patent - a form of intellectual property that grants to the holder exclusive rights to an invention for 20 years from the date of filing peptidomimetics - a form a lead optimization that attempts to develop a drug with good bioavailability from a typically poorly available peptide lead peptoid - a specific type of peptide isostere that is used to develop a peptidomimetic drug pharmacodynamics - the branch of medicinal chemistry that focuses the action of a drug at its site of action pharmacokinetics - the branch of medicinal chemistry that focuses on the movement of a drug from its site of administration, throughout the body, to its site of action, and out of the body pharmacophore - the core parts of a molecule that are required for a threshold level of activity phase I metabolism - oxidative, reductive, and hydrolytic chemical reactions on a drug phase II metabolism - reactions in which a drug or metabolite is connected to a group (generally very polar) to either detoxify the compound or assist excretion of the molecule phenotype - an observable trait of an organism. Symptoms of a disease are an example of a phenotype, and drugs can modify the symptoms. plasma - the non-cellular portion of whole blood. Plasma consists of water, electrolytes, signal molecules, and proteins. plasma concentration (Cp) - the concentration of a drug within the blood plasma polymorphism - the ability for most molecules, including drugs, to pack together in multiple, different arrangements. Each polymorph of a drug potential has different physical properties and is legally considered a different composition of matter.
Published on May 6, 2014