tb
AMONG PREGNANT WOMEN
TB is the leading cause of death among pregnant women, particularly those who are HIV+. Pregnant women who have TB are more likely to deliver infants that are stillborn, or born premature and underweight. And, there is increased risk for acquiring TB after giving birth, but we do not fully understand what that looks like in the immune system. Thus there are no guidelines for how to identify and treat pregnant women who are at risk for developing TB after they deliver. Because there is very little data about drug toxicity in pregnant women, India does not provide preventive therapy to all HIV-infected pregnant women, as recommended by the WHO. We are investigating the immunological and physiological changes that occur during different stages of pregnancy and how they contribute to greater risk for acquiring TB. We also are researching what impact those changes have on the effectiveness of TB treatment.
2017 Studies
Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis Vaginal Microbiota in HIV Infected Pregnant Women Studying the Molecular Mechanisms Leading to Suppressed Immunity in Pregnancy and Studying the Relationship between Diet, Gut Microbiome and Inflammation during Pregnancy Temporal Dynamics of Gut Microbiota in HIV-infected Pregnant Women Predictive Value of TB Symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India: Substudy on Inflammation in HIV-Infected Pregnant Women: Relationship with Diet, Gut Microbiome and Preterm Birth Diagnosis of Latent Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India Zika Surveillance among ANC Outpatients in BJ Govt Medical College and Sassoon General Hospitals, Pune, India Investigating Maternal Antibodies to Modify Infant Tuberculosis Acquisition (MAMA Study)
CLINICAL RESEARCH