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Contents Cell & Tissue Engineering ..........................................3 Design & Rehabilitation ......................................14 BioMEMS..............................................................17 Solid & Fluid Mechanics ......................................19 Biotransport..........................................................25 General Books in Bioengineering ........................27 Page 3

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Forthcoming ........................................................37

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Cell & Tissue Engineering

Red Blood Cell Aggregation Oguz Baskurt Akdeniz University, Turkey

Björn Neu Nanyang Technology University, Singapore

Herbert J. Meiselman University of Southern California, USA

Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses— the bridging model and the depletion model— that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.

• Provides extensive coverage of the basic mechanisms of RBC aggregation and supporting experimental evidence • Covers the in vivo hemodynamic mechanisms influenced by RBC aggregation, including pathophysiological and clinical consequences • Presents methods to measure RBC aggregation for research and clinical purposes • Describes experimental methods to modify RBC aggregation (in vitro and in vivo) and related hemodynamic methodology • Discusses comparative data on RBC aggregation and related evolutionary concepts • Contains more than 150 illustrations • Includes extensive references at the end of each chapter for additional study Selected Contents Introduction Determinants of Red Blood Cell Aggregation Mechanism of Red Blood Cell Aggregation Measurement of Red Blood Cell Aggregation Effect of Red Blood Cell Aggregation on In Vitro Blood Rheology Effect of Red Blood Cell Aggregation on Tube Flow In Vivo Hemodynamics and Red Blood Cell Aggregation Alterations in Red Blood Cell Aggregation Comparative Aspects of Red Blood Cell Aggregation Index Catalog no. K11945, September 2011, 318 pp. ISBN: 978-1-4398-4180-8, $119.95 / £82.00 Also available as eBook

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3


Cell & Tissue Engineering

Coming Soon!

Biomaterials and Stem Cells in Regenerative Medicine Edited by

Murugan Ramalingam University of Strasbourg, France

Seeram Ramakrishna National University of Singapore, Singapore

Serena Best University of Cambridge, UK

Biomaterials and Stem Cells in Regenerative Medicine bridges the gap in experimental approaches and understanding among the key areas of biomedical research. It provides allimportant aspects dealing with the basic science involved in structure and properties, techniques and technological innovations in processing and characterizations, and applications of biomaterials and stem cells in tissue regeneration. The coverage ranges from fundamental principles to current technological advancements in the major field of regenerative medicine at the macro/micro/nano/molecular scales. It includes breakthroughs in biomaterials, stem cells, tissue engineering, and drug delivery and the current perspectives of these key elements in the context of regenerative medicine. • Provides a self-contained resource for understanding the current perspectives on biomaterials and stem cells in regenerative medicine • Offers extensive coverage of a range of biomaterials and their interaction with stem cells and other cellular elements • Covers different length scales such as macro/micro/nano/molecular level • Supplies an integrated approach to the organization of materials science and engineering, micro/nanotechnology, bioengineering, and biomedical sciences • Incorporates useful figures and tables with current data Selected Contents Identification and Application of Polymers as Biomaterials for Tissue Engineering and Regenerative Medicine. Hydrogel as Stem Cell Niche for In Vivo Applications in Regenerative Medicine. Fabrication and Application of Gradient Hydrogels in Cell and Tissue Engineering. Smart Biomaterial Scaffold for In Situ Tissue Regeneration. Fabrication of 3D

4

Selected Contents continued... Scaffolds and Organ Printing for Tissue Regeneration. Natural Membranes as Scaffold for Biocompatible Aortic Valve Leaflets: Perspectives from Pericardium? Spatially Designed Nanofibrous Membranes for Periodontal Tissue Regeneration. Auto-Inductive Scaffolds for Osteogenic Differentiation of Mesenchymal Stem Cells. Ophthalmic Applications of Biomaterials in Regenerative Medicine. Calcium Phosphates as Scaffolds for Mesenchymal Stem Cells. Bioactive Glasses as Composite Components: Technological Advantages and Bone Tissue Engineering Applications. Processing Metallic Biomaterials for a Better Cell Response. Osteogenic Adult Stem Cells and Titanium Constructs for Repair and Regeneration. Stem Cell Response to Biomaterial Topography. Growth Factors, Stem Cells, and Scaffolds and Biomaterials for Tendon Regeneration. Biomaterials and Stem Cells for Myocardial Repair. Perinatal Stem Cells in Regenerative Medicine. Adult Stem Cell Survival Strategies. Immunobiology of Biomaterial – Mesenchymal Stem Cell Interactions. Autologous Mesenchymal Stem Cells for Tissue Engineering in Urology. Umbilical Cord Matrix Mesenchymal Stem Cells: A Potential Allogenic Cell Source for Tissue Engineering and Regenerative Medicine. Human Embryonic Stem Cells and Tissue Regeneration. Clinical Applications of Mesenchymal Stem CellBiomaterial Constructs for Tissue Reconstruction. Clinical Aspects of the Use of Stem Cells and Biomaterials for Bone Repair and Regeneration. Clinical Translation of Tissue Engineering and Regenerative Medicine Technologies. Catalog no. K13711, June 2012, 608 pp. ISBN: 978-1-4398-7925-2, $149.95 / £95.00 Also available as eBook

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Cell & Tissue Engineering

Nanobiomaterials Handbook Edited by

Balaji Sitharaman State University of New York at Stony Brook, USA

Nanobiomaterials exhibit distinctive characteristics, including mechanical, electrical, and optical properties, which make them suitable for a variety of biological applications. Because of their versatility, they are poised to play a central role in nanobiotechnology and make significant contributions to biomedical research and healthcare. Nanobiomaterials Handbook offers broad introduction for those new to the subject and serves as a useful reference for advanced professionals. Analyzing major topics and disciplines in this arena, this volume: • Defines the scope, current status, and future prospects of nanobiomaterials • Surveys nanobiomaterials and examines various synthesis and processing techniques important for developing nanobiomaterials • Explores the unique nanoscopic physicochemical properties of nanobiomaterials • Discusses potential applications, emphasizing unique challenges in the design, fabrication, and evaluation of biomaterials for a particular application or field • Provides a detailed overview of the interactions between bionanomaterials/ biological systems and the biocompatibility issues associated with bionanomaterials Advances in nanobiomaterials requires a multidisciplinary approach spanning major fields in physical and biological sciences, engineering, and medicine with considerable collaboration between ethicists, regulatory bodies, and industry. This volume brings together the work of a team of world-renowned experts from various fields who discuss the vast potential for nanobiomaterials in a myriad of applications. Selected Contents Nanobiomaterials: Current and Future Prospects. Multifunctional Gold Nanoparticles for Cancer Therapy. Synthesis, Processing, and Characterization of Ceramic Nanobiomaterials for Biomedical Applications. Synthesis, Properties, Characterization, and Processing of Polymeric Nanobiomaterials for Biomedical Applications. Carbon-Based Nanomedicine. Synthetic and Toxicological Characteristics of Silica Nanomaterials for Imaging and Drug Delivery Applications. Peptide-Based SelfAssembled Nanofibers for Biomedical Applications. Electrostatically Self-Assembled

Selected Contents continued... Nanomaterials. Peptide-Based Nanomaterials for siRNA Delivery: Design, Evaluation, and Challenges. Nucleic Acid Nanobiomaterials. Emerging Technologies in Nanomedicine. Nanomaterials for Therapeutic Drug Delivery. Nanobiomaterials for Nonviral Gene Delivery. Nanobiomaterials for Cancer-Targeting Therapy. Nanobiomaterials for Ocular Applications. Nucleic Acid Based Nanobiosensing. Nanobiomaterials for Molecular Imaging. Gadolinium-Based Bionanomaterials for Magnetic Resonance Imaging. Nanostructured Materials for Improved Magnetic Resonance Imaging. Nanobiomaterials for Dual-Mode Molecular Imaging: Advances in Probes for MR/Optical Imaging Applications. Nanoscale Probes for the Imaging of RNA in Living Cells. Nanomaterials for Artificial Cells. Nanobiomaterials for Musculoskeletal Tissue Engineering. Nanocomposite Polymer Biomaterials for Tissue Repair of Bone and Cartilage: A Material Science Perspective. Collagen: A Natural Nanobiomaterial for High-Resolution Studies in Tissue Engineering. Nanotopography on Implant Biomaterials. Nanoarray Bionanotechnology. Photopatternable Multifunctional Nanobiomaterials. Nanobiomaterials for Preclinical Studies and Clinical Diagnostic. Biocompatibility of Nanomaterials: Physical and Chemical Properties of Nanomaterials Relevant to Toxicological Studies, In Vitro and In Vivo. Hemocompatibility of Nanoparticles. Breaking the Carbon Barrier: Nanobiomaterials and Communal Ethics. Index. Catalog no. 94661, June 2011, 737 pp. ISBN: 978-1-4200-9466-4, $169.95 / £108.00 Also available as eBook

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5


Cell & Tissue Engineering

Coming Soon!

Biomaterials Science An Integrated Clinical and Engineering Approach Edited by

Yitzhak Rosen Superior NanoBioSystems, Washington DC, USA

Noel Elman Cambridge, Massachusetts, USA

Rather than approaching biomaterials science from just a materials science and engineering perspective, this book also covers the clinical side. The goal is to engage biomaterials engineers and physicians in a much-needed discussion that integrates both fields at many levels in order to increase the rate of successful deployment of biomaterials, lower the side effects of such a deployment, and accumulate knowledge for improving current methodologies and meeting future challenges. Leading contributors address topics such as hemocompatibility, carcinogenesis, infections, cellular mechanisms, signal transduction, clinical trials, MEMS, nanotechnology, FDA regulations, and ethical issues. • Discusses hemocompatibility • Covers biomaterials and carcinogenesis and infections • Includes coverage of clinical trials of biomaterial designs • Details the implementation of nanotechnology and MEMs in biomaterials • Addresses ethical issues and FDA standards

Selected Contents Introduction Principles of Clinical and Engineering Integration in Hemocompatibility Medical Applications of Micro-ElectroMechanical Systems (MEMS) Technology Nanoparticles to Cross Biological Barriers Biomaterials, Dental Materials, and Device Retrieval and Analysis Biomaterials and the Central Nervous System: Neurosurgical Applications of Materials Science Biomaterials in Obstetrics and Gynecology Tissue Engineering: Focus on the Cardiovascular System Tissue Engineering: Focus on the Musculoskeletal System Regulatory Challenges in Biomaterials: Focus on Medical Devices Innovative Product Development and Technology Adoption for Medical Applications Appendix: Some Examples of FDA-Approved Products Catalog no. K10223, May 2012, c. 328 pp. ISBN: 978-1-4398-0404-9, $149.95 / £95.00 Also available as eBook

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Cell & Tissue Engineering Lecture and Lab Textbooks for Your Biomaterials Courses New Edition of Bestseller!

An Introduction to Biomaterials Second Edition Edited by

Jeffrey O. Hollinger Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

The second edition of this popular text includes nine new chapters that provide a comprehensive and up-to-date educational framework for biomaterials education. A new chapter on the biology of wound healing sets the stage for the basic requirements of standardized biomaterials testing and explains the reactions between biomaterials and the living system into which it is implanted. The book explains in vitro and in vivo testing paradigms and provides numerous examples in the chapters on experimental design, laboratory assays, and animal models. Emphasizing the importance of the regulatory process, it describes how innovation in the biomaterials process relates to patentability and inventorship. • Covers wound healing biology and host response to implanted biomaterials • Examines the regulatory process, including standardized product testing • Reviews the innovativeness of biomaterials, with inventorship and patents in mind • Considers experimental design, basic scientific methods, and statistics • Contains end-of-chapter questions and answers Solutions manual available upon qualifying course adoption

Selected Contents Consensus Definitions, Fundamental Concepts, and a Standardized Approach to Applied Biomaterials Sciences. Biology, Biomechanics, Biomaterial Interactions: Wound Healing Biology. Biology, Biomechanics, Biomaterial Interactions: Cellular Mechanics. Biology, Biomechanics, Biomaterial Interactions: Materials–Host Interactions. Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Standardized Materials Testing. Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Statistics. Biomaterials Compositions. Biomaterials Applications. Index. Catalog no. K10637, November 2011, 644 pp. ISBN: 978-1-4398-1256-3, $119.95 / £48.99 Also available as eBook

A Laboratory Course in Biomaterials Wujing Xian University of Illinois at Urbana-Champaign, USA

A teaching tool for instructors in biomaterials and bioengineering, this is a comprehensive laboratory textbook. It trains readers in laboratory skills, data analysis, problem solving, and scientific writing. It integrates a variety of principles that include materials science, chemistry, biochemistry, molecular and cell biology, and engineering. Providing detailed descriptions, explanations, and illustrations of experiments, the text also includes a series of questions and answers at the end of each chapter to clarify concepts. Many of the experiments presented are adapted from research papers to reflect current progress in biomaterials and bioengineering. • Presents detailed, step-by-step descriptions of lab procedures and explanations for the underlying principles • Contains user-friendly graphic illustrations for the experiments • Provides a series of questions and answers at the end of each chapter to clarify concepts and induce critical thinking • Includes text boxes with in-depth information, case studies, and lab tips • Offers information on equipment, reagents, and supplies for instructors Selected Contents Basic Laboratory Skills. Module I: Drug Delivery: Controlled Release of Encapsulated Protein from PLGA Microspheres. Module II: Natural Biomaterials: Collagen and Chitosan. Basic Laboratory Skills II: Cell Culture and Microscopy. Module III: Biocompatibility Testing: Cytotoxicity and Adhesion. Module IV: Tissue Engineering: Organotypic Cultures of Skin Equivalents. Module V: Bioceramics: Porous Hydroxyapatite Composite. Appendix: Answers. Index. Catalog no. 75829, June 2009, 216 pp. Soft Cover, ISBN: 978-1-4200-7582-3 $64.95 / £41.99

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7


Cell & Tissue Engineering The Physiology of Bioelectricity in Development, Tissue Regeneration, and Cancer

Nanotechnology in Tissue Engineering and Regenerative Medicine

Edited by

Ketul Popat

Christine E. Pullar

Colorado State University, Fort Collins, USA

University of Leicester, UK

Exploring their role in the physiology of development and wound repair and pathophysiologies, such as cancer, this book describes the importance of biological electric fields and their use as tools to influence tissue repair, regeneration, and cancer. The text considers the generation and measurement of these fields, intercellular communication regarding local electrical guidance cues, and the role of bioelectricity in tissue development, regeneration, wound repair, and cancer. • Focuses on the most relevant topics poised to drive the next generation of medical breakthroughs • Demonstrates the role of bioelectricity in the directionality and speed of cell migration, proliferation, apoptosis, differentiation, and orientation • Discusses the role of bioelectricity in cancer progression and the potential for bioelectricitybased therapies to target both the tumor and metastatic cancer cells • Features contributions from world-class experts in the field • Includes clinical applications and extensive references to enhance additional study Selected Contents Measuring Endogenous Electric Fields. Investigation Systems to Study the Biological Effects of Weak Physiological Electric Fields. Endogenous Bioelectric Signals as Morphogenetic Controls of Development, Regeneration, and Neoplasm. Stem Cell Physiological Responses to Noninvasive Electrical Stimulation. Electrical Signals Control Corneal Epithelial Cell Physiology and Wound Repair. Physiological Electric Fields Can Direct Keratinocyte Migration and Promote Healing in Chronic Wounds. Electrical Control of Angiogenesis. Inflammatory Cell Electrotaxis. Effects of DC Electric Fields on Migration of Cells of the Musculoskeletal System. Neuronal Growth Cone Guidance by Physiological DC Electric Fields. ... Catalog no. K11686, March 2011, 342 pp. ISBN: 978-1-4398-3723-8, $119.95 / £76.99 Also available as eBook

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Edited by

Skillfully edited, with contributions from an expert panel of researchers, Nanotechnology in Tissue Engineering and Regenerative Medicine discusses the use of nanotechnology for medical applications with a focus on its use for drug delivery and tissue engineering. It sheds light on the challenges facing the field and examines research that may provide solutions. Topics covered include: • Patterning of biomimetic substrates with AFM lithography, primarily focusing on DPN nanotemplating polymer melts • Nanotechnology-based approaches in the treatment of injuries to tendons and ligaments • Progress in the use of electrospinning processing techniques for fabricating nanofiber scaffolds for neural applications • Nanotopography techniques for tissueengineered scaffolds and the effects of nanotopography on cells and tissues • Vertically aligned TiO2 nanotube surface structuring for optimization of Ti implants utilizing nanotechnology • Applications originating from the harmony of nanotechnology to biological systems, especially for the regeneration in the nervous system • Current understanding of the mechanisms by which cells sense nano-scale structure at the molecular level and how this understanding can be useful in developing novel antifouling materials While there are books available on tissue engineering and nanotechnology and others about regenerative medicine, most do not comprehensively cover applications of nanotechnology to both these areas. Focusing chiefly on drug delivery, tissue engineering, and regenerative medicine, the book uses an application-based approach to relate laboratory-based research to the development of technologies that can be readily adaptable to an industrial environment. Catalog no. K10090, November 2010, 302 pp. ISBN: 978-1-4398-0141-3, $125.95 / £80.99 Also available as eBook

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Cell & Tissue Engineering

Computational Hydrodynamics of Capsules and Biological Cells

Cell Mechanics From Single ScaleBased Models to Multiscale Modeling

Edited by

Edited by

C. Pozrikidis

Arnaud Chauvière, Luigi Preziosi, and Claude Verdier

University of Massachusetts, Amherst, USA

“This book gives a quite extensive overview of different possible formulations for the motion of rigid or deforming particles and for the solution of flow-induced deformations. A wide range of numerical and methodological approaches are illustrated … The presence of many numerical examples allows one to appreciate the capabilities of the approaches proposed and provides useful reference material. … This book is a highly valuable reference for any graduate student or researcher interested in cellular mechanics, biofluid dynamics, bio-rheology or, in general, applications involving the transport of micro-capsules or cells by a fluid.” —Luca Formaggia, Mathematical Reviews, 2012a

A roadmap to the current state of the art in computational cellular mechanics and biofluid dynamics, this book provides a comprehensive and rigorous introduction to the fundamental concepts, mathematical formulation, alternative approaches, and predictions of this evolving field. • Covers advanced numerical methods for simulating the motion of rigid particles (platelets) and the flow-induced deformation of liquid capsules and cells enclosed by viscoelastic membranes • Enables readers to compare solutions produced by different numerical approaches and assess the efficiency of alternative formulations • Provides MATLAB® code and other data on the book’s website Selected Contents

Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling brings together insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior of cells, specifically tumor cells. The first part of the book discusses the powerful tool of microrheology for investigating cell mechanical properties, multiphysics and multiscale approaches for studying intracellular mechanisms in cell motility, and the role of subcellular effects involving certain genes for inducing cell motility in cancer. Focusing on models based on physical, mathematical, and computational approaches, the second part develops tools for describing the complex interplay of cell adhesion molecules and the dynamic evolution of the cell cytoskeleton. The third part explores cell interactions with the environment, particularly the role of external mechanical forces and their effects on cell behavior. The final part presents innovative models of multicellular systems for developmental biology, cancer, and embryogenesis. This book collects novel methods to apply to cells and tissues through a multiscale approach. It presents numerous existing tools while stimulating the discovery of new approaches that can lead to more effective and accurate predictions of pathologies.

Flow-Induced Deformation of Two-Dimensional Biconcave Capsules. Flow-Induced Deformation of Artificial Capsules. A High-Resolution Fast Boundary-Integral Method for Multiple Interacting Blood Cells. Simulating Microscopic Hemodynamics and Hemorheology with the Immersed-Boundary Lattice-Boltzmann Method. Front-Tracking Methods for Capsules, Vesicles, and Blood Cells. ...

• Illustrates how phenomena occurring at various scales can be modeled and coupled to account for multiscale aspects • Discusses experimental and theoretical topics, including biological and complex modeling issues • Links subcellular effects to cellular properties • Covers the modeling of cell migration and multicellular systems • Examines cell interactions with the environment

Catalog no. K11057, June 2010, 327 pp. ISBN: 978-1-4398-2005-6, $135.95 / £87.00 Also available as eBook

Catalog no. C4548, January 2010, 482 pp. ISBN: 978-1-4200-9454-1, $125.95 / £80.99 Also available as eBook

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9


Cell & Tissue Engineering Nanotechnology and Tissue Engineering Biomaterials

The Scaffold

A Nano Approach

Edited by

Seeram Ramakrishna, Murugan Ramalingam, T.S. Sampath Kumar, and Winston O. Soboyejo

Cato T. Laurencin

There are several well-known books on the market that cover biomaterials in a general way, but none provide adequate focus on the future of and potential for actual uses of emerging nanontechnology in this burgeoning field. Biomaterials: A Nano Approach is written from a multi-disciplinary point of view that integrates aspects of materials science and engineering, nanotechnology, bioengineering, and biosciences. The book fills a glaring void in the literature by providing a comprehensive discussion of biomaterials and a scientifically plausible extrapolation of likely scenarios in which nanotechnology could play a significant role. The authors introduce and examine basic concepts, processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials that are specific to biomedical applications. A Self-Contained Book Illustrating Past, Present, and Future Trends in Biomaterials Spanning from the historical development of biomaterials to advances in the field, the text describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. With its illustrative examples and presentation of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human healthcare systems. It is an ideal companion resource for students, researchers, and industrial scientists who specialize in biomaterials and nanobiomaterials. Selected Contents Overview of Biomaterials. Basics of Human Biology. Degradation and Corrosion of Biomaterials. Failure and Tribology of Biomaterials. Nanoscale Phenomena. Metallic Biomaterials. Ceramic Biomaterials. Polymeric Biomaterials. Composite Biomaterials. Nanobiomaterials for Tissue Engineering. Glossary. Exercises. References. Catalog no. 47817, June 2010, 372 pp. ISBN: 978-1-4200-4781-3, $99.95 / £69.99

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University of Virginia, Charlottesville, USA

Lakshmi S. Nair University of Connecticut, Farmington, USA

With chapters written by world-famous researchers involved with various facets of nanostructured scaffolds, this is the first resource that brings together research and background information on a complete range of engineering processes that have led to the development of a number of highly useful tissues. It details the fundamental and advanced aspects of nanofabrication and includes an examination of cellular interactions at the nanoscale level. The book also discusses clinical implications and applications, making it a critical resource for clinicians, engineers, and other scientists seeking to advance the field. • Provides background information on the importance of scaffolds in tissue engineering • Discusses the structure and functions of the extra-cellular matrix • Includes a comprehensive detailing of cell responses to nano-features • Offers the contributions of experts with outstanding reputations in the field Selected Contents Section I: Importance of Scaffolds in Tissue Engineering Tissue Engineering: The Therapeutic Strategy of the Twenty-First Century. Top-Down Analysis of a Dynamic Environment. ... Section II: Effect of Nanostructures on Cellular Responses and Tissue Regeneration Cell Response to Nanoscale Features and Its Implications in Tissue Regeneration: An Orthopedic Perspective. ... Section III: Promising Nanofabrication Techniques to Develop Scaffolds for Tissue Engineering Electrospun Polymeric Nanofiber Scaffolds for Tissue Regeneration. Structure and Mechanical Properties of Electrospun Nanofibers and Nanocomposites. ... Section IV: Applications of Nanostructured Scaffolds in Biology and Medicine Nanotechnologies in Neural Tissue Engineering. ... Catalog no. 51822, June 2008, 384 pp. ISBN: 978-1-4200-5182-7, $169.95 / £108.00 Also available as eBook

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Cell & Tissue Engineering Coming Soon!

Optical Imaging Techniques in Cell Biology

Biological Performance of Materials

Edited by

Fundamentals of Biocompatibility, Fourth Edition

Guy Cox

Jonathan Black

University of Sydney, New South Wales, Australia

Clemson University (Professor Emeritus), South Carolina, USA

A reference on optical imaging techniques, this book covers the field, from the basics of the optical microscope to highly advanced techniques such as Forster resonant energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM), in a uniform style and format. It provides an understanding of the underlying principles, so readers can understand the benefits and limitations of each technique described. Topics covered include optical contrasting techniques, fluorescence and fluorescence microscopes, threedimensional imaging, the confocal microscope, non-linear microscopy, advanced fluorescence techniques, and breaking the diffraction limit.

Biological Performance of Materials focuses on principles of biological performance at a fundamental level, analyzing interactions between organisms and nonliving materials used in medical devices. The book is divided into three sections: the material response to biological systems, host response to biomaterials, and test methods for determining biological response in vitro as well as in animal models and clinical settings. Subsections summarize the physical properties of commonly used metallic, polymeric, and ceramic biomaterials and provide a guide to understanding the clinical performance of implanted biomaterials.

Catalog no. K12150, June 2012, c. 320 pp. ISBN: 978-1-4398-4825-8, $149.95 / £95.00 Also available as eBook

Catalog no. 3959, December 2005, 520 pp. ISBN: 978-0-8493-3959-2, $115.95 / £73.99

Second Edition

Porous Media Applications in Biological Systems and Biotechnology

Biomaterials Fabrication and Processing Handbook Edited by

Paul K. Chu

Edited by

City University of Hong Kong, Kowloon

Kambiz Vafai

Xuanyong Liu

University of California, Riverside, USA

Shanghai Institute of Ceramics, China

This volume explores innovative approaches to effectively apply existing porous media technologies to biomedical applications. In each peerreviewed chapter, world-class scientists and engineers address significant problems and discuss exciting research in biological systems. They cover various transport processes, mechanical behavior, and material properties of biological tissues from a porous media point of view. The book also presents pertinent aspects of experimental work and numerical techniques and discusses the modeling of several phenomena, including flow changes in cerebral aneurysms, biomass growth, marine systems, and tissue homeostasis and repair.

Comprehensive in scope, this book focuses on a variety of production and processing aspects of biomaterials. It discusses how scaffolds are used in tissue engineering and describes common implant materials, such as hard tissue, blood contacting, and soft tissue. The book also examines the important role nanotechnology plays in the preparation of drugs, protein delivery, tissue engineering, cardiovascular biomaterials, hard tissue replacements, biosensors, and bio-MEMS. With contributions from renowned international experts and extensive reference lists in each chapter, this book provides detailed, practical guidance on producing biomaterials and employing them in biomedicine.

Catalog no. 65416, August 2010, 632 pp. ISBN: 978-1-4200-6541-1, $149.95 / £95.00 Also available as eBook

Catalog no. 7973, March 2008, 720 pp. ISBN: 978-0-8493-7973-4, $169.95 / £108.00 Also available as eBook

For more information and complete contents, visit www.crcpress.com

11


Cell & Tissue Engineering

Edited by

Fundamentals of Biofilm Research

Joyce Y. Wong

Zbigniew Lewandowski

Boston University, Massachusetts, USA

Montana State University, Bozeman, USA

Joseph D. Bronzino

Haluk Beyenal

Trinity College, Hartford, Connecticut, USA

Washington State University, Pullman, USA

To make sure that medical devices placed inside the body are safe, reliable, economical, and biologically and physiologically compatible, the modern biomedical engineer must have a broad knowledge of currently available materials and the properties that affect their in-service performance. In chapters drawn from the third edition of the bestselling Biomedical Engineering Handbook, Biomaterials surveys the wide variety of biomaterials in use as well as materials resulting from novel micro- and nanoscale technologies. In addition to material from the Handbook, nearly one-third of this sharply focused work is new.

“... describes the fundamentals of biofilm research from a bioengineering perspective in an easy-toread and straightforward manner. This is an interesting, logical and well-written book . . . a comprehensive and well rounded book which is complementary to other literature in this area.”

Biomaterials

Catalog no. 7888, June 2007, 296 pp. ISBN: 978-0-8493-7888-1, $104.95 / £66.99 Also available as eBook

Tissue Engineering

—Microbiology Today

This book discusses compatible tools and measurements that can be used to conduct biofilm studies and interpret their results in a consistent manner. The authors introduce conceptual, physical, computational, and virtual tools to help achieve reproducible results, align research specific parameters, and ease difficulties in communication. Catalog no. 3541, May 2007, 480 pp. ISBN: 978-0-8493-3541-9, $149.95 / £96.00

Biomaterials for MEMS

Edited by

John P. Fisher University of Maryland, College Park, USA

Edited by

Antonios G. Mikos

University of British Columbia, Vancouver, Canada

Mu Chiao

Rice University, Houston, exas, USA

J.C. Chiao

Joseph D. Bronzino Trinity College, Hartford, Connecticut, USA

University of Texas at Arlington, USA

The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering, integrating all aspects of every sub-discipline in the field. Bringing in a diverse group of international contributors with backgrounds in academia, clinical medicine, and industry, this book surveys advances in this relatively young area. Divided into three sections, it discusses the fundamental concepts of tissue engineering, enabling technologies, and tissue engineering applications. It examines strategies that incorporate scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques that are being applied in regenerative medicine.

This book serves as a guide for practicing engineers, researchers and students interested in MEMS devices and biomaterials and biomedical applications. It is also suitable for engineers and researchers interested in MEMS and its applications but who do not have the necessary background in biomaterials. The book highlights important features and issues of biomaterials that have been used in MEMS and biomedical areas, including the fabrication of devices using biomaterials, biocompatible coatings and issues, thin-film biomaterials and MEMS for tissue engineering, and applications involving MEMS and biomaterials.

Catalog no. 9026, May 2007, 600 pp. ISBN: 978-0-8493-9026-5, $104.95 / £66.99 Also available as eBook

Catalog no. N10421, March 2011, 292 pp. ISBN: 978-981-4241-46-5, $149.95 / £95.00 Also available as an eBook

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Cell & Tissue Engineering Biointegration of Medical Implant Materials Science and Design Edited by

Chandra P. Sharma Sree Chitra Tirunal Institute for Medical Sciences and Technology, India

New!

Handbook of Intelligent Scaffold for Tissue Engineering and Regenerative Medicine Edited by

Gilson Khang Chonbuk National University, Jeonju, North Korea

This book provides a review of research into material and tissue interaction and integration. The first section discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering, and vascular grafts. The second section reviews techniques in drug delivery, including inorganic nanoparticles for targeted drug delivery and alginate-based drug delivery devices. The third section covers design considerations, exploring biocompatibility of materials and its relevance to drug delivery and tissue engineering, mechanisms of failure of medical implants during long-term use, and rapid prototyping in biomedical engineering.

Providing detailed knowledge about fullerene nanowhiskers and the related low-dimensional fullerene nanomaterials, this book introduces tubular nanofibers made of fullerenes, fullerene nanotubes, as well as the single crystalline thin film made of C60, called fullerene nanosheet. It is the first publication featuring the fullerene nanowhiskers made of C60, C70, and C60 derivatives. It demonstrates the synthetic method (liquid–liquid interfacial precipitation method) and the physical and chemical properties such as electrical, mechanical, optical, magnetic, thermodynamic, and surface properties for the fullerene nanowhiskers, including their electronic device application.

Catalog no. N10181, August 2010, 384 pp. ISBN: 978-1-4398-3064-2, $229.95 / £146.00

Catalog no. N10464, February 2012, 974 pp. ISBN: 978-981-4267-85-4, $499.95 / £318.00 Also available as eBook

Biomaterials and Tissue Engineering in Urology Edited by

John Denstedt University of Western Ontario. Canada

Regenerative Medicine and Biomaterials for the Repair of Connective Tissues

Anthony Atala

Edited by

Wake Forest University, Winston-Salem, North Carolina, USA

Charles Archer and Jim Ralphs

An invaluable resource for clinicians as well as for researchers in materials and biomedical devices, this text summarizes research on the use of biomaterials and tissue engineering in the treatment of urological disorders. The book reviews the fundamentals and then discusses advances in biomaterials and the design of urological devices such as metal ureteral stents, self-lubricating catheter materials, and penile implants. The final section addresses urological tissue engineering, covering artificial and natural biomaterials, nanotechnology, and placental stem cells used for the regeneration of urological tissue and organs.

Cardiff University, UK

Regenerative medicine for the repair of connective tissues is a fast moving field that generates a lot of interest. The biomaterials and biomechanics for soft tissue repair has been under-represented in the past; particularly the natural connection between cartilage, tendons, and ligaments is often not made. This book addresses the gap by exploring the natural association of cartilage, tendons, and ligaments to provide a review of the different structures and biomechanics and to provide a discussion of practical techniques and biomaterials that are being used to repair connective tissues.

Catalog no. N10041, June 2009, 500 pp. ISBN: 978-1-4398-0177-2, $247.95 / £150.00

Catalog no. N10011, February 2010, 600 pp. ISBN: 978-1-4398-0110-9, $249.95 / £159.00

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13


Design & Rehabilitation

New!

Assistive Technology Assessment Handbook Edited by

Stefano Federici University of Perugia, Italy

Marcia J. Scherer Institute for Matching Person & Technology, Webster, New York, USA

Assistive Technology Assessment Handbook fills the need for a reference that helps assistive technology experts perform assessments that more effectively connect the person and the technology. Emphasizing the well-being of the individual with a disability, the book proposes an ideal model of the assistive technology assessment process and outlines how this model can be applied in practice internationally. Organized into three parts, the handbook: • Gives readers a toolkit for performing assessments • Describes the roles of the assessment team members, among them the new profession of the psychotechnologist, who is skilled in understanding individuals and their psychosocial and technological needs and preferences • Reviews cutting-edge technologies for rehabilitation and independent living, including brain–computer interfaces and microswitches The book synthesizes information scattered throughout the international literature, focusing on aspects that are particularly representative or innovative. It also addresses the challenges posed by the variety of health and social care systems and the different ways that individuals who need aid are defined—are they users, patients, clients, or consumers, and how does that affect the assessment? Edited by Stefano Federici and Marcia J. Scherer, internationally renowned leaders in the field of assistive technology assessment, this cross-cultural handbook includes contributions from leading experts across five continents. Guiding readers in matching the person and the appropriate assistive technology, it offers a framework for future practice and research. Catalog no. K11756, March 2012, 484 pp. ISBN: 978-1-4398-3865-5, $139.95 / £82.00 Also available a eBook

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“These colleagues are at the forefront of work within the field of assistive technology and have pioneered much of the current thinking resulting in both the delivery of services to individuals and transformational research. ... This edited volume includes contributions from five continents and reinforces the global approach to responding to the needs of individuals and in some cases communities requiring support and intervention. ... this book in the way it has brought together such a wide range of committed individuals has as its underpinning philosophy a commitment to listening to and responding positively to the voice of the individual participant.” —from the Foreword by Dave J. Muller, Editor-in-Chief, Disability and Rehabilitation

Selected Contents Section I: The Assistive Technology Assessment Model and Basic Definitions: Assessing Individual Functioning and Disability. Measuring Individual Functioning. Measuring the Assistive Technology Match. The Assessment of the Environments of AT Use: Accessibility, Sustainability, and Universal Design. Measuring the Impact of AT on Family Caregivers. Section II: Assessment Professionals: Working on the Multidisciplinary Team: The Cognitive Therapist. The Special Educator. The Psychologist. The Psychotechnologist: A New Profession in the Assistive Technology Assessment. The Optometrist. The Occupational Therapist: Enabling Activities and Participation Using Assistive Technology. Pediatric Specialists in Assistive Solutions. The Geriatrician. Role of Speech–Language Pathologists in Assistive Technology Assessments. Section III: Assistive Technology Devices and Services: Systemic User Experience. Web Solutions for Rehabilitation and Daily Life. Brain–Computer Interfaces: The New Landscape in Assistive Technology. ...

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Design & Rehabilitation

Usability Testing of Medical Devices Michael Wiklund, Jonathan Kendler, and Allison Yale Strochlic Wiklund Research Design, Inc., Concord, Massachusetts, USA

“A comprehensive guide to Human Factors testing for medical device development. This book is an excellent resource to guide your human factors decision making throughout the development process. A must have, as today's medical devices become more and more targeted to users without formal medical training.” —Dean Kamen, founder of DEKA Research & Development

“I highly recommend this text for anyone whose work involves any aspect of human factors and medical devices. It is an excellent, easy-to-read, and comprehensive guide on usability testing and medical devices. It will be an extremely valuable resource for ECRI Institute's future evaluation efforts.” —James P. Keller, Vice President, Health Technology Evaluation and Safety, ECRI Institute

“Today, usability testing of medical devices is a regulatory and quality assurance imperative. Personally, I believe usability is a significant, under-recognized patient safety issue. This book complements the latest standards with plenty of down-to-earth, ‘how-to’ advice for test managers.” —Doug Hansell, M.D., Chief Medical Officer & Vice President, Covidien, Respiratory & Monitoring Solutions

Informative, practical, and engaging, this handbook covers how to conduct usability tests of medical devices. Recognizing that the intended readers are busy and disinclined to read lengthy textbooks, this book has been carefully designed to be concise and visual, allowing readers to jump from one section to another as needed. The book provides a general understanding of usability testing and reviews key concepts. It highlights the challenges of validating that protects against dangerous errors that could lead to patient injury and death. • Provides a singular source of guidance on conducting a usability test in an industryspecific manner, as opposed to a manner

better suited to evaluating consumer, and business products, for example, that pose different demands • Presents the information in a highly visual format, making it appealing to the audience comprised mostly marketers, engineers, and regulatory affairs specialists • Draws on the experience of a widely recognized authority in the medical industry on usability testing of medical devices • Includes an accompanying CD that contains videos of mock usability tests, demonstrating the techniques described in the book • Supplies sample test plans for practitioners who would prefer to "plug" content into an authoritative template Selected Contents Introduction Risk Management and Usability Testing The Commercial Imperative Testing Costs Anatomy of a Usability Test Types of Tests Writing a Test Plan Choosing a Participant Sample and Recruiting Participants Test Environments Adding Realism Selecting Tasks Conducting the Test Interacting with Test Participants Documenting the Test Analyzing Test Data Reporting Results Validation Testing Resources Index Catalog no. K10595, December 2010, 412 pp. ISBN: 978-1-4398-1183-2, $72.95 / £45.99 Also available as an eBook

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15


Design & Rehabilitation Second Edition of a Bestseller!

Ergonomics for Rehabilitation Professionals Edited by

Second Edition

Shrawan Kumar

Paul H. King

University of North Texas, Fort Worth, USA

Designed to meet the diverse needs of therapists, this book presents a new approach to rehabilitation that integrates ergonomics concepts to address the wide range of problems commonly encountered by professionals. It addresses general concepts such as anthropometry and tissue mechanics and examines whole body biomechanics, demonstrating the ergonomic effects of physiological and biomechanical factors. The author also focuses on regional biomechanics, explaining the rationale for ergonomic intervention, and discusses the ergonomic paradigm in rehabilitation, including the use of physical demands analysis. Catalog no. 8146, April 2009, 640 pp. ISBN: 978-0-8493-8146-1, $107.95 / £69.99 Also available as eBook

Paediatric Rehabilitation Engineering From Disability to Possibility

Vanderbilt University, Nashville, Tennessee, USA

Richard C. Fries Baxter Healthcare, Round Lake, Illinois, USA

The second edition of a bestseller, this book provides a comprehensive overview of biomedical device and system design—including topics related to databases, process analysis, and device improvement—from a strong design perspective. It covers all aspects of design that must be considered for complex biomedical projects. Updated to reflect advances in the field, this second edition features information on device definition and reliability, as well as testing and hardware verification. The book includes case studies. Catalog no. 61798, August 2008, 424 pp. ISBN: 978-1-4200-6179-6, $129.95 / £82.99 Also available as eBook

Designing Usability into Medical Products Michael E. Wiklund Wiklund Research & Design, Inc., Concord, Massachusetts, USA

Edited by

Tom Chau

Stephen B. Wilcox

Bloorview Kids Rehab, Toronto, Canada

Design Science, Philadelphia, Pennsylvania, USA

Jillian Fairley Written by international experts, Paediatric Rehabilitation Engineering provides a synopsis of advances in research in pediatric rehabilitation engineering. Offering a single comprehensive resource on current findings, each chapter details a particular area of technology or those developments of particular clinical relevance to pediatric rehabilitation. Each chapter also includes a conceptual description of the technology or underlying scientific principles, followed by a synthesis of relevant literature, research advances, selected clinical case studies (where applicable), and perspectives for future directions. Catalog no. K10416, December 2010, 366 pp. ISBN: 978-1-4398-0842-9, $145.95 / £93.00

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Design of Biomedical Devices and Systems

“This book should be on the shelf of anyone involved in the development of medical products. Today devices are getting more and more complex while caregivers as a whole are much less experienced. User centered interface design has to make up the difference and this book gives you a plan.” —Nicholas Barker, Vice President - Design, Datascope Corp

Advocating a user-centered approach to medical technology design, this book covers the essential processes and specific techniques necessary to produce safe, effective, usable, and appealing medical systems and products. Catalog no. 2843, February 2005, 376 pp. ISBN: 978-0-8493-2843-5, $139.95 / £89.00 Also available as eBook

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BioMEMS Third Edition of a Bestseller! Coming Soon!

Introduction to BioMEMS Albert Folch University of Washington, Seattle, USA

“The field has been waiting for a true textbook that provides a practical, historical, authoritative and comprehensive introduction to bioMEMS. It has finally arrived, courtesy of Albert Folch, complete with PowerPoint lectures and thoughtful homework questions. I highly recommend it.” —David J. Beebe, University of Wisconsin–Madison

“A comprehensive, colorful textbook on the important field of bioMEMS. I will definitely recommend to my students!” —Albert van den Berg, University of Twente

“Dr. Folch’s book is a monumental achievement which brings an authoritative and comprehensive account to the rapidly growing, multidisciplinary field of bioMEMS. Many working scientists and engineers as well as students will find this book fascinating.” —Mehmet Toner, Helen Andrus Benedict Professor of Bioengineering, Harvard Medical School

“This book successfully integrates microfabrication and the physics of microfluidics with numerous biological applications. It provides a visual feast of images that lead to a comprehensive understanding of many complex concepts. Applications presented range from biomolecules to cells, tissues, and organisms, and are presented in clear, logical steps. It serves as an outstanding text for advanced undergraduates and graduate students, as well as an excellent review for researchers who are new to the field.” —Dr. Fawwaz Habbal, Harvard University

“An excellent, easy-to-ready textbook for everyone who wants to obtain a fundamental understanding of bioMEMS technology and get inspired about micro/nano bioengineering.” —Professor Nikos Chronis, University of Michigan

“With extensive citations of the current literature, explanations that really put the technology in context, clear enunciation of the motivations for miniaturization, and historical perspective, the author has made the material very accessible and clear … I definitely recommend this textbook for bioengineering students.” —Professor Karen C. Cheung, University of British Columbia

Catalog no. K10966, May 2012, c. 528 pp. ISBN: 978-1-4398-1839-8, $89.95 / £57.99 Also available as eBook

From MEMS to Bio-MEMS and Bio-NEMS Manufacturing Techniques and Applications Marc J. Madou University of California, Irvine, USA

The third volume in Fundamentals of Microfabrication and Nanotechnology, Third Edition, ThreeVolume Set, this book details manufacturing techniques applicable to bio-nanotechnology. After reviewing MEMS techniques, materials, and modeling, the author covers nanofabrication, genetically engineered proteins, artificial cells, nanochemistry, and self-assembly. He also discusses scaling laws in MEMS and NEMS, actuators, fluidics, and power and brains in miniature devices. Coverage includes various MEMS and NEMS applications. The book discusses top-down and bottom-up manufacturing methods and explains how to use nature as a guide. It provides a better understanding of how to match different manufacturing options with a given application that students can use to identify additional killer MEMS and NEMS applications. Fully illustrated in color, the text contains end-of-chapter problems, worked examples, extensive references for further reading, and an extensive glossary of terms. Solutions manual, PowerPoint® lecture slides, and electronic figures available upon qualifying course adoption

Selected Contents From Traditional Manufacturing to Nanotechnology: Nonlithography-Based (Traditional) and Lithography-Based (Nontraditional) Manufacturing Compared. Nature as an Engineering Guide: Biomimetics. Nanotechnology: Top-Down and Bottom-Up Manufacturing Approaches Compared. ... Catalog no. 5516X, June 2011, 650 pp. ISBN: 978-1-4200-5516-0, $99.95 / £63.99 Also available as eBook Also Available as Part of a Set

Fundamentals of Microfabrication and Nanotechnology Third Edition, Three-Volume Set Marc J. Madou University of California, Irvine, USA

Catalog no. 3180, August 2011, 1992 pp. ISBN: 978-0-8493-3180-0, $249.95 / £159.00

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17


BioMEMS BioMEMS Science and Engineering Perspectives

Biomedical Microsystems

Simona Badilescu and Muthukumaran Packirisamy

Ellis Meng University of Southern California, Los Angeles, USA

Concordia University, Montreal, Canada

Because BioMEMS research and development require the input of experts who use different technical languages and come from varying disciplines and backgrounds, scientists and students can avoid potential difficulties in communication and understanding only if they possess a skill set and understanding that enables them to work at the interface of engineering and biosciences. Keeping this duality in mind throughout, BioMEMS: Science and Engineering Perspectives supports and expedites the multidisciplinary learning involved in the development of biomicrosystems. Divided into nine chapters, it starts with a balanced introduction of biological, engineering, application, and commercialization aspects of the field. With a focus on molecules of biological interest, the book explores the building blocks of cells and viruses, as well as molecules that form the selfassembled monolayers (SAMs), linkers, and hydrogels used for making different surfaces biocompatible through functionalization. The book also discusses: • Different materials and platforms used to develop biomicrosystems • Various biological entities and pathogens (in ascending order of complexity) • The multidisciplinary aspects of engineering bioactive surfaces • Engineering perspectives, including methods of manufacturing bioactive surfaces and devices • Microfluidics modeling and experimentation • Device-level implementation of BioMEMS concepts for different applications Because BioMEMS is an application-driven field, the book also highlights the concepts of lab-ona-chip (LOC) and micro total analysis system ( TAS), along with their pertinence to emerging point-of-care (POC) and point-of-need (PON) applications.

Biomedical Microsystems covers the fundamentals of miniaturization, biomaterials, microfabrication, and nanotechnology, along with relevant applications. Written by an active researcher who was recently named one of Technology Review’s Young Innovators Under 35, the book begins with an introduction to the benefits of miniaturization. It then introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author also covers fundamental principles and building blocks, including microfluidic concepts, lab-on-achip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. Features • Presents a rigorous, in-depth treatment of bioMEMS materials, methods, processes, and concepts • Emphasizes practical knowledge useful for application to real-world problems • Describes research and commercialized bioMEMS devices as well as emerging applications • Includes detailed examples, laboratory exercises, and a variety of homework problems • Contains numerous illustrations of concepts, processes, and devices For readers with a limited background in MEMS and bioMEMS, this book provides a practical introduction to the technology used to make these devices, the principles that govern their operation, and examples of their application. It offers a starting point for understanding advanced topics and encourages readers to begin to formulate their own ideas about the design of novel bioMEMS. Solutions manual available upon qualifying course adoption

Selected Contents

Solutions manual available upon qualifying course adoption

Introduction. BioMEMS Materials. Microfabrication Methods and Processes for BioMEMS. Microfluidics. ...

Catalog no. K10877, April 2011, 368 pp. ISBN: 978-1-4398-1699-8, $99.95 / £63.99 Also available as an eBook

Catalog no. 51229, September 2010, 408 pp. ISBN: 978-1-4200-5122-3, $94.95 / £59.99 Also available as an eBook

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Solid & Fluid Mechanics

New!

Biofluid Mechanics The Human Circulation, Second Edition Krishnan B. Chandran University of Iowa, Iowa City, USA

Ajit P. Yoganathan Georgia Institute of Technology, Atlanta, USA

Stanley E. Rittgers University of Akron, Ohio, USA

“... the book provides a good platform in fluid mechanics prior to progressing to the physiological applications which make it an appropriate textbook for BME students.” —Professor Tim McGloughlin, Centre for Applied Biomedical Engineering Research and Department of Mechanical Aeronautical and Biomedical Engineering, University of Limerick

Designed for senior undergraduate or first-year graduate students in biomedical engineering, Biofluid Mechanics: The Human Circulation, Second Edition teaches students how fluid mechanics is applied to the study of the human circulatory system. Reflecting changes in the field since the publication of its predecessor, this second edition has been extensively revised and updated. New to the Second Edition

• Provides a classroom-tested textbook for a first course on fluid mechanics in human circulation, focusing on the heart and major arteries • Reviews fluid and solid mechanics and normal cardiovascular physiology • Explains how to model steady and unsteady flows • Evaluates the design and development of artificial heart valves, stent implants, and vascular grafts • Describes various considerations and approaches involved in the computational modeling of cardiovascular diseases and therapies • Includes end-of-chapter references and problems as well as numerous figures throughout that have been selected from the publications of many eminent researchers Solutions manual available upon qualifying course adoption

• Improved figures and additional examples • More problems at the end of each chapter • A chapter on the computational fluid dynamic analysis of the human circulation, which reflects the rapidly increasing use of computational simulations in research and clinical arenas Drawing on the authors’ experience teaching courses on cardiovascular fluid mechanics, the book begins with introductory material on fluid and solid mechanics as well as a review of cardiovascular physiology pertinent to the topics covered in subsequent chapters. The authors then discuss fluid mechanics in the human circulation, primarily applied to blood flow at the arterial level. They also cover vascular implants and measurements in the cardiovascular system. The text includes end-of-chapter references and problems as well as numerous figures throughout that have been selected from the publications of many eminent researchers.

Selected Contents Fluid and Solid Mechanics and Cardiovascular Physiology Fundamentals of Fluid Mechanics. Introduction to Solid Mechanics. Cardiovascular Physiology. Biomechanics of the Human Circulation Rheology of Blood and Vascular Mechanics. Static and Steady Flow Models. Unsteady Flow and Nonuniform Geometric Models. Native Heart Valves. Cardiovascular Implants, Biomechanical Measurements, and Computational Simulations Prosthetic Heart Valve Dynamics. Vascular Therapeutic Techniques. Fluid Dynamic Measurement Techniques. Computational Fluid Dynamic Analysis of the Human Circulation. Index Catalog no. K12006, March 2012, 451 pp. ISBN: 978-1-4398-4516-5, $104.95 / £66.99 Also available as an eBook

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19


Solid & Fluid Mechanics

Mechanobiology Handbook Edited by

Jiro Nagatomi Clemson University, South Carolina, USA

Mechanobiology—the study of the effects of mechanical environments on the biological processes of cells—has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanobiologists aim to create new therapies and further biological understanding by quantifying the mechanical environment of cells and the molecular mechanisms of mechanically induced pathological conditions. To achieve these goals, investigators must be familiar with both the basic concepts of mechanics and the modern tools of cellular/molecular biology. Unfortunately, current literature contains numerous studies that misuse standard mechanical estimations and terminology, or fail to implement appropriate molecular analyses. Therefore, the Mechanobiology Handbook not only presents cutting-edge research findings across various fields and organ systems, but also provides the elementary chapters on mechanics and molecular analysis techniques to encourage cross-field understanding and appropriate planning. Aided by the continuous advancement of research tools in both mechanics and biology more sophisticated experiments and analyses are possible, thus fueling the growth of the field of mechanobiology. Considering the complexity of the mechanics and the biology of the human body, most of the world of biomechanics remains to be studied. Since the field is still developing, the Mechanobiology Handbook does not force one unified theory, but brings out many different viewpoints and approaches to stimulate further research questions. • Presents research data and viewpoints from diverse fields of mechanobiology • Includes background information in mechanics and cell biology • Explores application areas such as tissue engineering

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Selected Contents Basic Science Tools for Mechanobiology Research An Introductory Guide to Solid Mechanics. Fluid Mechanics. Molecular Analysis in Mechanobiology. Literature Review of Mechanobiology: Research Findings and Theories: Cardiovascular Systems Effects of Endovascular Intervention on Vascular Smooth Muscle Cell Function. Effects of Pressure on Vascular Smooth Muscle Cells. Mechanobiology of Heart Valves. Mechanobiology of Cardiac Fibroblasts. ... Musculoskeletal Systems Skeletal Mechanobiology. Mechanical Control of Bone Remodeling. Cartilage Mechanobiology. Cell Mechanobiology: The Forces Applied to Cells and Generated by Cells. Other Organ Systems Pulmonary Vascular Mechanobiology. Lung Echanobiology. Mechanical Signaling in the Urinary Bladder. Mechanobiology of Bladder Urothelial Cells. ... Frontiers of Mechanobiology Mechanostimulation in Bone and Tendon Tissue Engineering. Mechanobiology in the Stem Cell Niche: Integrating Physical and Chemical Regulation of Differentiation. Mesenchymal Stem Cell Mechanobiology. The Use of Microfluidic Technology in Mechanobiology Research. ... Index Catalog no. 91212, March 2011, 563 pp. ISBN: 978-1-4200-9121-2, $169.95 / £109.00 Also available as an eBook

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Solid & Fluid Mechanics

Biomechanics of the Upper Limbs Mechanics, Modeling and Musculoskeletal Injuries, Second Edition Andris Freivalds Pennsylvania State University, University Park, USA

Despite a spike in the number of work-related musculoskeletal disorders (WRMSDs) in the upper limbs due to a sharp increase in the amount of computer-related jobs, few books have focused exclusively on WRMSDs, until now. Biomechanics of the Upper Limbs: Mechanics, Modeling and Musculoskeletal Injuries, Second Edition offers vital information and tools to improve analysis of external forces and their effects on the human body. This can help ergonomists better understand job stressors and the role they play in the development of disorders, enabling them to modify the work environment and educate practitioners to better control harmful situations. Using the author’s medical and engineering expertise to distill essential subject matter and useful technical data, this comprehensive text explores: • Biomechanics of the upper limbs and the motor control system • The structure and physiology of the human musculoskeletal and neuromuscular systems • Recent research findings and solutions to various ergonomic problems • Models of various components of the neuromuscular systems, as well as larger systems in the upper limbs • Risk factors for disorders and tools used to identify their causes Designed as a textbook for a typical semesterlong graduate-level engineering or kinesiology course, this book includes a link to an ancillary website that offers materials such as PowerPoint® slides, sample exams, and an instructor's manual with complete solutions. It also serves as a practical, current, engineering-oriented resource for researchers, industrial ergonomists, industrial hygienists, and medical professionals who require supplementary material. Catalog no. 91190, February 2011, 564 pp. ISBN: 978-1-4200-9119-9, $119.95 / £76.99 Also available as eBook

Selected Contents Introduction to Biomechanics What Is Biomechanics? Basic Concepts. Coordinate Systems. Force Vector Algebra. Static Equilibrium. Anthropometry and Center of Mass Determination. Friction. Dynamics. Structure of the Musculoskeletal System Gross Overview of Movements. Skeletal System. Mechanical Properties of Bone. Soft Connective Tissue. Joints. Neuromuscular Physiology and Motor Control Introduction to Musculature. Structure of Muscle. Basic Cell Physiology. Nervous System. ... Modeling of Muscle Mechanics Laplace Transforms and Transfer Functions. Viscoelastic Theory. Hill’s Muscle Models. Frequency Analysis. ... Models of the Upper Limbs Anatomy of the Hand and Wrist. Static TendonPulley Models. ... Musculoskeletal Disorders and Risk Factors Extent of the Problem. Common Musculoskeletal Disorders and Their Etiology. Medical Diagnosis and Treatment of MSDs. ... Instrumentation Wrist- and Finger-Motion Measurements. Pressureand Force-Distribution Measurements. ... Job and Worksite Analysis The Need for Job Analysis. Reliability and Validity of Assessment Tools. Initial Identification of Musculoskeletal Injury Problems. ... Hand Tools General Biomechanical Considerations of Tools. Handles for Single-Handled Tools. Handles for Two-Handled Tools. ... The Office Environment General Musculoskeletal Problems. Seated Workplace. Keyboard. Mouse and Other CursorPositioning Devices. Notebooks and Handheld PCs. Interventions for Office Work.

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21


Solid & Fluid Mechanics

Microfluidics and Nanofluidics Handbook Two-Volume Set Edited by

Sushanta K. Mitra University of Alberta, Edmonton, Canada

Suman Chakraborty Indian Institute of Technology (IIT), Kharagpur, India

The Microfluidics and Nanofluidics Handbook: Two-Volume Set comprehensively captures the cross-disciplinary breadth of micro- and nanofluidics, which encompass the biological sciences, chemistry, physics and engineering applications. To fill the knowledge gap between engineering and the basic sciences, the editors pulled together key individuals, well known in their respective areas, to author chapters that help graduate students, scientists, and practicing engineers understand the overall area of microfluidics and nanofluidics. • Discusses basic microbiology and chemistry related to microfluidics • Explains fabrication techniques • Emphasizes applications of microfluidics in the energy sector • Describes micro-fuel cells and lab-on-a-chip • Presents example tables, graphs, and equations Covering physics and transport phenomena along with life sciences and related applications, Volume One: Chemistry, Physics, and Life Science Principles provides readers with the fundamental science background that are required for the study of microfluidics and nanofluidics. Volume Two: Fabrication, Implementation, and Applications focuses on topics related to experimental and numerical methods, followed by chapters on fabrications and other applications, ranging from aerospace to biological systems. Both volumes include as much interdisciplinary knowledge as possible to reflect the inherent nature of this area, making them valuable to students and practitioners. Buy the Set and Save Catalog no. K10859, September 2011, 1766 pp. ISBN: 978-1-4398-1671-4, $279.95 / £178.00 Also available as an eBook

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Microfluidics and Nanofluidics Handbook Chemistry, Physics, and Life Science Principles Selected Contents Physics and Transport Phenomena: An Overview of Continuum Description of Fluid Flow and Transport Processes. Microscale Gas Flow Dynamics and Molecular Models for Gas Flow and Heat Transfer. ... Life Sciences and Related Applications: Biotechnology for Bioengineers. Cellular Biomicrofluidics. Cell Lysis Techniques in Lab-on-a-Chip Technology. ... Catalog no. K10862, September 2011, 1125 pp. ISBN: 978-1-4398-1676-9, $179.95 / £109.00 Also available as an eBook

Microfluidics and Nanofluidics Handbook Fabrication, Implementation, and Applications Selected Contents Experimental and Numerical Methods: ImageBased Photonic Techniques for Microfluidics. Recent Developments in Microparticle Image Velocimetry. ... Fabrication and Other Applications: SU-8 Photolithography and Its Impact on Microfluidics. System Integration in Microfluidics. Fluidic Interconnects for Microfluidics: Chip to Chip and World to Chip. Micro Total Analysis Systems. Microparticle and Nanoparticle Manipulation. Optoelectric Particle Manipulation. Microfluidic Particle Counting Sensors. Magnetic-ParticleBased Microfluidics. ... Catalog no. K10860, September 2011, 641 pp. ISBN: 978-1-4398-1672-1, $179.95 / £109.00 Also available as eBook

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Solid & Fluid Mechanics Introduction to Engineering Mechanics A Continuum Approach Lafayette College, Easton, Pennsylvania, USA

Principles of Biomechanics

Clive L. Dym

Ronald L. Huston

Jenn Stroud Rossmann

Harvey Mudd College, Claremont, California, USA

“This book is a welcome addition to the family of resources for undergraduates majoring in mechanical, aerospace, civil, and other allied engineering fields. It offers a unified treatment for solid and fluid mechanics using a continuum mechanics approach. This approach helps students understand both disciplines and prepares them to face problems in interdisciplinary areas such as biomechanical engineering . . . Overall, this lucidly presented work provides a valuable introduction to engineering mechanics using a continuum approach.” —R. Kolar, Naval Postgraduate School, in Choice: Current Reviews for Academic Libraries

The essence of continuum mechanics—the internal response of materials to external loading—is often obscured by the complex mathematics of its formulation. By building gradually from one-dimensional to two- and three-dimensional formulations, this book provides an accessible introduction to the fundamentals of solid and fluid mechanics, covering stress and strain and other key topics. This undergraduate text presents several real-world case studies, such as the St. Francis Dam, to illustrate the mathematical connections between solid and fluid mechanics. The emphasis is on practical applications of these concepts to mechanical, civil, and electrical engineering structures and design. • Summarizes material usually covered over several semesters • Uses case studies to demonstrate the significance of concepts to historical and contemporary engineering design • Features a conversational style that makes it easily accessible to undergraduate students • Covers both continuum mechanics and mathematics • Makes explicit connections among concepts that are typically not understood until the graduate level Catalog no. 62719, November 2008, 485 pp. ISBN: 978-1-4200-6271-7, $99.95 / £63.99

University of Cincinnati, Ohio, USA

Presenting the fundamental concepts that are required for further research in this field, this volume emphasizes biodynamic modeling and human body models. Beginning with a review of gross human anatomy and a summary of basic terminology, it describes various methods of analysis, including elementary mathematics, elementary mechanics, and the mechanics of materials. Later chapters discuss the modeling of biosystems, tissue biomechanics, biodynamics, kinematics, kinetics, and the inertial properties of human body models. The book concludes with a review of sample applications of biodynamic models in activities such as lifting, maneuvering in space, walking, and swimming. • Focuses on fundamental principles in biosystems and the human body • Discusses biosystem modeling and elementary mechanics • Includes examples and problems to clarify material • Provides the basis for advanced study, research, and practice in biomechanics Selected Contents Introduction. Review of Human Anatomy and Some Basic Terminology. Methods of Analysis I: Review of Vectors, Dyadics, Matrices, and Determinants. Methods of Analysis II: Forces and Force Systems. Methods of Analysis III: Mechanics of Materials. Methods of Analysis IV: Modeling of Biosystems. Tissue Biomechanics. Kinematical Preliminaries: Fundamental Equations. Kinematic Preliminaries: Inertia Force Considerations. Human Body Inertia Properties. Kinematics of Human Body Models. Kinetics of Human Body Models. Dynamics of Human Body Models. Numerical Methods. Simulations and Applications. Appendix A. Anthropometric Data Tables. Glossary. Bibliography. Index. Catalog no. DK494X, December 2008, 442 pp. ISBN: 978-0-8493-3494-8, $115.95 / £73.99 Also available a eBook

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Solid & Fluid Mechanics Biomechanics Biomechanics in Ergonomics

Principles and Applications, Second Edition

Second Edition

Edited by

Edited by

University of Connecticut, Farmington, USA

Donald R. Peterson

Shrawan Kumar

Joseph D. Bronzino

University of North Texas, Fort Worth, USA

Safety or comfort? Can you truly have one without the other? Is it feasible to have both? Although by no means the only factor, a deep understanding of biomechanics plays a leading role in the design of work and workplaces that are both pain and injury free. Standing firmly on the foundation built by the previous edition, the second edition of Biomechanics in Ergonomics establishes an understanding of gross biomechanical loads on the human system at the tissue level, then brings that understanding through to the whole body level Produced under the aegis of editor Shrawan Kumar with contributors who are leading scholars in the field, the book contains unique chapters such as Exposure Assessment Tools and Techniques and Cumulative Load and Models. Also included is a chapter on hand tools, which has a real application to the field of ergonomics. The book dives deep into the biomechanics of the connective tissues then thoroughly covers upper and lower extremities, shoulder and neck, low back, and whole body mechanics. With chapters selected and designed to provide extensive coverage of ergonomically relevant biomechanics, the book supplies an integrated understanding of the inseparable relationship between ergonomics and biomechanics that can be translated into better safety design and better workplaces. • Features a whole body approach, including tissues, organs, and various regions of the body • Offers exposure assessment tools and techniques • Supplies scientific bases and mechanisms of how risk factors precipitate injuries • Considers posture, postural loads, posture correction, and their impact on body regions, working environments, and activities Catalog no. 7908, December 2007, 744 pp. ISBN: 978-0-8493-7908-6, $115.95 / £73.99 Also available as eBook

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Trinity College, Hartford, Connecticut, USA

Drawn from the third edition of the widely acclaimed The Biomedical Engineering Handbook, Biomechanics is a comprehensive presentation of the current principles and applications of biomechanics integrating both systems and subsystems models. Presenting substantial updates and revisions and a new chapter on current methods and strategies for modeling cellular mechanics, the book covers musculoskeletal mechanics including hard- and soft tissue and joint mechanics, biofluid mechanics and circulatory dynamics, the functioning of the ear, and the performance characteristics of the human body during exercise and exertion. Catalog no. 8534, September 2007, 352 pp., ISBN: 978-0-8493-8534-6, $104.95 / £66.99 Also available as eBook

Foot and Ankle Motion Analysis Clinical Treatment and Technology Edited by

Gerald F. Harris, Peter A. Smith, and Richard M. Marks Originating as a one-day workshop sponsored by the Shriner’s Hospitals and the National Institutes of Health, this text is a one-stop reference for assessment technologies and their clinical applications. Presenting basic and advanced clinical applications in pediatric and adult cases, the book also introduces the technological advances themselves from a quantitative perspective. It describes novel approaches and emerging horizons related to mechanical paradigms, imaging, kinetics, robotics and simulation, tri-planar force sensing, and more. The book also includes a chapter of references and sources of support for future research and development prospects. Catalog no. 3971, August 2007, 704 pp. ISBN: 978-0-8493-3971-4, $209.95 / £134.00 Also available as eBook

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Solid & Fluid Mechanics

Biomechanics and Exercise Physiology

Biotransport

Advances in Numerical Heat Transfer

Quantitative Modeling

Volume III

Arthur T. Johnson

W.J. Minkowycz, E.M. Sparrow, and J.P. Abraham

University of Maryland, College Park, USA

Using numerous worked examples to demonstrate what and when to calculate, this text covers more than just the fundamentals of exercise physiology; it demonstrates the vast amount of physiological material that can be quantitatively predicted and describes how to translate this information into applications. The book examines the energetics of exercise, biomechanics, circulation, respiration, and thermoregulation, and includes numerical examples and homework problems. With an emphasis on quantitative description, it includes tables and illustrations which make this book helpful for estimating magnitudes, determining trends, and illustrating concepts. Catalog no. DK5813, March 2007, 688 pp. ISBN: 978-1-57444-906-8, $135.95 / £87.00

Edited by

With contributions from a team of renowned international researchers who cover both fundamentals and applications, this volume provides a definitive treatment of the numerical simulation of bioheat transfer and fluid flow. It covers novel modeling techniques and numerical simulation for solving problems in biomedical engineering. The book presents various forms of the bioheat equation appropriate for several thermal therapies, such as laser irradiation. It also discusses tumor detection and treatment, shows how nanoparticles can be used to improve the efficacy of tumor treatment, and includes a detailed case study describing the thermal ablation of an enlarged prostate. Selected Contents

Biomechatronics in Medicine and Healthcare Edited by

Raymond Tong Kaiyu Hong Kong Polytechnic University, Hung Hom, Kowloon

This book presents experts’ insights into the emerging technologies and developments that are being or will be utilized in the medical profession to meet a variety of clinical challenges. It demonstrates the application of biomechatronics to provide better care and service. It also incorporates new and exciting multidisciplinary areas of research across the medical and engineering fields, such as robotic therapeutic training system for stroke rehabilitation, exoskeletons for daily activities on persons with disability, functional electrical stimulation, and wireless active capsule endoscopy. Each chapter provides substantial background material relevant to the particular subject.

Synthesis of Mathematical Models Representing Bioheat Transport. Numerical Models of Blood Flow Effects in Biological Tissues. Numerical Methods for Solving Bioheat Transfer Equations in Complex Situations. Discrete Vasculature (DIVA) Model Simulating the Thermal Impact of Individual Blood Vessels for In Vivo Heat Transfer. Numerical Bioheat Transfer in Tumor Detection and Treatment. Thermal Interactions between Blood and Tissue: Development of a Theoretical Approach in Predicting Body Temperature during Blood Cooling and Rewarming. Experimental and Numerical Investigation on Simulating Nanocryosurgery of Target Tissues Embedded with Large Blood Vessels. Whole-Body Human Thermal Models. Computational Infrastructure for the Real-Time Patient-Specific Treatment of Cancer. A Mathematical Model to Predict Tissue Temperatures and Necrosis during Microwave Thermal Ablation of the Prostate. Catalog no. 95218, March 2009, 400 pp. ISBN: 978-1-4200-9521-0, $174.95 / £112.00 Also available as an eBook

Catalog no. N10425, August 2011, 250 pp. ISBN: 978-981-4241-61-8, $149.95 / £95.00 Also available as eBook

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Biotransport

Basic Transport Phenomena in Biomedical Engineering Third Edition Ronald L. Fournier

University of Toledo, USA Encompassing a variety of engineering disciplines and life sciences, the very scope and breadth of biomedical engineering presents challenges to creating a concise, entry-level text that introduces basic concepts without getting overly specialized in subject matter or rarified in language. Basic Transport Phenomena in Biomedical Engineering, Third Edition meets and overcomes these challenges to provide the beginning student with the foundational tools and the confidence they need to apply these techniques to problems of ever greater complexity.

• Provides an introductory level text for students in bioengineering, chemical engineering, mechanical engineering, and the life sciences

Bringing together fundamental engineering and life science principles, this highly accessible text provides a focused coverage of key momentum and mass transport concepts in biomedical engineering. It offers a basic review of units and dimensions, material balances, and problemsolving tips, and then emphasizes those chemical and physical transport processes that have applications in the development of artificial and bioartificial organs, controlled drug delivery systems, and tissue engineering. The book also includes a discussion of thermodynamic concepts and covers topics such as body fluids, osmosis and membrane filtration, physical and flow properties of blood, solute and oxygen transport, and pharmacokinetic analysis. It concludes with the application of these principles to extracorporeal devices as well as tissue engineering and bioartificial organs.

• Contains an extensive bibliography of the research literature that supports the material in the text

Designed for the beginning student, this book provides a quantitative understanding of the underlying physical, chemical, and biological phenomena involved. Encouraging students to work examples with the mathematical software package of their choice, this text provides them the opportunity to explore various aspects of the solution on their own, or apply these techniques as starting points for the solution to their own problems

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• Presents a basic understanding and the theories of transport in biological systems • Shows real-world applications in the development and design of artificial organs, drug delivery systems, and tissue engineering • Includes numerous examples with a discussion of the numerical methods used to solve the problems

• Supplies homework problems that give students the opportunity to explore in greater detail the material covered in each chapter Solutions manual available upon qualifying course adoption

Selected Contents Introduction. A Review of Thermodynamic Concepts. Physical Properties of the Body Fluids and the Cell Membrane. The Physical and Flow Properties of Blood. Solute Transport in Biological Systems. Pharmacokinetic Analysis. Extracorporeal Devices. Tissue Engineering. Bioartificial Organs. Index. Catalog no. K11304, August 2011, 483 pp. ISBN: 978-1-4398-2670-6, $89.95 / £44.99 Also available as an eBook

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General Books in Bioengineering

New!

Introduction to Biomedical Engineering Technology Second Edition Laurence Street Rosedale, British Colombia, Canada

Medical devices are often very complex, but while there are differences in design from one manufacturer to another, the principles of operation and, more importantly, the physiological and anatomical characteristics on which they operate are universal. Introduction to Biomedical Engineering Technology, Second Edition explains the uses and applications of medical technology and the principles of medical equipment management to familiarize readers with their prospective work environment. Written by an experienced biomedical engineering technologist, the book describes the technological devices, various hardware, tools, and test equipment used in today’s health-care arena. Photographs of representative equipment; the technical, physiological, and anatomical basis for their function; and where they are commonly found in hospitals are detailed for a wide range of biomedical devices, from defibrillators to electrosurgery units. Throughout, the text incorporates real-life examples of the work that biomedical engineering technologists do. Appendices supply useful information such as normal medical values, a list of regulatory bodies, Internet resources, and information on training programs. Thoroughly revised and updated, this second edition includes more examples and illustrations as well as end-of-chapter questions to test readers’ understanding. This accessible text supplies an essential overview of clinical equipment and the devices that are used directly with patients in the course of their care for diagnostic or treatment purposes. The author’s practical approach and organization, outlining everyday functions and applications of the various medical devices, prepares readers for situations they will encounter on the job.

• Covers a wider range of devices and includes an expanded section on equipment management • Describes the day-to-day work of biomedical engineering technologists using extensive examples • Offers chapter summaries and questions to aid in reader comprehension • Contains more than 360 illustrations • Includes a 16-page grayscale insert with photographs of real-life equipment problems • Provides appendices listing normal medical values, biomedical associations, test equipment manufacturers, helpful Internet resources, and more Solutions manual available upon qualifying course adoption

Selected Contents Introduction. Diagnostic Devices: Part One. Diagnostic Devices: Part Two. Diagnostic Devices: Part Three. Diagnostic Imaging. Treatment Devices: Part One. Treatment Devices: Part Two. Treatment Devices: Part Three. Biomedical Engineering Technologist (BMET) Work. Testers and Tools. Batteries, Radiation, and Computers. Technology Management. Appendix A: Normal Values. Appendix B: Regulations and Standards. Appendix C: Biomedical Engineering Technology Programs in the United States and Canada. Appendix D: Biomedical Associations. Appendix E: Devices and Manufacturers. Appendix F: Test Equipment Manufacturers. Appendix G: Bibliography and Internet Resources. Index. Catalog no. K12781, October 2011, 391 pp. ISBN: 978-1-4398-6058-8, $89.95 / £56.99 Also available as eBook

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General Books in Bioengineering Healthcare Sensor Networks

Biomimetics

Challenges Toward Practical Implementation

Nature-Based Innovation Edited by

Edited by

Yoseph Bar-Cohen

Daniel Tze Huei Lai and Rezaul Begg

JPL/Caltech, Pasadena, California, USA

Victoria University, Melbourne, Australia

Humans have always looked to nature’s inventions as a source of inspiration. The observation of flying birds and insects leads to innovations in aeronautics. Collision avoidance sensors mimic the whiskers of rodents. Optimization algorithms are based on survival of the fittest, the seed-picking process of pigeons, or the behavior of ant colonies. In recent years these efforts have become more intensive, with researchers seeking rules, concepts, and principles of biology to inspire new possibilities in materials, mechanisms, algorithms, and fabrication processes. A review of the current state of the art, Biomimetics: Nature Based Innovation documents key biological solutions that provide a model for innovations in engineering and science. With contributions from leading experts, the book explores a wide range of applications of biomimetics across a variety of fields. Offering myriad examples of technologies inspired by biology, the book discusses artificial senses and organs; mimicry at the cell–materials interface; and modeling of plant cell wall architecture and tissue mechanics. It also covers biomimetic composites, artificial muscles, refreshable braille displays, and more. A series of chapters examines applications of biomimetics in manufacturing, products, medicine, and robotics—including medical devices, implants, and the development of human-like robots. Contributors also explore biologically inspired design as a tool for interdisciplinary education and describe the biomimetic process in artistic creation. The final chapter outlines the challenges to biomimetic-related innovation and offers a vision for the future. This book features an abundance of illustrations, including a 32-page full-color insert, and provides extensive references for engineers and scientists interested in delving deeper into the study of biomimetics. Catalog no. K11566, September 2011, 788 pp. ISBN: 978-1-4398-3476-3, $159.95 / £99.00 Also available as eBook

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Marimuthu Palaniswami University of Melbourne, Parkville, Victoria, Australia

From network deployment to secure monitoring, this book addresses the latest developments in healthcare sensor networks—medical monitoring devices implanted on the body or in the surrounding infrastructure. The text discusses fundamental concepts and provides examples of clinical applications, including sensors to monitor physical activity in children and wearable gait assistants for people with Parkinson’s. Each chapter details a separate challenge in design and implementation. Addressing topics ranging from sensor hardware and the demand for higher data bandwidth to portability and cost, the book highlights the key areas that require further research for HSNs to become a technological and commercially viable reality. • Presents new solutions to human motion monitoring with sensors • Addresses challenges in implementing HSNs • Explores low-power data communications using wireless transmissions through the human body • Highlights novel security measures for protecting confidential patient data • Discusses prospect of continuous sensor network operation based on energy harvesting technology • Offers practical case studies of healthcare sensor networks in use • Includes more than 140 illustrations Selected Contents Sensor Networks in Healthcare: A New Paradigm for Improving Future Global Health. Healthcare and Accelerometry: Applications for Activity Monitoring, Recognition, and Functional Assessment. Intrabody Communication Using Contact Electrodes in Low-Frequency Bands. ... Catalog no. K11159, September 2011, 462 pp. ISBN: 978-1-4398-2181-7, $149.95 / £95.00 Also available as an eBook

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General Books in Bioengineering Biomedical Engineering Principles

New!

Biologically Inspired Robotics

Second Edition Arthur B. Ritter, Vikki Hazelwood, and Antonio Valdevit Stevens Institute of Technology, New Jersey, USA

Edited by

Yunhui Liu The Chinese University of Hong Kong

Dong Sun

Alfred N. Ascione Alcatel-Lucent Technologies, New Jersey, USA

“[Provides] not only an in-breadth overview on current BME fields, but also an in-depth analysis of specific selected topics that are supported by appropriate mathematical models, equations, quantitative data charts and tables.” —Biomedical Engineering Online

“... an excellent textbook for a class. Each chapter contains numerous examples and contains many figures to enhance learning. ... Problems are included at the end of chapters, where they will best test the student's knowledge. ... For practicing engineers without biomedical engineering background, the book provides an excellent resource to explain the many intricacies of biomedical engineering and provides sufficient background material to make the subject understandable.” —Richard C. Fries, PE, CRE, Baxter Healthcare, Inc., in IEEE Engineering in Medicine and Biology Magazine

“This book is written at a reasonably high scientific level; it employs mathematics, basic physics, chemistry, and thermodynamics of the main medical processes. It is well illustrated with figures, schemes, various plots, and mathematical equations. This book will definitely be useful for biochemists, biophysicists, and specialists in cell biology and medicine.”

City University of Hong Kong, Kowloon

This reference contains cutting-edge material— considerably expanded and with additional analysis—from the 2009 IEEE International Conference on Robotics and Biomimetics. The 16 chapters cover biologically inspired robot design and control; micro/nano robots for bio-systems and biomedicine; biological measurement and actuation; and applications of robotics technology to biological problems. A state-of-the-art resource for graduate students and researchers in control engineering, robotics, and biomedical engineering, this text helps readers understand the technology and principles in this emerging field. • Highlights research trends and future development of biorobotics and biologically inspired robot design • Brings together contributions from well-known experts • Examines the use of micro and nano robots for biomedical applications and cybernetics • Includes a wealth of illustrations and equations Selected Contents

Introduction: Modeling of Physiological Processes. Cell Physiology and Transport. ...

Introduction to Biologically Inspired Robotics. CPG-Based Control of Serpentine Locomotion of a Snake-Like Robot. Analysis and Design of a Bionic Fitness Cycle. Human-Inspired Hyperdynamic Manipulation. A School of Robotic Fish for Pollution Detection in Port. Development of a Low-Noise Bio-Inspired Humanoid Robot Neck. Automatic Single-Cell Transfer Module. Biomechanical Characterization of Human Red Blood Cells with Optical Tweezers. Nanorobotic Manipulation for a Single Biological Cell. Measurement of Brain Activity Using Optical and Electrical Methods. Bowel Polyp Detection in Capsule Endoscopy Images with Color and Shape Features. Classification of Hand Motion Using Surface EMG Signals. Multifunctional Actuators Utilizing Magnetorheological Fluids for Assistive Knee Braces. Mathematical Modeling of Brain Circuitry during Cerebellar Movement Control. ...

Catalog no. K10621, May 2011, 540 pp. ISBN: 978-1-4398-1232-7, $99.95 / £63.99 Also available as eBook

Catalog no. K12555, December 2011, 340 pp. ISBN: 978-1-4398-5488-4, $99.95 / £63.99 Also available as eBook

—G. Ya. Wiederschain, Doctor of Biological Science, Moscow State University, Russia

Integrating engineering, medicine, biology, and physics, this book clearly defines basic principles in image processing and biomechanics, modeling physiological processes, and bioelectric signal analysis to build a solid understanding of devices and designs for improved functioning of the human body. Solutions manual and figure slides available upon qualifying course adoption

Selected Contents

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General Books in Bioengineering New! New!

Biological and Medical Sensor Technologies Edited by

Krzysztof Iniewski CMOS Emerging Technologies, Inc., Vancouver, British Columbia, Canada

Edited by a pioneer in the area of advanced semiconductor materials, Biological and Medical Sensor Technologies contains contributions from experts, exploring the development and use of sensors in biological and medical applications. It covers topics including advanced sensing and communications in biology, as well as physics and modeling of DNA-derivative architecture, and the use of enzyme and quartz crystal microbalance-based biosensors. The book also addresses biosensors in human behavior measurement, sweat rate wearable sensors, and the future of medical imaging, including developments in spatial and spectral resolution of semiconductor detectors. Contributors cover application of high-resolution CdTe detectors in gamma ray imaging, and recent advances in positron emission tomography technology. Selected Contents Part I: Sensors for Biological Applications Advanced Sensing and Communication in Biological World. Physics and Modeling of DNA-Derivative Architectures for LongWavelength Bio-Sensing. Label-Free Biosensors for Biomedical Applications: The Potential of Integrated Optical Biosensors and Silicon Photonics. Quartz Crystal Microbalance–Based Biosensors. Toward Printable Lab-on-a-Chip Technologies for Cell Analytics. Construction of Enzyme Biosensors Based on a Commercial Glucose Sensor Platform. Future Directions for Breath Sensors. Solid-State Gas Sensors for Clinical Diagnosis. Part II: Sensors for Medical Applications Biosensors and Human Behavior Measurement: A State-of-the-Art Review. Sweat Rate Wearable Sensors. Future of Medical Imaging. Spatial and Spectral Resolution of Semiconductor Detectors in Medical Imaging. Advances in CMOS SSPM Detectors. High-Resolution CdTe Detectors and Their Application to Gamma-Ray Imaging. Recent Advances in Positron Emission Tomography Technology. Catalog no. K13895, February 2012, 412 pp. ISBN: 978-1-4398-8267-2, $149.95 / £95.00 Also available as an eBook

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Analysis and Application of Analog Electronic Circuits to Biomedical Instrumentation Second Edition Robert B. Northrop University of Connecticut, Storrs, USA

This book helps biomedical engineers understand and design signal conditioning systems using analog integrated circuits. It explains the electronic components and subsystems—the "building blocks"—that are used in ECG, EEG, EMG, ERG, tomographic images, biochemical spectrograms, and other crucial medical applications. This second edition has been substantially updated and revised. It now features a glossary, new end-of-chapter problems, and three new chapters that address wireless patient monitoring using UHF telemetry; power amplifiers and their applications to biomedical instruments; and RFID, GPS, and ultrasonic tags used in ecological research. • Introduces the basic mathematical tools used to describe noise and its propagation through linear systems • Describes, at a basic level, how to improve signal-to-noise ratios with signal averaging and linear filtering • Shows how op amps can be used to build instrumentation amplifiers, isolation amplifiers, active filters, and many other systems and subsystems used in biomedical instrumentation • Provides end-of-chapter problems and examples that emphasize biomedical electronic applications Solutions manual available upon qualifying course adoption

Selected Contents Sources and Properties of Biomedical Signals. Properties and Models of Semiconductor Devices Used in Analog Electronic Systems. The Differential Amplifier. General Properties of Electronic, Single-Loop Feedback Systems. Feedback, Frequency Response, and Amplifier Stability. Operational Amplifiers and Comparators. ... Catalog no. K12982, March 2012, 578 pp., ISBN: 978-1-4398-6669-6, $119.95 / £76.99 Also available as an eBook

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General Books in Bioengineering New!

Biomedical Sensors and Instruments Second Edition

Electromagnetic Fields in Biological Systems

Tatsuo Togawa, Toshiyo Tamura, and P. Åke Öberg

Edited by

The living body is a difficult object to measure: accurate measurements of physiological signals require sensors and instruments capable of high specificity and selectivity that do not interfere with the systems under study. As a result, detailed knowledge of sensor and instrument properties is required to be able to select the “best” sensor from one of the many designed to meet these challenges.

As wireless technology becomes more sophisticated and accessible to more users, the interactions of electromagnetic fields with biological systems have captured the interest not only of the scientific community but also the general public. Unintended or deleterious biological effects of electromagnetic fields and radiation may indicate grounds for health and safety precautions in their use. Spanning static fields to terahertz waves, Electromagnetic Fields in Biological Systems explores the range of consequences these fields have on the human body. With contributions by an array of experts, topics discussed include:

From the underlying principles to practical applications, this updated edition of Biomedical Sensors and Instruments provides an easy-tounderstand introduction to the various kinds of biomedical sensors. The book presents state-ofthe-art discussions of sensors for the measurements of pressure, flow, motion, temperature, heat flow, evaporation, biopotential, biomagnetism, and chemical quantities. Features • Organizes topics so that it is easy to find the best possible choice of sensors for each measurement situation • Includes more than 300 updated figures and tables to facilitate an intuitive understanding • Supplies numerous examples of sensor applications to demonstrate practical methods of research Selected Contents Fundamental Concepts Pressure Measurements Flow Measurement Motion and Force Measurement Temperature, Heat Flow, and Evaporation Measurements Bioelectric and Biomagnetic Measurements Chemical Measurement Catalog no. 9078X, March 2011, 423 pp. ISBN: 978-1-4200-9078-9, $139.95 / £89.00 Also available as an eBook

James C. Lin University of Illinois at Chicago, USA

• Essential interactions and field coupling phenomena, highlighting their importance in research on biological effects and in scientific, industrial, and medical applications • Electric field interactions in cells, focusing on ultrashort, pulsed high-intensity fields • The effect of exposure to naturally occurring and human-made static, low-frequency, and pulsed magnetic fields in biological systems • Dosimetry or coupling of ELF fields into biological systems and the historical developments and recent trends in numerical dosimetry • Mobile communication devices and the dosimetry or coupling of RF radiation into the human body • Exposure and dosimetry associated with MRI and spectroscopy • Available data on the interaction of terahertz radiation with biological tissues, cells, organelles, and molecules There is great potential for communication, industrial, scientific, and medical use of electromagnetic fields and radiation. To help advance knowledge of the biological effects of such fields and to exploit their potential medical applications, this book highlights critical issues relating to their effects on living systems. Catalog no. K12740, October 2011, 458 pp. ISBN: 978-1-4398-5999-5, $149.95 / £95.00 Also available as an eBook

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General Books in Bioengineering

Practical Biomedical Signal Analysis Using MATLAB® K.J. Blinowska and J. Żygierewicz University of Warsaw, Poland

Practical Biomedical Signal Analysis Using MATLAB® presents a coherent treatment of various signal processing methods and applications. The book not only covers the current techniques of biomedical signal processing, but it also offers guidance on which methods are appropriate for a given task and different types of data. The first several chapters of the text describe signal analysis techniques—including the newest and most advanced methods—in an easy and accessible way. MATLAB routines are listed when available and freely available software is discussed where appropriate. The final chapter explores the application of the methods to a broad range of biomedical signals, highlighting problems encountered in practice. A unified overview of the field, this book explains how to properly use signal processing techniques for biomedical applications and avoid misinterpretations and pitfalls. It helps readers to choose the appropriate method as well as design their own methods. • Provides hands-on guidance for those working in the area of biomedical signal analysis • Covers tools for stationary and non-stationary signals, non-linear methods of signal analysis, and models and measures for multivariate signals • Compares the advantages and disadvantages of different methods in the context of applications • Refers to MATLAB routines and freely available software found on the Internet • Applies the methods to a variety of electric, magnetic, and acoustic signals Selected Contents

Introduction to Complexity and Complex Systems Robert B. Northrop University of Connecticut, Storrs, USA

The boundaries between simple and complicated, and complicated and complex system designations are fuzzy and debatable, even using quantitative measures of complexity. However, if you are a biomedical engineer, a biologist, physiologist, economist, politician, stock market speculator, or politician, you have encountered complex systems. Furthermore, your success depends on your ability to successfully interact with and manage a variety of complex systems. In order not to be blindsided by unexpected results, we need a systematic, comprehensive way of analyzing, modeling, and simulating complex systems to predict non-anticipated outcomes. In its engaging first chapters, the book introduces complex systems, Campbell's Law, and the Law of Unintended Consequences, and mathematics necessary for conversations in complex systems. Subsequent chapters illustrate concepts via commonly studied biological mechanisms. The final chapters focus on higher-level complexity problems, and introduce complexity in economic systems. Designed as a reference for biologists and biological engineers, Introduction to Complexity and Complex Systems lends itself to use in a classroom course to introduce advanced students studying biomedical engineering, biophysics, or physiology to complex systems. Engaging and illustrative, this book aids scientists and decision makers in managing biological complexity and complex systems. • Describes the characteristics of certain complex living systems • Provides dynamic models for various complex systems • Offers present-day examples for dealing with complex systems • Includes homework problems for better comprehension Selected Contents

Introductory Concepts. Single Channel (Univariate) Signal. Multiple Channels (Multivariate) Signals. Application to Biomedical Signals. References. Index.

Introduction to Complexity and Complex Systems. Introduction to Large Linear Systems. Introduction to Nonlinear Biochemical Systems and Biochemical Oscillators. ...

Catalog no. K10605, September 2011, 324 pp. ISBN: 978-1-4398-1202-0, $99.95 / £63.99 Also available as an eBook

Catalog no. K11775, December 2010, 551 pp. ISBN: 978-1-4398-3901-0, $83.95 / £53.99 Also available as eBook

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General Books in Bioengineering Dynamics of Biological Systems Michael Small Hong Kong Polytechnic University

From the spontaneous rapid firing of cortical neurons to the spatial diffusion of disease epidemics, biological systems exhibit rich dynamic behaviour over a vast range of time and space scales. Unifying many of these diverse phenomena, Dynamics of Biological Systems provides the computational and mathematical platform from which to understand the underlying processes of the phenomena. Through an extensive tour of various biological systems, the text introduces computational methods for simulating spatial diffusion processes in excitable media, such as the human heart, as well as mathematical tools for dealing with systems of nonlinear ordinary and partial differential equations, such as neuronal activation and disease diffusion. The mathematical models and computer simulations offer insight into the dynamics of temporal and spatial biological systems, including cardiac pacemakers, artificial electrical defibrillation, pandemics, pattern formation, flocking behaviour, the interaction of autonomous agents, and hierarchical and structured network topologies. Tools from complex systems and complex networks are also presented for dealing with real phenomenological systems. Features • Uses complex systems, complex networks, and dynamics to derive models and computer simulations of various biological systems • Presents a wide range of models, from ECG signal processing to pandemic modelling to population dynamics • Requires no advanced knowledge of mathematics • Includes exercises as well as computational and research projects at the end of each chapter This classroom-tested text shows readers how to apply a variety of mathematical and computational techniques to model and analyze the temporal and spatial phenomena of biological systems. MATLAB® implementations of algorithms and case studies are available on the author’s website. Solutions manual available upon qualifying course adoption

Catalog no. K12463, August 2011, 284 pp. ISBN: 978-1-4398-5336-8, $79.95 / £49.99 Also available as eBook

Biology for Engineers Arthur T. Johnson University of Maryland, College Park, USA

Biology is a critical application area for engineering analysis and design, and students in engineering programs must be well-versed in the fundamentals of biology as they relate to their field. Biology for Engineers is an introductory text that minimizes unnecessary memorization of connections and classifications and instead emphasizes concepts, technology, and the utilization of living things. Classroom-tested at the University of Maryland, this comprehensive text introduces concepts and terminology needed to understand more advanced biology literature. Filled with practical detailed examples, the book presents: • Scientific principles relevant to biology that all engineers must know • A discussion of biological responses from the perspective of a broad range of fields such as psychology, human factors, genetics, plant and animal physiology, imaging, control systems, actuary, and medicine • A thorough examination of the scaling of biological responses and attributes • A classification of different types of applications related to biological systems • Tables of useful information that are nearly impossible to find elsewhere Emphasizing the ever-present interactions between a biological unit and its physical, chemical, and biological environments, the book provides ample instruction on the basics of physics, chemistry, mathematics, and engineering. It brings together all of the concepts one needs to understand the role of biology in modern technology. Solutions manual available upon qualifying course adoption

Selected Contents Introduction. Principles from the Sciences. Responses of Living Systems. Scaling Factors. Utilizing Living Systems. Appendices. References. Index. Catalog no. 77635, September 2010, 775 pp. ISBN: 978-1-4200-7763-6, $104.95 / £66.99 Also available as eBook

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General Books in Bioengineering Signals and Systems Analysis in Biomedical Engineering

Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers

Second Edition Robert B. Northrop University of Connecticut, Storrs, USA

Robert B. Northrop and Anne N. Connor University of Connecticut, Storrs, USA

“The book provides a solid introduction and a foundation that the interested student might use as a basis for further study at a more advanced level.” —Books-On-Line

A unique introductory text, this book is written for engineers and scientists with little background in molecular biology, genomics, and proteomics, who are working with, or planning to work with, living systems. The authors assume familiarity with basic calculus, physics, and linear algebra. They describe the very complex biochemical relations that permit life to exist, highlighting the specialized organic molecules in living organisms, and how they interact and react. This is a professional primer, not intended as a replacement for formal, in-depth course work, but intended to broaden the background and pique the interest of those new to this area. • Defines complex terminology in a large, comprehensive glossary • Addresses ethical issues in stem cell research, cloning, and the creation of geneticallymodified plants and animals • Contains a sizeable bibliography for further independent study of discussed topics • Describes the role of stem cells in regenerative medicine and in cancer treatment • Comprises robust chapters on nucleic acids and proteins—the building blocks of molecular biology

The interdisciplinary field of biomedical engineering requires its practitioners to know and master not only engineering skills, but also a diversity of material in the biological sciences. This text helps biomedical engineering students and professionals strengthen their skills in the network of applied mathematics that ties together these diverse disciplines. Based on the author's 30 years of experience in teaching as well as his personal research on neurosensory systems, this book, now in its second edition, provides a ready source of information on the specialized mathematical techniques most useful in describing and analyzing biomedical signals. • Focuses on the mathematical tools required to analyze and describe the signals and systems found in biomedical engineering • Includes a comprehensive chapter on joint time-frequency analysis of nonstationary biomedical signals, and the use of wavelets in JTFA • Explores the mathematics of tomographic imaging • Describes the analytical signal and the Hilbert transform • Discusses the analysis of nonlinear systems, nonlinear oscillators, and biological clocks • Introduces the analysis of and modeling strategies for complex systems Solutions manual available upon qualifying course adoption

Selected Contents

Introduction. Life and Death. Review of Basic Cell Anatomy and Physiology. Introduction to Physical Biochemistry and Biochemical Systems Modeling. The Basis of Genetic Inheritance. Nucleic Acids and Their Functions. A Review of Proteins. The Genetic Basis for Certain Inheritable Diseases: Genomic Medicine. Some Instrumental Methods Used in Genomics, Proteomics, and Forensic Science. Applications of Genomics. ...

Introduction to Biomedical Signals and Systems. Review of Linear Systems Theory. The Laplace Transform and Its Applications. Fourier Series Analysis of Periodic Signals. The Continuous Fourier Transform. The Discrete Fourier Transform. Introduction to Joint TimeFrequency Analysis of Biomedical Signals. Introduction to the Analysis of Stationary Noise, and Signals Contaminated with Noise. Basic Mathematical Tools Used in the Characterization of Physiological Systems. Introduction to the Mathematics of Tomographic Imaging. ...

Catalog no. 61194, October 2008, 480 pp. ISBN: 978-1-4200-6119-2, $107.95 / £69.99

Catalog no. K10633, March 2010, 654 pp. ISBN: 978-1-4398-1251-8, $104.95 / £66.99

Selected Contents

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General Books in Bioengineering Applied Biomedical Engineering Mechanics

Technology and Medical Sciences

Dhanjoo N. Ghista

Edited by

Wayland, Massachusetts, USA

Combining topics from numerous applications in biomechanics, Applied Biomedical Engineering Mechanics demonstrates how to analyze physiological processes from an engineering perspective and apply the results to tertiary medical care. The book extends its discussion to the investigation of diagnostic and surgical procedures. It also presents guidelines for prostheses design and explains how to optimize performance in sports such as soccer, baseball, and gymnastics. Using a problem-based format, the book explains how to formulate diagnostic and interventional procedures based on the analysis of physiological and organ system-based processes and develop orthopedic surgical approaches using pre-surgical analysis. It goes on to cover how to assess and promote fitness and analyze sports games to maximize competency. • Incorporates material from solid mechanics, fluid mechanics, dynamics and vibrations, control systems, and mathematical modeling • Provides biomechanical guidelines for internal fixation of bone and spinal fractures as well as the treatment of herniated discs • Presents the mechanics of heart function, heart structures, the noninvasive determination of aortic pressure, and the characterization of left-ventricular afterload • Discusses the detection of infarcted myocardial segments • Assesses the constitutive properties and degeneration of heart valves • Covers the modeling of lung ventilation, its application to lung disease diagnosis, lung gas-transfer mechanism, and indices to assess its performance • Examines how human anatomical structures and physiological processes are designed for optimal functionalit The world-class instruction presented within Applied Biomedical Engineering Mechanics clearly demonstrates how to quantify physiological processes in order to formulate solutions to various medical problems. Catalog no. DK8315, July 2008, 552 pp. ISBN: 978-0-8247-5831-8, $149.95 / £96.00 Also available as eBook

Renato Natal Jorge, João Manuel R.S. Tavares, Marcos Pinotti, and Alan Peter Slade The use of more robust, affordable, and efficient techniques and technologies in the application of medicine is presently a subject of huge interest and demand. The main purpose of this book is to solidify knowledge in the fields of technology and medical sciences and to define their key stakeholders. It offers comprehensive coverage of the current state of the art, including computer assisted surgery, implantology, artificial organs, medical robotics, minimally invasive devices and techniques, bioengineering, technical aids, telemedicine, computer aided diagnosis, virtual reality, software development, simulation, and more. Catalog no. K13050, January 2011, 376 pp. ISBN: 978-0-415-66822-4, $139.00 / £89.00 Also available as eBook

Bionanotechnology II Global Prospects Edited by

David E. Reisner The Nano Group, Inc., Farmington, Connecticut, USA

A blend of information from the Biomedical Engineering Handbook and new material, this book draws on the experience of experts from around the world. Reflecting the increasing importance of nanomedicine and biotechnology, this material covers topics such as biomimicry, stem cells, optical togs, and nanocoatings. The book also provides insights into the food and cosmetics industries, as well as cardiac diagnosis, batteries, drug delivery, photonics, and DNA building blocks. It also discusses protein devices, quantum dots, bioanalysis, optics, nanomedicine, personalized medicine, and the business of emerging bionanotech companies. Catalog no. K10254, August 2011, 583 pp., ISBN: 978-1-4398-0463-6, $99.95 / £63.99 Also available as eBook

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General Books in Bioengineering Basic Introduction to Bioelectromagnetics

Bionanotechnology

Second Edition

Global Prospects

Cynthia Furse, Douglas A. Christensen, and Carl H. Durney

Edited by

University of Utah, Salt Lake City, USA

This revised and updated edition facilitates the process of interdisciplinary research by introducing life scientists to the basic concepts of electromagnetic fields. The book outlines elements of EM that are helpful to life scientists working with physicists and electrical engineers. Each concept is presented with an associated application and discussion. Example applications include MRI, NMR, ultrasound, hyperthermia, neural stimulation, and cardiac pacing/defibrillation. With the liberal use of diagrams and graphs, this text covers the entire frequency spectrum through optical frequencies from a qualitative perspective beneficial to life scientists. Catalog no. 55429, March 2009, 288 pp. ISBN: 978-1-4200-5542-9, $107.95 / £69.99 Also available as eBook

David E. Reisner The Nano Group, Inc., Farmington, Connecticut, USA

As the impact of nanotechnology continues to grow, it is important for biomedical engineers to have a deeply rooted understanding of bionanotechnologies. Featuring chapters drawn from the third edition of the bestselling Handbook of Biomedical Engineering as well as new contributions not found in the Handbook, Bionanotechnology takes a broad survey of the research and activities shaping this burgeoning field. Covering technical and non-technical areas, the book discusses the role of nanotechnology in novel medical devices, bioanalytical technologies, and nano-biomaterials, as well as intellectual property issues that are unique to nanotechnologies. Catalog no. 7528, July 2008, 368 pp. ISBN: 978-0-8493-7528-6, $104.95 / £66.99 Also available as eBook

Coming Soon!

Biosensors and Molecular Technologies for Cancer Diagnostics

Computational Intelligence in Biomedical Engineering Rezaul Begg

Edited by

Victoria University, Melbourne, Australia

Keith E. Herold and Avraham Rasooly

Daniel T.H. Lai and Marimuthu Palaniswami

Biosensors are expected to play an expanding role in the early detection and treatment of cancer. Addressing cancer molecular diagnostics from the perspective of biosensors and biodetection, this book examines the technology and applications of a range of sensor systems, including optical, electrochemical, and optomechanical sensors. Each chapter presents a different biosensor-based technology and then explains their limitations, how the sensors are created, how they function, and how they can be applied. The text also reviews allied subjects, such as ligands, molecular markers, and microfluidics, that are essential to understanding and developing new sensing technologies.

In recent years, there has been an explosion of interest in CI techniques as evidenced by numerous applications in various fields. Biomedical research and applications have benefited enormously as a result of applications of such tools and techniques. However, most of the scientific literature on the application of CI for modeling and pattern recognition is scattered in different journals and conference proceedings. This book provides a comprehensive account of recent research efforts in this emerging area. It brings together in a single volume research and applications of computational intelligence.

Catalog no. K11937, June 2012, c. 840 pp., ISBN: 978-1-4398-4165-5, $169.95 / £108.00 Also available as eBook

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University of Melbourne, Australia

Catalog no. 4080, December 2007, 392 pp. ISBN: 978-0-8493-4080-2, $149.95 / £96.00 Also available as eBook

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Forthcoming

Advanced Materials for Joint Implants Giuseppe Pezzotti Kyoto Institute of Technology, Japan

Catalog no. N10574, July 2012, c. 400 pp., ISBN: 978-981-4316-88-0, $179.95 / £114.00 Also available as eBook

The Biomedical Engineering Handbook Molecular Engineering, Fourth Edition Joseph D. Bronzino Donald R. Peterson University of Connecticut, Farmington, USA

Catalog no. K11202, August 2012, c. 1200 pp. Soft Cover, ISBN: 978-1-4398-2527-3 $159.95 / £99.00 Also available as eBook

A Laboratory Course in Tissue Engineering Edited by

The Medical Device R&D Handbook Second Edition Edited by

Theodore R. Kucklick TRKD Medical Devices, Los Gatos, California, USA

Catalog no. K10598, August 2012, c. 550 pp. ISBN: 978-1-4398-1189-4, $139.95 / £89.00 Also available as eBook

Heart Rate Variability (HRV) Signal Analysis Clinical Applications Edited by

Markad V. Kamath McMaster University, Hamilton, Ontario, Canada

Mari A. Watanabe Adrian Upton McMaster Medical Centre, Hamilton, Ontario, Canada

Catalog no. K12259, September 2012, c. 544 pp. ISBN: 978-1-4398-4980-4, $149.95 / £95.00

Bacterial Cellulose

University of California, San Diego, USA

A Sophisticated Multifunctional Material

Dawn Kilkenny

Miguel Gama

University of Toronto, Ontario, Canada

University of Minho, Braga, Portugal

Catalog no. K13694, August 2012, 256 pp. Soft Cover, ISBN: 978-1-4398-7893-4 $59.95 / £38.99 Also available as eBook

Catalog no. K13216, September 2012, c. 250 pp. ISBN: 978-1-4398-6991-8, $99.95 / £63.99 Also available as eBook

Melissa Kurtis Micou

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Forthcoming

Reliable Design of Medical Devices Third Edition Richard C. Fries

Fundamentals of Biomechanics Ronald L. Huston

Isorel, Inc., Fitchburg, Wisconsin, USA

University of Cincinnati, Ohio

Catalog no. K14218, September 2012, c. 416 pp. ISBN: 978-1-4398-9491-0, $179.95 / £114.00 Also available as eBook

Physics of Thermal Therapy Fundamentals and Clinical Applications

Catalog no. K14776, September 2012, c. 500 pp. ISBN: 978-1-4665-1037-1, $99.95 / £63.99

Regenerative Engineering Edited by

Cato T. Laurencin and Yusuf Khan

Edited by

Eduardo Moros Moffitt Cancer Center, Tampa, Florida, USA

University of Connecticut Health Center, Farmington, USA

Catalog no. K12209, September 2012, c. 400 pp. ISBN: 978-1-4398-4890-6, $149.95 / £95.00 Also available as eBook

Catalog no. K10724, September 2012, c. 400 pp. ISBN: 978-1-4398-1412-3, $99.95 / £63.99 Also available as eBook

Ambient Assisted Living

Advances in Therapeutic Engineering Edited by

Wenwei Yue

Nuno M. Garcia

Chiba University, Japan

Lusophone University of Humanities and Technologies, Lisbon, Portugal

Subhagata Chattopadhyay

Joel Jose P.C. Rodrigues Dirk Christian Elias

Teik-Cheng Lim

Fraunhofer Portugal, Porto

SIM University, Singapore

Miguel Sales Dias MSTF LDA, Quinta Do Conde, Portugal

Catalog no. K13212, September 2012, c. 450 pp. ISBN: 978-1-4398-6984-0, $149.95 / £95.00 Also available as eBook

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National Institute of Science and Technology, Orissa, India

Rajendra Acharya Ngee Ann Polytechnic, Singapore

Catalog no. K13287, September 2012, c. 488 pp. ISBN: 978-1-4398-7173-7, $179.95 / £109.00 Also available as eBook

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Resources for Every Engineer Contracts for Engineers Intellectual Property, Standards, and Ethics Robert D. Hunter Robert D. Hunter Associates, Austin, Texas, USA

As an engineer, you encounter various forms of contracts at nearly every turn in your career. This book helps you communicate contractual issues to lawyers and better understand the consequent legal advice you receive. Learn about intellectual property (including patents, copyright, trademarks, and trade secrets), standards, and ethics. Catalog no. K12434, September 2011, 368 pp. ISBN: 978-1-4398-5286-6 $69.95 / £44.99 Also available as eBook

Technical Writing A Practical Guide for Engineers and Scientists Phillip A. Laplante The Pennsylvania State University, Malvern, USA

Written by a renowned engineer and widely published technical author, this guide shows you how to write, edit, and publish materials of a technical nature, including books, articles, reports, and electronic media. Offering first-hand examples and personal anecdotes, it complements the traditional writer’s reference manuals and other books on technical writing. Catalog no. K11106, July 2011 250 pp., Soft Cover, ISBN: 978-1-4398-2085-8 $39.95 / £25.99 Also available as eBook


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