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Neurological Disorders

Cells 4health

Information for patients

Health People

Neurological Disorders treatment with autologous stem cells from your own bone marrow.

Neurological Disorders

Cells 4health

Parkinson's Disease

Is there any treatment?

What is the prognosis?

Parkinson's disease (PD) belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells. The four primary symptoms of PD are tremor, or trembling in hands, arms, legs, jaw, and face; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks. PD usually affectspeople over the age of 50. Early symptoms of PD are subtle and occur gradually. In some people the disease progresses more quickly than in others. As the disease progresses, the shaking, or tremor, which affects the majority of PD patients may begin to interfere with daily activities. Other symptoms may include depression and other emotional changes; difficulty in swallowing, chewing, and speaking; urinary problems or constipation; skin problems; and sleep disruptions. There are currently no blood or laboratory tests that have been proven to help in diagnosing sporadic PD. Therefore the diagnosis is based on medical history and a neurological examination. The disease can be difficult to diagnose accurately. Doctors may sometimes request brain scans or laboratory tests in order to rule out other diseases.

At present, there is no cure for PD, but a variety of medications provide dramatic relief from the symptoms. Usually, patients are given levodopa combined with carbidopa. Carbidopa delays the conversion of levodopa into dopamine until it reaches the brain. Nerve cells can use levodopa to make dopamine and replenish the brain's dwindling supply. Although levodopa helps at least three-quarters of parkinsonian cases, not all symptoms respond equally to the drug. Bradykinesia and rigidity respond best, while tremor may be only marginally reduced. Problems with balance and other symptoms may not be alleviated at all. Anticholinergics may help control tremor and rigidity. Other drugs, such as bromocriptine, pramipexole, and ropinirole, mimic the role of dopamine in the brain, causing the neurons to react as they would to dopamine. An antiviral drug, amantadine, also appears to reduce symptoms. In May 2006, the FDA approved rasagiline to be used along with levodopa for patients with advanced PD or as a singledrug treatment for early PD. Besides these kinds of treatments, stem cell therapy can be used to minimize the chronic consequences of Parkinson's disease.

PD is both chronic, meaning it persists over a long period of time, and progressive, meaning its symptoms grow worse over time. Although some people become severely disabled, others experience only minor motor disruptions. Tremor is the major symptom for some patients, while for others tremor is only a minor complaint and other symptoms are more troublesome. No one can predict which symptoms will affect an individual patient, and the intensity of the symptoms also varies from person to person. Cerebral Palsy The term cerebral palsy refers to any one of a number of neurological disorders that appear in infancy or early childhood and permanently affect body movement and muscle coordination but don't worsen over time. Even though cerebral palsy affects muscle movement, it isn't caused by problems in the muscles or nerves. It is caused by abnormalities in parts of the brain that control muscle movements. The majority of children with cerebral palsy are born with it, although it may not be detected until months or years later. 1

Neurological Disorders

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The early signs of cerebral palsy usually appear before a child reaches 3 years of age. The most common are a lack of muscle coordination when performing voluntary movements (ataxia); stiff or tight muscles and exaggerated reflexes (spasticity); walking with one foot or leg dragging; walking on the toes, a crouched gait, or a "scissored" gait; and muscle tone that is either too stiff or too floppy. A small number of children have cerebral palsy as the result of brain damage in the first few months or years of life, brain infections such as bacterial meningitis or viral encephalitis, or head injury from a motor vehicle accident, a fall, or child abuse. Is there any treatment? Cerebral palsy can't be cured, but treatment will often improve a child's capabilities. Many children go on to enjoy near-normal adult lives if their disabilities are properly managed. In general, the earlier treatment begins the better chance children have of overcoming developmental disabilities or learning new ways to accomplish the tasks that challenge them. Treatment may include physical and occupational therapy, speech therapy, drugs to control seizures, relax muscle spasms, and alleviate pain; surgery to correct anatomical abnor

malities or release tight muscles; braces and other orthotic devices; wheelchairs and rolling walkers; and communication aids such as computers with attached voice synthesizers. Besides these kinds of treatments, stem cell therapy can be used to minimize the chronic consequences of Cerebral Palsy. What is the prognosis? Cerebral palsy doesn't always cause profound disabilities. While one child with severe cerebral palsy might be unable to walk and need extensive, lifelong care, another with mild cerebral palsy might be only slightly awkward and require no special assistance. Supportive treatments, medications, and surgery can help many indivi-duals improve their motor skills and ability to communicate with the world.

About stem cells The discovery of the stem cell has lead to a revolution in modern medicine. Stem cells are in fact, the "smart cells" of our bodies. These cells migrate to injured areas within the body and transform themselves into new tissue cells that replace the damaged ones. The body repairs itself by continuously producing new cells and tissues in this manner. Stem cells have the capacity to multiply and to renew themselves almost indefinitely. This contrasts with nerve cells, muscle cells and blood cells, which cannot multiply themselves and have limited life spans.

Stem Cell

Other neurological diseases Other neurological diseases such us Huntington's Disease, movement disorders, ataxia, neurological intoxications, Alzheimer can be treated with the therapies described in this document.

Stem Cell e.g., hematopoietic stem cell

Specialized Cell (e.g., neuron)


Neurological Disorders

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Stem cells can also develop into specialized cells. Stem cells from the bone marrow can develop into cardiac muscle, as well as liver, brain, nerve, fat and skin tissue. Examples of bone marrow-derived stem cell development are illustrated below.


Adult Stem Cell

Skeletal muscle Brain Bone marrow Blood cell Epithelial cell Cardiac muscle

The Cells4health Neurological Disorder Treatment

Eligibility phase

The entire procedure consists of the following phases: eligibility, stem cell collection and processing, stem cell treatment, and follow-up.

If you meet the following conditions, you are eligible for treatment:

Objectives The goal of this treatment is to repair damaged tissue or to reactivate existing cells, thus recovering as much as possible, functions lost as a result of the particular neurological disorder. Type of treatment The Cells4health-ND procedure employs autologous adult stem cells. These cells are collected from your own bone marrow. A few days prior to treatment, the stem cells will be isolated from bone marrow taken from your hip (iliac crest).

- Neurological Disorder (as described above) diagnosis based on your medical history, imaging material such as MRT or CT scan, radiology and a neurological report. - Our medical team approves you for treatment. - Your bone marrow contains a sufficient quantity of viable stem cells. This is assessed during the processing phase.



Neurological Disorders

Cells 4health

Stem Cell Collection and Processing Prior to scheduling bone marrow collection, you will be asked to fill out the patient consent form. This form grants explicit written permission for bone marrow collection. You must discontinue using any blood diluting medications at least 10 days before your collection date. You should consult your physician before discontinuing the use of blood diluting drugs. When we greet you on collection day, we'll have everything prepared to begin collection and make it comfortable for you. Your physician will collect approximately 150 - 200 ml of bone marrow from your hip bone. Stem cell collection is performed as an out-patient procedure under local anesthesia in sterile conditions. It is comparable in pain to a dentist visit. During the collection, you will barely feel the needle insertion into your hip bone. Afterwards, the collection site might look likea "blue spot" and be a bit painful for 3 - 4 days. Normally, there are no other side-effects. Theoretically, there is a small risk of infection. We minimize this risk by working in a sterile environment.

These pictures show the Bone Marrow Collection Procedure

Bone Marrow Collection Procedure

Disinfection of the collection site


Application of local anesthetic

Needle insertion into the hip bone (iliac crest)

Sample collection


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Within 24 hours, the stem cell samples are processed and quality tested by a highly specialized laboratory in totally sterile, clean room conditions. Since they are kept in sterile tubes and never come into contact with the air, these samples cannot be contaminated. Bone marrow processing and quality testing consists of: - Stem cell isolation – stem cells are separated from the red blood cells and blood plasma. - Stem cell counting - Stem cell vitality measurement - Stem cell processing results are documented in an analysis report. The result is positive if: - There are more than two million (2,000,000) CD34+ stem cells present. - The CD34+ stem cells have a vitality greater than 80%

Neurological Disorders

Stem Cell Implantation Your high-quality stem cell sample will be implanted into the spinal canal via intrathecal injection. Intrathecal Injection Under a local anesthetic, your stem cells (in a volume of4ml-10 ml.) will be injected directly into the cerbrospinal fluid via lumbar puncture. Since the cerebrospinal fluid circulates, stem cells are transported directly to the damaged tissue in the brain or the spinal cord. The entire procedure usually takes about 30 minutes. Immediately after treatment, you will spend about three or four hours laying in bed in our recovery room for observation. As with any minimally invasive intervention, intrathecal stem cell implantation carries a very small risk of infection. We minimize this risk by working in a sterile environment and by prescribing prophylactic antibiotics to you. If there are no complications, you can return home or to your hotel.

- Positive isolated stem cell samples are stored in sterile tubes at -196°C in liquid nitrogen.


Neurological Disorders

Cells 4health

Possible Adverse Events from the treatment


After the procedure, you might experience the following adverse events. These events can be intense but usually subside within two or three days.

Once you have returned home, a member of our medical team will regularly monitor your progress via telephone and email. For your convenience, a telephone “hotline� is always at your disposal.

- Nausea - Headache - Backache and/or Leg pain Treatment Advantages - Simple - Out patient

Note: If your bone marrow sample is negative or the stem cells cannot be administered due to unforeseen medical circumstances, you will only be required to pay charges incurred to that point. In the case of a negative bone marrow sample, it might be possible to schedule another bone marrow collection.

General No additional charges will be incurred unless you are required to extent your stay at the medical center as a result of complications. Costs do not include additional stem cell treatments. If another treatment is necessary, we will discuss potential options with you. You will receive an invoice one week prior to treatment. This invoice must be paid in-full before treatment can begin.


Brochure patient_information_neuro  

Brochure patient_information_neuro

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