The two blood proteins most relevant to drug action are discussed below. serum albumin Blood is up to 5 wt% serum albumin. This is a remarkably high concentration of a single protein. Serum albumin has multiple potential binding sites. Although serum albumin can affect almost any drug, serum albumin tends to bind acid drugs most strongly. Two acidic drugs that are extensively bound by serum albumin are warfarin and ibuprofen, both shown below.
globulins Blood contains several different globulin proteins ‐ the α‐, β‐, and γ‐globulins. These proteins can comprise up to 2.5 wt% of blood. One specific protein, α1‐acid glycoprotein, tends to bind basic drugs, including disopyramide and lidocaine, which are shown below. Since the concentration of α1‐ acid glycoprotein is lower than serum albumin, the degree of drug binding tends to be somewhat lower.
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