med 1997;45:35A. Pestian JP, Isaacman DJ, Qureshi F, Zaritsky A, Littelman-Andersen C. The impact of pediatric asthma clinical pathways on emergency room quality and costs. Pediatr Emerg Care 1997 Aug;13(4):298A. Isaacman DJ, Gross TK, Heidt PE, Hannon P. Predictors of bacteremia in children 3-36 months of age. Ambulatory Child Health 1997;(3 Pt 2):185. Jones ME, Davis P, Veligeti H, Isaacman DJ. Practice pattern of emergency physicians and pediatric emergency medicine physicians managing fever without source in young children. Platform presentation. Southern Society for Pediatric Research Meeting. New Orleans, LA. March 17, 2000. Isaacman DJ, Kaminer K, Veligeti H, Jones M. Davis P, Mason J. Comparative practice pattern of emergency physicians and pediatric emergency medicine physicians managing fever without source in young children. Ped Research 47;2000: 110A


BIOGRAPHY ABSTRACTS (CONT) Isaacman DJ, Veligheti H, Jones M, Davis P. Practice patterns of pediatric emergency physicians managing fever without source in infants 0 to 3 months of age. Ped Research 47;2000: 110A. Doobinin KA, Maniktala A, Isaacman DJ. Clinical Utility of Serum Electrolytes in the Emergency Department Management of Dehydrated Children. Ped Research 47;2000: 106A. Isaacman DJ, Burke BL. Utility of the Serum C-Reactive Protein (CRP) for Detection of Occult Bacterial Infection in Children. Ped Research 51; 2002:93A Huang C, Poirier MP, Cantwell J, Ermis P, Isaacman DJ. The prudent layperson definition of an emergency medical condition. Ped Research 51; 2002:106A Wadsworth MR, McGowan JL, Burke B, Isaacman DJ. A Time Flow Study in a Pediatric Emergency Department: Identifying Opportunities for Process Improvement. Ped Research 51; 2002:90A Pruitt CW, Keriwala RD, Isaacman DJ, Doobinin KA. Injury Prevention Knowledge of Parents in a Pediatric Emergency Department. Ped Research 51; 2002 :182A Black S, France E, Bracken L, Lewis E, Gray G and Isaacman D. Ongoing surveillance for invasive pneumococcal disease (IPD) in children who received 7-valent conjugate vaccine in Northern California Kaiser Permanente. Ped Research 2006 Greenberg D, Vesikari T, Peltier C, Isaacman DJ et al: Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV-15) compared to Prevnar 13™ (PCV-13) in healthy infants. Pneumonia; 3: 2014; 101A.

GRANT SUPPORT (PAST TEN YEARS) Principal Investigator Daniel J. Isaacman, M.D. Title Implementing a Pediatric Asthma Guideline in Adult Emergency Department Period of Grant 2002-2005 Total Amount of Award $750,000 Source of Funding Maternal Child Health Bureau, Department of Health and Human Services

BIBLIOGRAPHY / REVIEWS AND CHAPTERS Isaacman DJ. Coma and Altered Mental Status. In: Barkin RM (editor). Pediatric Emergency

Medicine. St. Louis: Mosby Year Book, 1992:893-899. Isaacman DJ. Altered Level of Consciousness: Overview. In: Silverman B (editor). Advanced

Pediatric LifeS Support Teaching Manual. Dallas: American College of Emergency Physicians, 1993:177-185.


BIBLIOGRAPHY / REVIEWS AND CHAPTERS (CONT) Isaacman DJ, Post JC. Drainage and Packing of a Nasal Septal Hematoma. In: Henretig F, King C (editors). Textbook of PediatricEmergency Procedures. Baltimore: Williams & Wilkins, 1997:675680. Isaacman DJ, Post JC. Nasal Foreign Body Removal. In: Henretig F, King C (editors). Textbook of

Pediatric Emergency Procedures. Baltimore: Williams & Wilkins, 1997:681-687. Isaacman DJ. Coma and Altered Mental Status. In: Barkin RM, Caputo G, Jaffe D, Knapp J, Schafermeyer R (editors). Pediatric Emergency Medicine: Concepts and Clinical Practice, Second

Edition, 1997:974-981. Isaacman DJ. Altered level of consciousness. In: Strange G (editor). Advanced Pediatric Life

Support Teaching Manual - The PediatricEmergency Medicine Course. American Academy of Pediatrics and American College of Emergency Physicians, Elk Grove Village, IL, 1998;159-166. Isaacman DJ, Cantor RM. Altered mental status and coma. In: Orenstein J, Klein B, Mayer T (editors).

Pediastat: For Pediatric Urgent Care and Emergency Medicine (CD-ROM). CMC Research, Portland OR, 1998. Isaacman DJ, Bhisitkul D. Fever. In: Burg F, Ingelfinger J, Wald EA, Polin R (editors). Current

Pediatric Therapy. Philadelphia: WB Saunders, 1999:208-210. Isaacman DJ and Seward P. Fever and Infection: Management of the Child 0-2 Years of Age. In: Schwartz G, Editor, Isaacman DJ, Houton J (editors). Principles and Practice of Emergency

Medicine, Fourth Edition. Baltimore: Williams & Wilkins, 1999:1427-31. Isaacman DJ. Altered Mental Status in Children. In: Schwartz G, Editor, Isaacman DJ, Houton J, Associate Editors.

Principles andPractice of Emergency Medicine, Fourth Edition. Williams &

Wilkins, Baltimore. 1999:1403-04. Kelly R, Isaacman DJ. Thoracic Emergencies. In: Fleisher G, Ludwig L (editors). Textbook of

Pediatric Emergency Medicine, Fourth Edition. Baltimore: Williams and Wilkins, 2000:1539-59. Isaacman DJ, Qureshi F. High fever in a 3-week old girl. Pgs 102-105 in: Burg F, Vaughan V, Nelson K. Pediatrics: A Problem-Based Review. Philadelphia: WB Saunders, 2001. Isaacman DJ, Qureshi F. High fever in a 6-month old. Pgs 182-185 in: Burg F, Vaughan V, Nelson K.

Pediatrics: A Problem-Based Review. Philadelphia: WB Saunders, 2001. Isaacman DJ. Expert Commentary. 2001 Year Book of Pediatrics. St. Louis: Mosby-Year Book Publishers, 2001. Kelly RE and Isaacman DJ. Thoracic Emergencies. Pgs 562-571 in: Synopsis of Pediatric Emergency

Medicine. Eds. Fleisher GR and Ludwig S. Philadelphia: Lippincott Williams & Wilkins, 2002. Isaacman DJ, Trainor JL, Rothrock SG. Central Nervous System. In: Gausche-Hill M, Fuchs S, Yamamoto L (editors). APLS The Pediatric Emergency Medicine Resource, Fourth Edition. Sudbury, MA, 2004: 146-185.


BIBLIOGRAPHY / REVIEWS AND CHAPTERS (CONT) Maiers KA and Isaacman DJ. Sinusitis. In: The clinical practice of emergency medicine. 4th Edition. Wolfson AB editor. Philadelphia: Lippincott Williams and Wilkins, 2004; 174-177 Kelly RE and Isaacman DJ. Thoracic Emergencies. In: Textbook of Pediatric Emergency Medicine,

Fifth Edition. Eds. Fleisher GR and Ludwig S. Philadelphia: Lippincott Williams & Wilkins, 2005 Bridy-Pappas AE, Margolis MB, Center KJ, Isaacman DJ: Streptococcus pneumoniae: Description of the pathogen, disease epidemiology, treatment and prevention. Pharmacother. 2005; 25(9):11931212.

BIBLIOGRAPHY / BOOKS Associate Editor: Schwart R. Principles and Practice of Emergency Medicine, Fourth Edition. Baltimore: Williams & Wilkins, Baltimore 1999. Associate Editor, Pediatric Emergency Pocketbook, Third Edition. Tarascon Publishing, Loma Linda, CA, 1999.

HONORS AND AWARDS Pediatric Trauma and Acute Care Award. Outstanding Paper in Pediatric Emergency Medicine, American Academy of Pediatrics Annual Meeting. Scientific Session, Section on Emergency Medicine. San Francisco, CA. 1992. Willis Wingert Award. Outstanding Paper presented by a Fellow in Emergency Medicine. American Academy of Pediatrics Annual Meeting. Scientific Session, Section on Emergency Medicine. San Francisco, CA. 1988. Outstanding Achievement in Pediatrics, University of Pennsylvania School of Medicine. 1984. Magna Cum Laude, University of Pennsylvania. Faculty of Arts and Sciences.

PREVIOUS FUNDED RESEARCH (>10 YEARS PRIOR) Principal Investigator Daniel J. Isaacman, M.D. Title Implementing a Pediatric Asthma Guideline in Adult Emergency Department Period of Grant 2002-2005 Total Amount of Award $750,000 Source of Funding Maternal Child Health Bureau, Department of Health and Human Services


PREVIOUS FUNDED RESEARCH (>10 YEARS PRIOR) (CONT) Principal Investigator Daniel J. Isaacman, M.D. Title Methods for improving the detection of bacteremia in children. Period of Grant 1996-Present Total Amount of Award $110,000 Source of Funding Eastern Virginia Medical School, Department of Pediatrics Chairman’s Fund Principal Investigator Daniel J. Isaacman, M.D. Title Means for improving the detection of bacteremia in children. Period of Grant 1991-1993 Total Amount of Award $56,965 Source of Funding Children's Hospital of Pittsburgh, Start-up Funding and General Clinical Research Center Principal Investigator Daniel J. Isaacman, M.D. Title Utility of the polymerase chain reaction for the detection of bacteremia in children. Period of Grant 1991-1993 Total Amount of Award 1991-1993: $4,310

1993-1994: $30,471

Source of Funding 1991-1993: Children's Hospital of Pittsburgh, Seed Money, 1993-1994: Children's Hospital of Pittsburgh, General Clinical Research Center Co-Principal Investigator Daniel J. Isaacman, M.D. Title Effect of volume of blood and number of cultures on the detection of bacteremia in children. Period of Grant 1990-1993 Total Amount of Award $57,342 Source of Funding Children's Hospital of Pittsburgh, General Clinical Research Center Principal Investigator Daniel J. Isaacman, M.D. Title Utility of collected blood cultures through newly inserted intravenous catheters. Period of Grant 1989-1991 Total Amount of Award $3,864 Source of Funding Children's Hospital of Pittsburgh, General Clinical Research Center.


PREVIOUS FUNDED RESEARCH (>10 YEARS PRIOR) (CONT) Principal Investigator Daniel J. Isaacman, M.D. Title Utility of the polymerase chain reaction (PCR) for detection of pneumococcal bacteremiaclinical trial. Period of Grant 1994-1995 Total Amount of Award $12,395 Source of Funding Children's Hospital of Pittsburgh, Research Advisory Committee

Profile for Daniel J Isaacman, M.D., FAAP

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