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Hairy cell leukaemia

Hairy cell leukaemia is one of the most rare types of leukaemia, which is cancer of the white blood cells.


airy cell leukaemia gets its name from the fine, hair-like strands around the outside of the cancerous cells, which are visible under a microscope. It’s not known what causes hairy cell leukaemia. The condition most commonly affects people aged 40-60 and is more common in men than women.

If you have hairy cell leukaemia, it’s likely your red blood cell and platelet counts will be low. A bone marrow sample may also be taken, which gives the haematologist more detailed information about your condition. You may also need an ultrasound scan or a computerised tomography (CT) scan to examine your spleen.

Signs and symptoms


The symptoms of hairy cell leukaemia develop slowly and are similar to those of other types of leukaemia.

As hairy cell leukaemia develops slowly, immediate treatment may not be needed. You’ll have regular blood tests to monitor your condition. Treatment may be recommended if the number of abnormal white blood cells increases or if you develop symptoms. Chemotherapy is the main treatment for hairy cell leukaemia and is usually effective at destroying the cancerous cells. The two main chemotherapy medications used are: • cladribine – given as either an injection just under the skin, or through a drip directly into a vein (infusion) • pentostatin – given as an injection directly into a vein (intravenously) every two weeks Rituximab, a type of medication known as a monoclonal antibody, may sometimes be used in combination with chemotherapy. It works by attaching to a protein found on leukaemia cells and the immune system then targets and kills the cells. Surgery to remove the spleen is rarely used as a treatment for hairy cell leukaemia. However, removal of your spleen may be recommended if: • it’s enlarged and is causing pain or discomfort • it’s destroying large numbers of red blood cells or platelets • it hasn’t reduced in size after chemotherapy As with most types of cancer, the outlook for hairy cell leukaemia will depend on how far the condition has advanced at the time of diagnosis and how well it responds to treatment. As hairy cell leukaemia is a rare type of cancer, it’s difficult to accurately predict how it will affect individuals in the long term. The Cancer Research UK website has more information about: • Types of treatment for hairy cell leukaemia • Staging hairy cell leukaemia • Living with hairy cell leukaemia

They include: • unintentional weight loss • pale skin • weakness, tiredness and breathlessness (due to the lack of red blood cells) • frequent infections • bleeding or bruising easily • pain or swelling in your abdomen (tummy) (see below) As with other types of leukaemia, hairy cell leukaemia is a cancer of the white blood cells. Over time, the build-up of cancerous white blood cells disrupts the normal balance of cells in the blood. This means your body doesn’t have enough red blood cells, which carry oxygen around the body, or platelets, which help stop bleeding. This can lead to all of the symptoms listed above. Also, as the white blood cells are not properly developed, they are less effective at fighting bacteria and viruses, making you more vulnerable to infection. The abnormal white blood cells can accumulate in your spleen, causing it to increase in size. The spleen is an organ in the upper left side of your abdomen, behind your stomach and ribs. If your spleen is enlarged, it’s likely you’ll have a painful lump on the left side of your abdomen. If this is the case, you should visit your GP so the lump can be examined. An enlarged spleen may remove normal blood cells from your bloodstream. This can lead to a further reduction in the number of normal red and white blood cells and platelets in your blood.

Diagnosis If your GP suspects leukaemia, they may refer you to a haematologist (a specialist in blood disorders). The haematologist will carry out blood tests to determine how many different types of blood cells there are in your blood sample. This is known as a full blood count (FBC).

For more information on Chronic myeloid leukaemia, visit the NHS website


The C&K FUNdraising Magazine Issue 29 – 2019

Profile for Chartwell Cancer Trust

FUNDRAISING ISSUE 29 | The Chartwell Cancer Trust  

FUNDRAISING ISSUE 29 | The Chartwell Cancer Trust