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Contents Environmental Analysis ....................................3 General Analysis................................................5 Medicinal and Bioanalysis ..............................12 Separation Techniques ....................................19 Page 3

Page 13

Spectroscopy ..................................................26

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Page 28

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Environmental Analysis New!

Analytical Measurements in Aquatic Environments

Environmental Chemometrics Principles and Modern Applications

Edited by

Grady Hanrahan

Jacek Namiesnik and Piotr Szefer

California Lutheran University, Los Angeles, USA

Gdansk University of Technology, Poland

Covering the composition and underlying properties of freshwater and marine systems, this work provides a basis for understanding both. The contributors employ a range of examples to explain the behavior of trace constituents in aquatic environments. They discuss collection and preparation, modern extraction techniques, conservation, and storage. They also elucidate the use of passive dosimetry, mineralization techniques, speciation analytics, green analytical chemistry, and chemometric techniques. Extensive details on quality control and quality assurance provide a complete perspective on the difficulties of sample preparation in aquatic environments. Features • Provides a critical evaluation of a wide spectrum of extraction of organic and inorganic constituents from environmental samples • Includes coverage of preservation techniques of samples used in environmental studies • Explores the possibility of application of biotests as part of an integrated approach in evaluating the level of pollution of aquatic ecosystems • Presents green aspects of analytical protocols used in environmental studies • Describes the application of the Life Cycle Assessment (LCA) technique for evaluating the environmental impact of different analytical aspiration and processes • Contains a range of examples that demonstrate the behavior of trace constituents in aquatic environments Catalog no. 8268X, January 2010, 503 pp., ISBN: 978-1-4200-8268-5, $129.95 / £82.00

A delineation of modern environmental analysis and methods for effectively solving limitations through multivariate approaches, this book begins with an overview of chemometrics in relation to quantitative environmental analysis and a review of descriptive statistical concepts. It examines environmental sampling considerations, experimental design, optimization techniques, and multivariate analysis of environmental and chemical data sets. The book also covers quality assurance and method validation. The author’s presentation of the basic principles of these methods together with real applications in the field of environmental chemistry simplifies comprehension of complex environmental problems and chemically related concepts. The coverage of environmental analysis, backed by studies from experts in the field, elucidates the rapidly developing world of chemometric methods in environmental analysis. Features • Provides a modern introduction and practical guide to chemometrics methods written by a practicing expert • Covers classical and modern methods to improve the effectiveness and efficiency of environmental sampling and monitoring programs • Introduces modern chemometric methods, the basic theory behind them, and their incorporation into current environmental investigations • Presents basic principles of chemometric methods together with real applications in the field of environmental chemistry Catalog no. 67966, 2009, 310 pp., Soft Cover, ISBN: 978-1-4200-6796-5, $89.95 / £49.99

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Environmental Analysis Chromatographic Analysis of the Environment

Analysis of Pesticides in Food and Environmental Samples

Third Edition Edited by

Leo M.L. Nollet

Edited by

University College Ghent, Applied Engineering Sciences, Belgium

Jose L. Tadeo National Institute for Agricultural and Food Research and Technology (INIA), Madrid, Spain

“A nine page index (approximately 700 entries), copious references (1,072) to pertinent scientific literature and useful websites, and an abundance of tables, graphs, mathematical and chemical formulae, structures, schematics, diagrams, and photographs enable this book to impart a wealth of factual knowledge, protocols and analytical know-how. If your remit is to measure and evaluate pesticide levels and residues in environmental materials or foods, then this book is indispensible.” —Steve Mitchell, Imperial College, ISSX Newsletter, Summer 2009, Vol. 29, No. 2

Features • Provides a concise review of pesticide classes and their physicochemical properties • Describes specific analytical methods and instrumentation for measuring pesticides in food, soil, water, and air samples • Highlights effective new technologies for monitoring chemical contaminants • Covers trends in sample preparation, pesticide analysis, and quality assurance • Details extraction and determination techniques for analyzing real-world samples • Addresses regulatory aspects of pesticides in the environment • Includes extensive reference data on the levels of pesticides found in actual foods and environmental samples • Enables scientists to measure and predict the behavior and toxicity of pesticides with a higher degree of accuracy Catalog no. 7552, 2008, 384 pp. ISBN: 978-0-8493-7552-1, $159.95 / £99.00

“This totally renewed edition … is a detailed handbook on different chromatographic analytical techniques and chromatographic data for compounds found in air, water, soil, and sludge. The book discusses the parameters of each environmental compartment in a consistent format that highlights sample-preparation techniques, chromatographic separation methods, and detection modes. Most of the data are compiled in tables and illustrated with figures. These are well updated and are most useful for an easy access to the relevant literature. … This unique resource of chromatographic techniques, data, and references will be an attractive read for analytical chemists, chromatographic analysts, scientists, technologists, and engineers involved in the analysis of environmental compounds and in quality assurance and control.” —J. Albaigés, International Journal of Environmental Analytical Chemistry, Vol. 86, 2006

Features • Provides discussions of parameters of the different compartments of the environment in the same format • Covers the specific aspects of sampling in the environment and the different sample preparation methods • Discusses the importance of data processing • Presents data tables that make valuable information easy to find • Reviews analytical methods for nitrogen and sulfur compounds, organic and organometallic compounds, and VOCs, such as benzene, toluene, ethylbenzene, and xylene (BTEX) • Includes information and data relevant to insecticides and herbicides, oil and petroleum products, and surfactants Catalog no. DK3095, 2006, 1320 pp. ISBN: 978-0-8247-2629-4, $269.95 / £172.00


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General Analysis


Electroanalytical Chemistry A Series of Advances: Volume 23 Edited by

Allen J. Bard University of Texas, Austin, USA

Cynthia Zoski New Mexico State University, Las Cruces, USA

Praise for Previous Volumes “Highly recommended.” —Journal of the American Chemical Society

“Essential … [This is] a series which, from its very beginning, proved to be one of the most successful and most frequently cited … . The series has shaped the electrochemists of the last thirty years and, even more remarkably, each volume has turned out to be of lasting significance and influence.” —Journal of Solid State Electrochemistry

For more than three decades, this unique series has delivered the most in-depth and critical research related to issues in electrochemistry, offering state-of-the-art material to both specialists and non-specialists. While this volume provides a background and a starting point for graduate students looking for a place to focus their research, it also presents valuable findings and new methods for analytical and industrial chemists seeking to develop new products and applications, including new approaches to electroplating and corrosion resistance and fuel cell development. The book covers electroanalytical techniques being currently used in such diverse areas as electro-organic synthesis, fuel cell studies, and radical ion formation. These techniques are also employed to solve problems dealing with kinetics and mechanisms of electrode reactions, the effects of electrode surface phenomena, adsorption, and the electrical double layer of electrode reactions. Features • Examines electrochemistry activity at the liquid-liquid interfaces, demonstrating research that moves the concept from an exotic curiosity into one that shows the promise of new application development, especially in the field of energy-related chemistry • Explores an electrochemical approach to the reduction of platinum under superdry conditions in an effort to uncover the perfect working electrode • Investigates the impact of metal-ligand bonding interactions on the electron-transfer chemistry of transition-metal nanoparticles • Presents an introduction to sol-gel processing, with an emphasis on silicate formation, while looking at the dramatic advances in silicate science that electrochemists are technologically ready and eager to apply Catalog no. 84852, February 2010, c. 301 pp., ISBN: 978-1-4200-8485-6, $169.95 / £108.00

For more information and complete contents, visit


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General Analysis Quality Assurance and Quality Control in the Analytical Chemical Laboratory

The Scientist or Engineer as an Expert Witness James G. Speight CD & W Inc., Laramie, Wyoming, USA

A Practical Approach Piotr Konieczka and Jacek Namiesnik Gdansk University of Technology, Poland

Using an approach grounded in hands-on experience, this clearly written, well-organized book provides a strong foundation in the concepts of practical QA/QC. It begins with the theory behind QC systems and then discusses examples of tools, such as validation parameter measurements. The text also examines the use of statistical tests, describes the process of counting the margin of error, and discusses estimating uncertainty. The authors draw on their experience in traceability, statistics, proficiency tests, and method validation to craft a resource that provides practical guidance for each step of the quality assurance process. Features • Includes a CD-ROM with Excel datasheets that allow users to develop and customize their own models • Highlights the increasing importance of QA/QC in analytical and testing laboratories • Discusses all aspects of QA and measurements results, rather than selected aspects, such as method validation • Provides an integrated view on measures, such as the use of reference materials and method validation • Covers some frequently misunderstood concepts, including uncertainty and traceability • Presents discussions of radionuclides, green analytical chemistry, and chemometrics in relation to QA/QC

“…Speight, who has testified numerous times as an expert witness, provides guidance that gives witnesses all the information needed to testify confidently and effectively. … Highly detailed and exceedingly thorough in scope, the book is clear and readable.” —, January 2009, Issue 117

This book assists technical experts who must clearly convey often complicated information to a non-technical audience. It discusses the functions of the expert witness, describes how attorneys find experts, and explores the professional résumé and other tools expert witnesses can use to market themselves. It provides a primer on the rules of evidence and examines issues that arise during depositions. The book closes with a discussion of the trial itself and post-trial responsibilities. A complete glossary of terms further clarifies the material. Features • Reviews responsibilities before, during, and after trial • Conveys legal terms in an understandable manner for non-legal experts • Includes coverage of significant Supreme Court cases and rulings that determine the use of expert witnesses, including Frye and Daubert • Explains the traps and attempts to disqualify that witnesses may encounter and provides tips on how to counter them • Details the courtroom layout, the process of the trial, and the use of visual aids Catalog no. 52586, 2009, 216 pp. ISBN: 978-1-4200-5258-9, $89.95 / £57.99

Catalog no. 82701, 2009, 232 pp. ISBN: 978-1-4200-8270-8, $129.95 / £78.99


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General Analysis Second-Order Nonlinear Optical Characterization Techniques An Introduction Thierry Verbiest and Koen Clays Katholieke Universiteit Leuven, Belgium

Vincent Rodriguez University of Bordeaux 1, Talence, France

Designed for nonspecialists, this multidisciplinary book focuses on the potential of secondorder nonlinear optics as a powerful characterization tool. It stresses the reliability of nonlinear optical processes for probing surfaces and interfaces. Avoiding extensive mathematical details, the book does not require a background in advanced mathematics or physics. After introducing linear optics from the perspective of polarizability and linear susceptibility, the authors cover incoherent second-harmonic generation. They then deal with the study of surfaces and interfaces, exploiting the intrinsic surface sensitivity of second-harmonic generation and sum-frequency generation. The final chapter discusses second-order imaging techniques, including confocal microscopy and two-photon excited fluorescence microscopy. Features • Provides an overview of second-order nonlinear optical characterization techniques, such as second-harmonic generation and sum-frequency generation, that can be easily implemented in any lab • Presents an elementary description of nonlinear optics • Includes several practical examples that show how to use nonlinear optics as a versatile characterization tool • Describes how to implement nonlinear optical techniques for specific purposes, from the determination of surface symmetry and molecular orientation to biological imaging Catalog no. 70711, 2009, 192 pp. ISBN: 978-1-4200-7071-2, $119.95 / £72.99

Introduction to Multivariate Statistical Analysis in Chemometrics Kurt Varmuza and Peter Filzmoser Vienna University of Technology, Austria

Using formal descriptions, graphical illustrations, practical examples, and software tools, this introduction presents simple yet thorough explanations of the most important multivariate statistical methods for analyzing chemical data. Some of the statistical methods discussed include principal component analysis, regression analysis, classification methods, and clustering. Written by a chemometrician and a statistician, the book applies the methods to real data examples from chemistry. It also examines results of the different methods, comparing traditional approaches with their robust counterparts. The authors use the freely available R package to implement methods, encouraging readers to go through the examples and adapt the procedures to their own problems. The book effectively imparts a basic understanding of how to apply statistical methods to multivariate scientific data. Features • Includes important multivariate statistical methods, such as principal component analysis and support vector machines, for analyzing scientific data • Explains the methods using formulae, graphical illustrations, and schemes • Demonstrates R software tools with fully worked-out, real-world examples • Emphasizes the use of robust statistical methods • Offers practical advice on applying the methods Catalog no. 59475, 2009, 336 pp. ISBN: 978-1-4200-5947-2, $119.95 / £72.99

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General Analysis The Chemical Components of Tobacco and Tobacco Smoke

Ionic Liquids in Chemical Analysis

Alan Rodgman Winston-Salem, North Carolina, USA

Edited by

Thomas A. Perfetti

Tallinn University of Technology, Estonia

Mihkel Koel

Perfetti and Perfetti, LLC, Winston-Salem, North Carolina, USA

“I highly recommend this book as an indispensable reference source for tobacco and smoke chemists as well as other scientists involved in the study of tobacco and its products … Rodgman and Perfetti are commended for the foresight, hard work, and diligence required for publishing The Chemical Components of Tobacco and Tobacco Smoke.” —Charles R. Green, R.J. Reynolds Tobacco Company, Beiträgezur Tabakforschung International, May 2009, Vol. 23, No. 4

“…There will not be any other comprehensive work in the next 30-50 years about this topic— Rodgman/Perfetti will be the definitive book.” —Wolf-Dieter Heller, Karlsruhe, Germany

Features • Provides the first single-source reference published on the subject since 1968 • Reviews every chemical class of components found in tobacco and tobacco smoke • Catalogs and alphabetically indexes over 8400 tobacco and tobacco smoke components • Presents more than 6000 cited references that deal with many topics pertinent to the components in question • Lists the corresponding Chemical Abstracts Registry Number for most cataloged components • Examines adverse health-related problems assigned to specific components and the smoke components reported to negate such harmful effects • Includes a CD-ROM with a searchable, 300-page alphabetical component index

Exploring the future in chemical analysis research, this volume provides a broad overview of the applications of ionic liquids in various areas of analytical chemistry. It reviews the properties and structure of ionic liquids and the role of these materials in optical, electrochemical, and biochemical sensor technology. The book examines ionic liquids in gas, liquid, and countercurrent chromatography, along with their use as electrolyte additives in capillary electrophoresis. It also discusses gas solubilities, liquid-liquid extraction, and the separation of metal ions. The final chapters cover molecular, Raman, nuclear magnetic resonance, and mass spectroscopies. By showing how ionic liquids can improve measurement and reduce the amount of environmental waste, this book confirms the staying power of these materials in the years to come. Features • Collects the experience and knowledge of experts who use and study ionic liquids in a range of analytical chemistry areas • Discusses structure and physicochemical properties, activity coefficients, phase equilibrium with other liquids, and modeling • Presents different extraction techniques, from the separation of gases to metals • Examines the advantages of task-specific ionic liquids in analytical chemistry applications Catalog no. 46462, 2009, 448 pp. ISBN: 978-1-4200-4646-5, $149.95 / £95.00

Catalog no. 78836, 2009, 928 pp. ISBN: 978-1-4200-7883-1, $299.95 / £191.00


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General Analysis Bestseller!

Handbook for the Chemical Analysis of Plastic and Polymer Additives Michael Bolgar, Jack Hubball, and Susan Meronek AccuStandard, Inc, New Haven, Connecticut, USA

Joe Groeger Mantis Associates Inc., Storrs Mansfield, Connecticut, USA

Unique in its comprehensive presentation of chromatograms, mass spectral information, and analytical data as well as environmental and applications perspectives, this handbook provides a detailed reference for the analysis of the additives that are most widely used in plastics and polymers. Examining potential environmental effects of these additives, it presents a clear guide to viable isolation techniques and analysis methods for accurately assessing plastic and polymer mixtures. The book covers the techniques needed to extract, identify, and quantify additives in finished goods using common and readily available laboratory techniques. In addition to analytical data, it includes regulations issued by the US FDA, US EPA, EU agencies, and other groups. Features

Handbook of Acid-Base Indicators R.W. Sabnis Squire, Sanders & Dempsey LLP, San Francisco, California, USA

This handbook provides chemical information for over 200 acid-base indicators. Organized alphabetically, entries include common name, other names, CA index name, CAS registry number, Merck index number, chemical structure, chemical/dye class, molecular formula/weight, pH range, color change, pKa, physical form, solubility, UV-visible, melting/boiling points, synthesis, and toxicity data. The book also covers major applications, including semiconductors, displays, nanotechnology, fuel cells, pharmaceuticals, agrochemicals, and more. Catalog no. 8218, 2008, 416 pp. ISBN: 978-0-8493-8218-5, $209.95 / £134.00

Applied Pyrolysis Handbook Second Edition Edited by

• Includes chromatographic and mass spectral data obtained with commonly used analytical instruments • Provides a comprehensive listing of widely used additives in plastic and polymer mixtures • Cross-references additives by trade name, chemical name, CAS number, and even key mass unit ions from the GC/MS run • Explains how to analyze polymers through thermal desorption and the use of a GC with a mass selective detector

Thomas P. Wampler

Catalog no. 44877, 2008, 504 pp. ISBN: 978-1-4200-4487-4, $259.95 / £165.00

Catalog no. DK3999, 2007, 304 pp. ISBN: 978-1-57444-641-8, $164.95 / £105.00

CDS Analytical, Inc., Oxford, Pennsylvania, USA

“The Applied Pyrolysis Handbook is a practical guide to the application of pyrolysis techniques to various types of materials … This book is for chemists and researchers who use GC/MS to analyze materials and who need to add pyrolysis techniques to their analysis tools. It contains much practical information that could be useful to them.” —Electrical Insulation Magazine, May/June 2009, Vol. 25, No. 3

For more information and complete contents, visit


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General Analysis

Handbook of Photochemistry

Practical Guide to Chemometrics

Third Edition

Second Edition

Marco Montalti, Alberto Credi, Luca Prodi, and M. Teresa Gandolfi

Edited by

Paul Gemperline East Carolina University, Greenville, USA

University of Bologna, Italy

“…an accessible introduction to applicationoriented multivariate methods of data analysis and procedures that are highly beneficial to solving a variety of problems using analytical chemistry and statistics. … Numerous worked examples using MATLAB® code are offered to illustrate how easily these techniques can be adapted to various experimental scenarios. … This second edition has been completely revised…” —J. Albaigés, CID-CSIC, Barcelona, Spain, and Editor, International Journal of Environmental Analytical Chemistry, Vol. 86, 2006

Catalog no. DK4712, 2006, 552 pp. ISBN: 978-1-57444-783-5, $185.95 / £121.00

The latest edition of this handbook presents an exhaustive collection of information, organized in easy-to-use tables, useful in typical photochemical experiments. Written by leading world experts, this third edition includes overviews on the photochemical processes that occur in organic molecules and transition metal complexes. It contains sections focusing on metal complexes and organometallic compounds, offering photophysical and quenching data as well as reduction potential values. Catalog no. DK3093, 2006, 664 pp. ISBN: 978-0-8247-2377-4, $154.95 / £98.00

Undergraduate Instrumental Analysis

Instrumental Methods in Metal Ion Speciation

Sixth Edition James W. Robinson Louisiana State University, Baton Rouge, USA

Imran Ali

Eileen M. Skelly Frame

Jamia Millia Islamia, New Delhi, India

Rensselaer Polytechnic Institute, Troy, New York, USA

Hassan Y. Aboul-Enein National Research Center, Cairo, Egypt

George M. Frame II

“The book has been presented by well-known scientists … presents very interesting material … The book as a whole will certainly be a useful source of information for numerous analytical chemists [who] work in the timely important field of chemical analysis.”

“… Now in its sixth edition, [this book] has developed and grown in size and stature and is much improved … Each chapter comes with a useful collection of additional material such as bibliographies, sources of spectral databases, experiments and problems. … [the book effectively removes] the artificial boundary between the construction and function of the instrument and the understanding of the results that the instrument generates. …”

New York State Department of Health, Albany, USA

—Adam Hulanicki, Chemical Analysis, Vol. 52, No. 157, 2007

Catalog no. DK6024, 2006, 376 pp. ISBN: 978-0-8493-3736-9, $175.95 / £111.00

—Journal of Raman Spectroscopy, 2005

Catalog no. DK1308, 2005, 1079 pp. ISBN: 978-0-8247-5359-7, $89.95 / £39.99


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General Analysis Handbook of Detergents Part C Analysis Edited by

Heinrich Waldhoff Henkel KGaA, Dusseldorf, Germany

Rudiger Spilker Sasol Germany GmbH, Marl

Emphasizing techniques and methods that have proved effective and useful in daily work, the third installment of this handbook demonstrates the full spectrum of strategies, methods, and techniques for the analytical deformulation of modern detergents developed in the last decade. It covers typical ingredients of modern products, testing of detergent formulations, the determination of detergent ingredients in the environment, and the application of modern instrumental techniques. Catalog no. DK1334, 2005, 654 pp. ISBN: 978-0-8247-0351-6, $269.95 / £172.00

Detection Technologies for Chemical Warfare Agents and Toxic Vapors Yin Sun Advanced Analytical Technologies Group LLC, Bridgewater, New Jersey, USA

Kwok Y. Ong Retired, Joppa, Maryland, USA

“…this book not only features a comprehensive resource for technical and emergency response personnel, but also reviews detection requirements and protocols considered by the US government, discusses specific devices for detection, and describes laboratory techniques and analyses. … The book is well written, perfectly organized, and accessible to both technical and non-technical audiences. …” —A. Buekens, Free University of Brussels, International Journal of Environment and Pollution, Vol. 27, Nos. 1-3, 2006

Catalog no. L1668, 2005, 288 pp. ISBN: 978-1-56670-668-1, $154.95 / £98.00

Analytical Instrumentation Handbook Third Edition

Electrogenerated Chemiluminescence

Edited by

Edited by

Jack Cazes

Allen J. Bard

Lady Lake, Florida, USA

University of Texas, Austin, USA

“This is a practical reference handbook … [that] provides excellent descriptions about specific instrumental techniques and references dealing with more in-depth theory and methods. … The information is well-illustrated, and each of the chapters gives the reader a good basic understanding of how the technique works, various measurement methods and a list of applications and practical considerations … a must-have reference book.”

The first resource on this expanding analytical science, this reference explores advances in the instrumentation, design, and application of techniques with electrogenerated chemiluminescence (ECL). It examines the use and impact of ECL-based assays in clinical diagnostics, life science research, environmental testing, food and water evaluation, and the detection of biowarfare agents. Compiled by the pioneer of this highly innovative technology, this volume provides contributions from 16 leading authorities.

—IEEE Electrical Insulation Magazine, Vol. 22, No. 4, August 2006

Catalog no. DK1349, 2005, 1064 pp. ISBN: 978-0-8247-5348-1, $299.95 / £191.00

Catalog no. DK1129, 2005, 540 pp. ISBN: 978-0-8247-5347-4, $199.95 / £127.00

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Medicinal and Bioanalysis


Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery Paul C.H. Li Simon Fraser University, Burnaby, British Columbia, Canada

This comprehensive text presents the fundamentals of microfluidic lab-on-a-chip systems and provides an overview of the available technology, its limitations, and its breakthroughs. It emphasizes analytical applications of microfluidic technology and provides in-depth coverage of micromachining, nucleic acids, and mass spectrometry. The book also covers more recent advances in microdrops and nanoparticles. Ideal for students, the text includes historical background, expanded problem sets in each chapter, a comprehensive glossary, a complete index, and extensive references. Features • Reviews basic principles of micromachining and fluid flow and control for lab-on-a-chip technology • Adapts traditional principles of operation for the size of a chip, optimizing the miniaturization advantage and favorable scaling down • Presents problem sets in each chapter • Includes a glossary, complete index, and extensive references

Contents Introduction. Micromachining Methods. Micromachining of Silicon. Micromachining of Glass. Micromachining of Fused Quartz (or Fused Silica). Micromachining of Polymeric Chips. Metal Patterning. World-to-Chip Interface. Microfluidic Flow. Liquid Pumping Methods. Microfluidic Flow Control. Sample Introduction. Electrokinetic Injection. Hydrodynamic Injection. Other Sample Injection Methods. Sample Preconcentration. Sample Stacking. Extraction. Porous Membrane. Other Preconcentration Methods. Separation.Gas Chromatography. Capillary Electrophoresis. Chromatographic Separations. Coupled Separations.Detection Methods. Optical Detection Methods. Electrochemical Detection. Mass Spectrometry. Other Detection Methods. Applications to Cellular/Particle Analysis. Retention of Cells and Particles. Studies of Cells in a Flow. Other Cell Operations. Applications to Nucleic Acids Analysis. Nucleic Acids Extraction and Purification. Nucleic Acids Amplification. DNA Hybridization. Other Nucleic Acid Applications. Applications to Protein Analysis. Immunoassay. Protein Separation. Enzymatic Assays. Catalog no. K10977, February 2010, c. 352 pp., Soft Cover, ISBN: 978-1-4398-1855-8, $99.95 / £38.99


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Medicinal and Bioanalysis


Mass Spectrometry of Nucleosides and Nucleic Acids Edited by

Joseph H. Banoub Fisheries and Oceans Canada, Science Branch and Memorial University of Newfoundland, Canada

Patrick A. Limbach University of Cincinnati, Ohio, USA

Assembling the work of an international panel of researchers, this volume summarizes the latest developments in the field and provides a window on the next generation of analysis. It should inspire new findings and avenues of research. The book describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry. It then examines mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. The contributors analyze urinary modified nucleosides and explore DNA adducts. They also discuss isotope labeling of DNA-mass spectrometry and examine various uses of electrospray ionization mass spectrometry (ESI-MS). They review recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explore the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examine quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry. In addition, the book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. It discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates. The book concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids. Features • Reviews the progress of nucleic acid research by mass spectrometry • Highlights the most popular ionization methods • Illustrates the diverse strategies used in the characterization and sequencing of novel nucleosides and nucleotides • Covers complex DNA, single strands and duplexes, DNA-adducts, RNA oligomers of biomedical importance, DNA-drug complexes, and post-transcriptional modifications Catalog no. 44028, January 2010, 504 pp., ISBN: 978-1-4200-4402-7, $149.95 / £95.00

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Medicinal and Bioanalysis New!


Using Mass Spectrometry for Drug Metabolism Studies

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring

Second Edition

Edited by

Edited by

Amitava Dasgupta

Walter A. Korfmacher

University of Texas Health Sciences Center at Houston, USA

Schering-Plough Research Institute, Kenilworth, New Jersey, USA

Praise for the First Edition “… an invaluable reference … very well written … an informative look at the problems and successes of the modern drug discovery and development process.” —Journal of Medicinal Chemistry, Vol.48, 2005

The first edition of this now classic work helped establish mass spectrometry as the premier tool for drug metabolism studies. Keeping pace with rapid advances, the emergence of new approaches, and increasing demands by vendors, the second edition of this bestseller includes cutting-edge coverage of new instrumentation and software as well as significant new information on the latest findings regarding biomarkers and metabolomics. In addition to exploring all modern techniques and strategies, it offers an excellent overview of the entire drug discovery process, including the latest developments in molecular research. This edition also contains new chapters on both UPLC and DESI/DART. With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.

“…This excellent book reviews not only those drugs for which chromatographic techniques have long been used, but also drugs for which therapeutic monitoring is newer (e.g., antiretroviral agents, immunosuppressive drugs, antineoplastic compounds, antidepressant drugs, analgesics, cardioactive drugs, and antibiotics). … Edited by a distinguished authority on therapeutic drug monitoring, this book should serve as both an invaluable reference for analytical toxicologists and a practical guide for laboratory physicians and scientists who are involved in the monitoring of therapeutic agents.” —From the Foreword by David N. Bailey, Vice Chancellor for Health Affairs, Dean of the School of Medicine, and Professor of Pathology & Laboratory Medicine, University of California, Irvine, USA

Providing practical guidelines for implementing chromatographic methods, this volume describes the theory and application of therapeutic drug monitoring in clinical laboratories. It presents the theoretical framework and addresses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues related to pain management, and drug monitoring for a range of medications. The book also examines the interaction of herbal supplements with drugs being monitored. Catalog no. 67583, January 2010, 475 pp. ISBN: 978-1-4200-6758-3, $169.95 / £108.00

Catalog no. 92200, January 2010, 451 pp. ISBN: 978-1-4200-9220-2, $169.95 / £108.00


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Medicinal and Bioanalysis Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs Ray H. Liu

Biochemical Applications of Nonlinear Optical Spectroscopy Edited by

Vladislav Yakovlev University of Wisconsin, Milwaukee, USA

Birmingham, Alabama, USA

Dennis V. Canfield Federal Aviation Administration, Oklahoma City, Oklahoma USA

Sheng-Meng Wang Central Police University, Taoyuan Hsien, Taiwan

“Forensic toxicologists would benefit from this book most … This book shall remain a ready reference tool for me.” —Anil Aggrawal’s Internet Journal of Forensic Medicine and Toxicology, Vol. 11, No. 1

The availability and the selection of quality ion-pairs designating the analytes and their isotopically labeled analogs are important considerations in achieving the accuracy of quantitation results. With more than 1,500 full-scan mass spectra and quick access data tables, this text provides a valuable reference for labs involved in the analysis of abused and therapeutic drugs. The first part illustrates approaches, mechanisms, and challenges pertaining to the use of isotopic analogs as internal standards for drug quantitation.

This volume presents the most significant advances and future directions within this important field. It provides an understanding of the nonlinear optical response of complex molecules and reviews developments in ultrafast technology. In addition, the editor includes a theoretical analysis of nonlinear optical spectroscopies. Novel experimental approaches, such as spatial and temporal pulse shaping, are addressed as well as various nonlinear optical spectroscopic tools, including harmonics generation and Raman spectroscopy. The book also provides insight into the extension of nonlinear optical spectroscopy to the nanoscale through the use of plasmonic tip-enhanced arrangement. The book’s balanced coverage from a wide range of international contributors not only elucidates important achievements, but also outlines future directions in this dynamic and promising field. Features

The second section compiles mass spectra, including drugs and their analogs, as parent compounds and as derivatives resulting from various chemical derivatization approaches commonly encountered in today’s labs. The third part provides corresponding tables of ion-pairs that can potentially be adapted to designate the drugs and their analogs in the analytical processes. The unparalleled scope of this compilation makes it a critical onestop reference for those involved in drug analyses of biological specimens and interpretation of results.

• Reflects the latest technological advancement in the biomedical, biochemical, and biophotonics industry • Focuses on practical applications, such as photo echo, nonlinear optics, twodimensional IR, and stimulated Raman spectroscopy • Balances coverage of optical science, engineering, biology, chemistry, and physics • Includes contributions from an international panel drawing on experts from Japan, Germany, Israel, and the Netherlands

Catalog no. 94971, January 2010, 510 pp. ISBN: 978-1-4200-9497-8, $189.95 / £121.00

Catalog no. 68598, 2009, 290 pp. ISBN: 978-1-4200-6859-7, $149.95 / £89.00

For more information and complete contents, visit


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Medicinal and Bioanalysis Methods of Analysis for Functional Foods and Nutraceuticals

Biomolecular EPR Spectroscopy

Second Edition

Wilfred Raymond Hagen Delft University of Technology, The Netherlands

Edited by

“EPR is being increasingly used to investigate biological systems, but there is currently no text that biologists, biochemists, and bioinorganic chemists can use to understand the experimental and theoretical aspects of this technique without being experts in quantum mechanics … [this book] provides a valuable introductory text that can be recommended … The author is a prolific writer with a clear and concise writing style.”

Hershey Foods Technical Center, Pennsylvania, USA

W. Jeffrey Hurst

—Michael K. Johnson, University of Georgia, Athens, USA

Catalog no. 59572, 2009, 248 pp. ISBN: 978-1-4200-5957-1, $139.95 / £89.00

HighThroughput Analysis in the Pharmaceutical Industry

Providing an invaluable source of information for laboratories involved in the food, dietary supplement, and pharmaceutical industry, the second edition of this highly successful text reflects dramatic advances in the field of functional foods and nutraceuticals. It offers new techniques for the analysis of carotenoids, phytoestrogens, flavonoids, vitamins, and carbohydrates. This edition also includes three new chapters on polyphenol analysis along with 85 percent new or revised information. Catalog no. 7314, 2008, 552 pp. ISBN: 978-0-8493-7314-5, $149.95 / £95.00

Principles and Practice of Bioanalysis

Edited by

Second Edition

Perry G. Wang

Edited by

Teleflex, Wyomissing, Pennsylvania, USA

Richard F. Venn

“This book provides excellent up-to-date reviews on the newest developments of highthroughput analysis in drug discovery and development … has a good balance of both theoretical and practical information that should appeal to a broad base of readers … a quick and valuable resource for readers, ranging from professionals to academics, to gain knowledge about recent developments of high-throughput analysis in the pharmaceutical industry.”

“The book consists of 15 chapters written by internationally distinguished experts from biotech and pharmacological companies … This book is quite valuable theoretically and methodologically for specialists of various fields of analytical chemistry and biochemistry, molecular biology, and biotechnology. … an important desk book for researchers working with bioanalysis of various drugs and metabolites.”

Pfizer Central Research, Kent, UK

—Keyang Xu, Genentech, Inc., 2009

Catalog no. 5953X, 2009, 432 pp. ISBN: 978-1-4200-5953-3, $159.95 / £99.00


—G. Ya. Wiederschain, Biochemistry, 2008, Vol. 73, No. 12

Catalog no. 3857, 2008, 344 pp. ISBN: 978-0-8493-3857-1, $89.95 / £57.99

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Medicinal and Bioanalysis

Spectral Techniques in Proteomics Edited by

Thermal Analysis of Pharmaceuticals Edited by

Daniel S. Sem

Duncan Q.M. Craig and Mike Reading

Marquette University, Milwaukee, Wisconsin, USA

University of East Anglia, Norwich, UK

Providing insight into future directions in the application of spectral techniques in proteomics, this book presents the techniques used to analyze proteomes. It begins with an overview of structural proteomics and chemical proteomics and continues with an indepth exploration of widely used methods, such as ESI, MALDI, SELDI, ICAT, tandem MS, and shotgun proteomics. The book also examines spectroscopic tools, including SPR, EPR, NIR fluorescence, x-ray crystallography, and NMR.

“The editors did a really good job in creating a fine balance between topics of commonly used, well-established methods, and of techniques that are the focus of recent research efforts … Due to the high scientific value, timely industrial relevance, and didactic approach, this book is an invaluable information resource for readers both in academia and industry … . I warmly recommend this book … .”

Catalog no. DK3714, 2007, 464 pp. ISBN: 978-1-57444-580-0, $139.95 / £89.00

—Ádám Demeter, Gedeon Richter Plc, ChemMedChem, 2008, No. 3

Catalog no. DK2980, 2007, 416 pp. ISBN: 978-0-8247-5814-1, $154.95 / £98.00

Vanadium Chemistry, Biochemistry, Pharmacology and Practical Applications

Immunoassay and Other Bioanalytical Techniques

Alan S. Tracey

Edited by

Simon Fraser University, Burnaby, British Columbia, Canada (retired)

Jeanette M. van Emon

Gail R. Willsky and Esther S. Takeuchi University at Buffalo, New York, USA

“The first comprehensive resource on the chemistry of vanadium, this book has evolved from over a quarter century of research that concentrated on delineating the aqueous coordination reactions that characterize the vanadium oxidation state … [the book] make this information accessible to a wide range of readers …” —Anticancer Research, September/October 2007, Vol. 27, No. 5A

Catalog no. 46136, 2007, 250 pp. ISBN: 978-1-4200-4613-7, $154.95 / £98.00

US EPA, Las Vegas, Nevada, USA

Using an interdisciplinary approach, this volume describes the strength and the versatility of immunochemical and related bioanalytical methods for a wide range of environmental and biological measurement applications. It explores the wide base of immunoassay methods and discusses the evolution of the technology. It presents both standard and innovative applications of immunochemical and related methods as well as quality assurance guidelines. The book also offers insight into recently developed products and procedures. Catalog no. DK9421, 2007, 536 pp. ISBN: 978-0-8493-3942-4, $149.95 / £95.00

For more information and complete contents, visit


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Medicinal and Bioanalysis Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery

Fluorescence Sensors and Biosensors Edited by

Richard B. Thompson

Paul C.H. Li

University of Maryland, Baltimore, USA

“… emphasizes the most recent developments and emerging technologies with the broadest impacts in prominent fields such as fluorescence-activated cell sorting, DNA sequencing, high throughput screening, and clinical diagnostics. … an up-to-date account of fluorescence-based sensors focused on practical applications in biotechnology, analytical chemistry, and biomedicine.” —J. Albaigés, CID-CSIC, Barcelona, Spain, and Editor, International Journal of Environmental Analytical Chemistry, Vol. 86, 2006

Catalog no. DK2967, 2006, 416 pp. ISBN: 978-0-8247-2737-6, $144.95 / £92.00

Simon Fraser University, Burnaby, British Columbia, Canada

“…truly an awesome book … [a] well-documented book with a multitude of references … a great book to learn about instrument design, with numerous pictures and illustrations making the text much easier to understand. …” —Gary S. Vardon, Salt Lake Tribune, Journal of Materials, 2007

“…an excellent book, well thought out and written.” —P. Myers, Chromatographia, June 2007, Vol. 65

Catalog no. DK3682, 2006, 528 pp. ISBN: 978-1-57444-572-5, $175.95 / £111.00

NMR Spectroscopy of Biological Solids

Separation Methods in Proteomics

Edited by

A. Ramamoorthy

Edited by

Gary B. Smejkal and Alexander Lazarev

University of Michigan, Ann Arbor, USA

Pressure Biosciences, Inc., Woburn, Massachusetts, USA

This book examines the developments, implementation, and interpretation of solidstate NMR experiments and the advantages of applying them to biological systems. It emphasizes how these techniques can be used to realize the structure of noncrystalline systems of any size. The book provides a critical selection of solid-state NMR methods for solving a wide range of practical problems that arise in both academic and industrial research of biomolecules in the solid state.

“This volume provides a comprehensive examination of all major separation techniques for proteomics research. Written as a compilation of hands-on methods exemplified by the work of several recognized leaders in the field, this book may serve as a guide for the selection of optimal separation strategies to solve particular biological problems. …” —Anticancer Research, Vol. 26, 2006

Catalog no. DK3068, 2006, 536 pp. ISBN: 978-0-8247-2699-7, $164.95 / £105.00


Catalog no. DK3302, 2006, 368 pp. ISBN: 978-1-57444-496-4, $139.95 / £89.00

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Separation Techniques


High Performance Liquid Chromatography in Phytochemical Analysis Edited by

Monika Waksmundzka-Hajnos Medical University of Lublin, Poland

Joseph Sherma Lafayette College, Easton, Pennsylvania, USA

Practical and valuable across a range of fields, this volume presents up-to-date methods in high performance liquid chromatography (HPLC) applied to phytochemistry. This precise, rapid, versatile, and automated separations tool has broad applications in the separation, identification, and quantification of important components of medicinal plants. A team of well-respected industrial researchers, academicians, and regulators from around the world cover methods to determine plant taxonomy, structure, biochemistry, physiology, ecology, and genetics. These methods are essential for the standardization of plant-based drugs, identification of plant material, and creation of new herbal medicines. Applications for crop management and production are also addressed. Features • Provides a comprehensive source of phytochemical analysis to determine plant taxonomy, structure, biochemistry, physiology, ecology, and genetics. • Covers applications for crop management and production • Offers contributions from an international roster of contributing authors spanning industry, academia, and government regulatory agencies

Contents Overview of the Field of HPLC in Phytochemistry and Organization of the Book Herbal Drugs and the Role for Chromatographic Methods in Their Analysis Plant Products in Nutrition and Dietary Supplements: Quality Control Role of HPLC in Chemosystematics. Phytochemistry, Phytopharmacology, and Biological Role of Plant Metabolites. Sample Preparation of Plant Material. Stationary Phases and Columns in Analysis of Primary and Secondary Metabolites. Catalog no. 9260X, March 2010, c. 688 pp., ISBN: 978-1-4200-9260-8, $199.95 / £127.00

For more information and complete contents, visit


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Separation Techniques


Forensic Applications of High Performance Liquid Chromatography Shirley Bayne Teesside University, Middlesbrough, UK

Michelle Carlin University of Northumbria, Newcastle, UK

Chromatography has many roles in forensic science, ranging from toxicology to environmental analysis. In particular, high-performance liquid chromatography (HPLC) is a primary method of analysis in many types of laboratories. Maintaining a balance between practical solutions and the theoretical considerations involved in HPLC analysis, Forensic Applications of High Performance Liquid Chromatography uses real-life examples likely to be found within a forensic science laboratory to explain HPLC from a forensic perspective. Focusing chiefly on the reverse phase HPLC mode of separation, the book presents key point summaries and questions to enhance learning and test comprehension. It also includes a complete glossary of terms as well as references at the end of each chapter to facilitate further study. An invaluable guide for those in the early stages of their forensic analysis careers, this volume is also suitable as a textbook for students studying analytical chemistry, applied chemistry, forensic chemistry, or other courses with an element of HPLC within the course curriculum. Features • Examines the history of HPLC and the theory behind the separation process • Describes the requirements for successful analysis and best practice tips • Introduces the modes of separation and detection most appropriate for forensic science applications • Covers HPLC method development and evaluation • Presents the quality aspects of laboratory operation • Discusses troubleshooting HPLC systems and analyses • Explores applications of HPLC within the field of forensic science Catalog no. 91913, February 2010, c. 272 pp., Soft Cover, ISBN: 978-1-4200-9191-5, $59.95 / £38.99


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Separation Techniques


Advances in Chromatography Volume 48 Edited by

Eli Grushka Hebrew University of Jerusalem, Israel

Nelu Grinberg Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA

Praise for Previous Editions “… the articles are of high scientific standard, up to date, very well written, and interesting to read.” —Journal of Chromatography

“… a valuable contribution to the chromatography literature—belongs in every library used by chromatographers.” —Liquid Chromatography

“… maintains the high quality that chromatographers have come to expect from this valuable series.” —Journal of Pharmaceutical Science

For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. These volumes present timely, cutting-edge reviews on chromatography in the fields of bio, analytical, organic, polymer, and pharmaceutical chemistry. Each author’s clear presentation of topics and vivid illustrations make the material in Volume 48 accessible and engaging to biochemists and analytical, organic, polymer, and pharmaceutical chemists at all levels of technical skill. Topics covered include new advances in affinity interaction chromatography, simulated moving bed processes, retention mechanism in RP, silica hydride chemistry and applications, and UPLC. Features • Presents the most recent significant developments in separation science • Offers contributions from prominent international researchers • Includes chapters on issues of great timely concern, including one on leachables and extractables Catalog no. 84534, January 2010, 422 pp., ISBN: 978-1-4200-8453-5, $199.95 / £127.00

Recent volumes in the series Volume 47 Catalog no. 60368, 2009, 462 pp., ISBN: 978-1-4200-6036-2, $189.95 / £115.00

Volume 46 Catalog no. 60252, 2008, 488 pp., ISBN: 978-1-4200-6025-6, $189.95 / £121.00

Volume 45 Catalog no. DK4478, 2007, 285 pp., ISBN: 978-1-57444-735-4, $189.95 / £121.00

For complete contents of these and other volumes in the series, visit For more information and complete contents, visit


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Separation Techniques New!


Chiral Separations by Capillary Electrophoresis

Ion-Pair Chromatography and Related Techniques

Edited by

Teresa Cecchi

Ann Van Eeckhaut and Yvette Michotte

Istituto Tecnico Industriale Statale Montani, Fermo, Italy

Vrije Universiteit Brussel, Belgium

Ion-pair chromatography (IPC) is a rapidly evolving method for difficult analyses of organic and inorganic ions and ionogenic, neutral, and zwitterionic compounds. Providing a thorough exploration of the multiplicity of interactions involved in an IPC system, this book emphasizes the progress from theoretical modeling to application. It explores the practical potential of IPC in the life science, medicine, pharmacology, forensic, food, and environmental sectors. It examines the upgrade of column technology and instrumentation to improve data quality and increase sample throughput. The book also compares IPC to other instrumental methods of analysis and discusses the rising importance of the ion-pair concept in different analytical techniques.

With contributions from international experts, this volume provides a comprehensive, up-to-date overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available. It explains how this technique can be used in the separation of molecules, offering insight into both existing and emerging applications. The book discusses the most important as well as several new chiral selectors used in capillary electrophoresis. It reviews recent pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. The book also examines the quantitative aspects of capillary electrophoresis, the possibilities of capillary electrochromatography, and the various chiral columns available. Features • Presents a comprehensive, up-to-date overview of chiral separations with capillary electrophoresis • Describes recent techniques, such as capillary electrophoresis-mass spectrometry, capillary electrochromatography, and microchips • Explores new modes of chiral selectors, including microemulsion electrokinetic chromatography • Discusses the principles of separation, recent developments, and novel applications of the most common chiral selectors Catalog no. 69330, January 2010, 543 pp. ISBN: 978-1-4200-6933-4, $169.95 / £108.00


Features • Provides basic tips, decisive skills, and practical advice to experienced and novice chromatographers • Presents a theoretical description of the physico-chemical separation principle of IPC • Demonstrates applications showing the multiplicity of interactions involved in an IPC system • Describes upgrades to column technology and instrumentation • Reveals how to exploit the modification of the analyte hydrophobicity, via ion-pairing in different analytical techniques, to improve their versatility • Offers stimulating research suggestions and investigation needs Catalog no. K10075, January 2010, 215 pp. ISBN: 978-1-4398-0096-6, $129.95 / £82.00

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Separation Techniques


Encyclopedia of Chromatography Third Edition Edited by

Jack Cazes Lady Lake, Florida, USA

Praise for Previous Editions “…a wealth of information.” —Journal of Planar Chromatography

“…This encyclopedia should become a first and frequently used source of information on just about every conceivable chromatographic technique.” —The Chemical Educator

Thoroughly revised and expanded, this third edition is an authoritative guide to specific chromatographic techniques and theory. It provides a basic introduction to the science and technology of the method, offering key references that deal with the methodology for analyzing specific chemicals and applications in industry. With a focus on emerging technologies and uses, the text contains tables and figures that cogently illustrate and clarify technical points in the articles.

New to the Third Edition • • • • • • • • • • • • • • • •

Bioanalysis: Silica- and Polymer-Based Monolithic Columns Bioluminescence: Detection in TLC Chemical Warfare Agent Degradation Products: HPLC/MS Analysis Chemical Warfare Agents: TLC Analysis Cyclodextrins in GC and HPLC Detection in Ion Chromatography Drug Development: LC/MS Flash Chromatography Food Analysis: Ion Chromatography Inorganic and Organic Cations: Ion Chromatographic Determination Inverse GC Multidimensional Separations Spiral Column Assembly for HSCCC Thin Layer Radiochromatography Topological Indices: TLC UV-Visible Detection Including Multiple Wavelengths Available in print and online versions or as a combination of the two. Visit for more information.

Catalog no. 84593, January 2010, 2850 pp., ISBN: 978-1-4200-8459-7, $590.00 / £376.00

For more information and complete contents, visit


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Separation Techniques Thin Layer Chromatography in Phytochemistry

Liquid Chromatography -Mass Spectrometry

Edited by

Monika WaksmundzkaHajnos

Third Edition

Medical University of Lublin, Poland

Wilfried M.A. Niessen

Joseph Sherma Lafayette College, Easton, Pennsylvania, USA

Teresa Kowalska University of Silesia, Katowice, Poland

Worldwide TLC experts in diverse fields present the first resource to focus on TLC as it applies to the separation, identification, quantification, and isolation of medicinal plant components. The first part of the text offers a current overview of TLC and phytochemistry. The second section emphasizes real strategies and procedures for analyzing all types of primary and secondary plant metabolites. Organized by compound type, each chapter discusses key topics, such as sample preparation, plate development, and biodetection. From identification to commercial scale production and quality control, this text is an essential bench-top companion and reference on using TLC for the study of plantbased bioactive compounds. Features • Underscores the advantages of using TLC for locating and analyzing bioactive compounds from plant sources • Explains the benefits of using TLC over more expensive and complex chromatographic techniques • Reviews the techniques, materials, instrumentation, and procedures specific to the analysis and isolation of each compound class • Discusses methods for online derivatization, detection, identification, and quantification • Includes up-to-date tables, figures, and references throughout the text

hyphen MassSpec Consultancy, Leiden, The Netherlands

“… this book covers a variety of topics that are of interest to practitioners of LC-MS. The 22 chapters cover multiple topics and include practical tips as well as a useful list of references for the reader who wants to learn more about the particular topic. This book can be used as a reference book by both scientists with years of LC-MS experience as well as those scientists who are just beginning to utilize this excellent analytical tool.” —Walter A. Korfmacher, Schering-Plough Research Institute, American Society for Mass Spectrometry, 2007

"... well-rounded coverage of the latest technological developments and applications …" —Anticancer Research, October 2008

Featuring new chapters and extensive revisions throughout, this new edition explains how to use LC-MS and interpret data for various disciplines. This edition places a stronger emphasis on applications, dedicating more than two-thirds of the text to examining new developments of LC–MS in emerging application areas, including environmental, food safety, and clinical analysis as well as proteomics, pharmaceutical drug discovery, and natural products research. Supported by the most relevant literature available, each chapter examines how the strategies, technologies, and recent advances in LC-MS continue to shape many disciplines. Catalog no. DK2272, 2007, 632 pp. ISBN: 978-0-8247-4082-5, $185.95 / £121.00

Catalog no. 46772, 2008, 896 pp. ISBN: 978-1-4200-4677-9, $199.95 / £127.00


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Separation Techniques

Preparative Layer Chromatography Edited by

Separation Methods in Microanalytical Systems

Teresa Kowalska

Edited by

University of Silesia, Katowice, Poland

Jorg P. Kutter

Joseph Sherma

Technical University of Denmark, Lyngby

Lafayette College, Easton, Pennsylvania, USA

Yolanda Fintschenko

“… A valuable and important supplement to the existing vast chromatographic literature, [this book] demonstrates the potential of planar chromatography for separation and isolation of pure compounds, even from very complex mixtures.”

“This is just what I have been looking for. To my knowledge it’s the first time that anyone has put together a definitive book on the subject … The editors have done an excellent job in ensuring that the authors keep to their brief and do not cover data or examples given by other authors, but [still] have allowed the authors their individual styles … it is [of] great value, a book every researcher and student should have.”

—Journal of Liquid Chromatography, August 2006

“The book is quite well produced and has a large number of illustrations … a worthy addition to the PLC literature and a good place to start for the novice.” —I.D. Wilson, Chromatographia, January 2008, Vol. 67, No. 1/2

Preparative Layer Chromatography (PLC) explains how this method is used for separating large quantities of mixtures containing a wide variety of important compounds. It offers a broad review of PLC applications and adaptable working procedures for microseparations involving organic, inorganic, and organometallic compounds. The book describes procedures and strategies for selecting the most suitable eluents and designing application-specific PLC systems. It also discusses commercially available sorbents applicable to PLC, including bulk sorbents and precoated chromatographic plates available on the international market. Catalog no. 4039, 2006, 424 pp. ISBN: 978-0-8493-4039-0, $185.95 / £121.00

—P. Myers, Chromatographia, 2006, Vol. 63

Catalog no. DK3107, 2006, 592 pp. ISBN: 978-0-8247-2530-3, $185.95 / £121.00

Handbook of Affinity Chromatography Second Edition Edited by

David S. Hage University of Nebraska, Lincoln, USA

Jack Cazes Lady Lake, Florida, USA

“The topics are well illustrated and range from fields of biochemistry, molecular biology and biotechnology to analytical chemistry, pharmaceutical and environmental science. This handbook can be an excellent source of information not only to the students but also to the persons involved in research and academia.” —Carbohydrate Polymers

Catalog no. DK1199, 2006, 968 pp. ISBN: 978-0-8247-4057-3, $209.95 / £134.00

For more information and complete contents, visit


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Linearly Polarized IR Spectroscopy Theory and Applications for Structural Analysis Bojidarka Koleva Sofia University, Bulgaria

Tsonko Kolev Plovdiv University, Bulgaria

Reviewing theory but focusing on practice, Linearly Polarized IR Spectroscopy: Theory and Applications for Structural Analysis introduces linearly polarized IR spectroscopy as a method of molecular structural analysis, a technique that is useful in the study of pharmaceutical products and biological molecules. Examples demonstrate both the advantages and limitations of this technique. The text explains the possible applications of this new orientation method for the structural characterization of various chemicals. More specifically, it demonstrates how to obtain important information about the structure and spectral properties of oriented compounds. Features • Reviews the general theory of linearly polarized IR spectroscopy • Focuses on the use of the method for molecular structural analysis • Demonstrates the advantages and limitations of this technique through illustrative examples • Includes practical aspects associated with the characterization of inorganic chemicals and glasses as well as various classes of organic compounds

Contents Background of the Orientation Method Application for Spectroscopic and Structural Elucidation of Suspended Chemicals Inorganic Compounds and Glasses Organic Compounds Substituted Pyridines Amino Acids, Their Salts, and Ester-Amides of Squaric Acid Small Peptides and Their Salts Arylaliphatic Amines Pharmaceutical Products Organic Dyes Benzyls List of Acronyms Catalog no. K11223, March 2010, c. 232 pp., ISBN: 978-1-4398-2559-4, $129.95 / £82.00


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Spectroscopy New!

Practical Aspects of Trapped Ion Mass Spectrometry Volume V: Applications of Ion Trapping Devices Edited by

Raymond E. March Trent University, Ontario, Canada

John F.J. Todd University of Kent, Canterbury, UK

Widely used in medical research, pharmaceutical and fine chemicals industries, biological and physical sciences, and security and environmental agencies, mass spectrometry techniques are continually under development. In this volume, an international panel of authors presents a worldwide view of the practical aspects of recent progress using trapped ion devices. Spanning sixteen chapters, the text examines ion/neutral and ion/ion reactions, ion spectroscopy, and the structural characterization of proteins and peptides using quadropole ion trap mass spectrometry, Fourier transform -ion cyclotron resonance mass spectrometry, and traveling wave ion mobility mass spectrometry. It also provides practical examples of trapped-ion technology that reflect the wide diversity of applications of trapped-ion devices. Features • Compiles into one volume new and established mass spectrometric techniques utilizing trapped ions for prolonged investigation and increased sensitivity • Explores commonalities in theories of instrument operation, proteins, flavonoids, atomic clocks, and single ion mass spectrometry • Uses a consistent format and writing style in each chapter, explaining all terms, acronyms, procedures, and equations • Provides complete references for each chapter Catalog no. 83732, January 2010, 566 pp., ISBN: 978-1-4200-8373-6, $179.95 / £114.00

Other volumes in the set Volume IV: Theory and Instrumentation Catalog no. 83716, April 2010, c. 914 pp., ISBN: 978-1-4200-8371-2, $179.95 / £114.00

Volume III: Chemical, Environmental, and Biomedical Applications Catalog no. 8251, 1996, 544 pp., ISBN: 978-0-8493-8251-2, $209.95 / £134.00

Volume II: Ion Trap Instrumentation Catalog no. 8253, 1996, 352 pp., ISBN: 978-0-8493-8253-6, $259.95 / £165.00

Volume I: Fundamentals of Ion Trap Spectroscopy Catalog no. 4452, 1996, 448 pp., ISBN: 978-0-8493-4452-7, $259.95 / £165.00

For more information about these books, visit For more information and complete contents, visit


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Spectroscopy Differential Ion Mobility Spectrometry

TwoDimensional Optical Spectroscopy

Nonlinear Ion Transport and Fundamentals of FAIMS

Minhaeng Cho

Alexandre A. Shvartsburg

Korea University, Seoul, South Korea

Pacific Northwest Laboratory, Richland, Washington, USA

Effectively introducing a newly developed research field, this book provides a detailed account of basic theory required for an understanding of two-dimensional vibrational and electronic spectroscopy. It also bridges the gap between the formal development of nonlinear optical spectroscopy and the application of the theory to explain experimental results. The author presents novel definitions and theoretical frameworks for linear and nonlinear response spectroscopy and describes a range of two-dimensional spectroscopic techniques to compare the merits and disadvantages of each technique. From the development of the theory to novel applications, this book covers a gamut of topics in this field, including perturbation theory, coherent Raman scattering, pump-probe spectroscopy, photon echo spectroscopy, IRvisible four-wave mixing, and linear and nonlinear optical activity spectroscopy. Features

This state-of-the-art book explores a novel analytical technology that separates and characterizes ions by the difference between their mobility in gases at high and low electric fields. It also covers the novel topics of higher-order differential IMS and IMS with alignment of dipole direction. Incorporating some of his own unpublished research, the author integrates the fundamental physics of high-field ion mobility with practical considerations of FAIMS implementation. Catalog no. 51067, 2009, 322 pp. ISBN: 978-1-4200-5106-3, $159.95 / £99.00

Practical Guide to ICP-MS A Tutorial for Beginners, Second Edition Robert Thomas

• Provides the first published source of material on the principles of twodimensional optical spectroscopy • Presents novel definitions and theoretical frameworks for linear and nonlinear response spectroscopy • Describes a range of two-dimensional spectroscopic techniques to compare the merits and disadvantages of each • Includes various examples and applications to real molecular and electronic systems, such as chemical exchange systems, proteins, and light-harvesting complexes

This book offers key concepts in a readerfriendly format suitable for those with limited knowledge of the technique. Detailing the fundamental principles, analytical advantages, and practical capabilities of ICP-MS, this second edition features new and updated coverage of hyphenated techniques, user-friendly selection criteria for commercial ICP-MS equipment, and a new glossary of ICP-MS terms as well as specifications and features for commercial equipment.

Catalog no. 84291, 2009, 385 pp. ISBN: 978-1-4200-8429-0, $139.95 / £85.00

Catalog no. 67869, 2008, 376 pp. ISBN: 978-1-4200-6786-6, $109.95 / £69.99


Scientific Writing Solutions, Gaithersburg, Maryland, USA

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Core Level Spectroscopy of Solids Frank de Groot Debye Institute, Utrecht University, The Netherlands

Akio Kotani RIKEN/SPring-8, Hyogo, Japan

Handbook of Near-Infrared Analysis Third Edition Edited by

Donald A. Burns NIR Resources, Los Alamos, New Mexico, USA

Emil W. Ciurczak Cadrai Technologies, Goldens Bridge, New York, USA

This work presents the theoretical calculations, experimental data, and underlying physics of x-ray photoemission spectroscopy (XPS), x-ray absorption spectroscopy, x-ray magnetic circular dichroism, and resonant xray emission spectroscopy. It discusses hard XPS, resonant photoemission, spin polarization, electron energy loss spectroscopy, and resonant inelastic x-ray scattering. The authors also use the charge transfer multiplet theory to interpret core level spectroscopy for transition metal and rare earth metal systems.

Presenting nearly 50 percent new and revised material, this edition underscores accurate as well as time- and cost-effective current trends in sample preparation, calibration transfer, process control, data analysis, and commercial NIR instrumentation. Drawing on the experience of more than 60 experts in the field, new chapters highlight novel applications in pharmaceuticals, polymers, plastics, petrochemicals, textiles, foods and beverages, baked products, agricultural products, biomedicine, neutraceuticals, and counterfeit detection.

Catalog no. 9071, 2008, 512 pp. ISBN: 978-0-8493-9071-5, $149.95 / £95.00

Catalog no. 7393, 2008, 826 pp. ISBN: 978-0-8493-7393-0, $229.95 / £146.00

Practical Guide to Interpretive Near-Infrared Spectroscopy Jerry Workman Luminous Medical, Inc., Calrlsbad, California, USA

Lois Weyer Landenberg, Pennsylvania, USA

With an emphasis on structure correlation and interpretation of spectra, Practical Guide to Near Infrared Spectroscopy provides the necessary tools to interpret near infrared spectra. Organized by functional group type and chemical structure, chapters include more than 300 figures representing NIR frequency ranges and structural information for a broad range of functional groups, organic compounds, and polymers. Over 120 pages of tables and charts illustrate overlapping spectra. Catalog no. DK4715, 2008, 344 pp. ISBN: 978-1-57444-784-2, $99.95 / £63.99

Optical Spectroscopy of Lanthanides Magnetic and Hyperfine Interactions Brian G. Wybourne Nicolaus Copernicus University, Torun, Poland

Lidia Smentek Vanderbilt University, Nashville, Tennessee, USA

Highlighting the impact of lanthanides on modern technology, medicine, biochemistry, and molecular biology, this book documents the theory of the spectroscopic properties of lanthanides in various materials and the fundamental principles of their magnetic and hyperfine interactions. Enhanced with numerous examples, exercises, and sample programs, the text also explores a range of applications, including electronic data storage, lasers, superconductors, medicine, nuclear engineering, and nanomaterials. Catalog no. 7264, 2007, 352 pp. ISBN: 978-0-8493-7264-3, $164.95 / £105.00

For more information and complete contents, visit


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Spectroscopy CRC Handbook of Fundamental Spectroscopic Correlation Charts

Assigning Structures to Ions in Mass Spectrometry John L. Holmes, Christiane Aubry, and Paul M. Mayer

Thomas J. Bruno National Institute of Standards and Technology, Boulder, Colorado, USA

University of Ottawa, Ontario, Canada

Exploring the tools currently available for determining gas-phase ion structures, Assigning Structures to Ions in Mass Spectrometry surveys experimental methods for ion production and separation as well as those designed to reveal qualitative and quantitative aspects of gas-phase ions. It also examines how and when to apply computational chemistry and theoretical calculations. The book contains experimental data and key results collected over the past four decades. Catalog no. 1950, 2007, 472 pp. ISBN: 978-0-8493-1950-1, $175.95 / £111.00

Paris D.N. Svoronos City University of New York, Bayside, USA

Compiled from an extensive search of spectroscopic literature, this handbook provides a collection of spectroscopic information and correlation charts for use in the interpretation of spectroscopic measurements. Applicable to organic and inorganic materials, it provides useful analysis and assignment of spectra and structural elucidation of organic and organometallic molecules. An ideal companion in academic, industrial, and government labs, the book offers fundamental charts that are needed on a day-to-day basis. Catalog no. 3250, 2006, 240 pp., Soft Cover ISBN: 978-0-8493-3250-0, $99.95 / £63.99

Vibrational Spectroscopy of Biological and Polymeric Materials

Ion Mobility Spectrometry Second Edition

Edited by

G.A. Eiceman

Vasilis G. Gregoriou

New Mexico State University, Las Cruces, USA

Advent Technologies SA, Athens, Greece

Z. Karpas

Mark S. Braiman Syracuse University, New York, USA

Nuclear Research Center, Beer-Sheva, Israel

“It manages to stand out from most compiled texts consisting of contributions from many different authors by having instrumentation as the cohesive thread connecting the chapters. … [it] provid[es] detailed descriptions of instrumentation and the specific requirements of operation … the choice of topics and contributors does justice to recent advances in the area … .”

“…The second edition of this book provides a timely update to the fundamental theory, advancements in instrumentation, and the development of new applications of IMS … The CD [is] a useful and practical addition to this book … a well-balanced combination of theory and application … I highly recommend it to anyone interested in IMS.”

—Garth J. Simpson, Journal of the American Chemical Society, Vol. 128, No. 36, 2006

—Robert G. Ewing, New Mexico Institute of Mining and Technology, JACS, Vol. 128, 2006

Catalog no. DK3415, 2006, 448 pp. ISBN: 978-1-57444-539-8, $139.95 / £89.00


Catalog no. 2247, 2005, 370 pp. ISBN: 978-0-8493-2247-1, $185.95 / £121.00

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Analytical Chemistry Minicatalog  

Analytics Chemistry Books from CRC Press

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