Issuu on Google+

!""#$%&'&()

!"#"$%&'())


!"#$%&'()*+,"$'*-&'()./0.+&1(2(3454(6&,,78(9:8(;!<:(=>??@A


!"#$%&'()*+,"$'*-&'()./0.+&1(2(3454(6&,,78(9:8(;!<:(=>?B?A(


C-&$D$E*($F(!"#$%&'()*+,"$'*-&'()./0.+&1

*'+#,%-.#/01-234456 !71&8%9#"):;7&9)<%9#"-=>-:%?@#A#$%1+#&B#?#C%BB-1-8<#D-?<7-1#/EFFF6###"%8> !71&8%9#"):;7&9)<%9#"-=>-:%?#/34436#"%8>

G-.#,%-.#/0&H<234456 I-97?8%H:H#&B#C%H-?H-#&B#!71&8%9#"):;7&9)<%9#"-=>-:%?#/34456###"%8> C)8?:%9#!-''='?1#J%8-<%9H#&B#!71&8%9#"):;7&9)<%9#"-=>-:%?#$#9-''H#/34456##"%8> !71&8%9#"):;7&9)<%9#"-=>-:%?@#A#+%H-?H-#&B#A9<%K?<-+#!'&8?'#$#!-''H#/34E46##"%8> I%91&-8K%1&8:-8<#%8B'=-89-#%8#!""@#<7-#1&'-#&B#?8<%(-8#H<%:='?<%&8#/344L6##"%8> M7-#N<%&'&()#&B#!71&8%9#"):;7&9)<%9#"-=>-:%?@#A8&<7-1#'&&>#?<#<7-#O-'?<%&8H7%;#$-<.--8#$E#9-''H# ?8+#!""#/34E46###"%8>


C-&$D$E*($F(!"#$%&'()*+,"$'*-&'()./0.+&1 A=<&%::=8-#N<%&'&()#P#/0&H<234E46 !""2'%>-#I&8&9'&8?'#$29-''#"):;7&9)<&H%H#@#A1-#.-#?''#Q&=8+#<&#7?K-#%<P#/34E46###"%8> !""#$29-''H#1-9&(8%R-#H=1K%K?'#;1&:&<%8(#?8<%(-8H#%8#H<1&:?'#9-''H#/34E46#"%8>


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


H:2&I,4E

Q2!.DD(!"#$%&'()*+,"$'*-&'()./0.+&1 J(Q&#I($F(1(:&FF.#.%-(T.1-".#


H:2&I,4E

Q2!.DD(!"#$%&'()*+,"$'*-&'()./0.+&1 J(Q&#I($F(1(:&FF.#.%-(T.1-".#


H:2&I,4E

Q2!.DD(!"#$%&'()*+,"$'*-&'()./0.+&1 J(Q&#I($F(1(:&FF.#.%-(T.1-".#


J4E&I,4E


J4E&I,4E


J4E&I,4E


J4E&I,4E C)8?:%9#9-''='?1#>%8-<%9H#&B#971&8%9#'):;7&9)<%9#'-=>-:%?#$#9-''H

Q&#-"(1%I(I.1-"(#1-.7($F(Q2!))('.DD74(3".(-$-1D('D$%1D(H&#-"(#1-.78(68(1#.(I.,&'-.I( &%(E#1*4((3".(.##$#(H1#7(#.,#.7.%-(<C7($F(-".(.7-&+1-.74(3".(E#$K-"(#1-.(-#.%I7( 1#.(&%I&'1-.I(1'#$77(-".(-$,4(3".(I.1-"(#1-.7(K.#.('1D'/D1-.I(H*(7/H-#1'-&$%($F( -".(E#$K-"(#1-.(F#$+(-".(H&#-"(#1-.4(3".(<C($F(-".(I.1-"(#1-.7(K17('1D'/D1-.I(F#$+( -".(7R/1#.(#$$-($F(-".(7/+($F(7R/1#.7($F(-".(<C($F(-".(-$-1D('D$%1D(H&#-"(#1-.7(1%I( -".(<C($F(-".(E#$K-"(#1-.4


!""#I%91&-8K%1&8:-8<H


!))(31#E.-7U(3"#..(S#$-.'-&G.(V&'".78( M.#+&%1D(!.%-.#7((1%I(Q$%.(91##$K "):;7?<%9# T)H<-:

$'&&+H<1-?:

$&8-#I?11&.# G%97-H

"):;7#G&+-H G%97-H

C%H1=;<#$&8-# I?11&.#G%97-H

C%H1=;<#"):;7# G&+-H#G%97-H C&.81-(='?<-#U! !""#$29-''H#01&'%B-1?<%&8

C%H1=;<#$'&&+#G%97-H D&19-#!""#$29-''H#A;&;<&H%H


S#$-.'-&G.(V&'".7(F$#(!))(Q2!.DD7 $&8-#I?11&.#01&<-9<%K-#G%97-H !""#$29-''H#1-9&(8%R-#H=1K%K?'#;1&:&<%8(#?8<%(-8H#%8#Q&8-#:?11&.#H<1&:?'#9-''H#/34E46##("%8>

"):;7#G&+-H#01&<-9<%K-#G%97-H !CVL#?8+#!CE44#:&+='?<-##!""#$#9-''H#(1&.<7#?8+#H=1K%K?'#/34456(("%8>

$'&&+#01&<-9<%K-#G%97-H $'&&+#G=1H-2'%>-#!-''H#;1&<-9<#!""#$#9-''H#<71&=(7#TCD2E#/34446#(()&%0


L%F&D-#1-&$%(9.'"1%&7+($F(!))(Q2!.DD7 !"#$%&%'(&%))*+,"+-"./%"0/%1+2*,%"&%0%(.+&"34356"*,"7"0%88"0/&+,*0"891(/+09.*0"8%:2%1*;"*)" ;))+0*;.%<"=*./"*,0&%;)%<"-:,0.*+,;8"&%)(+,)%".+").&+1;8"0%88><%&*$%<"?@A>B""!"#$"%&'()*+++ !"!71&8%9#'):;7&9)<%9#'-=>-:%?#$#9-''H#-W;1-HH#B=89<%&8?'#!X!OY#97-:&>%8-#1-9-;<&1H# <7?<#:-+%?<-#H;&8<?8-&=H#:%(1?<%&8#Q-8-?<7#Q&8-#:?11&.#H<1&:?'#9-''HS##6:--27&)KKK

,)*K-1-W;1-HH%&8#&B#<7-#!X!O5#97-:&>%8-#1-9-;<&1Z#?8+#%<H#'%(?8+Z#!X!"EV#%8#$29-''# 971&8%9#'):;7&9)<%9#'-=>-:%?S##6:--27&'((L


!W!XYZ<:T2B(J[&7


)&%0


!!XYZ<:T2B(J[&7


!))(Q$%.(91##$K(V&'".7


!))(Q$%.(91##$K(V&'".7


3".(7-.+('.DD(%&'".7(&%(H$%.


3".(7-.+('.DD(%&'".7(&%(H$%.


Q$%.(91##$K(1%I(Q(!.DD7(M.%.#1-&$%(


Q(!.DD7(M.%.#1-&$%(1%I(S#$D&F.#1-&$%


L++/%.(<*7-.+(X.G&.K(=G&I.$A


)*+,"(V$I.(:.G.D$,+.%-(=G&I.$A


)*+,"(M.#+&%1D(!.%-.#7(=G&I.$A


#:.%I#&-&'(!.DD7(9&E#1-&$%(=G&I.$A


#J%-&E.%(S#.7.%-&%E(!.DD7((=G&I.$A


!""#I&'-9='?1#0?<7.?)H


M?1(-<H

[8+=9-#A;&;<&H%H

O-+=9-#A8(%&(-8-H%H

!1%'.#(N1DD+1#07

>???(T#1+.K$#0 >?BB(T#1+.K$#0

O-+=9-#U1&.<7

AK&%+#I-<?H<?H%H


!1%'.#(N1DD+1#07 M?1(-<H

[:;1&K-#!-''='?1#N8-1(-<%9H

>???(T#1+.K$#0 >?BB(T#1+.K$#0

T<1-8(<7-8#[::=8-#T)H<-:

O-+=9-#[8B'?::?<%&8


T1'-$#7(&%(!1%'.#(M#$K-"(=G&I.$A


J,$,-$7&7(S1-"K1*7(


J,$-$7&7( C[-#&%7&'(S1-"K1*7

J,$-$7&7(C[-#&%7&'(S1-"K1*7


L%I/'-&$%($F(C[-#&%7&'(J,$,-$7&7(=G&I.$A


SL\6(S1-"K1*(&%(!1%'.#(=G&I.$A


SL\6(+3]X(S1-"K1*(<-&+/D1-&$%(&%(!1%'.#


SL\6(+3]X(S1-"K1*(<-&+/D1-&$%(&%(!))


SL\6(+3]X(S1-"K1*(<-&+/D1-&$%(&%(!))

"%8>


SL\6ZJ63(M#$K-"(S1-"K1*7(=G&I.$A


SL\6ZJ63(S1-"K1*7(=G&I.$A


3*#$7&%.(6&%17.7(J'-&G1-&$%(=G&I.$A


3/+$#(</,,#.77$#(S3CV(=G&I.$A


Q(!.DD(X.'.,-$#(=Q!QXA(<&E%1D&%E(S1-"K1*

"%8>


!""#M1-?<:-8<H


(

T!X(2(:#4(3"$+17(5(6&,,78(;!<:


V.K(3#.1-+.%-7(2(:#4(3"$+17(54(6&,,78(;!<:(


!))(31#E.-.I(3#.1-+.%-7(2(M.%.-&'(9/-1-&$%7


T/-/#.(!))(3#.1-+.%-7


X&-/[&+1H(9.'"1%&7+7


X&-/[&+1H(9.'"1%&7+7


:.%I#&-&'(!.DD7(3#.1-+.%-(&%(!1%'.#


J%-&2J%E&$E.%.7&7(3#.1-+.%-7(&%(!1%'.#


CLL Biology