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Contents Nanomaterials ......................................................3 Complex Tissue & Organs....................................8 Engineering Cells ................................................11 Biotechnology ....................................................13 Page 3

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Materials Science ................................................15 Drug Delivery ....................................................21 Biomaterials Education........................................22 Medical Devices..................................................26 Industry Applications ..........................................29

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Nanomaterials New!

The Nanobiotechnology Handbook


Nanotechnology The Whole Story

Edited by

Ben Rogers and Jesse Adams

Yubing Xie

NevadaNano, USA

University at Albany, College of Nanoscale Science and Engineering, New York, USA

Sumita Pennathur University of California, Santa Barbara, USA

Offering a uniquely thorough overview of nanobiotechnology and its place in today’s advancements in applied science, this comprehensive survey combines contributions from physics, bioorganic and bioinorganic chemistry, molecular and cellular biology, materials science, and medicine as well as from mechanical, electrical, chemical, and biomedical engineering to address the full scope of current and future developments. World-class experts discuss the role of nanobiotechnology in bioanalysis, biomolecular nanotechnology, biosensors, and the use of nanotechnology in biofuels. Focusing on major research trends, the book highlights the importance of nanobiotechnology to a range of medical applications such as stem cell technology and tissue engineering, drug development and delivery, imaging, diagnostics, and therapeutics.

This book communicates, in easy-to-understand language, the sometimes tough-to-understand concepts of nanotechnology, providing a comprehensive reference for technically interested/trained laymen in the general public who want to learn more about this revolutionary, high-impact field of technology. The amount and level of math used in the pedagogy of the text has been minimized to cater to a general audience. The book includes behind-the-scenes stories of Nobel-prize-winning scientists—complete with eureka moments—as well as back-of-the-envelope calculations showing the real numbers of nanotechnology. Thematic figures have been created to pique the interest and guide readers.

• Provides a thoroughly comprehensive overview of all major aspects of nanobiotechnology • Discusses nanofabrication techniques and applications of nanotechnology for bioprocessing • Covers nanotoxicity, responsible nanotechnology, and educational and workforce development

• Delves into the history of nanotechnology, with special emphasis on key personalities and early milestones • Discusses the effects this new industry could have on human life, careers, education, and the environment • Covers scaling laws, giving us intuition about the physical ramifications of miniaturization

• Offers extensive references within each chapter to facilitate further study

• Tackles the eight main disciplines: nanomaterials, nanomechanics, nanoelectronics, nanoscale heat transfer, nanophotonics, nanoscale fluid mechanics, nanobiotechnology, and nanomedicine

• Includes a companion CD that contains all figures in the book

• Uses real-world applications to teach key concepts

Selected Contents:

Selected Contents:

Biomimetic Nanotechnology. Nanobiofabrication. Nanobioprocessing. Biomolecular and Cellular Manipulation and Detection. Biomedical Nanotechnology. Nanobiotechnology Impacts. Index.

Big Picture of the Small World. Introduction to Miniaturization. Introduction to Nanoscale Physics. Nanomaterials. Nanomechanics. Nanophotonics. Nanoscale Fluid Mechanics. Nanobiotechnology. Nanomedicine.

Catalog no. K11758, November 2012, 692 pp. ISBN: 978-1-4398-3869-3, $169.95 / £108.00 Also available as an eBook

Catalog no. K14290, March 2013, 395 pp. ISBN: 978-1-4398-9780-5, $69.95 / £44.99 Also available as an eBook

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Nanomaterials Forthcoming!


Development and Applications

Biosensors Based on Nanomaterials and Nanodevices

Edited by

Edited by

Dong Kee Yi

Jun Li


Kyungwon University, Gyeonggido, Republic of Korea

Kansas State University, Manhattan, USA

Georgia C. Papaefthymiou-Davis

Nianqiang Wu

Villanova University, Pennsylvania, USA

West Virginia University, Morgantown, USA

This book provides new findings and applications in nanoscale material preparation and multidisciplinary bionanomaterials research. It presents 12 chapters contributed by an international team of investigators, who are actively engaged in cutting-edge research in their respective disciplines. The book is divided into four parts, the first covering nanomaterial preparation, characterization, and applications in nanobiotechnology, the second covering the assembly of biomolecules to form soft nanobuilding blocks, the third covering nanomaterial application in biomechanics and micro scale fabrication process, and the fourth covering nanomaterial applications in eco-research and cytotoxicity.

This book provides readers with a quick overview of the exciting potential and critical challenges of emerging biosensors based on nanomaterials and nanodevices for future health monitoring, disease diagnosis, and therapeutic treatments. The book highlights the fundamental principles of biosensing utilizing the unique properties of nanoscale sensing mechanisms. It is a comprehensive resource for researchers, graduate students, and industrial engineers in this area, with the emphasis on the unique signal transducing mechanisms and potential applications of nanoscale biosensors.

• Offers readers a better appreciation of the importance of this interdisciplinary field to biotechnology, biomedicine, and environmental remediation • Discusses magnetic nanoparticles, bioimaging, biomedical applications, cancer therapy, tissue engineering, and more

Selected Contents: Nanomaterial in Nanobiotechnologies: Preparation, Characterization and Applications. Bio-inspired Magnetic Nanoparticles. Nanoparticles for Bioimaging. Biomedical Applications of Dendrimer Porphyrin or Phthalocyanine. Polymeric Nanoparticles in Cancer Therapy. Fullerene and Carbon Nanotube Bioconjugates. Biocatalytic Nanosystems. Soft Nanobuilding Blocks: New Types of Soft Nanomaterial Preparation Using Biomolecules. Engineered Biomolecules as a Nanomaterial. DNA Tiles as Nanostructuring Building Blocks: Fabrications and Applications. Nanomaterials and BioMEMS: Nano and Nicro Scale Hybridization of Materials and Applications. Microfluidic based Polymer Scaffold Design for Tissue Engineering. Fabrication of Mobile Hybrid Microswimmers using Micro/Nanoparticles and Bacterial Flagella. NanoToxicity Study and Applications in Eco-Bio Systems. Environmental Applications of Nanomaterials. Nanoparticle toxicity: recommendation for NanoMedicine. Catalog no. K13550, August 2013, c. 488 pp. ISBN: 978-1-4398-7641-1, $149.95 / £99.00 Also available as an eBook


Catalog no. K15174, September 2013, c. 250 pp. ISBN: 978-1-4665-5151-0, $159.95 / £99.00 Also available as an eBook


Nanotechnology and Human Health Edited by

Ineke Malsch Malsch Techno Valuation, Utrecht, Netherlands

Claude Emond Addressing expectations for human health, this book reviews current scientific and technical developments in nanotechnology for biomedical, agrofood, and environmental applications. This collection of perspectives on the ethical, legal, and societal implications of bionanotechnology provides unique insight into contemporary technological developments. Readers with a technical background will benefit from the overview of the state-of-the-art research in their field, while readers with a social science background will benefit from the discussion of realistic prospects of nanotechnology. The text also includes a glossary as well as extensive end-of-chapter references. Catalog no. 8144, August 2013, c. 384 pp. ISBN: 978-0-8493-8144-7, $139.95 / £89.00 Also available as an eBook

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Nanomaterials Forthcoming! Forthcoming!

DNA Nanotechnology Satyam Priyadarshy RKR Group, Inc., Herndon, Virginia, USA

Latha Shankar While DNA has proven to be a versatile molecule that is ideal for building complex structures at the nanometer scale, until now scientists have lacked a cohesive reference that details nanotechnology applications in which DNA plays a key role. This work describes current applications across many fields, including robotics, lithography, computation, electronics, and fabrication. Whether you are building biomedical scaffolds, designing molecular motors, or producing nanowires, this work informs you as to what has been accomplished and expands your understanding of what is possible. Catalog no. 86332, September 2013, c. 464 pp. ISBN: 978-1-4200-8633-1, $149.95 / £95.00 Also available as an eBook

Carbon Nanomaterials Second Edition Edited by

Yury Gogotsi and Volker Presser Drexel University, Philadelphia, Pennsylvania, USA Series: Advanced Materials and Technologies

This book provides information on synthesis, properties, and applications of carbon nanomaterials. With novel materials, such as graphene (atomically flat carbon) or carbon onions (carbon nanospheres), the family of carbon nanomaterials is rapidly growing. This book provides a state-of-the-art overview and indepth analysis of the most important carbon nanomaterials. Each chapter is written by a leading expert in the field, which ensures that both a review on the subject along with emerging perspectives are provided to the readers. Catalog no. K14293, August 2013, c. 600 pp. ISBN: 978-1-4398-9781-2, $169.95 / £108.00 Also available as an eBook


RNA Nanotechnology and Therapeutics Edited by

Peixuan Guo University of Kentucky, Lexington, USA

Farzin Haque Interest in RNA nanotechnology has increased as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and RNA conjugation and labeling. Catalog no. K14577, August 2013, c. 616 pp. ISBN: 978-1-4665-0566-7, $179.95 / £114.00 Also available as an eBook

Bionanotechnology Concepts & Applications Maheshwar Sharon IIT Bombay (retired), Birla College, Nanotechnology Research Center, India

Madhuri Sharon Monad Nanotech Pvt. Limited, Mumbai, India

Highlighting the human applications of the science, this volume discusses the fundamental concepts and underlying science of bionanotechnology, and the bionanomachines that result from research into this exciting new field. Distilling the authors' research and groundbreaking original experimentation, chapters cover bionanomachines and their use with and manipulation of DNA, RNA, proteins, carbohydrates, and lipids. Well-documented and authoritative, this book offers students and scientists alike the foundational information required to advance this powerful and potentially life-altering field. Catalog no. K12393, May 2012, 300 pp. ISBN: 978-1-4398-5214-9, $79.95 / £49.99

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Nanobiomaterials Handbook

Nanotechnology in Tissue Engineering and Regenerative Medicine

Edited by

Edited by

Balaji Sitharaman

Ketul Popat

State University of New York at Stony Brook, USA

Colorado State University, Fort Collins, USA

Nanobiomaterials exhibit distinctive characteristics, which make them suitable for a variety of biological applications. This volume provides a comprehensive overview of the field, offering a broad introduction for those new to the subject as well as a useful reference for advanced professionals. The book examines various synthesis and processing techniques important for developing nanobiomaterials, explores their unique nanoscopic physicochemical properties, discusses potential applications as well as biocompatibility issues, and provides a detailed overview of the interactions between bionanomaterials and biological systems.

Referred to as "nanomedicine" or "nanobiomedicine," the application of nanotechnology to medicine can impact diagnosis, monitoring, and treatment of diseases, as well as the control and understanding of biological systems. Bringing together an unparalleled field of experts, this volume explores various aspects of nanotechnology and its applications in biomedical fields. The book uses an application-oriented approach to relate laboratory-based research to the development of technologies that are easily adaptable to an industry environment, focusing chiefly on drug delivery, tissue engineering, and regenerative medicine.

Catalog no. 94661, June 2011, 737 pp. ISBN: 978-1-4200-9466-4, $179.95 / £115.00 Also available as an eBook

Catalog no. K10090, November 2010, 302 pp. ISBN: 978-1-4398-0141-3, $129.95 / £83.00 Also available as an eBook


Nano- and Biocomposites

Fundamentals of Microfabrication and Nanotechnology Third Edition, Three-Volume Set

Alan Kin-tak Lau University of Southern Queensland, Australia and The Hong Kong Polytechnic University, Kowloon

Farzana Hussain

Marc J. Madou University of California, Irvine, USA

“… offers the widest and yet the most detailed coverage of all essential and fundamental aspects of microfabrication and nanotechnology. The author has done an excellent and remarkable job in synthesizing such diverse material under a single umbrella.” —Suman Chakraborty, IIT Kharagpur, India

“Once again, Professor Madou has made an incredible contribution to the MEMS/NEMS global community in writing this series of books.” —Nico de Rooij, Director, Institute of Microengineering, EPFL, Switzerland A solutions manual, instructor’s manual, and figure slides are available upon qualifying course adoption

Catalog no. 3180, August 2011, 1992 pp. ISBN: 978-0-8493-3180-0, $259.95 / £166.00


Edited by

Oregon State University, Corvallis, USA

Khalid Lafdi University of Dayton, Ohio, USA

Advances in nanotechnology are leading to the creation of composites with a myriad of medical applications. This forward-thinking book is one of the first to meld research in biocomposites with advances in nanocomposite technology to provide an interdisciplinary resource on advanced materials for the biomedical industry. It covers nanostructured polymer composites, nano/bio composites, developments in tissue engineering, safer resins for tooth and bone repair, and improved artificial joints, along with potential opportunities for continued research. Catalog no. 8027X, August 2009, 408 pp. ISBN: 978-1-4200-8027-8, $184.95 / £118.00 Also available as an eBook

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Nanomaterials Forthcoming!

Understanding Nanomedicine An Introductory Textbook Rob Burgess Medical Nanotechnologies Incorporated, Richardson, Texas, USA

“In a single book, Dr. Burgess has done an excellent job in providing the much-needed background in the numerous physical, chemical, and biological methods that are used to enable nanomedicine. This book will be a useful reference for any student in the field of nanomedicine and describes many examples where nanotechnology promises to improve the diagnosis, monitoring, and treatment of disease.” —Dr. Gareth Hughes, Medical Nanotechnologies, Inc., USA

Catalog no. N10477, June 2012, 524 pp. ISBN: 978-981-4316-38-5, $149.95 / £95.00 Also available as an eBook

Nanostructures in Biological Systems Theory and Applications Aleš Iglič, Damjana Drobne, and Veronika Kralj-Iglič University of Ljubljana, Slovenia

This book surveys recent theoretical and experimental results on nanostructures in biological systems and explores possible applications. It presents the theoretical approach, which is useful in describing electrical and elastic phenomena in nanostructures in biological systems. The authors use biophysical methods to describe and indicate manipulation of clinically relevant problems, presenting potential clinical uses in hemostasis, inflammation, and spreading of cancer. They also cover interactions between biological membranes and inorganic nanostructures. Catalog no. N10694, July 2013, c. 300 pp. ISBN: 978-981-4267-20-5, $149.95 / £95.00 Also available as an eBook


Coming Soon!

Molecular Motors in Bionanotechnology

Nanotechnology Commercialization

Keith Firman and James Youell University of Portsmouth, UK

Many techniques have evolved to study and characterize molecular motors at the single-molecule level, such as the use of molecular tweezer devices for single-molecule studies. This book describes a wide range of molecular motors, from chemical to biological. It introduces readers to the concepts and benefits of each technique and looks at structural information and how this helps understand function. The book also examines how some of these motors are being used or may be used in the future as part of a synthetic biology approach to building devices and sensors. Catalog no. N10568, November 2012, 300 pp. ISBN: 978-981-4267-02-1, $149.95 / £95.00 Also available as an eBook

Takuya Tsuzuki Deakin University, Geelong, Australia

In terms of commercialization, nanomaterials occupy a unique place in nanotechnology. Engineered nanomaterials, especially nanoparticulate materials, are the leading sector in nanotechnology commercialization. In addition, the nanomaterial sector has attracted much more heated debate than any other nanotechnology sector with regard to safety, regulation, standardization, and ethics. This is the first book on nanotechnology commercialization that deals exclusively with nanomaterials. It provides overviews of the current trends in, and the issues associated with, the commercialization of nanomaterials by some of the foremost nanotechnology experts in their fields. Catalog no. N10812, May 2013, c. 450 pp. ISBN: 978-981-4303-28-6, $99.95 / £63.99 Also available as an eBook

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Complex Tissue & Organs Tissue Engineering and Regenerative Medicine


Tissue Engineering Principles and Practices

A Nano Approach

Edited by

Edited by

John P. Fisher, Antonios G. Mikos, Joseph D. Bronzino, and Donald R. Peterson

Murugan Ramalingam, Pekka Vallittu, Ugo Ripamonti, and Wan-Ju Li

Putting the numerous advances in the field into a broad context, this book explores current thoughts on the development of engineered tissues. It begins with coverage of the fundamentals, details the supporting technology, and then elucidates their applications in tissue engineering. It explores strategic directions, nonobiomaterials, biomimetics, gene therapy, cell engineering, and more. The chapters then examine the applications of these technologies in areas such as bone engineering, cartilage tissue, dental tissue, vascular engineering, and neural engineering. It provides a very comprehensive overview of major research topics in tissue engineering.

"This book broadly covers current topics of tissue engineering. In particular, it would be helpful for those who are studying in this field based on nanotechnology and biomaterial science."

• Includes contributions from experts and pioneers • Covers emerging topics such as regenerative medicine, presenting synthetic tissues and organs that are currently under development • Discusses the impact of tissue engineering products could have on the future of medicine

Selected Contents: Fundamentals: Strategic Directions. Calcium Phosphates. Protein Based Biomaterials. Synthetic Biomaterials. Morphogens. Signal Expression. Embryonic Stem Cells. Hematopoietic Stem Cells. Mesenchymal Stem Cells. Enabling Technologies: Nanobiomaterials. Biomimetics. Molecular Biology Techniques. Biomaterial Mechanics. Mechanical Conditioning. Micropatterned Surfaces. Drug Delivery. Gene Therapy. Cell Engineering. Cell Encapsulation. Cocultures. Bioreactors. Shear Forces. Vascularization. Bioimaging. Modeling. Applications: Bone Engineering. Craniofacial Engineering. Tendon & Ligament Engineering. Cartilage Tissue Engineering. TMJ Engineering. Interfacial Tissue Engineering. Dental Tissue Engineering. Urological Tissue Engineering. Vascular Engineering. Neural Engineering. Engineering Tumors.

—Shoji Takeuchi, The University of Tokyo

This book bridges the gap between nanotechnology and regenerative medicine to facilitate their transition from lab to the clinic. It compiles important aspects of basic science and fundamental principles as well as clinical relevance for current nanotechnological innovations in biomaterials and cell, tissue, and organ engineering. It also discusses future trends in regenerative medicine. It is intended for a wide audience including students, researchers, professors, and industrial experts working in the fields of biomaterial science and engineering, nanoscience and nanotechnology, bioengineering, cell biology, biomedical sciences, tissue engineering, and nanomedicine. • Supplies an integrated approach to the organization of nanotechnology, biomaterials, bioengineering, and biomedical sciences • Explains current perspectives and nanotechnological advances in tissue engineering and regenerative medicine • Covers a range of biomaterials, cells, and their interaction for the development of tissues and organs • Provides vision for global healthcare systems at the nanoscale level • Incorporates color figures and tables with current technical and clinical data Catalog no. K13868, September 2012, 592 pp. ISBN: 978-1-4398-8185-9, $149.95 / £95.00 Also available as an eBook

Catalog no. K13429, December 2012, 771 pp. ISBN: 978-1-4398-7400-4, $149.95 / £95.00 Also available as an eBook


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Complex Tissue & Organs New!

Coming Soon!

Advances in Therapeutic Engineering

Imaging in Cellular and Tissue Engineering

Edited by

Wenwei Yu, Subhagata Chattopadhyay, Teik-Cheng Lim, and U. Rajendra Acharya Through engineering algorithms that provide technological solutions, therapeutic engineering aims to elevate the quality of life of disabled individuals. This volume describes various therapeutic processes and mechanisms currently applied to healthcare in a range of areas, including mobility, communications, hearing, vision, and mental health and cognition. From prosthetics to sensory substitution and medical robotics, the book will prove enlightening to researchers and practitioners in a host of disciplines who want to understand the recent advances achieved globally in the field of therapeutic engineering. Catalog no. K13287, December 2012, 496 pp. ISBN: 978-1-4398-7173-7, $179.95 / £109.00 Also available as an eBook

Edited by

Hanry Yu and Nur Aida Abdul Rahim National University of Singapore Series in Cellular and Clinical Imaging

This book covers the full range of available imaging modalities and optical methods used to help evaluate material and biological behavior. It also highlights a wide range of optical and biological applications, both in vitro and in vivo. Each chapter in the text describes a specific application and discusses relevant instrumentation, governing physical principles, data processing procedures, as well as advantages and disadvantages of each modality. Catalog no. K12139, May 2013, c. 294 pp. ISBN: 978-1-4398-4803-6, $149.95 / £95.00 Also available as an eBook

Forthcoming! New!

Articular Cartilage Kyriacos A. Athanasiou, Eric M. Darling, Grayson D. DuRaine, Jerry C. Hu, and A. Hari Reddi Multitudes of treatments have been devised for articular cartilage injuries, which often degenerate inexplicably to disastrous impairment, but no satisfactory long-term solutions have been established. However, over the past two decades, the swift growth and development of new knowledge and technologies for cartilage formation, pathology, and repair have been exciting and inspirational. Written by world-class experts, this book covers all the latest research and clinical applications related to cartilage tissue engineering. It explores the role of nanotechnology and also provides extensive references at the end of each chapter. Catalog no. K12457, March 2013, 439 pp. ISBN: 978-1-4398-5324-5, $169.95 / £108.00 Also available as an eBook

The Law of Regenerative Medicine and Tissue Engineering David S. Smith Pepper Hamilton LLP, Pittsburgh, Pennsylvania, USA

Numerous clinical trials are currently in progress for complex tissue constructs and cell therapies. Providing an overview of those legal and regulatory elements that can significantly impact the clinical introduction of cell- and tissue-based products, this timely volume is an important reference at both the federal and state level. It discusses guidelines for the numerous current clinical trials for complex tissue constructs and cell therapies and considers the development of strategies for building patent portfolios and navigating FDA review for market approval. Catalog no. K11293, August 2013, c. 270 pp. Soft Cover, ISBN: 978-1-4398-2650-8 $59.95 / £38.99 Also available as an eBook

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Complex Tissue & Organs Polymers for Vascular and Urogenital Applications


Myocardial Tissue Engineering

Edited by

Edited by

Shalaby W. Shalaby Poly-Med Inc., Anderson, South Carolina, USA

Karen J.L. Burg Clemson University, South Carolina, USA

Waleed Shalaby Chadds Ford, Pennsylvania, USA

This book covers attributes of polymers used for vascular, urological, and gynecological materials. It provides a brief analysis of how the use of polymers in vascular and urogenital applications has evolved in the past five decades and outlines their common and specific functional requirements. It features small, readable monographs that provide a brief description of the evolving role of a particular material, and presents topics in materials processing and in vitro and in vivo evaluation, complete with case studies. Catalog no. 76949, May 2012, 270 pp. ISBN: 978-1-4200-7694-3, $179.95 / £114.00 Also available as an eBook

Tissue Engineering

Tatsuya Shimizu and Katsuhisa Matsuura Tokyo Women's Medical University, Japan

This book broadly summarizes myocardial tissue engineering and regenerative medicine, which consists of myocardial cell sources, cell therapy for damaged hearts, and tissue engineering technologies for fabricating beating hearts. It focuses on myocardial cell source, cardiac cells differentiated from embryonic stem/induced pluripotent stem cells. Several chapters highlight innovative technologies developed to overcome the vascularization problem. Remarkable results obtained in the past and the present and challenges for the future in the myocardial tissue engineering research field are described in the book. Catalog no. N10829, July 2013, c. 400 pp. ISBN: 978-981-4411-31-8, $149.95 / £95.00 Also available as an eBook


Edited by

Skin Bioscience

John P. Fisher University of Maryland, College Park, USA

A Molecular Approach

Antonios G. Mikos

Edited by

Rice University, Houston, Texas, USA

Toyoko Imae

Joseph D. Bronzino Trinity College, Hartford, Connecticut, USA

The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering, integrating all aspects of every sub-discipline in the field. Bringing in a diverse group of international contributors with backgrounds in academia, clinical medicine, and industry, this volume surveys the latest advances in this arena. The book discusses the fundamental concepts of tissue engineering, enabling technologies, and related applications, examining strategies that incorporate scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques. Catalog no. 9026, May 2007, 600 pp. ISBN: 978-0-8493-9026-5, $109.95 / £69.99 Also available as an eBook


National Taiwan University of Science & Technology, Taipei

This book introduces skin bioscience with a specific focus on the molecular approach. Following the description of the fundamental structure and unique functionality of the skin, it examines the response of the skin to exterior stimulation. It also focuses on the beautification and regeneration of the skin. With contributions written by specialists from biophysics and physical chemistry to regeneration medicine and cosmetics, this book provides readers with the molecular knowledge of the skin and stimulates their interest in further investigation and development of skin bioscience. Catalog no. N10701, June 2013, c. 200 pp. ISBN: 978-981-4364-95-9, $149.95 / £95.00 Also available as an eBook

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Complex Tissue & Organs

Engineering Cells New!


Advanced Materials for Joint Implants Giuseppe Pezzotti Kyoto Institute of Technology, Japan

This book details cutting-edge research in bioceramics science based on an interdisciplinary approach that directly bridges orthopedic concepts to surface science, physical chemistry, biomedical optics, and nanomechanics. Raman and cathodoluminescence spectroscopy are, among more conventional spectroscopic characterization techniques, cited in the book, used to their most advanced extents to unveil molecular scale phenomena of both chemical and mechanical origin occurring at the sliding surfaces of bioceramic joints. The concepts are relevant to the development of new biomaterials. Catalog no. N10574, April 2013, 400 pp. ISBN: 978-981-4316-88-0, $179.95 / £114.00 Also available as an eBook


Neuromorphic Olfaction Edited by

Krishna C. Persaud The University of Manchester, UK

Santiago Marco and Augustin GutierrezGalvez

Bacterial NanoCellulose A Sophisticated Multifunctional Material Edited by

Miguel Gama, Paul Gatenholm, and Dieter Klemm Series: Perspectives in Nanotechnology

The first book dedicated to the potential applications and unique properties of bacterial cellulose (BC), this seminal work covers the basic science, technology, and economic impact of this bulk chemical as well as the companies and patents that are driving the field. It reviews the biosynthesis and properties of BC, including genetics and characterization; discusses the advancing technology as it relates to product development, bioreactors, and production; and analyzes the economic impact of BC on a diverse range of industry applications, including materials and biomaterials, biological and polymer sciences, and electromechanical engineering. • Describes the effects of cultivation conditions on the bacterial nanocellulose (BNC) network formation, including controlled architecture for tissue engineering • Reviews a variety of approaches that are available for generation of BNC in different forms • Describes commercially available products of BNC, including nata de coco, wound dressings, cosmetic materials, and tubular BNC blood vessel grafts • Presents current results concerning the chemical polymerization of conducting polymers

University of Barcelona, Spain

Selected Contents:

Frontiers in Neuroengineering Series

Biosynthesis of Bacterial Cellulose. Tough Bacterial Nanocellulose Hydrogels Based on the DoubleNetwork Technique. Bacterial Cellulose Surface Modifications. Nematic Ordered Cellulose Templates. Wound Dressings and Cosmetic Materials from Bacterial Nanocellulose. Bacterial Nanocellulose Hydrogels Designed as Bioartificial Medical Implants. Biomimetic Mineralization of Apatite on Bacterial Cellulose.

Current understanding of biological components of chemical sensing systems makes it possible to consider biomimetic models of olfaction and how they may be translated into functional engineering devices. This book presents an innovative interdisciplinary biomimetic approach to olfaction, including biology, hardware, software, and sensors. The text explores contributions to the realization of novel chemical sensing systems inspired by biological pathways, describing cutting-edge research such as engineering aspects of olfaction, odor coding of neurons, chemical sensor arrays, and biologically modeled sensor robots.

Catalog no. K13216, November 2012, 304 pp. ISBN: 978-1-4398-6991-8, $129.95 / £82.00 Also available as an eBook

Catalog no. K13286, April 2013, 234 pp. ISBN: 978-1-4398-7171-3, $149.95 / £95.00 Also available as an eBook

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Engineering Cells New!


Mechanics of Cellular Bone Remodeling

Biology of Oral Cancer Key Apoptotic Regulators

Coupled Thermal, Electrical, and Mechanical Field Effects

Prakash S. Bisen Defense Research & Development Establishment, Gwalior, India

Qing-Hua Qin Australian National University, Acton

This volume presents a unified exploration of recent advances in bone remodeling, including its mathematical representation, giving readers a sound understanding of the process at both the macro- and cellular level. Beginning with a description of the basic concept of bone remodeling from a mathematical point of view, the book details the development of each of the techniques and ideas. From there it progresses to the derivation and construction of multifield and cellular bone remodeling and shows how they arise naturally in response to external multifield loads. Catalog no. K16026, January 2013, 320 pp. ISBN: 978-1-4665-6416-9, $139.95 / £89.00 Also available as an eBook

Zakir Khan Saurabh Bundela One new approach in dealing with cancer is through apoptotic regulators, which is the process of controlling cell growth by abnormally prolonging cell survival, facilitating the accumulation of transforming mutations and promoting resistance. With contributions from world-class experts, this book uses oral cancers as the specific means to demonstrate this technique with this particular type of cancer, which is quite prevalent (and deadly) in India and other parts of Asia, in particular. Catalog no. K16715, July 2013, c. 328 pp. ISBN: 978-1-4665-7558-5, $139.95 / £89.00 Also available as an eBook


Biomaterials for Stem Cell Therapy State of Art and Vision for the Future Edited by

Mechanobiology Handbook

Loredana De Bartolo

Edited by

Institute on Membrane Technology, Rende, Italy

Clemson University, South Carolina, USA

Augustinus Bader Center for Biotechnology and Biomedicine (BBZ), Leipzig, Germany

This book provides state-of-the-art developments with a focus on the interaction of stem cells with biomaterials for constructing and regenerating tissues and organs integrating strategies from basic biology, to materials for remodeling, to production processes. Stem cells of embryonic and adult origin are discussed with applications including nerve regeneration, liver, pancreas, skin, trachea, cartilage and bone repair, and cardiovascular therapy. All developments in the field reflecting the design and construction of the human body and its principal anatomy are discussed from a materials point of view. Catalog no. K16738, January 2013, 662 pp. ISBN: 978-1-4665-7639-1, $199.95 / £127.00 Also available as an eBook


Jiro Nagatomi Mechanobiology examines effects of mechanical force stimuli on cellular biological functions. At appropriate levels, mechanical stimuli are necessary for growth and maintenance of healthy tissues and organs. The past two decades have seen a dramatic increase in the level of research in mechanobiology. Collecting the cutting-edge research findings from a diverse range of scientists, this volume presents basic materials in mechanics and cell biology. The book is an appropriate reference for those new to the field and is designed to stimulate new ways of thinking in current mechanobiology researchers. Catalog no. 91212, March 2011, 563 pp. ISBN: 978-1-4200-9121-2, $179.95 / £115.00 Also available as an eBook

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Engineering Cells Biomaterials and Stem Cells in Regenerative Medicine Edited by

Murugan Ramalingam Seeram Ramakrishna National University of Singapore

Serena Best University of Cambridge, UK

This book brings together current knowledge on biomaterials and stem cells in the context of regenerative medicine. It explores key scientific and clinical aspects, including the basic science involved in structure and properties, techniques and technological innovations in processing and characterization, and applications. The text bridges the gaps in experimental approaches and understanding among the materials science and engineering, biological sciences, and biomedical science and engineering communities, making it a valuable reference for multidisciplinary biomedical research. Catalog no. K13711, July 2012, 564 pp. ISBN: 978-1-4398-7925-2, $149.95 / £95.00 Also available as an eBook


Biotechnology New!

OMICS Applications in Biomedical, Agricultural, and Environmental Sciences Edited by

Debmalya Barh, Vasudeo Zambare, and Vasco Azevedo Featuring contributions from active researchers around the world, this book explores current and emerging fields such as glycomics, miRNA, metagenomics, and environomics and their various applications. It examines a wide range of applications across the life sciences, demonstrating the real diversity of omics. This timely book discusses toxicogenomics in the assessment of environmental pollutants, plant metabolomics, nutrigenomics and its therapeutic applications, microalgal omics, omics for biofuel development, omics approaches for crop improvement and environmental sustainability, breast cancer biomarkers, and much more. Catalog no. K15973, March 2013, 713 pp. ISBN: 978-1-4665-6281-3, $169.95 / £108.00 Also available as an eBook

Handbook of Therapeutic Biomarkers in Cancer


Edited by

Institute of Integrative Omics and Applied Biotechnology (IIOAB), Purba Medinipur, West Bengal, India

Sherry X. Yang National Cancer Institute, Bethesda, Maryland, USA

Janet E. Dancey Ontario Institute for Cancer Research, Toronto, Canada

In this volume, a team of internationally recognized experts provides an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology. Catalog no. N10578, April 2013, 450 pp. ISBN: 978-981-4364-65-2, $179.95 / £114.00 Also available as an eBook

Biomedical Perspectives and Applications Edited by

Debmalya Barh

Kenneth Blum and Margaret A. Madigan LifeGen, San Diego, California, USA

A reflection of the explosion of research and development in this field, this book explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. It collates recent developments in the field into a state-of-the-art framework for this discipline. A select panel of experts discusses their cutting-edge omics research and novel technologies, supplying a basic platform of methods and applications as well as a multi-omics approach to future endeavors in the fertile areas of omics research. Catalog no. K12277, November 2011, 613 pp. ISBN: 978-1-4398-5008-4, $159.95 / £99.00 Also available as an eBook

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Healthcare Biotechnology A Practical Guide

Biological and Biomedical Coatings Handbook Two-Volume Set Edited by Sam Zhang Nanyang Technological University, Singapore

Important in today’s nanotechnology, biological and biomedical coatings have been studied extensively and are receiving much attention from researchers. A timely reference for experts and newcomers, this handbook explores the latest developments in films and coatings for biological and biomedical applications. The text covers a wide array of material types, including sol-gel, bio-ceramics, polymers, glass, nanomaterials, and chitosan. It also addresses various processes for developing and implementing these coatings, including CVD and PVD, drug delivery, released-control coatings, and spectroscopy. • Covers processing, properties, and performance • Includes information on drug delivery and released-control coatings • Presents cutting-edge developments from world leaders in films and coatings research • Serves as a simplified introductory stepping stone for new entrants to the field • Gives experts up-to-date figures, tables, plots, and images to aid their own work Catalog no. K11126, May 2011, 976 pp. ISBN: 978-1-4398-2125-1, $259.95 / £166.00 Also available as an eBook

Also available as individual volumes

Biological and Biomedical Coatings Handbook

Processing and Characterization

Catalog no. K12269, May 2011, 456 pp. ISBN: 978-1-4398-4995-8, $146.95 / £94.00

Biological and Biomedical Coatings Handbook


Catalog no. K12270, May 2011, 520 pp. ISBN: 978-1-4398-4996-5, $146.95 / £94.00 Individual volumes also available as eBooks


Dimitris Dogramatzis Dogramatzis Pharmacy, Athens, Greece

Focusing on the management of healthcare-related biotechnology, this text is a practical guide assisting all healthcare related biotech professionals in their day-today activities. It contains chapters on bioeconomy, biolicensing, biofinance, biopartnering, biodrug research, biomarket planning, biopromotion, product life cycle management, and biobusiness models. Written by a well-established professional and registered pharmacist, this reference is appropriate for graduate students and industry professionals. It contains over 350 tables and figures, and end-of-section problems and extensive references accompany each chapter. A solutions manual, instructor's manual, and figure slides are available upon qualifying course adoption

Catalog no. K12108, December 2010, 689 pp. ISBN: 978-1-4398-4746-6, $109.95 / £69.99 Also available as an eBook

Biotechnology Operations Principles and Practices Michael J. Roy University of Wisconsin-Madison, USA

This book introduces key biotechnology developments and covers critical elements, such as project management, regulatory affairs, quality assurance, biomanufacturing, quality control, nonclinical safety testing, and clinical evaluation. The author discusses these subjects in relation to development planning, process and pathways, management of integrated projects, and the business and economic aspects of development. Using simple language and explanatory figures, it describes the functional areas that must be successfully integrated to safely and efficiently bring a biotechnology product to market. A solutions manual and figure slides are available upon qualifying course adoption

Catalog no. K11486, March 2011, 416 pp. ISBN: 978-1-4398-3027-7, $104.95 / £66.99 Also available as an eBook

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Materials Science New!

Porous Media Applications in Biological Systems and Biotechnology Edited by

Kambiz Vafai University of California, Riverside, USA

This volume explores innovative approaches to effectively apply existing porous media technologies to biomedical applications. In each peer-reviewed chapter, world-class scientists and engineers address significant problems and discuss exciting research in biological systems. They cover various transport processes, mechanical behavior, and material properties of biological tissues from a porous media point of view. The book also presents pertinent aspects of experimental work and numerical techniques and discusses the modeling of several phenomena, including flow changes in cerebral aneurysms, biomass growth, marine systems, and tissue homeostasis and repair. Catalog no. 65416, August 2010, 632 pp. ISBN: 978-1-4200-6541-1, $157.95 / £101.00 Also available as an eBook

Macroporous Polymers Production Properties and Biotechnological/ Biomedical Applications Edited by

Bo Mattiasson Lund University, Sweden

Ashok Kumar Indian Institute of Technology, Kampur, India

Igor Yu. Galeaev Lund University, Sweden

Presented in a systematic way, this book addresses the production, characterization, and application of these polymers. The text considers traditional methods of production, including phase separation polymerization, leaching, foaming, and double emulsion, as well as newly merging methods such as cryogelation. The chapters also detail the various applications of macroporous gels for the separation of biomolecules and for the cultivation of mammalian cells in bioreactors, as well as for tissue engineering.

Biomaterials Principles and Practices Edited by

Joyce Y. Wong Boston University, Massachusetts, USA

Joseph D. Bronzino Simsbury, Connecticut, USA

Donald R. Peterson University of Connecticut, Farmington, USA

Most current applications of biomaterials involve structural functions—even in those organs and systems that are not primarily structural in their nature— or very simple chemical or electrical functions. Complex chemical functions such as those of the liver and complex electrical or electrochemical functions such as those of the brain and sense organs cannot be carried out by biomaterials at this time. With these basic concepts in mind, this book focuses on biomaterials consisting of different materials such as metallic, ceramic, polymeric, and composite. It highlights the impact of recent advances in the area of nanoand microtechnology on biomaterial design. • Discusses the uses of materials in medicine and dentistry • Covers recent advances in the development of biomaterials • Include contributions from experts and pioneers in this field • Examines how the role of biomaterials has been influenced by advances in many areas of biotechnology and science

Selected Contents: Metallic Biomaterials. Ceramic Biomaterials. Polymeric Biomaterials. Composite Biomaterials. Biodegradable Polymeric Biomaterials: An Updated Overview. Biologic Biomaterials: Tissue-Derived Biomaterials (Collagen). Biologic Biomaterials: Silk. Biofunctional Hydrogels. Soft Tissue Replacements. Hard Tissue Replacements. Catalog no. K13339, December 2012, 281 pp. ISBN: 978-1-4398-7251-2, $139.95 / £89.00 Also available as an eBook

Catalog no. 84615, December 2009, 525 pp. ISBN: 978-1-4200-8461-0, $146.95 / £94.00 Also available as an eBook

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Materials Science New!

Marine Biomaterials

Szycher's Handbook of Polyurethanes

Characterization, Isolation and Applications

Second Edition Edited by

Edited by

Michael Szycher, Ph.D

Se-Kwon Kim Pukyong National University, Busan, South Korea

Presenting a groundbreaking platform to assist in development of new biotechnology start-ups and enterprises, this book describes current trends in marine materials for a range of fields including tissue engineering, drug delivery, bioenergy, and adhesive products from preliminary research to clinical trial. Essential reading for the novice and expert alike, it details the isolation and characterization of appropriate materials, methods for the extraction and application of marine materials, the viability of low-cost marine biomaterials, and the potential role of the biological applications to diseases such as inflammation, diabetes, arthritis, and cancer. • Offers very thorough coverage of isolation and characterization as well as the industrial and medical applications of marine materials • Delineates the potential role of the biological applications to diseases such as inflammation, diabetes, arthritis, and cancer • Expounds on the viability of low-cost marine biomaterials as compared to synthetic biomaterials which possess unwanted degradative characteristics • Contains an extensive reference list in each chapter to encourage further study

Selected Contents: Introduction to Marine Biomaterials: Background Study. History of Marine Biomaterials. Scope of Marine Biomaterials. Source, Isolation and Characterization Aspects of Marine Biomaterials: Ceramics. Carbohydrates. Enzymes or Peptides. Algae Based Products (Nanoparticles). Lipids. Pigments. Toxins. Corals. Biological Application of Marine Biomaterials: Antioxidant. Anti inflammation. Anticancer. Anticoagulant. Antiviral Activity. Catalog no. K14576, April 2013, 848 pp. ISBN: 978-1-4665-0564-3, $189.95 / £121.00 Also available as an eBook


Sterling Biomedical, Inc., Lynnfield, Massachusetts

"... a valuable resource ... brings together information from a wide variety of academic and commercial sources. The handbook contains a wealth of information from the patent literature which reflects the commercial importance of polyurethanes and provides direction for future research and development activities." —Andrew M. Reed, Ph.D., President, AMRAR, LLC

Written as a reference for polyurethane technologists and end users, raw materials suppliers, and students in the field, this second edition covers the technical advances in the field over the past ten years. It includes new data on green polyurethanes, automotive applications, new coatings, new manufacturing equipment, new healthcare uses, and other topics. Individuals from all major polyurethane intermediate suppliers and equipment manufacturers contributed to this updated handbook, and discuss current products and provide a comprehensive list of product portfolios. • Includes comprehensive coverage of all polyurethane applications • Provides a multi-source compilation of current polyurethane technologies • Offers information on suppliers, equipment, and laboratory analysis • Presents figures, charts, graphs, and photographs

Selected Contents: Basic Concepts in Polyurethane Chemistry and Technology. Structure–Property Relations in Polyurethanes. Isocyanate Chemistry. Polyols. Chain Extenders. Flexible and Semiflexible Foams. Rigid Polyurethane Foams. Polyurethane Foam Surfactants. Catalysis of Isocyanate Reactions. Elastomers. Reaction Injection Molding. Polyurethane Adhesives. Waterborne Polyurethanes. Health and Safety. Radiation-Curable Adhesives and Coatings. Catalog no. K11811, July 2012, 1144 pp. ISBN: 978-1-4398-3958-4, $199.95 / £127.00 Also available as an eBook

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Materials Science Materials in Biology and Medicine Edited by

Sunggyu Lee Ohio University, Athens, USA

David Henthorn St. Louis University, Missouri, USA Series: Green Chemistry and Chemical Engineering

"… a timely addition to the field … Cutting-edge articles by leading experts review critical areas covering biomaterials and biomimetic materials, materials function and response modification, and medical device development. Each application-oriented chapter provides the relevant scientific and engineering background with extensive references for further study and research. The contributors use multiple examples to provide rich insights into a broad array of biomaterial applications for a target audience consisting of graduate students, materials scientists, research engineers, and academic physicians and surgeons." —Dr. Sunil K. Kesavan, Akebono Inc., Farmington Hills, Michigan, USA

• Illustrates the emerging technological advances in the field • Provides the necessary scientific background of all application areas covered • Explains the technological details underlying the applications

Biomaterials Science An Integrated Clinical and Engineering Approach Edited by

Yitzhak Rosen Superior NanoBioSystems, Silver Spring, Maryland, USA

Noel Elman Cambridge, Massachusetts, USA

"… offers a good overview of biomaterials as medical devices, drug delivery and tissue engineering systems. The emphasis is on integrating clinical and engineering approaches. In particular, the book covers various applications of biomaterials in unmet clinical needs in variety of fields … covers areas such as regulatory challenges and commercialization issues." —From the Foreword by Robert Langer, Massachusetts Institute of Technology, Boston, USA

"This book is essential when designing, developing and studying biomedical materials.… provides an excellent review—from a patient, disease, and even genetic point of view—of materials engineering for the biomedical field. I found very interesting facts about patient study combined with clinical study of materials. This well-presented book strongly insists on how the materials can influence patients’ needs, the ultimate drive for biomedical engineering. —Fanny Raisin-Dadre, BioInteractions Ltd., Berkshire, England

• Promotes novel process and product development efforts using green chemistry and engineering

• Discusses hemocompatibility

• Emphasizes the enhancement and modifications of the functionality of materials

• Explores biomaterials in dental, neurosurgical, obstetrics/gynecology, and medical device applications

Selected Contents: Introduction: Materials in Biology and Medicine. Biomaterials. Hydrophilic Polymers for Biomedical Applications. Hydrogels. Polyanhydrides. Functional Biomaterials. Molecularly Imprinted Polymers. Functionalization of Carbon Nanotubes. Animal Cell Culture. Tissue Engineering. Bioactive Devices. Cell Encapsulation. BioMEMS. Immobilized Enzyme Technology. Biocompatibility-Imparting Nanofilm Coating.

• Covers medical applications of BioMEMS and nanotechnologies

• Addresses tissue engineering with focus on cardiovascular and musculoskeletal systems • Talks about regulatory challenges and innovative product development and technology adoption • Examines controlled drug delivery Catalog no. K10223, June 2012, 310 pp. ISBN: 978-1-4398-0404-9, $149.95 / £95.00 Also available as an eBook

Catalog no. K13848, March 2012, 260 pp. ISBN: 978-1-4398-8169-9, $169.95 / £108.00 Also available as an eBook

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Materials Science New!


Corrosion of Ceramic Materials

Polymer and Polymer-Hybrid Nanoparticles

Third Edition

From Synthesis to Biomedical Applications

Ronald A. McCauley Rutgers, The State University of New Jersey, Piscataway, USA Series: Corrosion Technology

“… a comprehensive guide to the fundamental aspects of corrosion in inorganic crystalline and glassy materials. The book is a thorough description of fundamentals, mechanisms, testing, and methods to reduce corrosion for a wide range of engineering applications. This text provides an introductory treatment of corrosion of ceramics that enables both engineering students as well as working professionals to understand and advance their knowledge on the subject. Research scientists and engineers in ceramics, metallurgy, and other materials-related industries will find the book particularly valuable for this reason.” —Richard Haber, Rutgers University

Catalog no. K11066, January 2013, 462 pp. ISBN: 978-1-4398-2022-3, $159.95 / £99.00 Also available as an eBook

Coming Soon!

Hydroxyapatite Coatings for Biomedical Applications Edited by

Stanislav Rangelov Asterios Pispas Written for graduate students and researchers in the fields of chemistry, pharmacy, nanosciences, and biomedical engineering, this timely reference reviews polymer synthesis and macromolecular design and various applications of polymer-based nanomaterials in bionanotechnology and medicine. It provides a description of the current state of the art of the field, summarizing important developments in the field and condensing the relevant research into a comprehensive reference. Differing from other references of similar topic, this book provides an interdisciplinary bridge between polymer synthesis and characterization and biomedical aspects. Catalog no. K13166, August 2013, c. 544 pp. ISBN: 978-1-4398-6907-9, $149.95 / £95.00 Also available as an eBook


Optical Techniques in Regenerative Medicine Edited by

Sam Zhang

Stephen P. Morgan and Felicity R.A.J. Rose

Nanyang Technological University, Singapore Series: Advances in Materials Science and Engineering

“This is a well-written book containing important up-to-date information pertaining to the fabrication, properties, and applications of hydroxyapatite coatings. I highly recommend this book to engineers and researchers working in the field, particularly graduate students.”

University of Nottingham, UK

Steve J. Matcher University of Sheffield, UK

This handbook covers characterization and applications of Hydroxyapatite (HA). It details HA coatings and use in dental implants, biomimetic HA materials, electrochemical and pulsed laser deposition, drug delivery, and more. Seasoned professionals at every level will find it a valuable resource.

This book is focused on optical techniques that can be applied to regenerative medicine, including optical coherence tomography, acousto-optic imaging, Raman spectroscopy, machine vision, fibre optic sensors, second harmonic generation, polarized light imaging, and more. Each chapter gives an overview of a particular technique, its advantages and limitations in terms of structural and functional information provided, and examples of applications in regenerative medicine. The book provides a practical guide to the most appropriate techniques for a given application and offers a summary of major recent advances.

Catalog no. K14030, May 2013, c. 471 pp. ISBN: 978-1-4398-8693-9, $219.95 / £140.00 Also available as an eBook

Catalog no. K12560, August 2013, c. 488 pp. ISBN: 978-1-4398-5495-2, $129.95 / £82.00 Also available as an eBook

—Paul K. Chu, City University of Hong Kong


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Materials Science New!

Polymeric Biomaterials 2 Volume Set, Third Edition

Physical Properties of Materials

Edited by

Second Edition

Severian Dumitriu University of Sherbrooke, Canada

Valentin Popa Technical University of Iasi, Romania

The third edition of a bestseller, this comprehensive reference presents the latest polymer developments and most up-to-date applications of polymeric biomaterials in medicine. This substantially larger resource contains 53 chapters in two volumes, which include state-of-the-art research and successful breakthroughs in applications that have occurred in the last ten years. Completely revised and expanded, the third edition covers the structure and properties of synthetic and natural polymers as well as applications of polymeric biomaterials including drug delivery, tissue engineering, anticancer therapies, hydrogels, and bioartificial organs. Catalog no. 94726, January 2013, 1710 pp. ISBN: 978-1-4200-9472-5, $329.95 / £210.00 Also available as an eBook

Biological and Medical Sensor Technologies Edited by

Krzysztof Iniewski CMOS Emerging Technologies, Inc., Vancouver, British Columbia, Canada

Mary Anne White Dalhousie University, Halifax, Nova Scotia, Canada

“This book stands out as a unique resource for students and established scientists working at the modern materials/chemistry/technology interface. It conveys a tremendous amount of information and distills the physics and chemistry down to an intuitive level that can be appreciated by both developing scientists as well as more established scientists looking for a teaching aid/text or a tune-up in their own knowledge.” —Timothy M. Swager, Massachusetts Institute of Technology, Cambridge, USA A solutions manual and figure slides are available upon qualifying course adoption

Catalog no. K12969, June 2011, 469 pp. ISBN: 978-1-4398-6651-1, $83.95 / £52.99 Also available as an eBook

Biomimetics Nature-Based Innovation Edited by

Yoseph Bar-Cohen

Series: Devices, Circuits, and Systems

JPL/Caltech, Pasadena, California, USA

Edited by a pioneer in the area of advanced semiconductor materials, this book contains contributions from experts, exploring the development and use of sensors in biological and medical applications. It covers topics including advanced sensing and communications in biology, as well as physics and modeling of DNA-derivative architecture, and the use of enzyme and quartz crystal microbalance-based biosensors. The book also addresses biosensors in human behavior measurement, sweat rate wearable sensors, and the future of medical imaging.

This book documents key biological solutions that provide a model for innovations in engineering and science. Leading experts explore a wide range of topics, including artificial senses and organs; mimicry at the cell–materials interface; modeling of plant cell wall architecture; biomimetic composites; artificial muscles; biomimetic optics; and the mimicking of birds, insects, and marine biology. The book also discusses applications of biomimetics in manufacturing, products, medicine, and robotics; biologically inspired design as a tool for interdisciplinary education; and the biomimetic process in artistic creation.

Catalog no. K13895, February 2012, 412 pp. ISBN: 978-1-4398-8267-2, $149.95 / £95.00 Also available as an eBook

Catalog no. K11566, September 2011, 788 pp. ISBN: 978-1-4398-3476-3, $167.95 / £107.00 Also available as an eBook

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Materials Science Chitosan-Based Hydrogels Functions and Applications Edited by

Kangde Yao, Junjie Li, Fanglian Yao, and Yuji Yin


Biofunctional Surface Engineering Edited by

Martin Scholz

Tianjin University, People's Republic of China

LEUKOCARE AG, Munich, Germany

This work details the latest progress in the research and development of chitosan-based biomaterials, providing the foundation for future research. The book introduces the formation and chemical structure of chitosan-based hydrogels. It also discusses the relationship between their structure and functions, which provides a theoretical basis for the design of biomaterials. In addition, many real-world examples illustrate the potential application of chitosan-based hydrogels in various fields, including materials science, biotechnology, pharmaceuticals, regenerative medicine, and cell engineering.

The lack of effective sterilization techniques for biologics has spawned discussions about the reduction of regulatory requirements, which might impose significant safety risks. On the other hand, novel and safe technologies enable the coupling, stabilization, and protection of effector molecules in a way that allows terminal sterilization without loss of function. This book provides a comprehensive overview on the state of the art and the future of "biofunctional surface engineering" and will be of major interest for all those working in the fields of medicine and medical devices.

Catalog no. K11120, July 2011, 521 pp. ISBN: 978-1-4398-2114-5, $199.95 / £127.00 Also available as an eBook

Polyurethane Shape Memory Polymers W.M. Huang Nanyang Techological University, Singapore

Bin Yang Helvoet Rubber & Plastic Technologies Pte Ltd., Singapore

Catalog no. N10827, August 2013, c. 300 pp. ISBN: 978-981-4411-60-8, $149.95 / £95.00 Also available as an eBook


Advances in the Engineering of Polysaccharide Materials by PhosphorylaseCatalyzed Enzymatic Chain-Elongation

Yong Qing Fu

Jun-ichi Kadokawa and Yoshiro Kaneko

Heriot Watt University, Edinburgh, UK

Kagoshima University, Japan

"One in all, the authors managed to write a book which gives a comprehensive overview on polyurethane shape memory polymer research. Due to the authors’ long-term research experience, I am optimistic that Polyurethane Shape Memory Polymers will be a success story. Everyone, who wants to learn about these fascinating materials or get inspired, will find plenty of information and a valuable source of inspiration." —Dr. Thorsten Pretsch, BAM Federal Institute for Materials Research and Testing, Berlin, Germany

Polysaccharides and related compounds are attracting much attention due to their potential as new functional materials in many research fields such as medicine, pharmaceutics, foods, and cosmetics. Therefore, precision synthesis of new polysaccharides with welldefined structure is increasingly important. For this purpose, enzymatic method is a very powerful tool because the reaction proceeds in a highly stereo- and region-controlled manner. This book focuses on advances in the practical synthesis of polysaccharides by phosphorylase-catalyzed chain-elongation from the perspective of polysaccharide engineering.

Catalog no. K11723, September 2011, 383 pp. ISBN: 978-1-4398-3800-6, $189.95 / £121.00 Also available as an eBook

Catalog no. N10553, March 2013, 200 pp. ISBN: 978-981-4364-45-4, $129.95 / £82.00 Also available as an eBook


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Drug Delivery Nanomedicine in Drug Delivery


Edited by

Drug Inhalation Therapy

Arun Kumar Marshall University, Huntington, West Virginia, USA

Heidi M. Mansour University of Kentucky, Lexington, USA

Adam Friedman Albert Einstein College of Medicine, Bronx, New York, USA

Eric Blough Marshall University, Huntington, WV, USA

"The book covers a wide range of interesting topics, which are well organized, covering both the physicochemical characterization of the drug delivery systems and their potential clinical applications. ... In the upcoming decade, nanotechnologies are expected to provide innovative delivering devices to meet crucial clinical needs. In this context, the main strength of this book is to provide a comprehensive discussion about the most promising approaches for diagnosis and treatment of diseases. The editors are worldwide recognised experts in the field and have gathered a team of contributors to cover the several applications of nanosized materials in medical and life-sciences fields. This book will help both beginners and experienced professionals working in the field of drug delivery."

Nanoparticles Edited by

Akira Tsuda Harvard University, Cambridge, Massachusetts, USA

Peter Gehr University of Bern, Switzerland

Nanoparticles have a physical dimension comparable to the size of molecular structures on the cell surface. Therefore, nanoparticles are considered to behave differently than larger particles when they interact with cells. This book describes the sequence of events that airborne nanoparticles encounter in the lungs when they move from air to the bloodstream. This includes deposition, events occurring on the alveolar surface (retention and clearance, and interaction with surfactant and with alveolar lining fluid), crossing the air–blood tissue barrier, and finally getting into the bloodstream. Catalog no. K14165, September 2013, c. 500 pp. ISBN: 978-1-4398-9279-4, $179.95 / £114.00 Also available as an eBook

—Eliana B. Souto, Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Porto, Portugal

Focusing exclusively on the design, synthesis, and application of nanoparticles in a range of applications, this book illustrates how nanotechnology can tackle drug delivery challenges as well as addressing the uses of nanotechnology for both diagnosis and treatment of disease. It addresses nanoparticulate use in several biomedical applications including administration routes, controlled release, and MRI contrast enhancement. Drawing on contributions by leading experts in the field, it presents a wide range of clinical applications supported by examples and case studies. • Focuses exclusively on nanomedicine/drug delivery combination • Illustrates nanoparticle descriptions in all drug delivery systems • Covers several biomedical applications of nanoparticles along with administration routes and controlled release • Presents clinical application-oriented material with examples and case studies • Draws on contributions by the leading experts of the field Catalog no. K14612, June 2013, c. 464 pp. ISBN: 978-1-4665-0616-9, $159.95 / £99.00 Also available as an eBook

Nanotechnology for the Delivery of Therapeutic Nucleic Acids Edited by

Dan Peer Tel Aviv University, Israel

Written by world experts in the field of nanotechnology for nucleic acid (NA) delivery, the authors explore the state of the art in delivery strategies using lipids, polymers, chemical conjugates, NA aptamers, and proteins. They strongly emphasize issues and aspects that are of essence to the pharmaceutical industry working in areas such as stability, general toxicity, immune-toxicity, pharmacokinetics, and the efficacy and validation of new drug targets in vivo by using unique approaches based on exquisite nanotechnology strategies. The contributing authors are world leaders in their respective fields and founders of different approaches. Catalog no. N10808, March 2013, c. 400 pp. ISBN: 978-981-4411-04-2, $149.95 / £95.00 Also available as an eBook

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Biomaterials Education Ultrasonic and Electromagnetic NDE for Structure and Material Characterization Engineering and Biomedical Applications


Regenerative Engineering Edited by

Cato T. Laurencin and Yusuf Khan University of Connecticut Health Center, Farmington, USA

Edited by

Tribikram Kundu The University of Arizona, Tucson, USA

"The book comprises an essential reference for researchers and graduate students working in ultrasonic or electromagnetic NDE. The different chapters contributed by recognized experts in the field cover both fundamental theory as well as current research areas." —Dr. Paul Fromme, University College London, UK

"Professor Kundu is to be congratulated for bringing together this list of experts, each with many years of experience, as contributors to this much-needed book. The book provides a comprehensive and rigorous approach of the fundamentals of linear and nonlinear ultrasonics and electromagnetic methods, including a chapter on the newly emerging THz technique. The book also provides enough advanced engineering and biological applications to make the reader familiar with these technologies, including applications of guided waves, nonlinear ultrasonics, laser-ultrasonics, acoustic microscopy, and fiber optics.” —Henrique Reis, Department of Industrial and Enterprise Systems Engineering, University of Illinois at UrbanaChampaign, USA

Regenerative engineering is the intersection of regenerative medicine and tissue engineering. Regenerative medicine focuses on the biological aspects of tissue regeneration via stem cells, factors, and cytokines, while tissue engineering focuses on the integration of materials science and life sciences. This book integrates these two areas, presenting each concept in the framework of regenerative engineering. Through the combination of fundamental lecture-based teaching and problem-based learning approaches, it is the goal of this textbook to develop students into future researchers capable of completing the translation of their work from the benchtop to the bedside. • Addresses both tissue engineering and regenerative medicine • Synergizes the fields of tissue engineering, materials science, and regenerative medicine • Guides the reader in research based on clinically relevant issues using a problem-based learning approach • Includes examples, case studies, and extensive references A solutions manual and figure slides are available upon qualifying course adoption

Selected Contents:

A solutions manual and figure slides are available upon qualifying course adoption


Selected Contents:

Morphogenesis and Developmental Biology

Mechanics of Elastic Waves and Ultrasonic Nondestructive Evaluation. Modeling of Ultrasonic Fields by Distributed Point Source Method. Electromagnetic Nondestructive Evaluation. Distributed Point Source Method for Imaging in Electrostatic and Electromagnetic Problems. Guided Waves for Plate and Pipe Inspection. Fundamentals and Applications of Nonlinear Ultrasonic Nondestructive Evaluation. Theory and Applications of Laser Ultrasonic Techniques. Material Characterization by Nonlinear Ultrasonic Technique. Toward Structural Health Monitoring Solutions for Bolted Joints.

Basic Anatomy and Physiology

Catalog no. K11655, June 2012, 890 pp. ISBN: 978-1-4398-3663-7, $149.95 / £95.00 Also available as an eBook


Basic Cell Biology

Basic Materials Science Biomaterials Introduction to Regenerative Engineering Organ Regenerative Engineering Cardiovascular Regenerative Engineering Musculoskeletal Regenerative Engineering Neural Regenerative Engineering Catalog no. K10724, July 2013, c. 432 pp. ISBN: 978-1-4398-1412-3, $99.95 / £63.99 Also available as an eBook

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Biomaterials Education


Learning Bio-MicroNanotechnology

Introduction to Biomedical Engineering Technology Second Edition

Mel I. Mendelson

Laurence Street

Loyola Marymount University, Los Angeles, California, USA

Rosedale, British Colombia, Canada

"… a great combination of two key disciplines in the coming quarter of this century, biotechnology and nanotechnology. This will be a good guidebook for the academic adventure as well as a bible for the pioneer in the engineering and scientific field."

Thoroughly revised and updated, this second edition describes current technological devices, the physiological and anatomical basis of their function, their practical applications, and their common locations in hospitals. Written by an experienced biomedical engineering technologist, the text discusses tools and test equipment, examines the integration of equipment within the hospital system, and presents an overview of various kinds of hardware related to medical equipment. Throughout, this accessible book incorporates real-life examples of the work that biomedical engineering technologists do, preparing students for situations they will encounter on the job.

—Hideyuki Kanematsu, Suzuka National College of Technology

"… provides an excellent, multi-dimensional approach to learning that I have not seen in other nanotechnology textbooks. … I really like the multitude of ways the author has the students think about the material through problems, group activities, thinking exercises, etc." —Kory Goldammer, Richland College

A primary text for undergraduate nanotechnology courses, this book is designed for students who lack a cross-disciplinary background and knowledge of micro- and nanotechnology. Clearly and concisely written, it contains many examples, questions, and problems divided into three hierarchical learning skills: understanding, analyzing, and evaluating the concepts. The author attempts to break down the boundaries between biology, chemistry, physics, engineering and ethics. He accomplishes this by co-mingling the vocabulary and concepts of these disciplines around bio-applications. Copiously illustrated, this new text leans heavily towards biological and biomedical applications and includes a comprehensive chapter on ethics. A solutions manual is available upon qualifying course adoption

Selected Contents: Thinking Small and Big. Biomolecules and Cells. Molecular Chemistry. Bit of Physics. Engineering Bits and Bytes. Seeing Small Things. Nanoelectronics. Microelectromechanical Systems. Nanotechnology and Cancer. Risks: Nano or Mega? Ethics and Social Relevance. Self-Assembled Future. Appendices.

• Covers a wider range of devices and includes an expanded section on equipment management • Offers chapter summaries and questions to aid in reader comprehension • Contains more than 360 illustrations • Includes a 16-page grayscale insert with photographs of real-life equipment problems A solutions manual and figure slides are available upon qualifying course adoption

Selected Contents: Introduction. Diagnostic Devices: Part One. Diagnostic Devices: Part Two. Diagnostic Devices: Part Three. Diagnostic Imaging. Treatment Devices: Part One. Treatment Devices: Part Two. Treatment Devices: Part Three. Biomedical Engineering Technologist (BMET) Work. Testers and Tools. Batteries, Radiation, and Computers. Technology Management. Appendix A: Normal Values. Appendix B: Regulations and Standards. Appendix C: Biomedical Engineering Technology Programs in the United States and Canada. Catalog no. K12781, October 2011, 391 pp. ISBN: 978-1-4398-6058-8, $93.95 / £59.99 Also available as an eBook

Catalog no. 82035, January 2013, 611 pp. ISBN: 978-1-4200-8203-6, $89.95 / £57.99 Also available as an eBook

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Biomaterials Education Forthcoming!

Coming Soon!

A Laboratory Manual in Biophotonics

The Textbook of Nanoneurosurgery

Vadim Backman

Edited by

Northwestern University, Evanston, Illinois, USA

Babak Kateb

Adam Wax Hao Zhang

Cedars Sinai Medical Center, West Hollywood, California, USA

From its basic concepts to more advanced topics and applications, this book provides a complete guide to biophotonics. The author offers both descriptive and quantitative perspectives as well as a comprehensive overview of major areas of research in the field. The text includes coverage of topics such as light tissue interaction, optical instrumentation, microscopic and macroscopic tissue imaging, tissue spectroscopy, therapeutic applications of optics, and molecular imaging.

National Institute of Health, Bethesda, Maryland, USA

A solutions manual and figure slides are available upon qualifying course adoption

Catalog no. K10524, September 2013, c. 500 pp. ISBN: 978-1-4398-1051-4, $89.95 / £57.99

A Laboratory Course in Tissue Engineering Melissa Kurtis Micou University of California, San Diego, USA

Dawn M. Kilkenny University of Toronto, Ontario, Canada

“This book has a protocol-like style and can actually be used directly by teachers to prepare lab courses as well as by people with lab experience that enter the field of tissue engineering. … provides students with good insight in methods, techniques and approaches in the field of tissue engineering.” —Gerjo J.V.M. van Osch, Erasmus MC, University Medical Center Rotterdam, the Netherlands

"… provides comprehensive coverage of laboratory techniques in tissue engineering, including detailed experimental protocols." —Adam Higgins, Oregon State University, Corvallis

John D. Heiss Reviewing the state of the nanoneurosurgery field, this book provides current information about nanoplatforms and their use in neurosurgery, neurology, neuroscience and neuroradiology. It focuses on the educational gap across different disciplines, emphasizing the importance of integrating nanotechnology into clinical neurosurgery, neurology, neuroscience, and radiology/medicine. The authors cover currently available nanoplatforms developed for cancer imaging, drug delivery and therapeutics as well as traumatic brain injury and neurodegenerative disorders. The text also provides links to online videos illustrating the different nanoplatforms that are being used in vivo and in vitro. Catalog no. K12237, May 2013, c. 576 pp. ISBN: 978-1-4398-4941-5, $299.95 / £191.00 Also available as an eBook


Introduction to BioMEMS Albert Folch University of Washington, Seattle, USA

“The field has been waiting for a true textbook that provides a practical, historical, authoritative, and comprehensive introduction to bioMEMS. It has finally arrived, courtesy of Albert Folch, complete with PowerPoint lectures and thoughtful homework questions. I highly recommend it.” —David J. Beebe, University of Wisconsin–Madison

“Dr. Folch’s book is a monumental achievement which brings an authoritative and comprehensive account to the rapidly growing, multidisciplinary field of bioMEMS.” —Mehmet Toner, Harvard Medical School

A solutions manual and figure slides are available upon qualifying course adoption

An instructor's manual is available upon qualifying course adoption

Catalog no. K13694, August 2012, 304 pp., Soft Cover, ISBN: 978-1-4398-7893-4, $59.95 / £38.99 Also available as an eBook

Catalog no. K10966, August 2012, 528 pp. ISBN: 978-1-4398-1839-8, $89.95 / £57.99 Also available as an eBook


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Biomaterials Education For the Lab

A Laboratory Course in Biomaterials Wujing Xian University of Illinois at UrbanaChampaign, USA

A teaching tool for instructors in biomaterials and bioengineering, this volume is a comprehensive laboratory textbook. It trains students in laboratory skills, data analysis, problem solving, and scientific writing. It integrates a variety of principles that include materials science, chemistry, biochemistry, molecular and cell biology, and engineering. Providing detailed descriptions, explanations, and illustrations of experiments, the text also includes a series of questions and answers at the end of each chapter to clarify concepts. Many of the experiments presented are adapted from research papers in biomaterials and bioengineering. Catalog no. 75829, June 2009, 216 pp., Soft Cover ISBN: 978-1-4200-7582-3, $67.95 / £43.99

For the Classroom

An Introduction to Biomaterials Second Edition Edited by

Jeffrey O. Hollinger Carnegie Mellon University, Pittsburgh, Pennsylvania, USA Series: Biomedical Engineering

The second edition of this popular text includes nine new chapters that provide a comprehensive and upto-date educational framework for biomaterials education. The book explains in vivo and in vitro testing paradigms and provides numerous examples in the chapters on experimental design, laboratory assays, and animal models. Emphasizing the importance of the regulatory process, it describes how innovation in the biomaterials process relates to patentability and inventorship. The text contains end-of-chapter questions and extensive references. A solutions manual, instructor's manual and figure slides are available upon qualifying course adoption

Catalog no. K10637, November 2011, 644 pp. ISBN: 978-1-4398-1256-3, $119.95 / £49.99 Also available as an eBook

Biomedical Engineering Principles Second Edition Arthur B. Ritter, Vikki Hazelwood, and Antonio Valdevit Stevens Institute of Technology, Hoboken, New Jersey, USA

Alfred N. Ascione Alcatel-Lucent Technologies, New Jersey, USA

Integrating engineering, medicine, biology, and physics, this book clearly defines basic principles in image processing and biomechanics, modeling physiological processes and bioelectric signal analysis to build a solid understanding of devices and designs for improved functioning of the human body. It includes cutting-edge discussions of tissue engineering, cardiovascular components, bone regrowth, and nerve regeneration. Other topics include technologies at the forefront of cardiac care as well as issues related to minimally invasive and robotic surgery, next-generation imaging devices, and nanodevices. A solutions manual and figure slides are available upon qualifying course adoption

Catalog no. K10621, May 2011, 540 pp. ISBN: 978-1-4398-1232-7, $104.95 / £66.99 Also available as an eBook

BioMEMS Science and Engineering Perspectives Simona Badilescu and Muthukumaran Packirisamy Concordia University, Montreal, Quebec, Canada

Covering often overlooked areas in the field of bioMEMS, this volume spans topics associated with biomolecules and complex biological entities, as well as subjects directly linked to the design, fabrication, and characterization of devices. Unlike other references, this text aids in the fundamental physiochemical understanding of biological processes relevant to the performance of various biosensing devices. Useful for upper-level undergraduate and graduate students enrolled in engineering programs, the book includes problems in each chapter, in addition to case studies that provide real-life examples. A solutions manual is available upon qualifying course adoption

Catalog no. K10877, April 2011, 368 pp. ISBN: 978-1-4398-1699-8, $104.95 / £66.99 Also available as an eBook

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Biomaterials Education

Biomaterials A Nano Approach Seeram Ramakrishna, Murugan Ramalingam, T.S. Sampath Kumar, and Winston O. Soboyejo This book examines basic concepts, various processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials that are specific to biomedical applications. It spans their historical development and reviews recent advances in the field. It describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. Presenting illustrative examples and a variety of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human health care systems. Figure slides are available upon qualifying course adoption

Catalog no. 47817, June 2010, 372 pp. ISBN: 978-1-4200-4781-3, $104.95 / £73.99

Medical Devices

Reliable Design of Medical Devices Third Edition Richard C. Fries ISORel, Inc., Fitchburg, Wisconsin, USA

“This book focuses on an important topic ... that engineers need to understand in all of its aspects— philosophy, design, and testing and evaluation. They also need to know how they fit in to the larger picture (manufacturing, packaging, etc…). This book provides both an overview of those facets, along with details to implement them. It is thus a valuable resource for students, researchers, and industry [professionals] who wish to develop a product.” —Jon Sensinger, Rehabilitation Institute of Chicago, Illinois, USA

Following in the footsteps of the bestselling second edition, this book shows you how to improve reliability in the design of advanced medical devices. The organization of the book now mirrors the typical product development process, from the concept, feasibility, and design phases through to verification and validation, design transfer and manufacturing, and field activity. Updated throughout, it reflects recent changes in the medical device field, including in software development and hardware test procedures. • Explains the design process from conception to field monitoring

Biomedical Microsystems

• Discusses regulations and standards as well as human factors

Ellis Meng University of Southern California, Los Angeles, USA

Written by an active researcher named one of Technology Review’s Young Innovators Under 35, this book begins with an introduction to the benefits of miniaturization. It introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore important applications of bioMEMS, such as microdialysis, catheterbased sensors, MEMS implants, neural probes, and tissue engineering. Detailed examples, exercises, and illustrations help clarify the concepts.

• Emphasizes safety and risk analysis • Includes numerous illustrations, tables, sample forms, checklists of deliverables, references, and useful appendices

Selected Contents: The Basics of Reliability. The Concept Phase. The Feasibility Phase. The Design Phase. Verification and Validation. Design Transfer and Manufacturing. Field Activity. Appendices. Index. Catalog no. K14218, September 2012, 501 pp. ISBN: 978-1-4398-9491-0, $179.95 / £114.00 Also available as an eBook

A solutions manual is available upon qualifying course adoption

Catalog no. 51229, September 2010, 408 pp. ISBN: 978-1-4200-5122-3, $99.95 / £62.99 Also available as an eBook


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Medical Devices New!

The Medical Device R&D Handbook Second Edition


Biomedical Technology and Devices Handbook

Edited by

Second Edition

Theodore R. Kucklick

Edited by

TRKD Medical Devices, Los Gatos, California, USA

“This is a handbook in the classic sense of the word. It is a concise guide that is directed for those who want to develop products for the marketplace. …. I would say this would serve any professional well, and also be an excellent guide for senior design projects by those students studying biomedical engineering. The information in this book is priceless and represents an immense accumulation of practical knowledge. There is no other text like it. This is a must read for anyone entering the medical device industry. If you want to make a product— particularly a therapeutic device—you will find no better resource than this text. It should be on the bookshelf of each and every biomedical engineer.” —Brian Wong M.D., Ph.D., University of California–Irvine, USA

• Provides tools for quicker, more efficient development of innovative devices • Explains the basics of prototyping medical devices • Offers insights on strategic intellectual property management • Discusses new rapid-turn molding technologies, medical adhesives, and more • Includes tips on time- and money-saving techniques • Contains chapters on starting and building an entrepreneurial business

Selected Contents: Materials for Medical Device R&D. Processes for Medical Device R&D. Methods for Medical Device R&D. Interviews and Insights for the R&D Entrepreneur. Index. Catalog no. K10598, December 2012, 510 pp. ISBN: 978-1-4398-1189-4, $169.95 / £108.00 Also available as an eBook

James Moore Duncan Maitland Texas A&M, College Station, USA Handbook Series for Mechanical Engineering

Fully revised with ten new chapters, this reference illuminates the equipment, devices, and techniques used in modern medicine to diagnose, treat, and monitor human illnesses. With topics ranging from basic procedures like blood pressure measurements to cuttingedge imaging equipment, biological tests, and genetic engineering, the book is organized to navigate smoothly from simple procedures and concepts to more sophisticated and complex ones. Each section contains a description of the technique, its technical considerations, and its use according to its applications and relevant body systems. Catalog no. K12728, July 2013, c. 888 pp. ISBN: 978-1-4398-5959-9, $189.95 / £121.00 Also available as an eBook


Medical Instruments and Devices Principles and Practices Edited by

Steven Schreiner, Joseph D. Bronzino, and Donald R. Peterson This book draws on material from the medical instruments and devices section of The Biomedical Engineering Handbook, Fourth Edition. Edited by Schreiner, Bronzino, and Peterson, this reference brings together contributions by world-class experts in the field. Offering comprehensive treatment of the latest developments and research being conducted in biomedical instruments and devices, this is a useful resource for practitioners, scientists, and researchers working in the areas of medical devices and instrumentation, as well as graduate students studying bioengineering, instrumentation, and medical devices. Catalog no. K13272, September 2013, c. 400 pp. ISBN: 978-1-4398-7145-4, $99.95 / £63.99 Also available as an eBook

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Medical Devices Forthcoming!

Devices for Mobility and Manipulation for People with Reduced Abilities Teodiano Freire BastosFilho, Dinesh Kumar, and Sridhar Poosapadi Arjunan This book provides the details of mobility and manipulative technologies. It provides an insight into current research trends and also discusses technologies that are under development. Each chapter covers one specific technology, beginning with a general introduction, followed by technical details and an assessment from the user viewpoint, including user benefits, user suitability, cost, reliability, and required infrastructure. Each chapter also provides illustrations or photographs of the devices, targeted for lay and clinical audiences. It also identifies any shortcomings and possible development opportunities. Catalog no. K20293, July 2013, c. 400 pp. ISBN: 978-1-4665-8645-1, $139.95 / £89.00 Also available as an eBook

ISO 13485 A Complete Guide to Quality Management in the Medical Device Industry Itay Abuhav

Usability Testing of Medical Devices Michael Wiklund, Jonathan Kendler, and Allison Yale Strochlic Wiklund Research & Design, Inc., Concord, Massachusetts, USA

Informative, practical, and engaging, this handbook covers how to conduct usability tests of medical devices. Recognizing that the intended readers are busy and disinclined to read lengthy textbooks, this book has been carefully designed to be concise and visual, allowing readers to jump from one section to another as needed. The book provides a general understanding of usability testing and reviews key concepts. It highlights the challenges of validating that protect against dangerous errors that could lead to patient injury and death. Catalog no. K10595, December 2010, 412 pp. ISBN: 978-1-4398-1183-2, $76.95 / £48.99 Also available as an eBook

Designing Usability into Medical Products Michael E. Wiklund Wiklund Research & Design, Inc., Concord, Massachusetts, USA

Stephen B. Wilcox

Hinterforst, Switzerland

Design Science, Philadelphia, Pennsylvania, USA

The United States and European Union now require the ISO 13485 Standard certification for medical device manufacturers. Written by an experienced industry professional, this practical book provides a complete guide to the ISO 13485 Standard certification for medical device manufacturing in terms of quality control. It covers all the requirements of ISO 13485 and offers a step-by-step comparison between the ISO 13485 and ISO 9001, enabling a sound understanding of the new procedures. It also provides numerous implementation examples from various sectors.

This book covers the essential processes and specific techniques necessary to produce safe, effective, usable, and appealing medical systems and products. Written by experts on user-centered research, design, and evaluation, the book provides a range of alternative approaches. Wiklund and Wilcox explore how to make medical devices safe and effective by involving users in the design process. They discuss specific design and evaluation methods and tools, present case studies of user-friendly medical technologies and corporate human factors programs, and supply related resources for medical design professionals.

Catalog no. K12946, October 2011, 374 pp. ISBN: 978-1-4398-6611-5, $139.95 / £89.00 Also available as an eBook

Catalog no. 2843, February 2005, 376 pp. ISBN: 978-0-8493-2843-5, $146.95 / £94.00 Also available as an eBook


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Medical Devices Handbook of Human Factors in Medical Device Design Edited by

Matthew B. Weinger Vanderbilt University, Nashville, Tennessee, USA

Michael E. Wiklund Wiklund Research & Design, Inc., Concord, Massachusetts, USA

Industry Applications Forthcoming!

Measurement, Instrumentation, and Sensors Handbook Second Edition (Two-Volume Set) Edited by

John G. Webster University of Wisconsin, Madison, USA

Daryle J. Gardner-Bonneau

Halit Eren

Principal, Bonneau and Associates, Portage, Michigan, USA

Curtin University, Bentley, Australia

“... interesting, well-written, and achieves the goal of raising the reader's awareness of important design issues. I loved the book and now that I've told my colleagues, they want to read it as well, so we'll buy one for our library since I'm not giving up my copy! Although it is not intended to provide specific solutions to design problems, even a reader with experience in equipment design will most definitely gain new insights into the man-machine interface of medical devices.”

Series: Electrical Engineering Handbook

—Jonathan A Gaev, Biomedical Engineering Online

Catalog no. ER562X, December 2010, 844 pp. ISBN: 978-0-8058-5627-9, $145.95 / £93.00 Also available as an eBook


Handbook of Medical Device Regulatory Affairs in Asia Edited by

Jack Wong Asia Regulatory Professional Association, Kwun Tong, Kowloon, Hong Kong

Raymond Tong Kaiyu Hong Kong Polytechnic University, Hung Hom, Kowloon

This handbook covers medical device regulatory systems in different countries, ISO standards for medical devices, clinical trial and regulatory requirements, and documentation for application. Each chapter provides substantial background materials relevant to the particular area to have a better understanding of regulatory affairs. With contributions from authors working with regulatory bodies around the world, the handbook provides a better understanding of the Asian market and how to access it. It guides product developers through the global regulatory environment. Catalog no. N10745, February 2013, 450 pp. ISBN: 978-981-4411-21-9, $149.95 / £95.00 Also available as an eBook

Edited by renowned instrumentation experts, this new edition of a bestselling handbook brings together nearly 150 contributors in two volumes, covering all aspects of the design and implementation of instrumentation. It describes the use of instruments and techniques for performing practical measurements in engineering, physics, chemistry, and the life sciences. Organized according to measurement problem, each section addresses the different ways of making a measurement for a given variable. Each chapter is completely updated and presents basic information, a detailed mathematical treatment, advanced applications, evaluative options, and areas for future studies. Catalog no. K12205, October 2013, c. 2700 pp. ISBN: 978-1-4398-4883-8, $249.95 / £159.00 Also available as an eBook

Also available as individual volumes

Measurement, Instrumentation, and Sensors Handbook, Second Edition

Spatial, Time, and Mechanical Measurement Catalog no. K12208, August 2013, c. 1544 pp. ISBN: 978-1-4398-4888-3, $149.95 / £95.00

Measurement, Instrumentation, and Sensors Handbook, Second Edition

Electromagnetic, Optical, Radiation, Chemical, and Biomedical Measurement

Catalog no. K12210, October 2013, c. 1250 pp. ISBN: 978-1-4398-4891-3, $149.95 / £95.00 Individual volumes also available as eBooks

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Industry Applications Technical Writing



A Practical Guide for Engineers and Scientists

Packaging and Technology Edited by

Phillip A. Laplante

Vikas Choudhary Analog Devices, Bangalore, Karnataka, India

The Pennsylvania State University, Malvern, USA

Krzysztof Iniewski

Series: What Every Engineer Should Know

CMOS Emerging Technologies, Inc., Vancouver, British Columbia, Canada Series: Devices, Circuits, and Systems

Written by international experts, this book presents the latest research in the field of MEMS technology and the myriad applications that it has enabled. The text covers automotive, consumer, communication, and medical applications of MEMs. Some of the applications discussed include high-precision on-chip integrated oscillators for reference generations, gyroscopes in cameras for optical image stabilization, radio communication, bio-implantable kidneys, and mobile phones. Other chapters address MEMS packaging and MEMS resonators, providing a fundamental understanding to enable novel applications. Catalog no. K15054, June 2013, c. 472 pp. ISBN: 978-1-4665-1581-9, $149.95 / £95.00 Also available as an eBook

Biomaterials Fabrication and Processing Handbook Edited by

Paul K. Chu City University of Hong Kong, Kowloon

Xuanyong Liu Shanghai Institute of Ceramics, China

This volume focuses on a variety of production and processing aspects of the latest biomaterials. It discusses how scaffolds are used in tissue engineering and describes common implant materials. The book also examines the important role nanotechnology plays in the preparation of drugs, protein delivery, tissue engineering, cardiovascular biomaterials, hard tissue replacements, biosensors, and bioMEMS. With contributions from renowned international experts and extensive reference lists in each chapter, this book provides detailed, practical guidance on producing biomaterials and employing them in biomedicine. Catalog no. 7973, March 2008, 720 pp. ISBN: 978-0-8493-7973-4, $179.95 / £115.00 Also available as an eBook


Written by a renowned engineer and widely published technical author, this guide enables readers to write, edit, and publish materials of a technical nature, including books, articles, reports, and electronic media. Complementing the traditional writer’s reference manuals and other books on technical writing, it helps readers understand the practical considerations in writing technical content. Drawing on his own work, the author presents many first-hand examples of writing, editing, and publishing technical materials. These examples illustrate how a publication originated as well as various challenges and solutions. Catalog no. K11106, July 2011, 250 pp., Soft Cover ISBN: 978-1-4398-2085-8, $41.95 / £26.99 Also available as an eBook

Contracts for Engineers Intellectual Property, Standards, and Ethics Robert D. Hunter Robert D. Hunter Associates, Austin, Texas, USA

Engineers encounter various forms of contracts at nearly every turn in their careers. This book enhances their ability to communicate contractual issues to lawyers and then better understand the consequent legal advice they receive. The text introduces the related subjects of intellectual property (including patents, copyright, trademarks, and trade secrets) and standards (including conformity assessment and accreditation) at both the micro and macro levels, as well as the role of ethics. It also discusses typical terms of employee agreements, as well as information on government contracts. Catalog no. K12434, September 2011, 368 pp. ISBN: 978-1-4398-5286-6, $72.95 / £46.99 Also available as an eBook

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Don’t Miss Out!

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