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carbons

neuraminidase IC50 (nM)

entry

in R‐group 

R‐group

influenza A 

influenza B

5

4

CH2CH2CH2CH3

300

215

6

4

CH2CH(CH3)2

200

ND

7

4

10

7

9

2

8

4  

9

5

CH2CH2CH2CH2CH3

200

ND

10

5

CH(CH2CH3)2 (oseltamivir)

1

3

11

6

CH2CH2CH2CH2CH2CH3

150

1,450

12

6

60

120

13

7

CH2CH2CH2CH2CH2CH2CH3

270

ND

14

8

CH2CH2CH2CH2CH2CH2CH2CH3

180

3,000

15

9

CH2CH2CH2CH2CH2CH2CH2CH2CH3

210

ND

16

10

CH2CH2CH2CH2CH2CH2CH2CH2CH2CH3

600

ND

17

10

1

4

MOOC Medicinal Chemistry  
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