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variable domain • Creative Biolabs offers clients a novel bispecific antibody (BsAb) format, the dual varia ble domain IgG (DVD-IgG), for many diverse studies in antibody engineering. We aim t o provide the reliable, efficient services to meet our customer’s individual requirement s. • • DVD-IgG is one type of bispecific antibody format, which is generated from two parent al mAbs by placing two variable domains from one parental antibody onto the heavy c hain and the light chain of another parental antibody, instead of one variable domain. The variable domain pairs can be derived from whole human, mouse or rat mAbs with phage/yeast display libraries. And the short peptides derived from the N-termini of CH 1 or CL link the outer variable domain (VD1) and the inner variable domain (VD2) toget her. The DVD-IgG retains the antigen-binding specificity, affinity, and biologic activities from its both parental antibodies, therefore, all of its four variable domains are functio nal. Many different DVD-IgGs have been designed and manufactured for treating comp lex diseases with multiple mediators contributing to overall disease pathogenesis.


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Services include: VD selection: pairing from parental mAbs. Arrangement of the inner/outer orientation of the selected VDs. Determination of the amino acid sequences used to link the VDs. DVD-IgG optimization: such as improving expression in mammalian cells, simplifing purification via standard approaches, etc. • Creative Biolabs has bispecific antibody design and construction ex perience in the field of antibody engineering, which makes us the i ncomparable supplier of DVD-IgGs with good drug-like biophysical and pharmacokinetic properties, and amenability for large-scale m anufacturing. We are confident to provide you with a first-class serv ice while at competitive cost.


variable domain  

Creative Biolabs offers clients a novel bispecific antibody (BsAb) format, the dual variable domain IgG (DVD-IgG), for many diverse studies...

variable domain  

Creative Biolabs offers clients a novel bispecific antibody (BsAb) format, the dual variable domain IgG (DVD-IgG), for many diverse studies...

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