Chapter 5 – Receptors Introduction to Chapter 5 Chapter 5 contains three subsections.
Types of Receptors
At the conclusion of this chapter, you should know the different types of receptors and what structural features distinguish one from another. You should also know the types of receptor ligands and be able to identify each based on a response vs. log [L] graph. Finally, you should understand the fundamental assumptions of occupancy theory and situations in which the assumptions fail. OPTIONAL‐Please participate in the online discussion forum.
5.1 Types of Receptors Receptor superfamilies video Please watch the online video (6 minutes 26 seconds). A condensed summary of this video can be found in the Video summary page. OPTIONAL‐Please participate in the online discussion forum.
PDB example of an ion channel Background: Ligand‐gated ion channels are membrane‐bound receptors. All membrane‐bound receptors are characterized by a large number of parallel α‐helices. The α‐helices allow the protein to criss‐cross the cell membrane and anchor itself in place. Instructions: In a separate window, bring up the Protein Data Bank website and look up entry 4HFH. Learning Goals: To appreciate the overall structure of ligand‐gated ion channels and gain more experience examining proteins in the Protein Data Bank. Please access the online Protein Data Bank website. Please complete the online exercise. OPTIONAL‐Please participate in the online discussion forum.
Published on May 6, 2014