Issuu on Google+

drug class

drugs included in test

data availability US

EU

CAN

GRAM NEGATIVE

A BAUMANNII Carbapenem

imipenem, meropenem

Aminoglycoside

gentamycin, tobramycin, amikacin

Ceftazidime

ceftazidime

Ampicillin-sulbactam ampicillin-sulbactam

Fluoroquinolone

Multidrug

ciprofloxacin, ofloxacin, levofloxacin Multidrug resistance defined as being resistant to one or more drug in at least three of the following classes: antipseudomonal penicillins, third generation cephalosporins with antipseudmonal aciton (ceftazidime), carbapenems, fluoroquinolones, aminoglycosides, sulbactams E COLI

Fluoroquinolone

ciprofloxacin, ofloxacin, levofloxacin

3rd gen. cephalosporin cefotaxime, ceftriaxone & ceftazidime

Aminoglycoside

gentamycin, tobramycin, amikacin

Aminopenicillin

ampicillin, amoxicillin

Trimethoprim-sulfa trimethoprim-sulfamethoxazole Multidrug resistance defined as being resistant to one or Multidrug more drug in the following classes: third generation cephalosporins, fluoroquinolones and aminoglycosides K PNEUMONIAE

✔ ✔

Fluoroquinolone

3rd gen. cephalosporin cefotaxime, ceftriaxone & ceftazidime

Aminoglycoside

gentamycin, tobramycin, amikacin

Carbapenem

imipenem, meropenem

ciprofloxacin, ofloxacin, levofloxacin

Trimethoprim-sulfa trimethoprim-sulfamethoxazole Multidrug resistance defined as being resistant to one or Multidrug more drug in the following classes: third generation cephalosporins, fluoroquinolones and aminoglycosides P AERUGINOSA

Fluoroquinolone

ciprofloxacin, ofloxacin, levofloxacin

Ceftazidime

ceftazidime

Piperacillin-tazobactam piperacillin-tazobactam, piperacillin

Aminoglycoside

gentamycin, tobramycin

Carbapenem

Multidrug

imipenem, meropenem Multidrug resistance defined as being resistant to one or more drug in at least three of the following classes: antipseudomonal penicillins (piperacillin), third generation cephalosporins with antipseudmonal aciton (ceftazidime), carbapenems, fluoroquinolones, aminoglycosides P MIRABILIS

Aminopenicillin

ampicillin, amoxicillin

3rd gen. cephalosporin cefotaxime, ceftriaxone & ceftazidime


Fluoroquinolone

ciprofloxacin, ofloxacin, levofloxacin

Aminoglycoside

gentamycin, tobramycin, amikacin

Trimethoprim-sulfa trimethoprim-sulfamethoxazole Multidrug resistance defined as being resistant to one or Multidrug more drug in the following classes: third generation cephalosporins, fluoroquinolones and aminoglycosides

✔ ✔

S PNEUMONIAE

Penicillin

penicillin

Macrolide

Multidrug

erythromycin, clarithromycin, azithromycin Multidrug resistance defined as simultaneous resistance to penicillin and macrolides S AUREUS

Oxacillin

oxacillin, methicillin

rifampin (rifampicin) see Increasing Role of Staphylococcus aureus and Community-Acquired Methicillin-Resistant Staphylococcus aureus Infections in the United States: A 10-Year Trend of CA and HA MRSA Replacement and Expansion R. M. Mera, J. A. Suaya, H. Amrine-Madsen, C. S. Hogea, L. A. Miller, E. P. Lu, D. F. Sahm, P. O'Hara and C. J. Acosta Microbial Drug Resistance 2011 17:2, 321-328 ENTEROCOCCS SPP

Vancomycin

vancomycin

Vancomycin

vancomycin

High level gentamicin high-level gentamycin (MIC > 1000mg/l)

High level gentamicin high-level gentamycin (MIC > 1000mg/l)

Vancomycin

GRAM POSITIVE

Rifampin

E faecium

vancomycin COAGULASE-NEGATIVE STAPHYLOCOCCI

Oxacillin

oxacillin, methicillin

Fluoroquinolone

ciprofloxacin, ofloxacin, levofloxacin

Clindamycin

clindamycin

Tetracyline

tetracycline

Trimethoprim-sulfa trimethoprim-sulfamethoxazole Multidrug resistance defined as being resistant to one or more drug in at least three of the following classes: Multidrug fluoroquinolones, tetracycline, clindamycin, tromethoprimsulfa, rofampin

✔ ✔



Data desc gn