binding therefore protects a drug from clearance by both the liver and kidneys. Drugs with a higher plasma protein binding, or lower fu, show a lower rate of clearance. impact on volume of distribution Plasma proteins are only found in the circulatory system. If a drug is highly bound to plasma proteins, then that drug will be largely confined to the volume of the plasma. This binding can greatly reduce a drug's Vd. overall impact The overall impact of plasma protein binding must be interpreted on a case‐by‐case basis. Both Vd and CL are decreased by protein binding, so the overall effect on kel and t1/2 cannot be immediately predicted. Regardless, protein binding does affect the pharmacokinetics of drugs and is monitored by drug discovery groups within a pharmaceutical company.
7.6 Oral Delivery I Oral bioavailability video Please watch the online video (7 minutes 9 seconds). A condensed summary of this video can be found in the Video summary page. OPTIONAL‐Please participate in the online discussion forum.
Estimating AUC for an oral drug Background: The calculation of area under curve (AUC) for a given dose of a drug is the first step for determining CL for a drug. Instructions: Use the Cp‐time data points for an oral drug to determine the AUC of the dose. Learning Goal: To understand how to use the trapezoid rule to approximate AUC for an oral drug. Please complete the online exercise. OPTIONAL‐Please participate in the online discussion forum.