is 1.7 kcal/mol, essentially equal to 2 × 0.8. Once we consider the effect of the additional CH2 groups, the strong binding of hit 4 is more reasonable. Please complete the online exercise. OPTIONAL‐Please participate in the online discussion forum.
10.3 Filtering Hits Pt 1 Visual inspection video Please watch the online video (8 minutes, 33 seconds). A condensed summary of this video can be found in the Video summary page. OPTIONAL‐Please participate in the online discussion forum.
Another structural alert Background: Compounds that contain functionality that may cause toxicity problems raise a structural alert. Anilines are perhaps the most common functional group that causes structural alert. Instructions: Read the passage below about arylacetic acids, which also trigger a structural alert. Learning Goal: To gain exposure to another functional group that forms reactive metabolites and is associated with structural alerts.
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