Department of Ob/Gyn 2018 Annual Report by Women & Infants Hospital of Rhode Island

Department of Obstetrics & Gynecology 2018 Annual Report

â&#x20AC;&#x153;Our vision is to be the premier Department of Obstetrics & Gynecology, recognized for excellence and quality in all aspects of our work including comprehensive patient care, research, education, innovation, and leadership.â&#x20AC;? Maureen G. Phipps, MD, MPH Chair, Department of Obstetrics & Gynecology

Our team of fellows – the next generation of women’s health leaders. Front row: May-Tal Sauerbrun-Cutler, MD; Anne Cooper, MD; Lauren Stewart, MD; Martha Kole, MD; G. Sarah Napoe, MD; Evelyn Hall, MD; Jenna Emerson, MD; Lindsey Beffa, MD. Back row: Jesse Casaubon, DO; Ashley Borgstadt, DO; Christopher Nau, MD; Reed Kuehn, MD; Michael Beninati, MD; Katherine Miller, MD; Nina Ayala, MD; Warren J. Huber, MD, PhD.

CONTENTS Message from the Chief. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2

Urogynecology and Reconstructive Pelvic Surgery . . . . . . . . . . . . 28

Message from Gary Frishman, MD . . . . . . . . . . . . . . . . . . . . . . . . . . 6

Surgical Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30

Message from Charles Rardin, MD . . . . . . . . . . . . . . . . . . . . . . . . . . 7

Simulation Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32

Ambulatory Care. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

Inpatient Obstetrics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34

Emergency Obstetrics & Gynecology. . . . . . . . . . . . . . . . . . . . . . . 10

Community-Based Faculty. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36

Gynecologic Oncology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

Community-Based Specialists. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38

Gynecologic Oncology – Breast Health. . . . . . . . . . . . . . . . . . . . . . 14

Hospital-Based Faculty . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42

Maternal-Fetal Medicine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

Grant Funding – 2018. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48

Midwifery Program. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18

Peer-Reviewed Publications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54

Reproductive Endocrinology & Infertility. . . . . . . . . . . . . . . . . . . . . 20

Editorial Positions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66

Clinical Research in Women’s Health . . . . . . . . . . . . . . . . . . . . . . . 22

Contact Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67

Medical Education . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 2018 Annual Report

Message from the Chief The Department of Obstetrics & Gynecology is dedicated to improving the lives of women, families, and communities in southern New England while serving as a role model nationally and internationally. Our vision is to be the premier Department of Obstetrics & Gynecology, recognized for excellence and quality in all aspects of our work including comprehensive patient care, research, education, innovation, and leadership. This is the mission of the Department of Obstetrics and Gynecology at The Warren Alpert Medical School of Brown University and Women & Infants Hospital of Rhode Island, a Care New England hospital, and these are the words that all 151 members of our department embody in every aspect of our work – in the care we provide to our patients, the research we conduct at the bench and in the community, the education we offer to the next generation of women’s health providers, the innovative approach to care delivery, and the leadership roles we are drawn to that address significant issues related to women’s health locally, nationally and internationally. Here are a few highlights from the past year that capture the commitment of our faculty to our mission. This year, Dr. Emily White of the Providence Community Health Centers was integral in the passage of a bill that now enables minors in the State of Rhode Island to consent for their own care. We continue to work collaboratively with our Rhode Island Department of Health to address the issue of maternal mortality with a particular emphasis on the disparities that continue to plague our nation.

And with the ever-challenging opioid crisis, our efforts continue to help women who are pregnant and parenting and coping with addiction disorders, putting them on the best path forward for themselves and their children. Indeed, this year, our Emergency Department under the direction of Dr. Roxanne Vrees, was presented with a Level 3 Certification as part of the Levels of Care for Rhode Island Emergency Departments and Hospitals for Treating Overdose and Opioid Use Disorder. Our plan has four fundamental areas focusing on treatment, overdose rescue, prevention, and recovery, and our team has developed organizational policies, clinical protocols, and institutional infrastructure to ensure that patients are managed appropriately. Our focus on research remained steadfast and unwavering, as we continue to find new ways to address health issues locally and share globally. Understanding that a strong research model requires rigor in approach, evaluation, and dissemination, we were pleased to name Dr. Kristen Matteson as director of the Division of Research. Dr. Matteson has been a tremendous leader for the department’s research mission including promoting research among trainees, junior faculty, and colleagues. Her commitment to scholarship, mentorship, and leadership is

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Department leadership team. Front row: Roxanne Vrees, MD; B. Star Hampton, MD; Maureen Phipps, MD, MPH; Deborah Myers, MD; Elisabeth Howard, PhD, CNM; Erika Werner, MD; Renee Eger, MD. Back row: Gary Frishman, MD; Dayna Burrell, MD; Kristen Matteson, MD, MPH; Ruben Alvero, MD; Paul DiSilvestro, MD.

part of everything she does from research and teaching to clinical care and committee work. Her vision for enhancing the department’s research program and supporting investigators with innovative initiatives will serve us well into the future. This year was also a time of transition in our department. We saw the retirements of friends and colleagues, including Dr. John Buster, who for more than four decades was a leader in the field of reproductive endocrinology and infertility, revolutionizing the standards for the treatment of women with infertility and those with genetic conditions they did not want to pass on to their child, directing the research team that performed the world’s first donated blastocyte embryo transfer, and leading a major study that demonstrated the effectiveness of an estradiol mist in menopausal women.

“Our focus on research remained steadfast and unwavering, as we continue to find new ways to address health issues locally and share globally.”

2018 Annual Report

Message from the Chief

Dr. Katharine Wenstrom, who served as director of our Division of Maternal-Fetal Medicine and co-led our Integrated Program for High-Risk Pregnancy for nine years, also retired this year. Dr. Wenstrom made a substantial impact on the department, the institution, and the community. She led the team through the growth of the division with the expansion of genetic counseling and consultative services, the strengthening of our high-risk pregnancy network throughout southern New England, growing partnerships with insurers and state organizations, the remarkable work of the Prematurity Task Force, the recruitment of new faculty, and the enhancement of research and educational programs. Following a national search, Dr. Erika Werner was appointed director of the division, and we look forward to her continued focus on excellence in clinical care, research, and education in maternal-fetal medicine and high-risk pregnancy. We saw transitions in two other key areas of our department. In the Division of Reproductive Endocrinology and Infertility, Dr. Ruben Alvero announced his plans to pursue an opportunity near his family on the West Coast. We are tremendously grateful to Dr. Alvero who had a transformational impact on the REI division, inspiring a dedicated team of nurses, embryologists, doctors, and administrative staff in their mission to help patients achieve their goals. We were delighted when Dr. Gary Frishman, who has worked at Women & Infants for 27 years, agreed to accept the position of interim division director. At that time, Dr. Frishman transitioned out of his role as director of the Residency Program, a position he held for 10 years. Under Dr. Frishman’s leadership, the program experienced transformational improvements and has been consistently ranked as a Top 10 Residency Program in the country. A search was conducted to identify a new leader to further build upon the growth of the Residency Program. In the 4

fall of 2018, Dr. Dayna Burrell was appointed Residency Program director. An academic specialist in general obstetrics and gynecology, Dr. Burrell spent eight years at Johns Hopkins University School of Medicine, including two years as associate director of their Residency Program. Since joining the Women & Infants/Brown faculty, Dr. Burrell has established herself as an outstanding teacher, mentor, leader, and advisor, and we know our trainees will benefit from her creativity, positive approach, humility, and collaborative leadership style.

“Undoubtedly, the generosity of others in supporting our work at Women & Infants Hospital is crucial and most appreciated.” Also transitioning this year is Dr. Kathleen Cote Bowling, who stepped down as team chief after 19 years. During this time, she participated in the training of hundreds of ob/gyn residents providing clinical support, guidance, and oversight of patient care and teaching. In addition to numerous leadership roles, Dr. Bowling previously served as the assistant chief for the Department of Obstetrics and Gynecology. We are grateful for Dr. Bowling’s leadership and are heartened that she will continue to train our residents and students while caring for patients in her practice and at our hospital. Perhaps there is nothing more exciting than when we see research put into practice, as is the case with the ARRIVE Study. Dr. Dwight Rouse serves as our principal investigator and Dr. Erika Werner serves as co-PI for the Women & Infants NICHD Maternal Fetal Medicine Units Network site.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

“I want to thank each and every one of our clinicians, researchers, educators, and staff for their unwavering commitment to women’s health. I am, as always, honored and humbled to lead this amazing group.” The study found that healthy, first-time mothers whose labor was induced in the 39th week of pregnancy were less likely to deliver by cesarean section compared with those who waited for labor to begin naturally. Indeed, this study is now sparking discussion about potentially changing clinical care recommendations at Women & Infants Hospital and at hospitals across our nation. Undoubtedly, the generosity of others in supporting our work at Women & Infants Hospital is crucial and most appreciated. On a nice summer day, more than 650 swimmers of all ages and skill levels participated in the ninth annual Swim Across America fundraising swim in beautiful Narragansett Bay, raising more than $227,000 to support research in Women & Infants Hospital’s Program in Women’s Oncology and the Department of Pathology and Laboratory Medicine. Recognizing the importance of advancing women’s health and gender-based research, Women & Infants’ former president Constance Howes established the Constance A. Howes Health Innovation Research Fund. Since 2014, the fund has awarded three grants each year to projects with the potential for advancing knowledge and care models related to women’s health, innovation, and creativity. This year, two of the grants were awarded to Department of Obstetrics and Gynecology faculty – Dr. Valery Danilack for her work studying experiences and preferences with labor induction, and Dr. Paul DiSilvestro for his work on miRNA biomarkers for early detection of ovarian cancer.

And on a crisp fall evening, more than 300 guests joined together for “One Enchanted Evening,” an event that raised more than $507,000 for Women & Infants’ Birth Center. Now in its planning stages, the new Birth Center will continue to drive the modern standard of clinical care for women and newborns. I want to thank each and every one of our clinicians, researchers, educators, and staff for their unwavering commitment to women’s health. I am, as always, honored and humbled to lead this amazing group.

Maureen G. Phipps, MD, MPH Chair and Chace-Joukowsky Professor of Obstetrics & Gynecology Assistant Dean for Teaching and Research in Women’s Health The Warren Alpert Medical School of Brown University Professor of Epidemiology Brown University School of Public Health Chief of Obstetrics & Gynecology Women & Infants Hospital of Rhode Island Care New England

2018 Annual Report

Message from Gary Frishman, MD

“Being president of AAGL has been one of the singular highlights of my professional career.” – Gary Frishman, MD, president of AAGL

Being president of AAGL has been one of the singular highlights of my professional career. AAGL (formerly the American Association of Gynecologic Laparoscopists) is the largest international gynecologic society in the United States and the largest society devoted to gynecologic surgery. With approximately 7,500 members from roughly 100 countries, our mission is to improve the gynecologic health care of women both in the United States and around the world. Towards this end, we employ a multi-faceted approach. Our Fellowship in Minimally Invasive Gynecology Surgery (MIGS) has more than 40 sites and graduates surgeons proficient in minimally invasive techniques. The MIGS fellowships have consistently been among the most competitive fellowship in obstetrics and gynecology with the greatest number of applicants to positions offered, reflecting its high demand. In fact, we just added our first international site in South America! The Journal of Minimally Invasive Gynecology is devoted to minimally invasive gynecologic surgery. I had the privilege of serving as deputy editor for the last five years, and we have seen our “impact factor” essentially double over that

time. Publication in the journal is highly desired, and our acceptance rate runs at 20 percent. The AAGL has strong connections throughout the world. Our board includes international members, and we partner with close to 50 sister societies across the globe for educational initiatives and joint meetings. This past year, I traveled to Colombia, France, and Australia to participate in conferences and exchange ideas. Most recently I was in Beijing where I co-chaired the Chinese Obstetric Gynecologic Association and AAGL 14th International Conference of Gynecologic Minimally Invasive Surgery. In addition, our annual Global Congress routinely draws gynecologists from around the world with a wide array of post-graduate courses, master classes, live telesurgery, and other educational opportunities. My presidency has been a tremendous privilege and an extraordinary amount of work. However, it has truly been a labor of love and a source of pride and satisfaction to participate in such an incredible organization with such a profound impact on the lives of the women for whom we are privileged to provide care.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Message from Charles Rardin, MD “I was honored to have the opportunity to conclude the State of the Society Presidential Address to the General Session audience in Chicago with the observation that I personally, and the society as a whole, are both stronger for having had the opportunity to do some reflecting over the course of this exciting and challenging year.” – Charles Rardin, MD

This October, in Chicago, IL, the American Urogynecologic Society (AUGS) held its 38th annual Scientific Meeting, during what is known as Pelvic Floor Disorders (PFD) Week. This week is the highlight of the year for AUGS, the premier society serving the needs of women with pelvic floor disorders and the health providers who care for them. With a membership more than 2,000 individuals in AUGS, this meeting marks the opportunity for members to hear the latest, highestquality research around care for women with PFDs, including several multicenter, randomized surgical trials for women with pelvic organ prolapse and urinary incontinence. As it always does, this meeting also provides the opportunity to network, to share ideas, and to reflect on the state of female pelvic medicine and reconstructive surgery (FPMRS), the newest of the formal subspecialties in both urology and gynecology.

Pelvic Surgery, and program director of the FPMRS Fellowship at The Warren Alpert Medical School of Brown University, I was thrilled to have been elected to the presidential line back in 2015. This year of my presidency included several new initiatives and opportunities, including new in-person courses such as the master class in surgical techniques, and a new course expressly designed for advance practice providers in FPMRS. I was honored to have the opportunity to conclude the State of the Society Presidential Address to the General Session audience in Chicago with the observation that I personally, and the society as a whole, are both stronger for having had the opportunity to do some reflecting over the course of this exciting and challenging year.

This meeting also represented the conclusion of my term as president of the Society. A member of Women & Infants Hospital’s Division of Urogynecology and Reconstructive 2018 Annual Report

Ambulatory Care

EXPERTISE The Obstetrics and Gynecology Care Center (OGCC) has delivered essential obstetrics and gynecologic services to a multicultural, ethnically diverse population for more than 35 years. The team, that includes physicians, nurse practitioners, social services, behavioral health, financial advocacy, nursing, medical assistants, clinical support, and administrative support, is focused on quality, while advocating for a diverse and unique patient population. In fiscal year 2018, the OGCC had more than 15,000 patient visits for services including general obstetric and gynecologic care, evaluation and treatment of cervical dysplasia and vulvar disorders, pediatric gynecology, urogynecology, reproductive endocrinology, pelvic pain, family planning and complex contraception, preoperative evaluation and planning, and a menopause program. The team continues to be a leader in the Baby Friendly USA® campaign with comprehensive efforts in breastfeeding education and support for our patients to ensure the best health for mothers and babies. The team also continues to work with the Rhode Island Department of Health in the design and implementation of screening tools for patients at risk for exposure to the Zika virus. Among many research projects at the OGCC, our researchers are actively participating in a multicenter randomized controlled trial of emergency contraception comparing 30 mg of ulipristal acetate, 1.5 mg of levonorgestrel, and 3 mg of levonorgestrel in women weighing more than 176 pounds sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development Contraceptive Clinical Trials Network. The OGCC team is committed to improving patient access and continuity of care. The team led the way in establishing same-day visits for patients with urgent problems. In academic year 2018, the OGCC clinic structure changed to allow residents in the same year of training to come to the OGCC on the same day, at the same time, each week. This has enhanced patient-provider relationships by providing consistency in care. Residents now are a part of a clinical team functioning as a group practice that will remain intact during their four-year residency. Patients identify their resident providers as being a part of one of these teams. 8

ACHIEVEMENTS • During FY2018 the staff at the OGCC saw 1,121 new obstetric patients, performed 405 colposcopic examinations, placed 104 subdermal contraceptive implants, inserted 302 intrauterine devices, and administered more than 1,800 immunizations. • Rebecca Allen, MD, MPH, was asked to serve on the American College of Obstetricians and Gynecologists’ Committee on Gynecologic Practice and joined the Editorial Board of Obstetrics and Gynecology. She also co-authored a chapter in the latest edition of Contraceptive Technology on Contraception for Women with Medical Conditions. She serves as the supervising provider for the PGY2 resident continuity clinics. • E. Christine Brousseau, MD, MPH, is completing her final year of the Women’s Reproductive Health Research Scholar Program of the NICHD. Her research interests center around improving reproductive health to underserved women by providing reproductive health services to women during periods of incarceration. She serves as the physician consultant for women’s health at the Adult Correctional Institute in Rhode Island. She supervises PGY1 residents during their continuity clinics. • Rebecca Crichton, MD, completed her ninth year as director of the Vulvar Clinic, overseeing a team that provides comprehensive evaluation and treatment of acute, chronic, and recurrent conditions of the vulva or vagina. • Renee Eger, MD, the medical director of the OGCC, was the 2018 recipient of the American College of Obstetricians and Gynecologists Council on Resident Education in Obstetrics and Gynecology National Faculty Award. She continues to lead the Menopause Program at the OGCC and is the supervising provider for PGY1 and PGY4 continuity clinics. • Bridget Kelly, MD, the associate director of the Residency Program, joined the OGCC staff as supervising provider for the PGY3 continuity clinics. • James O’Brien, MD, Women & Infants Hospital’s director of inpatient obstetrics, provides expertise in obstetrics management in the ambulatory setting.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

MEDICAL DIRECTOR: Renee Eger, MD

Front row: Patricia O’Connell, RNP; Rebecca Allen, MD, MPH; Renee Eger, MD; Erin Dobson, RNP. Back row: Maureen Phipps, MD, MPH; Jay O’Brien, MD; Rebecca Crichton, MD. Missing from photo: E. Christine Brousseau, MD, MPH; Ann Cooper, RNP; Bridget Kelly, MD; Drew Romanelli, MS, NP; Anne Stulik, RNP

FOCUS ON EDUCATION The OGCC is the primary teaching site for ambulatory obstetrics and gynecology for both the Brown University obstetrics and gynecology residency program and The Warren Alpert Medical School third year obstetrics and gynecology clerkship. The changes in the structure of the resident clinic have provided the opportunity to institute a new four-year, comprehensive educational curriculum for obstetrics and gynecology residents. Dedicated time for review of training year-specific topics precedes each day’s clinic. This complements the handson clinical teaching of obstetric, preventive women’s health, and complex gynecologic care, as well as subspecialty training. Medical students work oneon-one with dedicated nurse practitioners as well as obstetrics and gynecology residents, learning the basic skills of history and note-taking, as well as physical examinations. Residents and nurse practitioners play an instrumental role in administration of the OSCE exams for medical students. Nurse practitioner students from the University of Rhode Island and Boston College gain longitudinal experience at the OGCC, learning from nurse practitioners’ deep fund of knowledge.

2018 Annual Report

Emergency Obstetrics & Gynecology

EXPERTISE Women & Infants Hospital’s Emergency Department (ED) is one of the primary hospital-based clinical sites for the Department of Obstetrics and Gynecology’s academic specialists in general obstetrics and gynecology. The team provides highly specialized 24/7 emergency care to women of all ages. As a unique licensed specialty Emergency Department in Rhode Island, Women & Infants ED provides medical expertise to women of all ages presenting with acute obstetric, gynecologic, and women’s cancer-related issues. The dedicated ED clinical team is comprised of emergency care nurses, board certified and board eligible specialists in general obstetrics and gynecology, women’s health nurse practitioners, academic nurse midwives, certified nursing assistants, unit secretaries, and trainees from multiple specialties including obstetrics and gynecology, family medicine, pediatrics, and emergency medicine. The specialist in general obstetrics and gynecology team also works in other ambulatory and inpatient areas focused on medical education and providing high quality, patientcentered, trauma informed care. The spirit of collaboration guides the work with members of the community to provide exemplary health care to vulnerable patients across Rhode Island. Examples of collaborative effort include work with the Women & Infants Obstetrics and Gynecology Care Center, the Rhode Island Adult Correctional Institution, Saint Joseph’s Hospital Health Center, Thundermist Health Center, Women’s Care Inc., University Ob/Gyn, and Blackstone Valley Community Health Center. The team continues to explore opportunities to grow and foster collaboration with the entire community of specialists in general obstetrics and gynecology .

ACHIEVEMENTS • Benjamin Brown, MD; Libby Flores, MD; and Meena Theva, MD, joined the faculty this year. • Women & Infants Emergency Department has made plans to break ground on construction of the provider work space to enhance staff and provider communication. • Dayna Burrell, MD, was awarded a position in the APGO Scholars and Leaders Program and was named director of the Women & Infants/Brown University Residency Program. • Erin Cleary, MD, was first author on the publication “A Cry for Equity in the Operating Room: Standardizing Skin-to-Skin Practices” in The Journal of Perinatal and Neonatal Nursing. Dr. Cleary matched in the Maternal-Fetal Medicine Fellowship Program at The Ohio State University (fellowship starts 2019). • Heather Smith, MD, is a member of the American Medical Association (AMA) Council of Legislation, served as ACOG delegate to the AMA House of Delegates, and was featured nationally with her article “This National Doctor’s Day, conquer the physician shortage one mentor at a time.” • Roxanne Vrees, MD, was guest editor for the Rhode Island Medical Journal special feature in Obstetrics and Gynecology. Dr. Vrees received The Warren Alpert Medical School Mentorship Award in Diversity and Equity in Medicine (MADE), which recognizes faculty members for their extraordinary dedication to mentoring medical students and residents in the promotion of diversity, inclusion, and health equity. She was also named as top doc for emergency medicine in Rhode Island Monthly.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

MEDICAL DIRECTOR: Roxanne Vrees, MD Front row: Roxanne Vrees, MD; Asra Jawed, MD. Second row: Chelsey Caren, MD; Libertad Flores, MD; Kate Zaluski, MD; Erin Cleary, MD; Meena Theva, MD. Back row: E. Christine Brousseau, MD, MPH; Heather Smith, MD, MPH; Dayna Burrell, MD; Benjamin Brown, MD; Michael Sisitsky, MD; Bridget Kelly, MD. Missing from photo: Christian Pope, MD..

FROM TRIAGE TO EMERGENCY ROOM: BUILDING A NATIONAL MODEL FOR HIGHLY SPECIALIZED OBSTETRIC AND GYNECOLOGIC CARE IN THE EMERGENCY ROOM SETTING All health care providers have had patients, friends, family, colleagues, and perhaps even themselves encounter care in an Emergency Department (ED). While most EDs may look similar on the surface, not all Emergency Departments are created equal, and the Women & Infants model clearly exemplifies that EDs are not one size fits all. Women & Infants is home to a unique Emergency Department that started off as a traditional â&#x20AC;&#x153;OB Triageâ&#x20AC;? area and functioned largely as a repository for resident training and an extension of local offices. Over the past 10 years, it has evolved into a full-scale specialty Emergency Department that accordingly complies with the Consolidated Omnibus Reconciliation Act (COBRA); the Emergency Medical Treatment and Labor Act (EMTALA); the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) Regulations for Emergency Services/Ambulatory Care; the Anatomical Gift Act; State and Federal requirements; and mandated reporting requirements. The clinical scope includes but is not limited to benign gynecology, sexual assault, gynecologic and breast oncology, high-risk pregnancy, antenatal care, fetal evaluation, labor assessment, postpartum, and surgical complications.

The Women & Infants Emergency Department is a primary referral and treatment site for adult female victims of sexual assault and maintains the only comprehensive Sexual Assault Nurse Examiner (SANE) Program and post assault follow-up clinic in Rhode Island, setting the standard for both acute and long-term care to female adult survivors in Rhode Island. The department was designated by the state and federal government as a Special Pathogen Assessment Site for Rhode Island and maintains the capability to evaluate and care for obstetric patients with Ebola (special pathogen) for up to 96 hours following initial presentation. The team continues to participate in statewide special pathogens emergency preparedness exercises as well as departmental training that includes development of specific policies and patient care protocols related to patients suspected to have a seriously communicable disease. Patients presenting for care with conditions beyond scope are promptly transferred to an appropriate acute care facility per EMTALA guidelines. The team pulls from the best and the brightest to provide exceptional patient- and family-centered care while maintaining medical education programs to train, mentor, and support the future providers in the field of obstetrics and gynecology. 2018 Annual Report

Gynecologic Oncology

EXPERTISE The Program in Women’s Oncology is nationally recognized for excellence in clinical care, research, and education in the treatment of gynecologic and breast cancers. The program focuses on the needs of its patients, both now and in the future, and training the future leaders in cancer care. Research in the Program in Women’s Oncology continues to focus on delivering high impact clinical trials to patients and developing novel therapeutics. The Integrative Care program helps patients through the diagnosis, treatment, and follow-up of their cancers. Focusing on “What matters matter” and guided by “What would you want done for your loved ones?”, the providers in the Program in Women’s Oncology strive to create the treatment strategy that best fits each patient’s needs and gives them the best possible chance for a positive outcome.

ACHIEVEMENTS • Paul DiSilvestro, MD, was appointed co-chair of the NRG Oncology Gynecologic Cancer Committee. • Cornelius (Skip) Granai, MD, was awarded the Kaali Award for Humanism and Inspiration in Medicine at the 6th Annual Kaali Celebration in Budapest, Hungary, where he also served as keynote speaker.

• Liza Lokich, MD, a former graduate of the Women & Infants/Brown gynecologic oncology fellowship, returned to join the faculty this year and is focusing on quality improvement initiatives and education. • Cara Mathews, MD, was awarded an Advance-CTR grant for her study on “Anti-angiogenic therapy in the treatment of ovarian cancer and other GYN malignancies.” • Mathew Oliver, MD, a recent graduate of the gynecologic oncology fellowship, joined the faculty and will be pursuing a focus on translational science research as a Women’s Reproductive Health Research Scholar.. • Katina Robison, MD, was appointed to the Society of Gynecologic Oncology’s Clinical Practice Committee and elected to the board of the Scientific Network on Female Sexual Health and Cancer. • Ashley Stuckey, MD, received funding for Fisher Trust Grant to evaluate “A Care Delivery Model for Universal Genetic Testing Among Women with Ovarian Cancer.” • The Program in Women’s Oncology, in conjunction with the Department of Pathology and Laboratory Medicine at Women & Infants, was the recipient of the Swim Across America research grant for the ninth straight year. This year’s swim raised more than $227,000 in support of current oncology research at Women & Infants related to ovarian cancer biomarkers and early tissue markers that may identify women at risk for developing endometrial cancer.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

DIVISION DIRECTOR: Paul DiSilvestro, MD

Front row: Katina Robison, MD; Cara Mathews, MD; Ashley Stuckey, MD. Back row: Paul DiSilvestro, MD; Elizabeth Lokich, MD; Matthew Oliver, MD. Missing from Photo: C.O. ‘Skip’ Granai, MD.

TRANSLATIONAL RESEARCH Translational research includes the process of applying knowledge from basic biology and clinical trials to techniques and tools that address critical medical needs. In cancer care, translational research includes taking knowledge gained in the basic science lab and applying that knowledge to developing targeted treatments to help improve cancer outcomes. The Program in Women’s Oncology (PWO) is committed to this aspirational effort as part of its mission. Under the direction of Jennifer Ribeiro, PhD, and with the recent addition of Nicole James, PhD, the PWO lab is studying these basic processes at multiple levels. For example, the use of MicroRNA analysis will help us to better understand the mechanisms that may put patients at risk for the development of ovarian cancer. This effort is funded through a grant from the Constance A. Howes Women’s Health

Innovation Research Fund. In addition, the PWO lab has received funding through the Centers of Biomedical Research Excellence to study the molecular mechanisms and clinical correlates of He-4 mediated immune suppression in ovarian cancer. The goal of this research is to better understand how cancers may suppress a patient’s immune system and contribute to the development or progression of their disease. Matthew Oliver, MD, a recent graduate of the PWO fellowship in gynecologic oncology, will be dedicating a significant portion of his time through the Women’s Reproductive Health Research scholar program to translational science and has already begun to collaborate with researchers at Brown University. In addition, Cara Mathews, MD, was awarded a research grant from Advance CTR to evaluate the role that microRNAs play in mediating the side effect of hypertension from one of our commonly used treatments. The PWO will continue to expand these efforts through these talented researchers and collaboration within our institution, across the region, and on a national level.

2018 Annual Report

Gynecologic Oncology – Breast Health

EXPERTISE The Breast Health Center, part of the Program in Women’s Oncology, has developed a model program addressing total breast care, fully integrating clinical, educational, and support needs. A regional and national leader in clinical research and medical education, the Breast Health Center has been accredited by the National Accreditation Program for Breast Centers since 2010. During the past five years, the Center has participated in numerous cooperative groups, industry- and institutional-based trials. This year, the division’s Cancer Genetic and Prevention Program secured Progeny, a platform facilitating genetic counseling and test results analysis.

ACHIEVEMENTS • Hannah Bansil, MD, was part of a team that published “Comparing preoperative imaging modalities in patient selection for breast intraoperative radiotherapy” in the Journal of Surgical Oncology. • David Edmonson, MD, brought LOCalizer™ technology to Women & Infants Hospital, a new technology that eliminates guidewire placement the day of surgery. The approach has been well received by patients and streamlined the day of surgery. • Jennifer Gass, MD, was named to the Oncoplastic Committee of American Society of Breast Surgeons, and co-chair of the Oncoplastic Beginner Course. • Robert Legare, MD, leading the genetics team, continues to study hereditary predisposition to cancer, presenting data at this year’s San Antonio Breast Cancer Symposium highlighting the important consideration of multigene panel testing in women and their families who harbor a known germline mutation. • Sonali Pandya, MD, secured participation in the SHAVE2 Trial, a multicenter trial of cavity shave technique for breast cancer margin clearance and a Lifecycle grant to provide the funding. • William Sikov, MD, and Ashley Stuckey, MD, were named members of the Breast Cancer Committee and Breast Working Group within NRG Oncology.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

CO-DIRECTOR: Jennifer Gass, MD

CO-DIRECTOR: Robert Legare, MD

Front row: Jennifer Gass, MD; Ashley Stuckey, MD; David Edmonson, MD; Sonali Pandya, MD. Back row: Robert Legare, MD; William Sikov, MD; Hannah Bansil, MD; Bachir Sakr, MD.

BREAST HEALTH FELLOWSHIP The Women & Infants Breast Health Center of the Program in Womenâ&#x20AC;&#x2122;s Oncology continues to pioneer best treatment paradigms for breast cancer care in southern New England. New local and cooperative group research trials continue to be selected to help Women & Infants advance breast cancer care in the realms of cancer surgery, adjuvant systemic therapy, radiation therapy, and cancer survivorship. The comprehensive Cancer Genetics and Prevention Program continues to assist patients and families as they aim to better understand the implications of a cancer diagnosis for

both themselves and their families. This year, the Programâ&#x20AC;&#x2122;s Society of Surgical Oncology Breast Fellowship was expanded to include two postgraduate surgeons. The result of the most recent fellowship site visit granted the Program its third full five-year certification and set the stage for expanding the fellowship curriculum to include two positions. With 22 fellow graduates, Women & Infants Breast Health Fellowship Program boasts breast surgeons in both academic and community settings, from Karachi, Pakistan to Sydney, Australia, and Kansas City, MO.

2018 Annual Report

Maternal-Fetal Medicine

EXPERTISE The Division of Maternal-Fetal Medicine (MFM) is growing to meet the demands of an increasingly medically complex pregnant population in Rhode Island and southeastern Massachusetts. The MFM division includes nine faculty physicians, four (soon to be five) fellows, five genetic counselors, a dedicated nutritionist, two diabetes nurse experts, and an outstanding ultrasound and nursing staff. This team offers world-class, full scope, high-risk pregnancy management to the obstetric community and women of the region. MFM physicians serve as consultants and primary obstetric providers for women with a wide range of chronic medical problems, obstetric complications, and fetal conditions. The MFM team also provides the highest quality prenatal diagnosis and therapy and pregnancy monitoring services. The team is dedicated to taking care of highrisk women through all stages of pregnancy and delivery, including pre-conception. In addition to clinical work, the MFM physicians educate medical students, residents, and fellows, advocate for women’s health, and conduct practicechanging research. Division physicians speak, serve, and publish in numerous regional, national, and international events, committees, and journals.

ACHIEVEMENTS • This year, two new maternal-fetal medicine physicians joined the division. Malavika Prabhu, MD, finished fellowship at Massachusetts General Hospital in June and joined the division in August, and Jami Star, MD, returned to Women & Infants in October after nearly a decade away.

• Tanya Booker, MD, was appointed to the Rhode Island March of Dimes Board of Directors. • Stephen Carr, MD, was part of a multidisciplinary/multi institutional effort that completed the first-in-New England in utero spina bifida repair. This was completed at 24 weeks of pregnancy and the baby was delivered at 35 weeks of pregnancy. • Sarah Davis, MD, is a research scholar in the Brown/Women & Infants Hospital Women’s Reproductive Health Research (WRHR) Program and is investigating novel means to predict pregnancy complications early in gestation. • Matthew Esposito, MD, is helping to lead state and hospital efforts to optimize care for women with a history of opioid abuse. • Dwight Rouse, MD, was re-appointed to serve another five-year term as associate editor for obstetrics for the journal Obstetrics & Gynecology. • Melissa Russo, MD, was appointed to the Marfan Society Board of Directors and to the ACOG Genetics Guideline committee. Dr. Russo also received $100,000 from the Marfan Society to investigate the complications associated with aortopathies in pregnancy. • Erika Werner, MD, became an associate editor of the American Journal of Perinatology and was elected to the Society for Maternal-Fetal Medicine Board of Directors. Dr. Werner also continues to work with the Hassenfeld Child Health Innovations Institute to build a more than 5,000 mother child cohort focused on improving child health and received a $50,000 gift to assist with this work.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

DIVISION DIRECTOR: Erika Werner, MD

Front row: Melissa Russo, MD; Erika Werner, MD; Jami Star, MD; Tanya Booker, MD; Malavika Prabhu, MD. Back row: Matthew Esposito, MD; Dwight Rouse, MD; Stephen Carr, MD; Sarah Davis, MD.

PRENATAL DIAGNOSIS AND TREATMENT Perhaps nothing has changed more over the last generation in obstetrics than prenatal diagnosis and treatment. The Women & Infants Division of Maternal-Fetal Medicine has two dedicated Prenatal Diagnosis Centers â&#x20AC;&#x201C; one in Providence, RI, and another in North Dartmouth, MA. Between these two sites, the maternal-fetal medicine team performs nearly 50,000 ultrasound exams and fetal monitoring procedures annually. This year, each of these centers received needed upgrades. The Prenatal Diagnosis Centers now have the best obstetrical ultrasound technology available, allowing for optimal diagnosis of a wide variety of fetal disorders. An additional ultrasound room was added to the Providence site allowing the team to increase access while maintaining the highest quality care. In the majority of situations, the MFM team is able to reassure families that their pregnancy is progressing well. However, when fetal anomalies are diagnosed, the MFM staff provides

all needed counseling, testing, and pregnancy management guidance. In partnership with Hasbro Childrenâ&#x20AC;&#x2122;s Hospital, the MFM division also serves as the only New England center to offer laser ablation for Twin-Twin-Transfusion and in utero surgery for myelomenigocele repair.

2018 Annual Report

Midwifery Program ACHIEVEMENTS • The midwifery team was awarded the Rhode Island Interprofessional Innovation Grant for a proposal entitled “Integrating a Team-based Approach to Normal Physiologic Birth: Development of an Interprofessional Simulation and Objective Structured Clinical Exam (OSCE).”

EXPERTISE The Midwifery Program is an academic practice nationally known for innovation in interprofessional education, clinical excellence, and quality improvement. The midwives’ teambased approach facilitates patient-centered care while supporting resident and medical student learning in the emergency, labor, antepartum, and mother/baby units. In addition to patient care and clinical education, they provide ongoing interdisciplinary curriculum development and support in the form of mentoring, lectures, workshops, original game-based interactive learning, and simulation experiences. The group’s core values include collaboration, innovation, compassion, and scholarship. The midwifery faculty are well represented in key leadership positions on both a state and national level, including the American Midwifery Certification Board, The Journal of Midwifery and Women’s Health Editorial Board, The Journal of Perinatal and Neonatal Nursing Editorial Board, the American College of Nurse-Midwives Reducing Primary Cesareans learning collaborative, the American College of NurseMidwives Political Action Committee Board, the Rhode Island Affiliate of American College of Nurse-Midwives, and the Rhode Island Interprofessional Education Collaborative.

• Midwifery staff champions the hospital’s involvement in the national multi-hospital quality improvement initiative “Reducing Primary Cesarean Project.” • Elisabeth Howard, PhD, CNM, FACNM, presented nationally at the American College of Nurse-Midwives, Association of Professors of Obstetrics and Gynecology, CREOG, and the Reducing Primary Cesareans, and internationally at the Normal Labor and Birth Conference. • Linda Hunter, EdD, CNM, FACNM, presented at the annual American College of Nurse midwives conference and assumed leadership of the American Midwifery Certification Board. • Elizabeth Kettyle, CNM, MPH, MSN, kicked off the fourth annual New England Regional Readiness Bootcamp at University of Vermont, as well as the development and implementation of the first resident wellness curriculum. • Edie McConaughey, CNM, MSN, received the Welch Award for Excellence in Patient and Family Centered Care. • Janet Singer, MSN, CNM, was selected for and completed the Brown Advocates for Social Change and Equity Fellowship. • Linda Steinhardt, CNM, FNP, MSN, was selected to present at the Association of Professors of Obstetrics and Gynecology’s annual faculty development conference on teaching leadership, innovation, and creative problem solving.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

PROGRAM DIRECTOR: Elisabeth Howard, PhD, CNM, FACNM Front row: Elizabeth Kettyle, CNM, MSN, MPH; Linda Steinhardt, CNM, FNP-C, MS; Janet Singer, MSN, CNM. Back row: Edie McConaughey, MSN, CNM; Elisabeth Howard, PhD, CNM, FACNM; Linda Hunter, EdD, CNM, FACNM.

WORKFORCE WELL-BEING The National Academy of Medicine (NAM) is among 130 organizations that are prioritizing clinician well-being as essential for safe, highquality patient care. Personal wellness and resilience are linked to finding meaning in work and include a focus on maintaining a positive outlook, embracing a philosophy of balance and a sense of priorities. Recognizing that prevention of burnout and promotion of clinician well-being is a national priority, the Midwifery Program developed an evidence-based curricula and activities to support clinician resilience and personal well-being. The first program is a series of workshops developed for nurses, midwives, and physicians who work with laboring women. It was developed to complete the Reducing Primary Cesareans quality initiative bundle “Promoting comfort and care in labor.” The workshops review evidence-based use of nonpharmacological approaches to support labor progress and coping with labor pain. These techniques have the potential to enhance best outcomes for the mother and infant and positively influence the patient experience. In addition to learning low intervention techniques to promote maternal relaxation, confidence, and comfort, a portion of the workshop focuses on nurturing the caregiver. Relaxation, mindfulness, and self-care techniques are integrated throughout the day, and the entire workshop is experiential.

Team building and engagement are key and begin prior to the workshop with taking the “true colors” personality test and watching several videos on the physiology of pain, stress, and coping. Recognition of both explicit and implicit bias is incorporated into each workshop through the innovative improvisational comedy course entitled ”Connecting with comedy.” This allows participants to experience in-the-moment collaboration through safe and fun games, and allows participants more freedom to fail, which can create opportunities for communication, connection, and empathy. Each of the games in this session reveals to participants and audience members the importance of compassion, the role of bias in everyday actions, and the simple ways in which rapport can be built. In addition to the workshops, a wellness curriculum was established for the obstetrics and gynecology residents that include a focused monthly noon conference. The conferences focus on topics such as yoga poses and breathing for stress reduction; mindfulness and guided imagery; and maintaining work-life balance while in training. These techniques have been shown to enhance selfawareness, wellness, and resilience. Additionally, they cultivate strong relationships with colleagues and patients, advance the quality of care, and reduce error. 2018 Annual Report

Reproductive Endocrinology and Infertility

EXPERTISE The Division of Reproductive Endocrinology and Infertility at Women & Infants Hospital was the first IVF center in Rhode Island, and the Women & Infants Fertility Center (WIFC) remains the only full-service infertility center in Rhode Island. The Center takes great pride in providing comprehensive fertility care that takes advantage of the latest techniques and technology while keeping the patient as the center of the treatment model. As technology evolves, clinicians analyze how to utilize it in a cost-effective and caring manner, giving all patients the best chance for having a healthy pregnancy.

ACHIEVEMENTS This year highlighted the depth and breadth of the Division’s members including their national and international contributions. • Ruben Alvero, MD, was appointed president of the International Gynecologic Society (IGS) for a two-year term effective May 19, 2018. • Lynae Brayboy, MD, was an invited speaker at National Academy of Sciences in Washington, DC, “The Promise of Genome Editing Tools to Advance Environmental Health Research.” The talk was entitled “Designing Research to Inform Medical Practice.”

• Eden Cardozo, MD, attended American Society for Reproductive Medicine (ASRM) Advocacy Academy and RESOLVE Advocacy Day serving as a panel speaker for the topic of “Fertility Preservation for At Risk Patients.” • Gary Frishman, MD, served as president of the AAGL. With 7,500 members from 100 countries, the AAGL is the largest society devoted to advancing the health care for women via minimally invasive gynecology. • Victoria Snegovskikh, MD, participated in 2018 National Institute of Child Health and Human Development (NICHD) Clinician Scientist Investigators Meeting, including serving as the leader of a mock grant proposal discussion panel. • Shunping Wang, PhD, presented two lectures titled “IVF Laboratory: Accreditation and Evaluation” and “IVF Laboratory: Quality Management Program and Personnel Training” in 2018 Taiwanese Society of Reproductive Medicine (TSRM). • Carol Wheeler, MD, passed the Focused Practice Designation Exam in Pediatric and Adolescent Gynecology. This is new designation introduced by American Board of Obstetrics and Gynecology in 2018 and Dr. Wheeler is one of the very first providers in the country so recognized in the field of Pediatric and Adolescent Gynecology.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

INTERIM DIVISION DIRECTOR: Gary Frishman, MD Front row: Shunping Wang, PhD; Carol Wheeler, MD; Eden Cardozo, MD; Gary Frishman, MD. Back row: Victoria Snegovskikh, MD; Ruben Alvero, MD; Lynae Brayboy, MD.

PREIMPLANTATION GENETIC TESTING Preimplantation genetic testing (PGT) is exciting, cutting-edge technology that the Women & Infants Fertility Center offers to give patients the best possible chance for a healthy baby. As women age, the risk of producing chromosomally abnormal embryos increases significantly. PGT, previously known as preimplantation genetic screening (PGS) and preimplantation genetic diagnosis (PGD), is performed to assess the chromosomes of each individual embryo. The name change to PGT reflects the comprehensive nature of this testing that allows identification of both normal and abnormal embryos. Selecting healthy embryos should reduce the risk of miscarriage and abnormal pregnancies and, importantly, result in higher pregnancy rate per embryo transferred. It is not unusual to see a 60 percent or even higher chance of pregnancy if patients have normal embryos for transfer. This chance of pregnancy is up to two to three times as high as in an unselected embryo transfer. Because of this significantly higher success rate, we are able to transfer a single embryo with more confidence, avoiding the health risks associated with twin or triplet pregnancies, which may result from transferring multiple embryos. PGT may also be used to screen for specific inheritable disorders such as cystic fibrosis. A couple who has tested positive as carriers for a condition or has had a child

affected by a genetic disease can have their embryos tested prior to becoming pregnant, avoiding potentially tragic conditions. At Women & Infants Fertility Center, after an IVF stimulated cycle and egg retrieval, embryos develop and then undergo PGT testing. The lab team biopsies embryos for PGT five or six days after fertilization in the IVF lab using laser to carefully remove five to 10 cells from the hundreds of cells in the early embryo. The team then assesses the chromosomes and freezes the biopsied embryos until the results are ready. Patients are counseled about the results of the testing and a plan is made based on these results. Over the past several years, the number of patients taking advantage of this technology has increased significantly, with 39 cycles in 2016, 46 in 2017, and 71 cycles in the first nine months of 2018. Technology continues to improve, enabling the Fertility Center to utilize cutting-edge techniques such as PGT to give patients the very best chance for a successful and healthy pregnancy. 2018 Annual Report

Clinical Research in Women’s Health

EXPERTISE The goal of the Division of Research is to promote and support the research and scholarly activities of the Department of Obstetrics and Gynecology and the Women & Infants Hospital community. Driven by collaboration, education, training, and investigator support, the staff works to support faculty within the Department of Obstetrics and Gynecology with their research needs, including grant submission, data management, and statistical work. Through its multidisciplinary team, the Division of Research provides expertise in epidemiology, statistics, database development, grant submissions, grants management, public health, and research support. By fostering an environment that encourages innovation in women’s health, the division works toward the goal of generating the scientific evidence needed to advance health care for women and transforming this evidence into practical information that can be shared with health care providers and the community.

ACHIEVEMENTS • The Division of Research provided statistical support and/or database support for 77 research projects. • The team assisted with the submission of 29 faculty applications for federal, local, and foundation research grant funding during the year. • E. Christine Brousseau, MD, MPH, was awarded funding from the Rhode Island Foundation for her research study “Improving obstetric care to underserved Rhode Island women: Expanding the role of prison health.” She also served as the secretary for the Rhode Island Medical Society and was named District I treasurer for the American College of Obstetricians and Gynecologists. • Valery Danilack, PhD, was awarded a Constance A. Howes Innovation Research Fund grant for her project “A qualitative study of experiences and preferences with labor induction.” • Sarah M. Davis, MD, received funding from the Hassenfeld Child Health Innovation Institute Award for her research project “Maternal and fetal telomere length, timing of delivery, and racial/socioeconomic disparities.” • Kristen A. Matteson, MD, MPH, presented the Samuel A. Cosgrove Lecture at the Annual Meeting of the American College of Obstetricians and Gynecologists (ACOG) in Austin, TX, in April 2018. In 2018, Dr. Matteson also was named the director of the Division of Research in the Department of Obstetrics and Gynecology and served as the chair of the Committee on Gynecologic Practice at the ACOG.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

DIVISION DIRECTOR: Kristen Matteson, MD, MPH

Front row: Robin Cram, MPA, CCRP; E. Christine Brousseau, MD, MPH; Sarah Davis, MD. Back Row: Valery Danilack, PhD, MPH; Kristen Matteson, MD, MPH; Susan Elmore; Mindy Marshall, MS, CCRP; Phinnara Has, MS.

By fostering an environment that encourages innovation in womenâ&#x20AC;&#x2122;s health, the division works toward the goal of generating the scientific evidence needed to advance health care for women and transforming this evidence into practical information that can be shared with health care providers and the community.

2018 Annual Report

Clinical Research in Women’s Health

RESEARCH EXCELLENCE IN THE DEPARTMENT OF OBSTETRICS AND GYNECOLOGY The Department of Obstetrics and Gynecology strives to be the recognized leader in innovative, high-quality, clinical and translational research that leads to true medical advances for women’s health. In 2017, the Department of Obstetrics and Gynecology had $5,548,860 in federal and non-federal grant expenditures and is one of only three such departments in the United States with a Women’s Reproductive Health Research (WRHR) program, Maternal Fetal Medicine Research Unit (MFMU), Pelvic Floor Disorders Network (PFDN), and Contraceptive Clinical Trials Network (CCTN). These programs, along with Women & Infants’ NRG Oncology program of the National Cancer Institute, are highlighted here. Pelvic Floor Disorders Network (PFDN) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the Office of Research on Women’s Health (ORWH) Vivian W. Sung, MD, MPH, principal investigator, and Deborah L. Myers, MD, alternate principal investigator The PFDN at Women & Infants Hospital, located in the Division of Urogynecology and Reconstructive Pelvic Surgery, has been federally funded since July 2011 and is one of only seven sites nationally. The mission of this program is to provide evidence-based clinical answers for the prevention and treatment of female pelvic floor disorders (urinary incontinence, pelvic organ prolapse, fecal incontinence, and other sensory and emptying abnormalities of the lower urinary and gastrointestinal tracts) through a network of academic medical centers with the recruitment capabilities and research expertise needed to conduct rigorous clinical and translational protocols. The Women & Infants PFDN site has had strong investigative leadership, leading both primary and supplementary protocols, and has maintained strong recruitment and retention rates while offering women in the southern New England region access to innovative treatment options through this network. 24

Maternal Fetal Medicine Units (MFMU) Network Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Dwight Rouse, MD, MSPH, principal investigator, and Erika Werner, MD, MS, alternate principal investigator The Women & Infants MFMU Program, housed within the Division of MaternalFetal Medicine, is one of 12 programs nationally and has been federally funded since 2001. The mission of the MFMU network is to conduct large, multi-site, practice-changing, randomized clinical trials in pregnancy. The results of the MFMU ARRIVE trial, the largest randomized trial of labor induction ever conducted, were published in the New England Journal of Medicine. [Grobman WA et al. Labor Induction versus Expectant Management in Low-Risk Nulliparous Women. New England Journal of Medicine. 2018: 379(6):513-523]. For two of the most recent clinical trials completed by the MFMU Network (including the ARRIVE trial), the Women & Infants site contributed more participants than any other participating hospital.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Contraceptive Clinical Trials Network (CCTN) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Rebecca H. Allen, MD, MPH, principal investigator, and Ruben Alvero, MD, co-principal investigator The CCTN of Women & Infants Hospital, located in the Obstetrics and Gynecology Care Center and in the Division of Reproductive Endocrinology and Infertility, has been federally funded since 2013 and is one of 19 programs nationally. The CCTN was established in 1996 to support research on male and female contraception and to conduct clinical trials of new contraceptive drugs and devices. Women & Infants Hospital has been approved to start enrolling for its first clinical trial in this network, “A multi-center, randomized study of the efficacy of emergency contraceptive methods in obese women.” NRG Oncology of the National Cancer Institute (formerly the Gynecologic Oncology Group) Paul DiSilvestro, MD, principal investigator, and William Sikov, MD, co-principal investigator The Women & Infants Program in Women’s Oncology is one of 220 Main Member sites for the NRG Oncology Group and has been funded since 2004. The NRG Oncology Program aims to conduct multi-institutional research that changes practice for the medical care provided to individuals with gender-specific malignancies and on locally advanced

cancers of all types. Women & Infants has been the second leading enroller nationally in gynecologic cancer clinical trials of the Gynecologic Oncology Group/NRG Oncology for the past 10 years. In 2017, Dr. Paul DiSilvestro was promoted to the position of co-chair of the Gynecologic Cancer Committee at NRG Oncology. Women’s Reproductive Health Research Scholars Program (WRHR) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maureen G. Phipps, MD, MPH, principal investigator, and Kristen A. Matteson, MD, MPH, research director Since 2005, the NICHD has awarded Women & Infants and Brown University grant funding to support the highly competitive Eunice Kennedy Shriver Women’s Reproductive Health Research (WRHR) Program. One of only 15 programs nationally, the Brown/ Women & Infants WRHR Program provides education and mentorship to enable well-qualified obstetricians and gynecologists to develop into academic leaders capable of high-quality research that genuinely improves health outcomes important to women. Current WRHR Scholars include E. Christine Brousseau, MD, MPH (specialist in academic general obstetrics and gynecology) and Sarah M. Davis, MD (maternal-fetal medicine specialist). By investing in the development of clinician-researchers in obstetrics and gynecology, Women & Infants is leading the way in developing and retaining women’s health physician-scientists as nationally recognized academic leaders.

2018 Annual Report

Medical Education ACHIEVEMENTS EXPERTISE The Department of Obstetrics and Gynecology at Women & Infants Hospital is the primary teaching site for The Warren Alpert Medical School of Brown University Undergraduate Medical Education Program for Obstetrics and Gynecology, and home to the only obstetrics and gynecology residency training program in Rhode Island. Trainees in these programs benefit from the teaching of outstanding residents, fellows, nurse practitioners, midwives, and physicians. Department faculty lead and participate in a spectrum of teaching activities for the Undergraduate Medical Education Program, including such programs as the preclinical Human Reproduction course, Scholarly Concentration in Women’s Reproductive Health, the third year core and longitudinal clerkship curricula, subinternships and clinical electives, and resident readiness courses, in addition to mentoring, career advice, and residency application assistance. The Obstetrics and Gynecology Residency Program provides outstanding and unparalleled training for eight residents per year, the next generation of women’s health leaders and providers. The clinical volume, interaction with, and exposure to national leaders in all divisions, mentoring programs, progressive responsibility, and focus on teaching and scholarly work are key features of the education mission for the program. Gary Frishman, MD, served as director of the Residency Program for more than 10 years, and transformed the residency into an acclaimed program through his engaging leadership style and vision. The end of 2018 brought a transition in leadership as Dayna Burrell, MD, took on the responsibilities of program director. Dr. Burrell brings an outstanding track record of curriculum development, teaching and mentoring excellence as well as educational leadership. The educational programs in the department, including divisionbased fellowship programs, the Simulation Program, and the Undergraduate and Graduate Medical Education Programs, continue to be national leaders and examples of outstanding, innovative programs.

•

The residency program maintains its position as a highly respected program, ranked in the top 10 Obstetrics and Gynecology Residency Programs by U.S. News & World Report/Doximity every year since they have published these results.

• The residency program continues to attract the best and brightest students from around the country with more than 650 applications from U.S. medical students for eight residency spots. •

This year the residency program maintained their record of a 100 percent match rate for residents applying for subspecialty fellowships, including one in gynecologic oncology, two in maternal-fetal medicine, one in reproductive endocrinology and infertility, one in global women’s health, and one in minimally invasive gynecologic surgery. One of the program’s residents plans to pursue a specialist position in obstetrics and gynecology locally, and one has accepted a position working for the Indian Health Services.

•

The unique Undergraduate Medical Education Career Mentoring Committee is a national model for medical student mentoring. Students participating in this program continue to have successful match results at highly desired institutions.

• In collaboration with the Office of Diversity and Multicultural Affairs, the department offered two Diversity in Medicine Visiting Student Scholarships this year. This program is a competitive application opportunity for qualified students from groups underrepresented in medicine and interested in pursuing obstetrics and gynecology as a career, to participate in a sub-internship of their choice in the department. •

Dayna Burrell, MD, residency program director, is a current member of the Association of Professors of Obstetrics and Gynecology (APGO) Scholars and Leaders Program and a graduate of APGO’s Surgical Scholars Program.

•

Gary Frishman, MD, former residency program director, is a member of the Accreditation Council for Graduate Medical Education (ACGME) Residency Review Committee for Obstetrics and Gynecology. This 15 member national committee oversees accreditation of all ACGME accredited obstetrics and gynecology residency and fellowship programs in the country.

• B. Star Hampton, MD, vice chair for education, chairs the APGO Undergraduate Medical Education Committee, is a board member for APGO, and serves as faculty for the national Clerkship Director School. •

Roxanne Vrees, MD, clerkship director, is the diversity ambassador for the Department of Obstetrics and Gynecology and currently chairs the department’s Diversity Committee. She is also a board member for the Alpert Medical School’s Office of Diversity and Multicultural Affairs.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

VICE CHAIR FOR EDUCATION: B. Star Hampton, MD

Front row: Roxanne Vrees, MD; Bridget Kelly, MD. Back row: Gary Frishman, MD; Matthew Esposito, MD; Dayna Burrell, MD; B. Star Hampton, MD.

ALUMNI EVENT With a long tradition of academic excellence, the Department of Obstetrics and Gynecology has been the foundation for training outstanding physicians who have improved the lives of countless women and changed the way medicine is practiced. The people in this department, national leaders, expert community physicians, outstanding midwives and nurse practitioners, are what make it rich in history and accomplishment. The department recognized the people who share this history with a successful Alumni Celebration in 2015, and held its second Alumni Weekend Symposium this spring. The weekend saw nearly 100 participants, with alumni traveling from as far as Argentina, and the residency class of 1995 having the most graduates (Renee Eger, MD; Jose Nores, MD; Lisa Domagalski, MD; Michele Gange, MD; and Lynn Norton, MD) in attendance.

The celebration began with an evening networking reception at the Warren Alpert Medical School, allowing for resident alumni and current members of the department to connect, catch up, and enjoy each other’s company. Honoring past leaders, structured learning time on Saturday entitled “Making an Impact on Women’s Health: Cancer Prevention, Managing Opioids, and Bringing Art to Medicine” started with the inaugural Donald Coustan, MD Alumni Lecture by alumnus Kathleen Schmeler, MD. A series of lectures by Brown faculty followed, addressing issues related to the opioid epidemic. The symposium concluded with a unique series of heartfelt presentations by current trainees, guided by Skip Granai, MD, which connected all to the place they all started from as physicians, and reminded all of the beautiful human connection that is the essence of practicing medicine. 2018 Annual Report

Urogynecology and Reconstructive Pelvic Surgery

EXPERTISE The Division of Urogynecology and Reconstructive Pelvic Surgery (URPS) is also known as the Center for Women’s Pelvic Medicine and Reconstructive Surgery. The faculty are subspecialty fellowship trained and board certified in Female Pelvic Medicine and Reconstructive Surgery with expertise in the diagnosis and treatment of pelvic floor disorders such as urinary incontinence and fecal incontinence, pelvic organ prolapse, defecatory dysfunction, interstitial cystitis, and fistulas. The Center offers both non-surgical and surgical treatment options.

ACHIEVEMENTS • Cassandra L. Carberry, MD, published “American Urogynecologic Society Best-Practice Statement: Recurrent urinary tract infection in adult women” in Female Pelvic Medicine and Reconstructive Surgery. • Nicole B. Korbly, MD, presented a roundtable discussion on “Genitourinary Syndrome of Menopause” at the American College of Obstetrics and Gynecology Annual Meeting. • B. Star Hampton, MD, served as chair of the Outreach Council for the American Urogynecologic Society. • Deborah L. Myers, MD, was the invited speaker for the 5th annual William B. Goddard lecture at the University of Colorado.

• Charles R. Rardin, MD, completed his term as president of the American Urogynecologic Society, which included national and international invitations to other subspecialty organizations. • Vivian W. Sung, MD, was the invited keynote speaker and faculty for the UroGynaecological Society of Australasia in South Australia. • Kyle J. Wohlrab, MD, served as member of the American Urogynecologic Society Fellowship Training Committee and its planning committee for the annual scientific meeting Fellows Day Workshop.

LEADERS IN PELVIC FLOOR DISORDERS Leaders in clinical care: The Division of Urogynecology and Reconstructive Pelvic Surgery is one of the largest academic practices in the nation dedicated to women’s pelvic floor disorders. All physicians are faculty members of The Warren Alpert Medical School of Brown University and subspecialty board certified in Female Pelvic Medicine and Reconstructive Surgery (FPMRS). For more than 30 years, the division has been committed to setting the standards of care and delivering world-class care to the women of Rhode Island and the region. Leaders in teaching: The division faculty members are committed educators and have been recognized with national and local teaching awards. Teaching is accomplished for trainees through didactics, hands-on workshops, and virtual models, with a commitment to teaching all approaches of pelvic reconstructive surgery – vaginal, open, laparoscopic, and robotic. In addition to teaching obstetrics and gynecology residents, faculty also teach residents in other specialties.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

DIVISION DIRECTOR: Deborah Myers, MD

Front row: B. Star Hampton, MD; Deborah Myers, MD; Vivian Sung, MD, MPH. Back row: Kyle Wohlrab, MD; Cassandra Carberry, MD; Nicole Korbly, MD; Charles Rardin, MD.

The division trains the Brown Female Pelvic Medicine and Pelvic Reconstructive Surgery (FPMRS) Fellowship Program which since 1998 has graduated more than 20 fellows, nearly all of whom are currently engaged as FPMRS fellowship faculty at institutions across the country. Leaders in research: Division members continue to make yearly presentations at the scientific meetings of the American Urogynecologic Society and Society of Gynecologic Surgeons. The division is one of just seven medical centers from across the United States to be selected by The Eunice Kennedy Shriver National Institutes of Child Health and Human Development to participate in the national Pelvic Floor Disorders Network (PFDN). The PFDN works collaboratively to develop and perform research studies related to women with pelvic floor

disorders. Under principal investigator Vivian W. Sung, MD, MPH, and in collaboration with Brown University, the division will be launching the innovative feasibility study â&#x20AC;&#x153;BioLIFTâ&#x20AC;? where samples of vaginal tissue from patients undergoing benign gynecologic surgery will be used to grow pelvic ligaments in the laboratory. Leaders of colleagues: The faculty in the division are leaders nationally. All faculty member are active on committees in the American Urogynecologic Society and Society of Gynecologic Surgeons, and three faculty members are past presidents. Division faculty also hold leadership roles in the APGO, ACOG, AAGL, ABOG , FDA , NIH panels and on editorial boards for related specialty and subspecialty journals.

2018 Annual Report

Surgical Services

EXPERTISE The term “minimally invasive surgery” means something different now than it did 15 or 20 years ago; at that time, it primarily referred to laparoscopy, and the ability, in some cases, to avoid larger, open incisions. With technologic advances and enhanced surgical training, the likelihood that a woman would require a laparotomy to achieve her surgical needs continued to decrease. Today, at Women & Infants Hospital, only about one in 10 hysterectomies is performed via laparotomy.

ACHIEVEMENTS • Surgeons at Women & Infants will perform the 3,000th robotic surgery there early next year. • Twenty-five individual surgeons have been through the robust training, proctoring, and credentialing process. • Simulation modules and training in robotic, laparoscopic, and vaginal surgery enhance the balanced approach Women & Infants Hospital brings to women’s surgery.

In 2010, when Women & Infants obtained its first da Vinci robotic surgical platform, the organization made a careful and forward-thinking decision to consider robotic surgery to be one of the several modalities of minimally invasive surgery, rather than a surgical program unto itself. Vaginal surgery, sometimes known as “the original minimally invasive surgery” continues to be an excellent surgical approach for many women. At many centers around the country, the number of vaginal hysterectomies dwindled significantly to the point where many surgeons began to feel unsafe or less prepared to offer that approach. Even while building a robust robotic surgery team and structure, Women & Infants continued to support and enhance the vaginal surgery as well as laparoscopic surgical services and training programs. Today, Women & Infants is very proud of the balanced approach that is offered: about 40 percent of hysterectomies are performed laparoscopically, 20 percent are performed vaginally, 20 percent robotically, and only 10 percent via laparotomy. This balanced approach enhances the likelihood that any woman who requires surgical services will be offered the type of surgery that is most appropriate for her individual circumstances. The team continues to strive to deliver the right procedure, by the right surgeon, for the best outcomes. 30

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Charles Rardin, MD; Beata DiZoglio, MD; Gary Wharton, MD.

Today, Women & Infants is very proud of the balanced approach that is offered: about 40 percent of hysterectomies are performed laparoscopically, 20 percent are performed vaginally, 20 percent robotically, and only 10 percent via laparotomy.

2018 Annual Report

Simulation Program EXPERTISE The Simulation Program at Women & Infants Hospital enhances patient safety through deliberate training and education. Enrichment of medical students, residents, fellows, and staff physicians is strengthened through team training, skills training, interprofessional and empathy workshops. Residents in obstetrics and gynecology participate in skills workshops, and many also participate in simulation research, advancing the science of ob/gyn education. National presentations in simulation include: • Kate Cohen, MD, PGY4, presented “Pearing Down the Vaginal Hysterectomy” at the ACOG National Meeting in Austin, TX. • Melissa Bowler, simulation specialist, presented “Teaching Empathy Through Comedy” at the Society of Simulation in Healthcare National Meeting in Los Angeles, CA. • Jai-me Potter-Rutledge, simulation manager, presented “The Simulation Manikin and Its Effect on the Human Condition” at The 39th Annual Humanities and Technology Association Conference in Newport, RI. • Kelly Benabou, MD, PGY4, presented “Immersive Virtual Reality Gaming Improves Two-Handed Efficiency on a Laparoscopic Skills Simulator in Ob/Gyn Trainees” at the AAGL National Meeting in Las Vegas, NV. • Fei Cai, MD, PGY3, presented “Can I Get a Suggestion? Improv Training to Teach Empathy in Ob/Gyn Residents” at the APGO/CREOG National Meeting in New Orleans, LA.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

2018 Annual Report

Inpatient Obstetrics

EXPERTISE In fiscal year 2018, Inpatient Obstetrics continued to focus on clinical performance as well as looking toward the future with the planning and construction of the new Women & Infants Birthing Center. Our performance on key metrics is benchmarked against other member hospitals of the Council of Women’s and Infants’ Specialty Hospitals (CWISH) and include impressive performance on The Joint Commission Perinatal Core Measures. There is growing excitement surrounding the planning of Women & Infants Birthing Center with initial meetings underway including architects, hospital leadership, and nursing and medical staff. In the course of the year, Inpatient Obstetrics has continued to modify the labor induction process to improve both patient satisfaction and efficiency. Although the current rate of labor inductions has remained stable at 30.6%, the publication of the ARRIVE Trial earlier this year stands to significantly increase that number. The trial demonstrated improved maternal outcomes with elective induction at 39 weeks gestation. As a result, a multidisciplinary team has been assembled to review the study and plan to accommodate the potential increase in inductions. After extensive planning and education, Women & Infants now offers patients the use of nitrous oxide for labor analgesia. In addition to labor support, this additional resource can provide pain and anxiety relief during labor that has the

potential to decrease early use of epidural analgesia, promote mobility in labor, and enhance opportunities for low intervention labor and birth. As part of continued efforts to safely reduce primary and total cesarean delivery rates, Women & Infants Hospital has continued its participation in the Reducing Primary Cesareans Project. Other initiatives include distributing primary cesarean delivery rates to all obstetrical providers as part of the department’s Ongoing Professional Practice Evaluation. During the past year, Women & Infants obstetrical activity included approximately 8,700 deliveries.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

MEDICAL DIRECTOR: James O’Brien, MD Indicator Cesarean Rate

WIH

Subgroup (CWISH)

Best CWISH Rate

Database

31.8%

33.9%

26.5%

33.9%

18.2%

15.7%

18.1%

15.0%

25.5%

14.0%

1.3%

0.5%

1.1%

4.9%

1.5%

5.2%

0.0088

0.0000

N/A

27.4%

17.4%

N/A

45.3%

78.7%

N/A

(5th ) Primary CS Rate (total del)

17.8% (7th)

VBAC Rate

18.4% (5th )

PP Readmission Rate

1.1% (5th )

Episiotomy Rate

5.7% (7th)

Elective Delivery < 39’0 (PC-01) NTSV Rate (PC-02) Exclusive Breast Feeding (PC-05)

0.0000 (1st ) 24.5% (3rd) 35.5% (9th )

2018 Annual Report

Community-Based Faculty

Women & Infants Hospital of Rhode Island has been training specialists in obstetrics and gynecology since the first resident graduated in 1959. Until 1982, when Donald R. Coustan, MD, was recruited to develop the Division of Maternal-Fetal Medicine, the responsibility of training future obstetrician-gynecologist specialists and core rotation education for medical students was that of the communitybased faculty. The community-based faculty members, in conjunction with the hospital-based faculty, continue to have a central role in medical education at The Warren Alpert Medical School of Brown University. Currently there are approximately 100 actively practicing community-based faculty members. The low risk obstetrics and gynecology services are covered by four teams comprised of community and hospital-based physicians. These physicians, along with the midwifery team of educators, supervise and educate physicians in training as they care for their patients. This is a 24/7 system. Members of the team supervise all procedures, admissions, and daily rounds. On Fridays, a discussion of active cases, interesting topics, and obstetrics and gynecology related pathology occurs at Team Chiefâ&#x20AC;&#x2122;s conference. Since 1959, 304 residents have been trained in the Brown University/Women & Infants program, with eight residents in each of the four years. The residents have two mentors each year, one a community-based faculty member and the other

from the hospital-based faculty. They also have a midwife who mentors them throughout their four years. This enables residents to have numerous opportunities to develop close relationships with the faculty. On many occasions, both faculty members meet with the resident together. This has also served to forge closer relationships between faculty members. Community-based faculty members are involved with the medical students during their core rotations while they are on Labor and Delivery and in the operating room. Students are in a private office for a half day during their rotation. Additionally, 74 community-based faculty physicians have had longitudinal students and 10 have worked with students in the Longitudinal Integration Clerkship. At the end of the academic year, the Department of Obstetrics and Gynecology comes together to celebrate its contributions to the education of both residents and medical students. Teaching awards are presented to community and hospital-based faculty by residents and medical students who have chosen to specialize in obstetrics and gynecology. The program has come a long way since 1959 and work continues to refine the program to provide the very best education and mentorship to those who will be its legacy.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Front row: Alexandra Friedman, MD; Kathleen C. Bowling, MD; Gary Frishman, MD; Bridget Kelly, MD; Cynthia Hanna, MD. Back row: Renee Eger, MD; Lisa Domagalski, MD; Michele Gange, MD; Dilek Cermik, MD; David Carcieri, MD; Laina Crowthers, MD; Debra Goldman, MD; Jane Sharp, MD; Maureen Phipps, MD; Anne Murray, MD; Mohamad Hamdi, MD.

The community-based faculty members, in conjunction with the hospital-based faculty, continue to have a central role in medical education at The Warren Alpert Medical School of Brown University.

2018 Annual Report

Community-Based Specialists

Physicians are listed here with their academic title in the Department of Obstetrics & Gynecology at The Warren Alpert Medical School of Brown University. M. David Beitle, MD Clinical Assistant Professor Rosa Bermudez-Emmanuelli, MD Clinical Assistant Professor Kathleen Cote Bowling, MD Team Chief Clinical Associate Professor Lisa Boyle, MD President, Medical Staff Clinical Assistant Professor Debra Brendel, MD Clinical Assistant Professor

David A. Carcieri, MD Designated Institutional Official Associate Team Chief Clinical Assistant Professor Marshall Carpenter, MD Maternal-Fetal Medicine Colleen Cavanaugh, MD Clinical Assistant Professor Dilek Cermik, MD Associate Team Chief Clinical Assistant Professor

Constance Brennan, MD

Kue Choi, MD Anesthesiology Clinical Assistant Professor

Cheryl Brodsky, MD Clinical Assistant Professor

Mauro Colavita, MD Clinical Assistant Professor

Fred A. Brosco, MD Clinical Assistant Professor

Jeannine Connolly, MD Associate Team Chief Clinical Assistant Professor

Karen Browning, MD Clinical Instructor Elizabeth Burchard, MD Clinical Assistant Professor Terrence F. Cahill, MD Clinical Associate Professor 38

Michael Coppa, MD Clinical Instructor Beth Cronin, MD Assistant Professor, Clinician Educator

Laina Crowthers, MD Associate Team Chief Clinical Assistant Professor Suzanne Dambek, MD Clinical Instructor Anh-Tai Dang, MD Clinical Assistant Professor Mary Catherine DeRosa, MD Clinical Assistant Professor Paula DeYoung, MD Clinical Instructor John DiOrio, Jr., MD Clinical Assistant Professor Beata DiZoglio, MD Co-Director, Robotics Surgery Program Clinical Assistant Professor Joseph DiZoglio, MD Clinical Assistant Professor Lisa Domagalski, MD Team Chief Clinical Assistant Professor Lindsay Clark Donat, MD Clinical Assistant Professor

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Obstetrics & Gynecology

Stephen Falkenberry, MD Gynecologic Oncology Clinical Associate Professor (4/1995 – 10/2018) Harris M. Galkin, MD Clinical Assistant Professor Elizabeth Gamble, MD Anesthesiology Clinical Assistant Professor Michele Gange, MD Team Chief Clinical Assistant Professor Alfredo Gil, MD Debra Goldman, MD Associate Team Chief Clinical Assistant Professor

Annmarie Jurczak, MD Clinical Assistant Professor

Althea Lindsay, DO Clinical Instructor

Amr Kader, MD Clinical Instructor

Audoen D. Maddock, MD Clinical Assistant Professor

Kerri Keselowsky, MD (8/2016 – 7/2018)

Nayana Manjunath, MD Clinical Assistant Professor

Erika Klein, MD Clinical Assistant Professor

Carol Manning, MD

Tolga Kokturk, MD Clinical Assistant Professor Altug Koymen, MD Clinical Assistant Professor Alicja Kreczko, MD Clinical Instructor Erin Kunkel, MD

Robin Gray, DO Clinical Assistant Professor Cynthia M. Hanna, MD Associate Team Chief Clinical Assistant Professor Tawfik F. Hawwa, MD Clinical Associate Professor

Donna LaFontaine, MD Clinical Associate Professor

Beth Marcaccio, MD Clinical Assistant Professor Elizabeth Mayhall, MD Clinical Instructor Karen McGoldrick, MD Clinical Assistant Professor Megan McMahon, MD Clinical Assistant Professor Carroll Medeiros, MD Team Chief Clinical Assistant Professor

Christine LaRose, MD Nicole Larrea, MD (7/2017 – 7/2018) Clinical Instructor

Jennifer Hosmer, MD Clinical Assistant Professor

Sung-Hee Lee, MD Anesthesiology Clinical Assistant Professor

Marc A. Jaffe, MD Clinical Assistant Professor

Stacey P. Lievense, MD Clinical Assistant Professor

Anne Murray, MD Associate Team Chief Clinical Assistant Professor Laura S. Nevel, MD Clinical Assistant Professor J. Douglas Nisbet II, MD Chief, Kent Hospital Obstetrics & Gynecology Clinical Assistant Professor 2018 Annual Report

Community-Based Specialists

Courtney Noonan, MD Clinical Instructor

Jessica Salak, MD Clinical Assistant Professor

Emily White, MD Clinical Associate Professor

Nwamaka M. Onwugbenu, MD Clinical Assistant Professor

Robert Salk, DO Clinical Assistant Professor

Doreen Wiggins, MD Clinical Assistant Professor

Frank Pensa, MD Clinical Associate Professor

Mark F. Scott, MD Clinical Assistant Professor

Bethany Wortman, MD Clinical Assistant Professor

Adrienne J. Perry, MD Clinical Assistant Professor

Bahram Shah-Hosseini, MD Clinical Assistant Professor

Martha Pizzarello, MD Clinical Assistant Professor

Jane Sharp, MD Associate Team Chief Clinical Assistant Professor

Emeritus Appointments in Obstetrics & Gynecology Wayne Clairborne, MD Clinical Associate Professor (Emeritus)

Marylin Powers, DO Clinical Assistant Professor Donald Ramos, MD Clinical Assistant Professor Rebecca W. Randall, MD Clinical Assistant Professor

Meera SimĂľes, MD Clinical Assistant Professor Caroline M. Skudlarek, DO Clinical Assistant Professor Timothy Spurrell, MD Adjunct Clinical Assistant Professor

Rajendrasinh Rathod, MD Clinical Assistant Professor

Michele Style, MD

Tina Rizack, MD, MPH Clinical Assistant Professor Medicine and Obstetrics & Gynecology

Elizabeth Sullivan, MD Associate Team Chief Clinical Assistant Professor

Pablo Rodriguez, MD Clinical Associate Professor

Marguerite Vigliani, MD Clinical Professor

Caitlin Saint-Aubin, MD Clinical Assistant Professor

Gary G. Wharton, MD Medical Director, Surgical Services Clinical Associate Professor

Nabil Khoury, MD Clinical Associate Professor (Emeritus) Henry G. Magendantz, MD Clinical Associate Professor (Emeritus) Samir Moubayed, MD Clinical Associate Professor (Emeritus) John Murphy, MD Clinical Assistant Professor (Emeritus) Reza Shah-Hosseini, MD Clinical Associate Professor (Emeritus) Santina L. Siena, MD Clinical Assistant Professor (Emerita) Benjamin Vogel, MD Clinical Assistant Professor (Emeritus)

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Obstetrics & Gynecology

2018 Annual Report

Hospital-Based Faculty

FACULTY LISTING Chair Maureen G. Phipps, MD, MPH Chace-Joukowsky Professor Professor, Obstetrics & Gynecology and Epidemiology

Libertad Flores, MD Assistant Professor, Clinician Educator Dennis Goulet, MD, MPH (7/2017 – 7/2018) Assistant Professor, Clinician Educator

Obstetrics and Gynecology Care Center Renee Eger, MD Medical Director Team Chief Assistant Professor, Clinician Educator

Vice Chair Deborah Myers, MD Professor

Mohamad Hamdi, MD (11/2015 – 11/2018) Associate Team Chief Assistant Professor, Clinician Educator

Rebecca H. Allen, MD, MPH Associate Professor, Obstetrics & Gynecology and Medical Science

Vice Chair for Education B. Star Hampton, MD Professor, Obstetrics & Gynecology and Medical Science

Asra Jawed, MD

Rebecca Crichton, MD Clinical Assistant Professor

Bridget Kelly, MD Associate Director, Residency Program Assistant Professor, Clinician Educator

James O’Brien, MD Associate Professor, Clinician Educator

Christian Pope, MD

Nurse Practitioners

Emergency Obstetrics and Gynecology Roxanne Vrees, MD Medical Director Director, Medical Student Core Clerkship Assistant Professor

Michael Sisitsky, MD Assistant Professor, Clinician Educator

Ann Cooper, RNP Senior Teaching Associate

Heather Smith, MD, MPH Assistant Professor, Clinician Educator

Erin Dobson, RNP Senior Teaching Associate

E. Christine Brousseau, MD, MPH Assistant Professor

Amy Snyder, MD (10/2009-6/2018) Assistant Professor, Clinician Educator

Patricia O’Connell, RNP Senior Teaching Associate

Benjamin Brown, MD Assistant Professor, Clinician Educator

Meena Theva, MD Assistant Professor, Clinician Educator

Darcy Renaghan, MSN, WHNI-BC (3/2018) Senior Teaching Associate

Dayna Burrell, MD Director, Residency Program Assistant Professor, Clinician Educator

Kate Zaluski, MD Assistant Professor, Clinician Educator

Drew Romanelli, MS, NP

Academic Specialists in Obstetrics and Gynecology

Chelsy Caren, MD Assistant Professor, Clinician Educator Erin Cleary, MD Assistant Professor, Clinician Educator

Nurse Practitioners Tara Capuano, MSN, WHCNP-C, SANE-A Teaching Associate Heather Aliotta, MSN, CNP (1/2005 – 9/2018) Kristin Gianelis, MSN, ANP-BC, WHNP-BC (1/2016 – 1/2018) Melissa Pragana, WHNP-BC

Anne Stulik, RNP Senior Teaching Associate Gynecologic Oncology and Breast Health Paul DiSilvestro, MD Division Director Professor

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Obstetrics & Gynecology

Hannah Bansil, MD David Edmonson, MD Associate Director, Breast Health Fellowship Assistant Professor Clinician Educator, Surgery and Obstetrics & Gynecology Jennifer Gass, MD Co-Director, Breast Health Center Chief of Surgery Director, Breast Health Fellowship Program Associate Professor, Surgery and Obstetrics & Gynecology C. O. (Skip) Granai III, MD Professor Robert D. Legare, MD Co-Director, Breast Health Center Director, Cancer Genetics and Prevention Program Associate Professor, Clinician Educator, Obstetrics & Gynecology and Medicine Elizabeth Lokich, MD Assistant Professor, Clinician Educator Cara Mathews, MD Assistant Professor Matthew Oliver, MD Sonali Pandya, MD Clinical Instructor, Surgery and Obstetrics & Gynecology Jennifer Ribeiro, PhD Assistant Professor (Research) Katina Robison, MD Director, Research Program Associate Professor

Dario Roque, MD (8/2016 â&#x20AC;&#x201C; 2/2018) Assistant Professor Bachir Sakr, MD Director, Medical Oncology Medical Director, Infusion Unit Assistant Professor, Clinician Educator Jennifer Scalia Wilbur, MS Teaching Associate William Sikov, MD Associate Director of Research Associate Professor, Clinician Educator, Medicine and Obstetrics & Gynecology Ashley Stuckey, MD Director, Fellowship Program Associate Professor, Obstetrics & Gynecology and Medical Science Rebecca Vanasse, MD Naohiro Yano, MD, PhD Research Associate Nurse Practitioners Laura Doherty, FNP-BC, MSN Patricia Karwan, DNP, RNP Molly Merlino, MSN, RNP Heather Murphy, MSN, RNP Elizabeth S. Ricci, RNP, MS Wendy Young, NP-C, MSN Maternal-Fetal Medicine Erika Werner, MD, MS Division Director Director, Fellowship Program Associate Professor, Obstetrics & Gynecology and Epidemiology

Tanya L. Booker, MD Director, Maternal-Fetal Medicine Clinic Assistant Professor, Clinician Educator Stephen Carr, MD Director, Providence Prenatal Diagnosis Center Professor Sarah Davis, MD Assistant Professor Matthew Esposito, MD Associate Director, Medical Student Clerkship Director, North Dartmouth Prenatal Diagnosis Center Assistant Professor, Clinician Educator Malavika Prabhu, MD Assistant Professor, Clinician Educator Dwight Rouse, MD, MSPH Professor, Obstetrics & Gynecology and Epidemiology Melissa Russo, MD Director, Prenatal Genetics Assistant Professor Jami Star, MD Assistant Professor, Clinician Educator Katharine Wenstrom, MD (5/2009 â&#x20AC;&#x201C; 6/2018) Division Director Professor Nurse Faculty Julie Daley, RN Teaching Associate

2018 Annual Report

Hospital-Based Faculty

Midwifery Elisabeth Howard, PhD, CNM, FACNM Program Director Associate Professor, Clinician Educator Linda Hunter, EdD, CNM, FACNM Associate Professor, Clinician Educator Elizabeth Kettyle, CNM, MSN, MPH Teaching Associate Edie McConaughey, MSN, CNM Senior Teaching Associate Janet Singer, MSN, CNM Senior Teaching Associate Linda Steinhardt, MS, FNP-C, CNM Senior Teaching Associate Reproductive Endocrinology and Infertility Gary Frishman, MD Interim Division Director Director, Residency Program (2008 – 2018) Professor Ruben Alvero, MD (8/2015 – 10/2018) Division Director Director, Fellowship Program Professor Lynae Brayboy, MD Assistant Professor (Research), Obstetrics & Gynecology and Molecular Biology, Cell Biology and Biochemistry John Buster, MD (5/2007 – 7/2018) Professor Eden Cardozo, MD Assistant Professor, Clinician Educator

Victoria Snegovskikh, MD Assistant Professor, Clinician Educator

Nicole B. Korbly, MD Assistant Professor, Clinician Educator

Shunping Wang, PhD Associate Professor, Clinician Educator Carol Wheeler, MD Professor, Clinician Educator

Charles R. Rardin, MD Director, Fellowship Program Director, Minimally-Invasive and Robotic Surgical Services Professor

Clinical Research in Women’s Health Kristen A. Matteson, MD, MPH Division Director Director, Resident Research Associate Professor

Vivian W. Sung, MD, MPH Director, Research Program Chair, Women & Infants Hospital Institutional Review Board Professor

E. Christine Brousseau, MD, MPH Assistant Professor

Kyle J. Wohlrab, MD Co-Director, Simulation Center Associate Director, Fellowship Program Associate Professor, Clinician Educator Nurse Practitioners Leah K. Moynihan, RNC, MSN Teaching Associate

Susan Cu-Uvin, MD Professor Valery Danilack, PhD, MPH Assistant Professor (Research) Sarah Davis, MD Assistant Professor Christina Raker, ScD Research Associate Urogynecology and Reconstructive Pelvic Surgery Deborah L. Myers, MD Division Director Professor Cassandra L. Carberry, MD, MS Assistant Professor, Clinician Educator B. Star Hampton, MD Professor, Obstetrics & Gynecology and Medical Science

Stacy Ramsey, RNP Inpatient Obstetrics James J. O’Brien, MD Medical Director Associate Professor, Clinician Educator Surgical Services Gary Wharton, MD Medical Director Clinical Associate Professor Secondary Appointments in Obstetrics & Gynecology Kenneth Chen, MD Assistant Professor, Clinician Educator

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Obstetrics & Gynecology

Jennifer Clarke, MD, MPH Associate Professor

Timothy Shafman, MD Adjunct Assistant Professor

Erica Hardy, MD Assistant Professor, Clinician Educator

Emeritus Appointments in Obstetrics & Gynecology Diane Angelini, EdD, CNM Professor, Clinician Educator (Emerita)

Francois Luks, MD Professor Niharika Mehta, MD Associate Professor Geralyn Lambert-Messerlian, PhD Professor Raymond Powrie, MD Professor David Savitz, PhD Professor Caron Zlotnick, PhD Professor Adjunct Appointments in Obstetrics & Gynecology Ruben Alvero, MD Adjunct Professor Sandra Carson, MD Adjunct Professor Melissa Clark, PhD Adjunct Professor, Obstetrics & Gynecology and Epidemiology Richard Moore, MD Adjunct Professor Brenda Roy, MD Adjunct Assistant Professor

Andrew Blazar, MD Clinical Professor (Emeritus) John Buster, MD Professor (Emeritus) Donald Coustan, MD Professor (Emeritus) Patrick Sweeney, MD, PhD Professor (Emeritus)

CURRENT RESIDENTS PG-1 (2018 – 2022) Wade Barton, MD Leticia Dwomor, MD Christy Gandhi, MD Laurie Griffin, MD Tambudzai Kudze, MD Christian Parobek, MD Ellie Proussaloglou, MD Kara Stoever, MD PG-2 (2017 – 2021) Ida Bernstein, MD Jia Jennifer Ding, MD Jessica DiSilvestro, MD Amita Kulkarni, MD Jennifer Narvaez, MD Alana Pinsky, MD Justine Reilly, MD Eva Reina, MD

PG-3 (2016 – 2020) Ralph Burns, MD Fei Cai, MD Andrey Dolinko, MD Leanne Free, MD Deanna Glassman, MD Merima Ruhotina, MD Julia Shinnick, MD Chi-Fong Wang, MD PG-4 (2015 – 2019) Kelly Benabou, MD Kathleen Cohen, MD Michael Cohen, MD Jenny David, DO Luwam Ghidei, MD Sebastian Ramos, MD Bridget Spelke, MD Hope Yu, MD

RECENT RESIDENT GRADUATES (2014 – 2018) Libertad Flores, MD Mary Friedman, MD Meghana Limaye, MD Caitlin MacGregor, MD Reeva Makhijani, MD Katherine Miller, MD Desmond Sutton, MD Meena Theva, MD

2018 Annual Report

Hospital-Based Faculty

CURRENT FELLOWS Program in Women’s Oncology (Gynecologic Oncology and Breast Health) Lindsey Beffa, MD (2016 – 2019) Ashley Borgstadt, DO (2018 –2021) Jesse Casaubon, DO (Breast Health) (2018 – 2019) Jenna Emerson, MD (2017 – 2020) Reed Keuhn, MD (Breast Health) (2018 – 2019) Katherine Miller, MD (2018 – 2021) Maternal – Fetal Medicine Nina Ayala, MD (2018 – 2021) Michael Beninati, MD (2016 – 2019) Martha Kole, MD (2017 – 2020) Christopher Nau, MD (2017 – 2020)

RECENT FELLOWSHIP GRADUATES Maureen Hamel, MD (2015 – 2018) Fellow in Maternal Fetal Medicine Abby Geletzke, MD (2017 – 2018) Fellow in Breast Oncology Matthew Oliver, MD (2015 – 2018) Fellow in Gynecologic Oncology Evelyn Cantillo, MD (2014 – 2018) Fellow in Gynecologic and Breast Oncology Kristin Jacobs, MD (2015 – 2018) Fellow in Female Pelvic Medicine and Reconstructive Surgery

Reproductive Endocrinology and Infertility Warren J. Huber, MD, PhD (2016 – 2019) May-Tal Sauerbrun-Cutler, MD (2017 – 2020) Female Pelvic Medicine and Reconstructive Surgery Anne Cooper, MD (2016 – 2019) Evelyn Hall, MD (2018 – 2021) G. Sarah Napoe, MD (2016 – 2019) Lauren Stewart, MD (2017 – 2020)

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Obstetrics & Gynecology

2018 Annual Report

Grant Funding â&#x20AC;&#x201D; 2018

Our grant funding agencies and foundations have included:

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Allen, RH: NICHD. Contraceptive Clinical Trials Network (HHSN275201300015I) 2013 – 2020. Role: Co-PI. Alvero, R: Role: Co-PI.

Cu-Uvin, S: NIH. “Results of Cryotherapy/LEEP among HIV-and HIV+ Women in Western Kenya.” (1U54 CA190151 (Loehrer)). 9/1/14 – 8/31/19. Role: Co-I.

Allen, RH: Bayer. “An open-label, non-randomized, prospective observational cohort study to assess post-procedural outcomes in two cohorts of women who chose to undergo either hysteroscopic sterilization (Essure®) or laparoscopic tubal sterilization.” 2017 – 2020. Role: Site PI. Matteson, K: Role: Co-I.

Cu-Uvin, S: NIH/NIAID. “Lifespan/Tufts/Brown Center for AIDS Research (CFAR).” (5P30AI042853 (Cu-Uvin)). 9/1/1998 – 03/31/2018. Role: HIV and Women’s Core Co-Director.

Booker, T: March of Dimes. “Provider and Patient Education on treatment with 17 Hydroxyprogesterone to Prevent Preterm Birth in Rhode Island.” 2018. Role: PI. Brayboy, L: NIH/NICHD Reproductive Scientist Development Program, “The Role of Multidrug Resistant Transporters in the Protection of the Ovary from Chemotherapy.” (K12HD000849 (Moley)) 7/1/2014 – 06/30/2019. Role: Physician Scientist. Brayboy, L: Reproductive Health COBRE. “Predicting Gestational Hypertensive Disease and Diabetes in Aged High-Risk Patients in the Preconception Period.” (P20 GM121298 (Sharma)). 4/1/2017 – 2/28/2022. Role: Junior Investigator. Brousseau, EC: Rhode Island Foundation. “Improving obstetric care to underserved Rhode Island Women: Expanding the role of prison health.” 07/01/2018 – 06/30/2019. Role: PI. Carr, S: NIH/NIDA. “Fetal Behavior, Brain & Stress Response: Ultrasound Markers of Maternal Smoking.” (R01 DA036999 (Stroud)). 09/01/2013 – 04/30/2019. Role: Co-I. CuUvin, S: NIH/NIAID. “HIV-1 Reservoirs in the Female Genital Tract.” (1R01AI108538-01A1 (Tsibris)). 5/1/14 – 4/30/19. Role: Co-I.

Danilack, V: Agency for Healthcare Research and Quality (AHRQ). “Comparative Effectiveness of Interventions for Labor Induction.” (K01HS025013 (Danilack)). 9/1/2016 – 8/31/2021. Role: PI. Phipps, MG: Role: Mentor. Savitz, D: Role: Mentor. Werner, E: Role: Collaborator. Danilack, V: Women & Infants Hospital Constance A. Howes Innovation Research Fund. “A qualitative study of experiences and preferences with labor induction.” 1/1/2018 – 12/31/2018. Role: PI. Davis, SM: Brown University and Women & Infants Hospital, William and May Oh – William and Elsa Zopfi Professorship in Pediatrics for Perinatal Research. Oh-Zopfi Pilot Project Grant Program. “Mechanisms underlying obstetric pathobiology: The study of cell-free fetal DNA, TLR9 mediated inflammation and parturition using human in vitro modeling.” 6/1/2017 – 5/30/2018. Role: PI. Davis, SM: Brown University Hassenfeld Child Health Innovation Institute. “Maternal and fetal telomere length, timing of delivery, and racial/socioeconomic disparities.” 2/5/2018 – 1/31/2019. Role: PI. Davis, SM: Center of Biomedical Research Excellence (COBRE) for Reproductive Health Pilot Project, Women & Infants Hospital, Brown University. “The study of cell-free DNA, inflammation, and trophoblast apoptosis.” 10/1/2017 – 3/31/2018. Role: PI.

2018 Annual Report

Grant Funding

DiSilvestro, P: NIH. “NRG Oncology of the NCI (formerly GOG), Women and Infants Hospital.” (CA-12-010). 3/2014 – present. Role: PI. DiSilvestro, P: GOG of NCI. “A Phase III Clinical Trial of Bevacizumab with IV versus IP Chemotherapy in Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma.” 2003 – present. Role: Group Wide Study Co-Chair GOG 252. DiSilvestro, P: Janssen Pharmaceuticals. “A randomized, openlabel study comparing the combination of YONDELIS and DOXIL/ CAELYS with DOXIL/CAELYX Monotherapy for the treatment of advanced-relapsed epithelial ovarian, primary peritoneal, or fallopian tube cancer.” 01/28/2014 – present. Role: PI.

Luks, FI: NIDDK. “Non-Operative Management of Pediatric Appendicitis: A Randomized Controlled Study.” (U34 1U34DK112584-01 (Luks/Chun)). 9/1/2017 – 8/31/2018. Role: Co-PI. Mathews, C: AstraZeneca. “A Phase III randomized, double blind, placebo controlled, multicenter study of Olaparib maintenance monotherapy in patients with BRCA mutated advanced (FIGO Stage III–IV) ovarian cancer following first line platinum based chemotherapy.” 01/14/2014 – present. Role: Site PI. DiSilvestro, P: Role: International Project PI.

DiSilvestro, P: Tesaro. “A randomized, open-label study of maintenance with Nariparib versus placebo in patients with platinum sensitive ovarian cancer.” 02/14/2014 – present. Role: PI.

Mathews, C: Brown University/Advanced CTR Core. “Antiangiogenic therapy in the treatment of ovarian cancer and other gyn malignancies agent-specific toxicity response and resistance.” 08/24/2018 – 04/30/2019 Role: PI.

DiSilvestro, P: Women & Infants Hospital Constance A. Howes Innovation Research Fund. “miRNA biomarkers for early detection of ovarian cancer.” 1/1/2018 – 12/31/2018. Role: PI.

Matteson, K: NIH/NICHD. “Levonorgestrel intrauterine system versus oral contraceptives for heavy menses.” (R01HD074751 (Matteson)). 02/15/2013 – 01/31/2018. Role: PI.

Lambert-Messerlian, GM: NIH. “Placental role in mediating adverse outcomes in obstructive sleep apnea.” (R01HD078515 (Bourjeily)). 09/10/2014 – 08/31/2019. Role: Co-Investigator/ Consortium PI.

Matteson, K: Brown Office of the Vice President of Research. “‘Right-sizing’ opioid prescription post-cesarean delivery and hysterectomy: Balancing excess medication and patient pain control.” (Risica/Matteson). 1/1/2018 – 12/31/2018. Role: Co-PI.

Lambert-Messerlian, GM: NIH “De novo predictors of OSA.” (R01 HL130702 (Bourjeily)). 08/01/2016 – 06/30/2018. Role: Co-I/Consortium PI.

Matteson, K: NIH/Food and Drug Administration. “Impact of Flavors and Design Features on Patterns of Waterpipe Use and Toxicity in Pregnant Mothers. (R01-DA042484 (Stroud). 04/01/2017 – 06/30/2019. Role: Co-I. Werner, E: Role: Co-I.

Lambert-Messerlian, GM: Perkin Elmer. “Validation of low cost aneuploidy screening.” (Palomaki). 12/01/2016 – 11/30/2018. Role: Co-I.

Lambert-Messerlian, GM: Fujirebio Diagnostics. C-peptide Precision. 2018. Role: PI.

Matteson, K: NIH. “The developing brain: Influences and outcomes.” (UG3OD023313 (Deoni)). 09/21/2016 – 08/31/2018. Role: Co-I.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Maternal-Fetal Medicine Units Research Team

Matteson, K: NIH/NIDA. “Prenatal marijuana: Impact on infant neurobehavior, stress, & epigenetic mechanisms.” (R01-DA044504 (Stroud)). 09/01/2017 – 07/31/2022. Role: Co-I. Werner, E: Role: Co-I. Phipps, MG: NIH/NICHD. “Brown University/Women & Infants Women’s Reproductive Health Research Program.” (K12 HD050108 (Phipps)). 9/27/05 – 6/30/20. Role: PI (01/11 to present) and Research Director (01/06 – 12/13). Matteson, KA: Role: Research Director (12/13 to present). Brousseau, EC: Role: Scholar (1/15/14 – 12/31/18). Davis, SM: Role: Scholar (2/2017 – present). Phipps, MG: NIH NIMH. “Project REACH: Preventing Postpartum Depression in Adolescent Mothers.” (R01 MH093342 (Phipps)). 8/2/11 – 10/31/18. Role: PI. Zlotnick, C: Role: Co-I. Phipps, MG: NIH NINR. “RCT of a tailored walking program to reduce stress among pregnant women.” (R01NR014540 (Battle / Salisbury)). 9/17/14 – 7/31/19. Role: Co-I.

Phipps, MG: NIH/NICHD. “Efficacy of a Prenatal YOGA Intervention for Antenatal Depression.” (R01 HD081868 (Battle)). 9/1/2015 – 6/30/2020. Role: Co-I. Phipps, MG: NIGMS. “COBRE for Reproductive Health.” (P20 GM121298 (Sharma)). 4/1/17 – 2/28/22. Role: Deputy Director. Rardin, C: Foundation for Female Health Awareness. “vaULT: Vaginal Uphold Hysteropexy and Laparoscopic Sacral Hysteropexy for the Treatment of Uterovaginal Pelvic Organ Prolapse: A Parallel Cohort Study.” 10/01/2010 – present. Role: PI. Rardin, C: Pelvalon, Inc. “LIBERATE: A Clinical Evaluation of the Eclipse™ System, a Vaginal Bowel Control (VBC) Therapy for Fecal Incontinence in Women.” 08/31/2015 – present. Role: RI Site PI. Rardin, C: Solace Therapeutics. “SUCCESS Trial: Stress Urinary inContinence Control/Efficacy and Safety Study. Randomized Controlled trial of the VesAir balloon system.” 01/22/2015 – 08/31/2018. Role: RI Site PI.

2018 Annual Report

Grant Funding

Ribeiro, J: Lifespan Center for Cancer Research Development/ COBRE Pilot Project. “Molecular Mechanisms and Clinical Correlates for HE4 Mediated Immune Suppression in Epithelial Ovarian Cancer.” 05/01/2018 – 04/30/2019. Role: PI. Robison, K: Patient Centered Outcomes Research Institute (PCORI) “Cancer of the Uterus and Treatment of Incontinence (CUTI).” (PCORI: FC14-1409-22034 (Robison)) 07/01/2015 – 05/31/2020. Role: PI. Wohlrab, K: Role: Co-PI. Sung, VW: Role: Co-I Robison, K: NIH/NCI. GOG Protocol 237, Comparative analysis of CA-IX, P16, proliferative markers, and human papilloma virus in the diagnosis of significant cervical lesions in patients with a cytologic diagnosis of atypical glandular cells (AGC). 2/2009 – 6/2018. Role: Site PI. Robison, K: Genentech, Inc./GOG Foundation, Inc. “GOG 3015/YO39523 A Phase III, Multicenter, Randomized, Study of Atezolizumab Versus Placebo Administered in Combination with Paclitaxel, Carboplatin, and Bevacizumab to Patients with NewlyDiagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer”. 04/07/2017 – present. Role: Site PI. Robison, K: National Cancer Institute. “GOG 278 Evaluation of Physical Function and QoL Before and After Non-Radical Surgical Therapy for Stage IA1 (LVSI+) and IA2-IB1 Cervical Cancer (NCT# 01649089). 6/1/2018 – present. Role: Site-PI. Robison, K: Nanology. “Nanopac Phase II Study of Four Concentrations of Intraperitoneal NanoPac® plus Six Cycles of IV Carboplatin and Paclitaxel in Patients with Platinum-Sensitive Recurrent Stage III Epithelial Ovarian Cancer Undergoing Second Cytoreductive Surgery.” 05/11/2017 – present. Role: Site-PI.

Robison, K. LaRue S. and Walter F. Fisher Memorial Trust. Evaluating a care delivery model for universal genetic testing among women with ovarian cancer. 9/15/18 – 9/15/19. Role: PI. Rouse, DJ: NIH/NICHD. “Cooperative Multicenter Network of Maternal Fetal Medicine Units.” (UG1HD040500 (Rouse)). 4/1/2011 – 3/31/2021. Role: PI. Werner, E: Role: Alternate PI. Rouse, DJ: NIH/NICHD. “Pulmonary Complications in a Birth Cohort after a Randomized Trial of Exposure to Antenatal Corticosteroids: The ALPS Follow-Up Study.” (R01 HL09835404 (Rouse)). 09/06/2016 – 07/31/18. Rouse, DJ: National Institute of General Medical Sciences. “COBRE for Reproductive Health.” (P20GM121298 (Sharma)). 4/1/17 – 2/28/22. Role: Clinical Translational Core Director Savitz, DA: NIH NICHD. “Effect of iatrogenic delivery at 34-38 weeks’ gestation on pregnancy outcome.” ( R01 HD077592 (Savitz)) 05/15/2014 – 4/30/19. Role: PI. Danilack, VA: Role: Investigator Rouse, DJ: Role: Investigator. Savitz, DA: Westat, Inc/NIEHS. “Children’s Health Exposure Analysis Resource (CHEAR): Coordinating Center (1U24ES026539-01 (O’Brien)). 9/30/15 – 8/31/19. Role: Co-I. Savitz, DA: NIH. “Environmental Influences on Neurodevelopmental Outcome in Infants Born Very Preterm.” (UG3OD023347 (Lester)). 9/21/16 – 08/31/18. Role: Co-I. Savitz, DA: NIH/NIEHS. “Human 3D Microtissues for Toxicity Testing via Integrated Imaging, Molecular and Functional Analysis.” (U01 ES028184-01 (Boekelheide)). 07/01/17 – 07/31/22. Role: Co-I.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Savitz, DA: Advance Clinical Translation Research and National Institute of General Medical Sciences. “Prenatal Opioid Exposure and Neonatal Health Impairment.” 5/1/2018 – 3/1/2019. Role: PI. Werner, E: Role: Site PI. Stuckey, A: RI Foundation/ Water Works for Women Fund. BioSpecimen Bank. (20165051). Role: Co-PI. Sung, VW: NIH NICHD. “The Pelvic Floor Disorders Network (PFDN) Brown/Women & Infants Site.” UG1 HD069013 08/16/2011 – 6/30/2021. Role: Site PI. Myers, DM: Role: Alternate PI. Rardin, C: Role: Co-I. Sung, VW: NIH/NIA. “Investigation to Minimize Prolapse Recurrence of the Vagina using Estrogen (IMPROVE).” (R01AG047290 (Rhan)). 8/15/2015 – 4/30/2020. Role: Site PI. Werner, E: ADA. “Assessing and avoiding barriers to post-partum glucose testing among women with gestational diabetes mellitus.” (I-16-ICTS-118 (Werner)). 1/2016 – 12/2018. Role: PI. Werner, E: Alpert Medical School of Brown University. “Hassenfeld Child Health Innovation Institute.” 07/01/2017 – 06/30/2019. Role: Birth Cohort PI; Obesity Co-I and Faculty Scholar. Werner, E: AHRQ. “Comparative Effectiveness of Interventions for Labor Induction.” (K01-HS025013). 09/01/2016-08/31/2018. Role: Collaborator.

Wohlrab, KJ: Society of Gynecologic Surgeons. “The Impact of a Robotic Simulation Curriculum on Resident Hysterectomy Training.” 01/01/2018 – 12/31/2019. Role: PI. Zlotnick, C: NIDA. “Computer-based Intervention for Battered Sheltered Women with Substance Use.” (R34 DA 038770). 04/15/15 – 02/28/18. Role: PI. Zlotnick, C: NICHD. “Dating Violence Prevention for Juvenile Justice Girls.” (R01 HD080780 (Rizzo)). 04/01/15 – 03/31/20. Role: Co-I. Zlotnick, C: Department of Defense. “Addressing the Health Concerns of VA Women with Sexual Trauma.” (W81XWH-14-1-0368 (Zlotnick)). 09/30/2014 – 09/29/2018. Role: PI. Zlotnick, C: CDC. “Preventing Sexual Aggression among High School Boys.” (U01CE002531 (Orchowski)). 09/30/2014 – 09/29/2018. Role: Co-I. Zlotnick, C: NIMH. Web-based Interactive Program to Prevent Postpartum Depression in High Risk Women. (R43 MH112216 (Fox/ Zlotnick)). 03/24/2017 – 09/23/2019. Role: Joint PI. Zlotnick, C: NIMH. Implementing to sustain: Determining the minimum necessary intervention to maintain a postpartum depression prevention program (ROSE) in clinics providing prenatal services to low-income women. (R01 MH114883 (Zlotnick/Johnson)) $2,498, 252. 01/01/2018 – 12/31/2018. Role: Joint PI.

Werner, E: NIH/NIDA. “Impact of Flavors and Design Features on Patterns of Waterpipe Use and Toxicity in Pregnant Mothers. (R01 DA042484 (Stroud/Salisbury)). 4/1/2017 – 6/30/2019. Role: Co-I. Werner, E: NIH/NIDA. “Electronic Cigarettes During Pregnancy: Impact on Fetal Development” (Stroud/Salisbury). 8/2018 – 5/2023. Role: Co-I. 2018 Annual Report

Peer-Reviewed Publications

Adam GP, Di M, Cu-Uvin S, Halladay C, Smith BT, Iyer S, Trikalinos TA. Strategies for improving the lives of US women aged 40 and above living with HIV/AIDS: An evidence map. Syst Rev. 2018 Feb 2;7(1):25. PMID: 29391059.

Allen RH, Singh RH. Society of Family Planning clinical Guidelines: Pain control for first trimester surgical abortion (Part 1). Contraception. 2018 Jan 30. [Epub ahead of print]. PMID: 29407363.

Adashi EY, Clodfelter RP, George P. Direct Primary Care: One Step Forward, Two Steps Back. JAMA. 2018 Aug 21; 320(7):637-638. PMID: 30003236.

Amundsen CL, Komesu YM, Chermansky C, Gregory WT, Myers DL, Honeycutt EF, Vasavada SP, Nguyen JN, Wilson TS, Harvie HS, Wallace D; Pelvic Floor Disorders Network. Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial. Eur Urol. 2018 Jul;74(1):66-73. Epub 2018 Feb 24. PMID: 29482936.

Adashi EY, Cohen IG. Preventing Mitochondrial Disease: A Path Forward. Obstet Gynecol. 2018 Mar;131(3):553-556. PMID: 29420413. Adashi EY, Cohen IG. Preventing Mitochondrial Disease: EmbryoSparing Donor-Independent Options. Trends Mol Med. 2018 May; 24(5):449-456. PMID: 29605176. Adashi EY, Gutman R. Delayed Childbearing: A Growing Heretofore Unrecognized Contributor to the National Plural Birth Excess. Obstet Gynecol. 2018 Oct;132(4):999-1006. PMID: 30204699. Adashi EY, Walters, L, Menikoff JA (2018). The Belmont Report at 40: Reckoning with Time. Am J Public Health 108(10)1345-1348. PMID: 30138058. Adashi EY, William D. Schlaff. Against All Odds: The First State Infertility Mandate (Maryland). Fertil Steril. 2018 Oct;110(5):824-825. PMID: 303164418. Adashi EY. Prognosis Is Guarded for California’s “Patient’s Right to Know Act.” JAMA. 2018 Jul 24; 320(4):329-330. PMID: 30043049. Adashi EY, Schlaff WD. Against all odds: the first state infertility mandate (Maryland). Fertil Steril. 2018 Oct;110(5):824-825. PMID: 30316418. Aghajanian C, Filiaci V, Dizon DS, Carlson JW, Powell MA, Secord AA, Tewari KS, Bender DP, O’Malley DM, Stuckey A, Gao J, Dao F, Soslow RA, Lankes HA, Moore K, Levine DA. A phase II study of frontline paclitaxel/carboplatin/bevaciumab, paclitaxel/carboplatin/ temsirolimus, or ixabepilone/carboplatin/bevacizumab in advanced/ recurrent endometrial cancer. Gynecol Oncol. 2018 Aug;150(2):274281. [Epub 2018 May 24]. PMID: 29804638. 54

Arya LA, Richter HE, Jelovsek E, Gantz M, Cichowski S, Zyczynski H, Dyer K, Siddiqui N, Carberry C, Broeckling C, Morrow C, Kashyap P, Meikle S. Metabolites and microbial composition of stool of women with fecal incontinence: study design and methods. Neurourol Urodyn. 2018 Feb;37(2): 634-641. PMID: 28763566. Babcock Gilbert S, Reading JI, Post MD, Alvero R, Al-Safi ZA. Cornual uterine diverticulum following a failed pregnancy. Gynecol Endocrinol. 2018 May 7:1-2. [Epub ahead of print] PMID: 29733747. Barrett ES, Vitek W, Mbowe O, Thurston SW, Legro RS, Alvero R, Baker V, Bates GW, Casson P, Coutifaris C, Eisenberg E, Hansen K, Krawetz S, Robinson R, Rosen M, Usadi R, Zhang H, Santoro N, Diamond M. Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Hum Reprod. 2018 Sep 1;33(9):1757-1766. PMID: 30085177. Berman L, Costanzo C, Smola SH, Taggi-Pinto A, Luks FI. Understanding the parent perspective on prenatal consultation for fetuses with congenital anomalies. Fetal Diagn Ther. 2018;44(2):9197. [Epub 2017 Sep 6]. PMID: 28873370. Berman L, Jackson J, Miller K, Kowalski R, Kolm P, Luks FI. Expert surgical consensus for prenatal counseling using the Delphi method. J Pediatr Surg. 2018 Aug;53(8):1592-1599. 2017 Nov 28. [Epub 2017 Nov 28]. PMID: 29274787. Bortoletto P, Prabhu M, Garry EM, Huybrechts KF, Anchan RM, Bateman BT. Opioid dispensing patterns after oocyte retrieval. Fertil. Steril. 2018 Oct;110(5):905-909. PMID: 30316436.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

2013–2014

Brayboy LM, McCoy K, Thamotharan S, Zhu E, Gil G, Houck C. The use of technology in the sexual health education especially among minority adolescent girls in the United States. Curr Opin Obstet Gynecol. 2018 Oct;30(5):305-309. PMID: 30153129. Brayboy LM, Clark H, Knapik LO, Schnirman RE, Wessel GM. Nitrogen mustard exposure perturbs oocyte mitochondrial physiology and alters reproductive outcomes. Reprod Toxicol. 2018 Oct 8. [Epub ahead of print] PMID: 30308227.

Chauhan SP, Weiner SJ, Saade GR, Belfort MA, Reddy UM, Thorp JM Jr, Tita ATN, Miller RS, Dinsmoor MJ, McKenna DS, Stetzer B, Rouse DJ, Gibbs RS, El-Sayed YY, Sorokin Y, Caritis SN; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Intrapartum Fetal Heart Rate Tracing Among Small-forGestational Age Compared With Appropriate-for-Gestational-Age Neonates. Obstet Gynecol. 2018 Oct; 132(4):1019-1025. PMID: 30204687.

Brayboy LM, Knapik LO, Long S, Westrick M. Wessel GM. Ovarian hormones modulate multidrug resistance transporters in the ovary. Contracept Reprod Med. 2018 Nov 15;3:26. eCollection 2018. PMID: 30460040.

Choe SA, Kauderer S, Eliot MN, Glazer KB, Kingsley SL, Carlson L, Awad YA, Schwartz JD, Savitz DA, Wellenius GA. Air Pollution, Land Use, and Complications of Pregnancy. Sci Total Environ. 2018 Dec 15;645:1057-1064. PMID: 30248831.

Bregar AJ, Cronin B, Luis C, DiSilvestro P, Schechter S, Pisharodi L, Raker C, Clark M, Robison K. Anal and Cervical High-Risk Human Papillomavirus Genotyping in Women With and Without Genital Neoplasia. J Low Genit Tract Dis. 2018 Feb 24. [Epub ahead of print]. PMID: 29481422.

Christianson MS, Legro RS, Jin S, Eisenberg E, Diamond MP, Hansen KR, Vitek W, Styer AK, Casson P, Coutifaris C, Christman GM, Alvero R, Puscheck EE, Christy AY, Sun F, Zhang H, Polotsky AJ, Santoro N. Comparison of sonohysterography to hysterosalpingogram for tubal patency assessment in a multicenter fertility treatment trial among women with polycystic ovary syndrome. J Assist Reprod Genet. 2018 Sep 7. [Epub ahead of print]. PMID: 30194618.

Brubaker L, Carberry C, Nardos R, Carter-Brooks C, Lowder JL. American Urogynecologic Society Best-Practice Statement: Recurrent Urinary Tract Infection in Adult Women. Female Pelvic Med Reconstr Surg. Sept/Oct 2018;24(5):321-335. PMID: 29369839. Cameron KE, Kole MB, Sammel MD, Ginsberg JP, Gosiengfiao Y, Mersereau JE, Su Hi, Gracia CR. Acute Menopausal Symptoms in Young Cancer Survivors Immediately following Chemotherapy. Oncology. 2018. [Epub ahead of print]. PMID: 29393227. Cardozo ER, Foster R, Karmon AE, Lee AE, Gatune LW, Rueda BR, Styer AK. MicroRNA 21a-5p overexpression impacts mediators of extracellular matrix formation in uterine leiomyoma. Reprod Biol Endocrinol. 2018 May 11;16(1):46. PMID: 29747655. Chatterjee A, Gass J, Burke MB, Kopkash K, El-Tamer MB, Holmes DR, Clark P, Reiland J. Results from the American Society of Breast Surgeons Oncoplastic Surgery Committee 2017 Survey: Current Practice and Future Directions. An Surg Onc. 2018 Oct;25(10):27902794. Epub 2018 Jul 12. PMID: 30003450.

Clark EAS, Weiner SJ, Rouse DJ, Mercer BM, Reddy UM, Iams JD, Wapner RJ, Sorokin Y, Malone FD, O’Sullivan MJ, Peaceman AM, Hankins GDV, Dudley DJ, Caritis SN; Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network. Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth. Am J Perinatol. 2018 Mar. [Epub ahead of print]. PMID: 29510423. Clarke JG, Martin RA, Gresko SA, Rich JD. The First Comprehensive Program for Opioid Use Disorder in a US Statewide Correctional System. Am J Public Health. 2018 Oct;108(10):13231325. PMID: 30207769. Cleary E, Cohen M, Howard ED. A Cry for Equity in the Operating Room: Standardizing Skin-to-Skin Practices. J Perinat Neonatal Nurs. 2018 Apr/Jun;32(2):97-101. No abstract available. PMID: 29689008.

2018 Annual Report

Peer-Reviewed Publications

Cohen IG, Adashi EY. Personhood and the Three Branches of Government. New Engl J Med. 2018 Jun 28; 378(26):2453-2455. PMID: 29949491.

Dickinson CM, Vidri RJ, Smith AD, Wills HE, Luks FI. Can time to healing in pediatric blunt splenic injury be predicted? Pediatr Surg Int. 2018 Sep 7. [Epub ahead of print]. PMID: 30194477.

Cohen SA, Carberry CL, Smilen SW. American Urogynecologic Society Consensus Statement: Cystoscopy at the Time of Prolapse Repair. Female Pelvic Med Reconstr Surg. 2018 Jul/Aug;24(4):258259. PMID: 29369837.

DiSilvestro P, Alvarez Secord A. Maintenance Treatment of Recurrent Ovarian Cancer: Is It Ready for Prime Time? Cancer Treat Rev. 2018 June 5;69:53-65. [Epub ahead of print]. PMID: 29908480.

Cohen IG, Fox D, Adashi EY. Losing Embryos, Finding Justice: Life, Liberty, and the Pursuit of Personhood. Ann Intern Med. 2018 Nov 20. [Epub ahead of print]. PMID: 30458508. Colón-Franco JM, Bossuyt PMM, Algeciras-Schimnich A, Bird C, Engstrom-Melnyk J, Fleisher M, Kattan M, Lambert-Messerlian G. Current and Emerging Multianalyte Assays with Algorithmic Analyses-Are Laboratories Ready for Clinical Adoption? Clin Chem. 2018 Jun; 64(6):885-891. [Epub 2018 Jan 17]. PMID: 29343536. Coustan DR, Barbour L. Insulin vs Glyburide for Gestational Diabetes. JAMA. 2018 May 1;319(17):1769-1770. No abstract available. PMID: 29715338. Craig LB, Buery-Joyner SD, Bliss S, Everett EN, Forstein DA, Graziano SC, Hampton BS, Mckenzie ML, Morgan H, PageRamsey SM, Pradhan A, Hopkins L. Undergraduate Medical Education Committee, Association of Professors of Gynecology and Obstetrics, To the Point: Gender differences in the Obstetrics and Gynecology clerkship. Am J Obstet Gynecol. 2018 May 29. [Epub ahead of print]. PMID: 29852154. Dahlke JD, Sperling JD, Has P, Lovgren TR, Connealy BD, Rouse DJ. Peripartum Morbidity after Cesarean Delivery for Arrest of Dilation at 4 to 5 cm Compared with 6 to 10 cm. Am J Perinatol. 2018 Apr. [Epub ahead of print]. PMID: 29689578. Danilack VA, Brousseau EC, Phipps MG The Effect of Gestational Weight Gain on Persistent Increase in Body Mass Index in Adolescents: A Longitudinal Study. J Womens Health (Larchmt). 2018 Apr 2. [Epub ahead of print]. PMID: 29608127.

Evans-Hoeker EA, Eisenberg E, Diamond MP, Legro RS, Alvero R, Coutifaris C, Casson PR, Christman GM, Hansen KR, Zhang H, Santoro N, Steiner AZ; Reproductive Medicine Network. Major depression, antidepressant use, and male and female fertility. Fertil Steril. 2018 May;109(5):879-887. PMID: 29778387. Expert Panel on Breast Imaging: Lourenco AP, Moy L, Baron P, Didwania AD, diFlorio RM, Heller SL, Holbrook, AI, Lewin AA, Mehta TS, Neill BL, Slantz PJ, Stuckey AR, Tuscano DS, Vincoff NS, Weinstein SP, Newell MS. ACR Appropriateness Criteria® Breast Implant Evaluation. J Am Coll Radiol . 2018 May;15(5S):S13-S25. PMID: 29724416. Expert Panel on Breast Imaging:, diFlorio-Alexander RM, Slanetz PJ, Moy L, Baron P, Didwania AD, Heller SL, Holbrook AI, Lewin AA, Lourenco AP, Mehta TS, Niell BL, Stuckey AR, Tuscano DS, Vincoff NS, Weinstein SP, Newell MS. ACR Appropriateness Criteria® Breast Imaging of Pregnant and Lactating Women. J Am Coll Radiol. 2018 Nov;15(11S):S263-S275. PMID: 30392595. Expert Panel on Breast Imaging:, Holbrook AI, Moy L, Akin EA, Baron P, Didwania AD, Heller SL, Le-Petross HT, Lewin AA, Lourenco AP, Mehta TS, Niell BL, Slanetz PJ, Stuckey AR, Tuscano DS, Vincoff NS, Weinstein SP, Newell MS. ACR Appropriateness Criteria® Breast Pain. J Am Coll Radiol. 2018 Nov;15(11S):S276-S282. PMID: 30392596. Expert Panel on Breast Imaging:, Niell BL, Lourenco AP, Moy L, Baron P, Didwania AD, diFlorio-Alexander RM, Heller SL, Holbrook AI, Le-Petross HT, Lewin AA, Mehta TS, Slanetz PJ, Stuckey AR, Tuscano DS, Ulaner GA, Vincoff NS, Weinstein SP, Newell MS. ACR Appropriateness Criteria® Evaluation of Symptomatic Male Breast. J Am Coll Radiol. 2018 Nov; 15(11S):S313-S320. PMID: 30392600.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Fiascone S, Danilack VA, Kao MJ, Cohen M, Singh K, Kalife E, Luis C, Lokich E, DiSilvestro P, Robison K. While Women Await Surgery for Type I Endometrial Cancer, Depot Medroxyprogesterone Acetate Reduces Tumor Glandular Cellularity. Am J Obstet Gynecol. 2018 Jul 28. [Epub ahead of print]. PMID: 30063901.

Gavarkovs AG, Risica PM, Parker DR, Jennings E, Mello J, Phipps MG. Self-Reported Environmental Tobacco Smoke Exposure and Avoidance Compared with Cotinine Confirmed Tobacco Smoke Exposure among Pregnant Women and Their Infants. Int J Environ Res Public Health. 2018 Apr 27;15(5). PMID: 29702552.

Francis PA, Pagani O, Fleming GF, Walley BA, Colleoni M, Láng I, Gómez HL, Tondini C, Ciruelos E, Burstein HJ, Bonnefoi HR, Bellet M, Martino S, Geyer CE Jr, Goetz MP, Stearns V, Pinotti G, Puglisi F, Spazzapan S, Climent MA, Pavesi L, Ruhstaller T, Davidson NE, Coleman R, Debled M, Buchholz S, Ingle JN, Winer EP, Maibach R, Rabaglio-Poretti M, Ruepp B, Di Leo A, Coates AS, Gelber RD, Goldhirsch A, Regan MM; SOFT and TEXT Investigators and the International Breast Cancer Study Group (Sikov WM). Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer. N Engl J Med. 2018 Jul 12;379(2):122-137. doi: 10.1056/ NEJMoa1803164. Epub 2018 Jun 4. PMID: 29863451.

Ghidei L, Ramos SZ, Brousseau EC, Clarke JG. Prison: Pipeline to Women’s Preventative Health. R I Med J. 2018 Oct 1;101(8):23-26. PMID: 30278597.

Free L, Cohen K, Allen RH. Perspective: Current Threats to Contraceptive Access. RI Med J (2013). 2018 Oct 1;101(8):27-29. PMID: 30278598. Friedman MA, Aguilar L, Heyward Q, Wheeler C, Caldamone A. Screening for Mullerian anomalies in patients with unilateral renal agenesis: Leveraging early detection to prevent complications. J Pediatr Urol. 2018 Feb 9. [Epub ahead of print]. PMID: 29459133. Friedmann PD, Wilson D, Hoskinson R Jr, Poshkus M, Clarke JG. Initiation of extended release naltrexone (XR-NTX) for opioid use disorder prior to release from prison. J Subst Abuse Treat. 2018 Feb;85:45-48. PMID: 28527855. Frishman GN. The Uterus From Inside to Out, Top to Bottom. J Minim Invasive Gynecol. 2018 Feb;25(2):198. PMID: 29284142. Frishman GN. Counselling women about lubricants and intercourse. BJOG. 2018 Nov; 125 (12):1549. Epub 2018 May 17. PMID: 29673045. Froehlich RJ, Maggio L, Has P, Vrees R, Hughes BL. Improving Obstetric Hypertensive Emergency Treatment in a Tertiary Care Women’s Emergency Department. Obstet Gynecol. 2018 Oct;132(4):850-858. PMID: 30130350.

Glazer KB, Eliot MN, Danilack VA, Carlson L, Phipps MG, Dadvand P, Savitz DA, Wellenius GA. Residential green space and birth outcomes in a coastal setting. Environ Res. 2018 Feb 9;163:97107. [Epub ahead of print]. PMID: 29433021. Graves JS, Henry RG, Cree BAC, Lambert-Messerlian G, Greenblatt RM, Waubant E, Cedars MI, Zhu A, Bacchetti P, Hauser SL, Oksenberg JR. Ovarian aging is associated with gray matter volume and disability in women with MS. Neurology. 2018 Jan 16;90(3):e254-e26. [Epub 2017 Dec 22]. PMID: 29273686. Graziano SC, McKenzie ML, Abbott JF, Buery-Joyner SD, Craig LB, Dalrymple JL, Forstein DA, Hampton BS, Page-Ramsey SM, Pradhan A, Wolf A, Hopkins L. Barriers and Strategies to Engaging Our Community-Based Preceptors. Teach Learn Med. 2018 Mar 26:1-7. [Epub ahead of print]. PMID: 29578818. Grobman WA, Rice MM, Reddy UM, Tita ATN, Silver RM, Mallett G, Hill K, Thom EA, El-Sayed YY, Perez-Delboy A, Rouse DJ, Saade GR, Boggess KA, Chauhan SP, Iams JD, Chien EK, Casey BM, Gibbs RS, Srinivas SK, Swamy GK, Simhan HN, Macones GA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network. Labor Induction versus Expectant Management in Low-Risk Nulliparous Women. New England Journal of Medicine. 2018 Aug, 9: 379(6):513523. PMID: 30089070. Guelfo JL, Marlow T, Klein DM, Savitz DA, Frickel S, Crimi M, Suuberg EM. Evaluation and Management Strategies for Per- and Polyfluoroalkyl Substances (PFASs) in Drinking Water Aquifers: Perspective from Impacted U.S. Northeast Communities. Environ Health Perspect. 2018 Jun 15; 126(6):065001. PMID: 29916808.

2018 Annual Report

Peer-Reviewed Publications

Haddad N, Allen RH, Szkwarko D, Forcier M, Paquette C. Eliminating parental consent for adolsecents receiving human papillomavirus vaccination. RI Med J (2013). 2018 Sep 4;101(7):1214. PMID: 30189697. Haddow JE, Lambert-Messerlian G, Eklund E, Neveux LM, Palomaki GE. Peripheral deiodinase activity: a potential explanation for the association between maternal weight and gestational hyperglycemia. Obstetric Medicine. 2018 June;11(2):73-78. [Epub 2017 Oct 12]. PMID: 29997689. Hall E, Robison K, Wohlrab K. Pelvic floor disorders in women with gynecologic malignancy. Curr Opin Obstet Gynecol. 2018 Dec;30(6):446-450. PMID: 30299322. Hansen KR, Eisenberg E, Baker V, Hill MJ, Chen S, Talken S, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Santoro N, Zhang H, Wild RA; NICHD Reproductive Medicine Network. Mid-luteal Progesterone: a Marker of Treatment Outcomes in Couples with Unexplained Infertility. J Clin Endocrinol Metab. 2018 May 14. [Epub ahead of print]. PMID: 29767754. Harrison MS, Thorsten VR, Dudley DJ, Parker CB, Koch MA, Hogue CJR, Stoll BJ, Silver RM, Varner MW, Pinar MH, Coustan DR, Saade GR, Bukowski RK, Conway DL, Willinger M, Reddy UM, Goldenberg RL. Stillbirth, Inflammatory Markers, and Obesity: Results from the Stillbirth Collaborative Research Network. Am J Perinatol. 2018 Sep;35(11):1071-1078. Epub 2018 Apr 2. PMID: 29609190. Harvie HS, Honeycutt AA, Neuwahl SJ, Barber MD, Richter HE, Visco AG, Sung VW, Shepherd JP, Rogers RG, Jakus-Waldman S, Mazloomdoost D; NICHD Pelvic Floor Disorders Network. Responsiveness and Minimally Important Difference of SF-6D and EQ-5D Utility Scores for the Treatment of Pelvic Organ Prolapse. Am J Obstet Gynecol. 2018 Nov 21. [Epub ahead of print]. PMID: 30471259. Hehir MP, Rouse DJ, Miller RS, Ananth CV, Wright JD, Siddiq Z, D’Alton ME, Friedman AM. Second-Stage Duration and Outcomes Among Women Who Labored After a Prior Cesarean Delivery. Obstet Gynecol. 2018 Feb 5. [Epub ahead of print] PMID: 29420394. 58

Hensley ML, Enserro D, Hatcher H, Ottevanger PB, Krarup-Hansen A, Blay JY, Fisher C, Moxley KM, Lele SB, Lea JS, Tewari KS, Thaker PH, Zivanovic O, O’Malley DM, Robison K, Miller DS. Adjuvant Gemcitabine Plus Docetaxel Followed by Doxorubicin Versus Observation for High-Grade Uterine Leiomyosarcoma: A Phase III NRG Oncology/Gynecologic Oncology Group Study. J Clin Oncol. 2018 Oct 5:JCO1800454. [Epub ahead of print]. PMID: 30289732. Hill EK, Stuckey A, Fiascone S, Brown A, Gordinier M, Raker C, Clark MA, Robison K. Gender and the Balance of Parenting and Professional Life among Gynecology Subspecialists. J Minim Invasive Gynecol. 2018 Oct 30. [Epub ahead of print]. PMID: 30389582. Hopkins L, Hampton BS, Abbott JF, Buery-Joyner SD, Craig LB, Dalrymple JL, Forstein DA, Graziano SC, Mckenzie ML, Pradham A, Wolf A, Page-Ramsey SM, “To the Point: Medical Education, Technology, and the Millennial Learner,” American Journal of Obstetrics and Gynecology, 2018; 218(2):188-192. PMID: 28599897. Howard ED. Transitions in Care: Risk, Recovery, and Best Practices. J. Perinat Neonatal Nurs. 2018 Jan/Mar;32(1):7-11. No abstract available. PMID: 29373412. Howard ED. Reassuring Well-being in the Workplace: A Safety Imperative. J Perinat Neonatal Nurs. 2018 July/Sep;32(3):201-203. PMID: 30036300. Howard ED. Promoting Maternal Confidence, Coping, and Comfort in Latent Labor: Evidence-Based Strategies and Resources. J Perinat Neonatal Nurs. 2018 Oct/Dec;32(4):291-294. No abstract available. PMID: 30358665. Huguelet PS, ChelvaKumar G, Conner L, Dumont T, Fleming N, Abraham M, Karjane NW, Sheeder J, Talib HJ, Teelin KK, Wheeler C, Kaul P. Improving resident knowledge in pediatric and adolescent gynecology: An evaluation of the North American Society for Pediatric and Adolescent Gynecology short curriculum. J Pediatr Adolesc Gynecol. 2018 Aug;31(4):356-361. Epub 2018 Mar 2. PMID: 29499376.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

2018 Obstetrics & Gynecology Residency Graduation

James NE, Cantillo E, Oliver MT, Rowswell-Turner RB, Ribeiro JR, Kim KK, Chichester CO 3rd, DiSilvestro PA, Moore RG, Singh RK, Yano N, Zhao TC. HE4 suppresses the expression of osteopontin in mononuclear cells and compromises their cytotoxicity against ovarian cancer cells. Clin Exp Immunol. 2018 May. [Epub ahead of print]. PMID: 29745428.

Komesu YM, Richter HE, Carper B, Dinwiddie DL, Lukacz ES, Siddiqui NY,Â Sung VW, Zyczynski HM, Ridgeway B, Rogers RG, Arya LA, Mazloomdoost D, Gantz MG; Pelvic Floor Disorders Network. The urinary microbiome in women with mixed urinary incontinence compared to similarly aged controls. Int Urogynecol J. 2018 Jun 16. [Epub ahead of print]. PMID:29909556.

Johnson JE, Wiltsey-Stirman S, Sikorskii A, Miller T, King A., Blume JL, Pham X, Moore Simas TA, Poleshuck E, Weinberg R, Zlotnick C. Protocol for the ROSE Sustainment (ROSES) Study, a sequential multiple assignment randomized trial to determine the minimum necessary intervention to maintain a postpartum depression prevention program in prenatal clinics serving low-income women. Implementation Science. 2018 Aug. 22; 13(1): 115. PMID: 30134941.

Kominiarek MA, Saade G, Mele L, Bailit J, Reddy UM, Wapner RJ, Varner MW, Thorp JM Jr, Caritis SN, Prasad M, Tita ATN, Sorokin Y, Rouse DJ, Blackwell SC, Tolosa JE; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Association Between Gestational Weight Gain and Perinatal Outcomes. Obstet Gynecol. 2018 Oct; 132(4): 875-881. PMID: 30204701.

Kent J, Dodson WC, Kunselman A, Pauli J, Stone A, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Rosen RM, Hansen KR, Robinson R, Baker V, Usadi R, Santoro N, Zhang H, Eisenberg E, Legro R; Reproductive Medicine Network. Gestational Weight Gain in Women with Polycystic Ovary Syndrome: A Controlled Study. J Clin Endocrinol Metab. 2018 Aug 1. [Epub ahead of print] PMID: 30085187.

Kominiarek MA, Smid MC, Mele L, Casey BM, Sorokin Y, Reddy UM, Wapner RJ, Thorp JM Jr, Saade GR, Tita ATN,Â Rouse DJ, Sibai B, Iams JD, Mercer BM, Tolosa J, Caritis SN; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units Network (MFMU). Child Neurodevelopmental Outcomes by Prepregnancy Body Mass Index and Gestational Weight Gain. Obstet Gynecol. 2018 Nov 5. [Epub ahead of print]. PMID: 30399108.

Kojic EM, Conley L, Bush T, Cu-Uvin S, Unger ER, Henry K, Hammer J, Escota G, Darragh TM, Palefsky JM, Brooks JT, Patel P. Prevalence and Incidence of Anal and Cervical High-Risk Human Papillomavirus (HPV) Types covered by Current HPV Vaccines among HIV-infected Women in the SUN Study. J Infect Dis. 2018 Apr 23;217(10):1544-1552. PMID: 29452366.

Kuo CC, Rosen RK, Zlotnick C, Wechsberg WM, Peabody M, Johnson JE. Sexual health prevention for incarcerated women: eroticising safe sex during re-entry to the community. BMJ Sexual & Reproductive Health. 2018 Jun 28. PMID: 29954877.

2018 Annual Report

Peer-Reviewed Publications

Landercasper J, Fayanju OM, Bailey L, Berry TS, Borgert AJ, Buras R, Chen SL, Degnim AC, Froman J, Gass J, Greenberg C, Mautner SK, Krontiras H, Ramirez LD, Sowden M, Wexelman B, Wilke L, Rao R. Benchmarking the American Society of Breast Surgeon Member Performance for More Than a Million Quality MeasurePatient Encounters”. Ann Surg Oncol. 2018 Feb 25(2):501-511. PMID: 29168099. Landon MB, Mele L, Varner MW, Casey BM, Reddy UM, Wapner RJ, Rouse DJ, Tita ATN, Thorp JM, Chien EK, Saade G, Grobman W, Blackwell SC, VanDorsten JP; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. The relationship of maternal glycemia to childhood obesity and metabolic dysfunction. J Matern Fetal Neonatal Med. 2018 Jul. [Epub ahead of print] PMID: 30021494. Lee MS, Cardozo ER, Karmon AE, Wright DL, Toth TL. Impact of transfer time on pregnancy outcomes in frozen-embryo transfer cycles. Fertil Steril. 2018 Mar 7. [Epub ahead of print.] PMID: 29525691.

Maher CF, Basssler KK, Barbara MD, Cheon C, Consten ECJ, Cooper KG, Deffieuz X, Dietz V, Butman RE, van Iersel JJ, Nager CW, Sung VW, de Tayrac R. Summary: 2017 International Consultation on Incontinence Evidence-Based Surgical Pathway for Pelvic Organ Prolapse. Female Pelvic Med Reconstr Surg. 2018 Apr 28 [Epub ahead of print]. PMID: 29727373. Maredia H, Hawley NL, Lambert-Messerlian G, Fidow U, Reupena MS, Naseri T, McGarvey ST. Reproductive health, obesity, and cardiometabolic risk factors among Samoan women. Am J Hum Biol. 2018 May;30(3): e23106. [Epub 2018 Apr 16]. PMID: 29663637. Mason SM, Schnitzer PG, Danilack VA, Elston B, Savitz DA. Risk factors for maltreatment-related infant hospitalizations in New York City, 1995-2004. Ann Epidemiol. 2018 Sep;28(9):590-596. Epub 2018 Jun 2. PMID: 30153909. Matteson KA, Robison K, Jacoby VL. Opportunities for Early Detection of Endometrial Cancer in Women with Postmenopausal Bleeding. JAMA Intern Med. 2018 Sep 1;178(9):1222-1223. No abstract available. PMID: 30083765.

Loibl S, O’Shaughnessy J, Untch M, Sikov WM, Rugo HS, McKee MD, Huober J, Golshan M, von Minckwitz G, Maag D, Sullivan D, Wolmark N, McIntyre K, Ponce Lorenzo JJ, Metzger Filho O, Rastogi P, Symmans WF, Liu X, Geyer CE Jr. Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): a randomized, phase 3 trial. Lancet Oncol. 2018 Feb 28. [Epub ahead of print]. PMID: 29501363.

McCammon K, Jacoby K, Kalota S, Snyder J, Cline K, Robertson K, Rardin C, Kahan R, Green L, Zuckerman J, Rovner E. Three-month primary efficacy data for the SUCCESS Trial; a phase III, multicenter, prospective, randomized, controlled study treating female stress urinary incontinence with the vesair intravesical balloon. Neurourol Urodyn. 2018 Jan;37(1):440-448. PMID: 29095516.

Macklin S, Gass J, Mitri G, Atwal PS, Hines S. The role of screening MRI in the era of next generation sequencing and moderate-risk genetic mutations. Fam Cancer. 2018 Jan; 17(1):167-173. PMID: 28643015.

McCarthy, WA, Makhijani R, Miller K, Rojas K, Beffa L, Mathews C, Robison K, Quddus MR. Gastric-Type Endometrial Adenocarcinoma: Report of Two Cases in Patients From the United States. Int J Surg Pathol. 2017 Dec 1:1066896917743010. [Epub ahead of print]. PMID: 29281925.

Madsen AM, Raker C, Sung VW. Trends in Hysteropexy and Apical Support for Uterovaginal Prolapse in the United States from 2002 to 2012. Female Pelvic Med Reconstr Surg. 2017 Nov/Dec;23(6):365371. PMID: 28723720. Madsen AM, Stark LM, Has P, Emerson JB, Schulkin J, Matteson KA. Opioid Knowledge and Prescribing Practices Among Obstetrician-Gynecologists. Obstet Gynecol. 2018 Jan;131(1):150157. PMID: 29215508. 60

Meldrum DR, Adashi EY, Garzo VG, Gleicher N, Parinaud J, Pinborg A, Van Voorhis B. Fertile Battles: Prevention of in vitro fertilization twins should focus on maximizing single embryo trasfer versus twins are an acceptable complication of in vitro fertilization. Fertil Steril. 2018 Feb; 109(2):223-229. PMID: 29447664.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Miller TA, Allen RH, Kaunitz AM, Cwiak CA. Contraception for Midlife Women. Menopause. 2018 Feb 16. [Epub ahead of print]. PMID: 29462093. Mitchell S, Gass J, Hanna M. How Well Informed Do Patient Feel about Their Breast Cancer Surgery Options? Findings from a Nationwide Survey of Women who Reported Lumpectomy and/ or Mastectomy. J Am Coll Surg. 2018. Feb: 226(2):134-146. PMID: 29246706. Mishra K, Locci-Molina NC, Chauhan B, Raker CA, Sung VW. Delay in Seeking Care for Pelvic Floor Disorders Among Caregivers. Female Pelvic Med Reconstr Surg. 2018 July 24 [Epub ahead of print]. PMID: 30045052. Monteagudo J, Dickinson CM, Wakeley M, Mangray S, Wills HE, Luks FI. Proximity to the diaphragm predicts the presence of rhabdomyomatous dysplasia in congenital pulmonary airway malformations. Eur J Pediatr Surg. 2018 Aug 13. [Epub ahead of print]. PMID: 30103238. Moore K, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Banerjee S, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, Lowe ES, Bloomfield R, DiSilvestro P. Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer. N Engl J Med. 2018 Oct 21. [Epub ahead of print]. PMID: 30345884.

Murphy M, Berns AL, Bandyopadhyay U, Rich J, Quilliam DN, Clarke J, Kane K, Salas C, Yousaf A, Reece R. Varicella in the prison setting: A report of three outbreaks in Rhode Island and a review of the literature. Vaccine. 2018 Sep 5;36(37):5651-5656. [Epub 2018 Aug 10]. PMID: 30104118. Nager CW, Zyczynski H, Rogers RG, Barber MD, Richter HE, Visco AG, Rardin CR, Harvie H, Wallace D, Meikle SF, Pelvic Floor Disorders Network. The Design of a Randomized Trial of Vaginal Surgery for Uterovaginal Prolapse: Vaginal Hysterectomy With Native Tissue Vault Suspension Versus Mesh Hysteropexy Suspension (The Study of Uterine Prolapse Procedures Randomized Trial). Female Pelvic Medicine Reconstr Surg. 2017;22(4):182-9. PMID: 27054798. Newman DK, Borello-France D, Sung VW. Structured behavioral treatment research protocol for women with mixed urinary incontinence and overactive bladder symptoms. Neurourol Urodyn. 2018;37(1):14-26. PMID: 28464426. Orchowski LM, Barnett N, Berkowitz A, Borsari B, Oesterle D, Zlotnick C. Sexual assault prevention for heavy drinking college men: Development and feasibility of an integrated approach. Violence Against Women. 2018 Sep;24(11):1369-1396. PMID: 30078368.

Moore KE, Gobin RL, McCauley HL, Kao CW, Anthony SM, Kubiak S, Zlotnick C, Johnson JE. The relation of borderline personality disorder to aggression, victimization, and institutional misconduct among prisoners. Comprehensive Psychiatry. 2018 Jul. PMID: 29660674.

Pasko DN, McGee P, Grobman WA, Bailit JL, Reddy UM, Wapner RJ, Varner MW, Thorp JM Jr, Leveno KJ, Caritis SN, Prasad M, Saade G, Sorokin Y, Rouse DJ, Blackwell SC, Tolosa JE; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Variation in the Nulliparous, Term, Singleton, Vertex Cesarean Delivery Rate. Obstet Gynecol. 2018 Jun; 131(6): 10391048. PMID: 29742665.

Munro MG, Critchley HOD, Fraser IS; FIGO Menstrual Disorders Committee (Matteson KA). The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet. 2018 Dec;143(3):393-408. doi: 10.1002/ ijgo.12666. Epub 2018 Oct 10. PMID: 30198563.

Phelan S, Wing RR, Brannen A, McHugh A, Hagobian TA, Schaffner A, Jelalian E, Hart CN, Scholl TO, Munoz-Christian K, Yin E, Phipps MG, Keadle S, Abrams B. Randomized controlled clinical trial of behavioral lifestyle intervention with partial meal replacement to reduce excessive gestational weight gain. Am J Clin Nutr. 2018 Feb 1;107(2):183-194. PMID: 29529157.

2018 Annual Report

Peer-Reviewed Publications

Phelan S, Wing RR, Brannen A, McHugh A, Hagobian T, Schaffner A, Jelalian E, Hart CN, Scholl TO, Muñoz-Christian K, Yin E, Phipps MG, Keadle S, Abrams B. Does Partial Meal Replacement During Pregnancy Reduce 12-Month Postpartum Weight Retention? Obesity (Silver Spring). 2018 Nov 13. [Epub ahead of print]. PMID: 30421864. Phipps MG, Venkatesh KK, Ware C, Lightfoot M, Raker C, Rodriguez P. Project ESCUCHE: A Spanish-language Radio-based Intervention to Increase Science Literacy. R I Med J (2013). 2018 Dec 3;101(10):41-45. PMID: 30509007. Prabhu M, Clapp MA, McQuaid-Hanson E, Ona S, O’Donnell T, James K, Bateman BT, Wylie BJ, Barth WH Jr. Liposomal Bupivacaine Block at the Time of Cesarean Delivery to Decrease Postoperative Pain: A Randomized Controlled Trial. Obstet Gynecol. 2018 Jul;132(1):70-78. PMID: 29889750. Prabhu M, Dubois H, James K, Leffert LR, Riley LE, Bateman BT, Henderson M. Implementation of a Quality Improvement Initiative to Decrease Opioid Prescribing After Cesarean Delivery. 2018 Sep;132(3):631-636. PMID 30095765. Prabhu M, Garry EM, Hernandez-Diaz S, MacDonald SC, Huybrechts KF, Bateman BT. Frequency of Opioid Dispensing After Vaginal Delivery. Obstetrics Gynecology 2018 Aug;132(2):459-465. doi: 10.1097 PMID: 29995732. Prabhu M, Melahmed A, Bryant AS. Risk of Cesarean Delivery among Nulliparous Asian-Indian Women with Term Singleton Pregnancies. Am J Perinatol. 2018. October 3. [Epub ahead of print]. PMID: 30282108. Rehfeldt M, Eklund E, Struck J, Sparwasser A, O’Brien B, Palomaki G, Köhrle J, Bergmann A, Lambert-Messerlian G.Relaxin-2 connecting peptide (pro-RLX2) levels in second trimester serum samples to predict preeclampsia. Pregnancy Hypertens. 2018 Jan;11:124-128. [Epub 2017 Nov 7]. PMID: 29133069. Ribeiro JR, Gaudet HM, Khan M, Schorl C, James NE, Oliver MT, DiSilvestro PA, Moore RG, Yano N.; Human Epididymis Protein 4 Promotes Events Associated with Metastatic Ovarian Cancer via Regulation of the Extracelluar Matrix. Front Oncol. 2018 Jan 22;7:332. PMID: 29404274. 62

Rice MM, Landon MB, Varner MW, Casey BM, Reddy UM, Wapner RJ, Rouse DJ, Tita ATN, Thorp JM Jr, Chien EK, Saade G, Peaceman AM, Blackwell SC; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. PregnancyAssociated Hypertension and Offspring Cardiometabolic Health. Obstet Gynecol. 2018 Jan. [Epub ahead of print]. PMID: 29324603. Riggs TW, Rouse DJ. Noninferiority Complex. Obstet Gynecol. Oct 2018; 132(4): 833-834. No abstract available. PMID: 30211766. Rizzo CJ, Joppa M, Barker D, Collibee C, Zlotnick C, Brown LK. Project Date SMART: a Dating Violence (DV) and Sexual Risk Prevention Program for Adolescent Girls with Prior DV Exposure. Prevention Science. 2018 Jan 20. PMID: 29352400. Rogers RG, Nolen TL, Weidner AC, Richter HE, Jelovsek JE, Shepherd JP, Harvie HS, Brubaker L, Menefee SA, Myers D, Hsu Y, Schaffer JI, Wallace D, Meikle SF; Eunice Kennedy Shriver National Institute of Child Health and Human Development Pelvic Floor Disorders Network. Surgical Outcomes After Apical Repair for Vault Compared With Uterovaginal Prolapse. Obstet Gynecol. 2018 Mar;131(3):475-483. PMID: 29420409. Rogers R, Nolen T, Weidner A, Richter H, Jelovsek Je, Shepherd J Harvie H, Brubaker L, Menefee S, Myers D, Hsu Y, Schaffer J, Wallace D,. Meikle S, NICHD Pelvic Floor Disorders Network et al. Open Sacrocolpopexy and vaginal apical repair: Retrospective comparison of success and serious complications Int Urogynecol J. 2018 Aug;29(8):1101-1110. Epub May 25. PMID: 29802413. Rouse DJ, Schorge JO. Of Salpingectomy and Sample Size. Obstet Gynecol. 2018 Jul; 132 (1): 18-19. PMID: 29889770. Russo ML, Sukhavasi N, Mathur V, Morris SA. Obstetric Management of Loeys-Dietz Syndrome. Obstet Gynecol. 2018 May 7. [Epub ahead of print]. PMID: 29742657. Saravanan S, Gomathi S, Delong A, Kausalya, Sivamalar S, Poongulali S, Brooks K, Kumarasamy N, Balakrishnan P, Solomon SS, Cu-Uvin S, Kantor R. High Discordance in blood and genital tract HIV-1 drug resistance in Indian women failing first-line therapy. J Antimicrob Chemother. 2018 May 24. [Epub ahead of print]. PMID: 29800305.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Sears CG, Braun JM, Ryan PH, Xu Y, Werner EF, Lanphear BP, Wellenius GA. The association of traffic-related air and noise pollution with maternal blood pressure and hypertensive disorders of pregnancy in the HOME study cohort. Environ Int. 2018 Dec;121(pt 1):574-581. Epub 2018 Oct 6. PMID: 30300815. Shuford SH, Gjelsvik A, Clarke J, van den Berg JJ. Depression among Women Released from Prison or Jail in the United States. J Health Care Poor Underserved. 2018;29(3):914-929. doi: 10.1353/ hpu.2018.0068. PMID: 30122672. Snegovskikh D, Souza D, Walton Z, Dai F, Rachler R, Garay A, Snegovskikh VV, Braveman FR, Norwitz ER. Point-of-care viscoelastic testing improves the outcome of pregnancies complicated by severe postpartum hemorrhage. J Clin Anesth. 2018 Feb;44:50-56. PMID: 29121548. Snegovskikh D, Souza D, Walton Z, Dai F, Rachier R, Garay A, Snegovskikh VV, Braveman FR, Norwitz ER. Corrigendum to “Pointof-care viscoelastic testing improves the outcome of pregnancies complicated by severe postpartum hemorrhage” J Clin Anesth 44(2018) 50-56. 2018 Aug;48:8. Epub 2018 Apr 15. PMID: 29669303. Spelke B, Werner E. The Fourth Trimester of Pregnancy: Committing to Maternal Health & Well-Being Postpartum. RI Med J (2013). 2018 Oct 1; 101(8): 30-33. PMID 30278599. Spelke B, Ramos S, Yu H, Cohen M, Booker TL. On the Future of Maternal Mortality Review in Rhode Island. RI Med J (2013). 2018 Oct 1;101(8):34-36. PMID: 30278600. Steenland K, Barry V, Savitz D. Serum Perfluro-octanoic Acid (PFOA) and Birthweight: An Updated Meta-analysis with Bias Analysis. Epidemiology. 2018 Nov;29(6):765-776. PMID: 30063543. Stewart LE, Hall E, Carberry CL. Cystoscopy at the time of incontinence and prolapse surgery. Curr Opin Obstet Gynecol. 2018 Dec;39(6): 441-445. PMID: 30399017. Stringer EM, Kendall MA, Lockman S, Campbell TB, Nielsen-Saines K, Sawe F, Cu-Uvin S, Wu X, Currier JS. Pregnancy outcomes among HIV-infected women who conceived on antiretroviral therapy. PLoS One. 2018 July 18; 13(7): e0199555. PMID: 30020964.

Sudhoff LS, Has P, Rouse DJ, Hughes BL. Choice of Trial of Labor after Cesarean and Association with Likelihood of Success. Am J Perinatol. 2018 Feb 8. doi: 10.1055/s-0038-1626714. [Epub ahead of print] PMID: 29421833. Talib HJ, Karjane N, Teelin K, Abraham M, Holt S, Chelvakumar G, Dumont T, Huguelet PS, Conner L, Wheeler C, Fleming N. Resident Education Curriculum in Pediatric and Adolescent Gynecology: The Short Curriculum 2.0. J Pediatr Adolesc Gynecol. 2018 Apr;31(2):7176. PMID: 29566846. Tew WP, Sill MW, Walker JL, Secord AA, Bonebrake AJ, Schilder JM, Stuckey A, Rice L, Tewari KS, Aghajanian CA. Randomized phase II trial of bevacizumab plus everolimus versus bevacizumab alone for recurrent or persistent ovarian, fallopian tube or peritoneal carcinoma: An NRG oncology/gynecology oncology group study. Gynecol Oncol. 2018 Nov;151(2):257-263. Epub 2018 Aug 31. PMID: 30177462. Tita ATN, Jablonski KA, Bailit JL, Grobman WA, Wapner RJ, Reddy UM, Varner MW, Thorp JM Jr, Leveno KJ, Caritis SN, Iams JD, Saade G, Sorokin Y, Rouse DJ, Blackwell SC, Tolosa JE; MSCE for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Neonatal Outcomes of Elective Early Term Births after Demonstrated Fetal Lung Maturity. Am J Obstet Gynecol. 2018 May 22. [Epub ahead of print] PMID: 29800541. Tzilos Wernette G, Plegue M, Kahler CW, Sen A, Zlotnick C. A Pilot Randomized Controlled Trial of a Computer-Delivered Brief Intervention for Substance Use and Risky Sex During Pregnancy. Journal of Women’s Health. 2018 Jan. PMID: 28981379. US Preventive Services Task Force, Grossman DC, Curry SJ, Owens DK, Barry MJ, Davidson KW, Doubeni CA, Epling JW Jr, Kemper AR, Krist AH, Kurth AE, Landefeld CS, Mangione CM, Phipps MG, Silverstein M, Simon MA, Tseng CW. Screening for Adolescent Idiopathic Scoliosis: US Preventive Services Task Force Recommendation Statement. JAMA. 2018 Jan 9;319(2):165-172. doi: 10.1001/jama.2017.19342. PMID: 29318284.

2018 Annual Report

Peer-Reviewed Publications

US Preventive Services Task Force, Grossman DC, Curry SJ, Owens DK, Barry MJ, Davidson CA, Epling JW Jr, Kemper AR, Krist AH, Kurth AE, Landefeld CS, Mangione CM, Phipps MG, Silverstein M, Simon MA, Tseng CW. Screening for Ovarian Cancer: US Preventive Services Task Force Recommendation Statement. JAMA. 2018 Feb 13;219(6):588-594. PMID: 29450531. US Preventive Services Task Force, Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, Doubeni CA, Epling JW Jr, Kemper AR, Kubik M, Landefeld CS, Mangione CM, Phipps MG, Pignone M, Silverstein M, Simon MA, Tseng CW, Wong JB. Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement. JAMA. 2018 Jun 26;319(24):2521-2531. PMID: 29946735. US Preventive Services Task Force, Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, Doubeni CA, Epling JW Jr, Kemper AR, Kubik M, Landefeld CS, Mangione CM, Phipps MG, Silverstein M, Simon MA, Tseng CW, Wong JB. Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement. JAMA. 2018 Aug 21;320(7):674-686. PMID: 30140884. US Preventive Services Task Force, Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, Doubeni CA, Epling JW Jr, Kemper AR, Kubik M, Kurth AE, Landefeld CS, Mangione CM, Phipps MG, Silverstein M, Simon MA, Tseng CW, Wong JB. Screening for Syphilis Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement. JAMA. 2018 Sep 4;320(9):911-917. PMID: 30193283. US Preventive Services Task Force, Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, Doubeni CA, Epling JW Jr, Grossman DC, Kemper AR, Kubik M, Landefeld CS, Mangione CM, Phipps MG, Silverstein M, Simon MA, Tseng CW, Wong JB. Behavioral Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2018 Sep 18;320(11):1163-1171. PMID: 30326502. van den Berg JJ, Adeyemo S, Roberts MB, Bock BC, Stein LAR, Martin RA, Parker DR, Clarke JG. Comparing the Validity of SelfReport and Urinalysis for Substance Use among Former Inmates in the Northeastern United States. Subst Use Misuse. 2018 Aug 24;53(10):1756-1761. PMID: 29419341. 64

Varner MW, Mele L, Casey BM, Peaceman AM, Sorokin Y, Reddy UM, Wapner RJ, Thorp JM, Saade GR, Tita ATN, Rouse DJ, Sibai B, Iams JD, Mercer BM, Tolosa J, Caritis SN; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia. Journal of Perinatology. 2018 September 5. [Epub ahead of print]. PMID: 30185931. Vrees R. The Obstetrician/Gynecologist (OB/GYN): Revisiting the Past, Exploring the Present and Preparing for the Future. R I Med J (2013). 2018 Oct 1;101(8):21-22. No abstract available. PMID: 30278596. Wang S, Zhang Y, Mensah V, Huber WJ 3rd, Huang YT, Alvero R. Discordant anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) among women undergoing in vitro fertilization (IVF): which one is the better predictor for live birth? J Ovarian Res. 2018 Jul 16;11(1):60. PMID: 30012195. Wang Y, Abrahams VS, Luo G, Norwitz NG, Snegovskikh VV, Ng SW, Norwitz ER. Progesterone inhibits apoptosis in fetal membranes by altering expression of both pro- and antiapoptotic patients. Reprod Sci. 2018 Aug;25(8):1161-1167. Epub 2018 Feb 20. PMID 29463188. Warsi QA, Huang AJ, Hess R, Arya LA, Richter HE, Bradley CS, Rogers RG, Myers DL, Johnson KC, Winkelman WD, Gregory WT, Kraus SR, Schembri M, Brown JS, Stone KL, Subak LL. Association of Pharmacologic Treatment of Urgency Urinary Incontinence With Sleep Quality and Daytime Sleepiness. Obstet Gynecol. 2018 Jan 9. [Epub ahead of print]. PMID: 29324595. Wenstrom KD, D’Alton ME, O’Keefe DF. Maternal-Fetal Medicine Workforce Survey: Are We Ready for Regionalized Levels of Maternal Care? Am J Perinatol. 2018 Mar. [Epub ahead of print]. PMID: 29548042. Werner EF, Has P, Kanno L, Sullivan A, Clark MA. Barriers to Postpartum Glucose Testing in Women with Gestational Diabetes Mellitus. Am J Perinatol. 2018 Jul 30. doi: 10.1055/s-0038-1667290. [Epub ahead of print] PMID: 30060291.

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Wexler DJ, Powe CE, Barbour LA, Buchanan T, Coustan DR, Corcoy R, Damm P, Dunn F, Feig DS, Ferrara A, Harper LM, Landon MB, Meltzer SJ, Metzger BE, Roeder H, Rowan JA, Sacks DA, Simmons D, Umans JG, Catalano PM. Research Gaps in Gestational Diabetes Mellitus: Executive Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Obstet Gynecol. 2018 Aug;132(2):496-505. PMID: 29995731. Wheeler C, Browner-Elhanan KJ, Evans Y, Fleming N, Huguelet PS, Karjane NW, Loveless M, Talib HJ, Kaul P. Creation and Dissemination of a Multispecialty Graduate Medical Education Curriculum in Pediatric and Adolescent Gynecology: The North American Society for Pediatric and Adolescent Gynecology Resident Education Committee Experiences. J Pediatr Adolesc Gynecol. 2018 Feb;31(1):3-6. PMID: 28919148.

Winkelman WD, Warsi A, Huang AJ, Schembri M, Rogers RG, Richter HE, Myers DL, Kraus SR, Johnson KC, Hess R, Gregory T, Bradley CS, Arya LA, Brown JS, Stone KL, Subak LL. Sleep Quality and Daytime Sleepiness Among Women With Urgency Predominant Urinary Incontinence. Female Pelvic Med Reconstr Surg. 2018 Jan 3. [Epub ahead of print] PMID: 29300259. Winkler H, Jacoby K, Kalota S, Snyder J, Cline K, Robertson K, Kahan R, Green L, McCammon K, Rovner E, Rardin C. TwelveMonth Efficacy and Safety Data for the “Stress Incontinence Control, Efficacy and Safety Study”: A Phase III, Multicenter, Prospective, Randomized, Controlled Study Treating Female Stress Urinary Incontinence Using the Vesair Intravesical Balloon. Female Pelvic Med Reconstr Surg. 2018 May/Jun;24(3):222-231. PMID: 28953076.

OTHER PUBLICATIONS Adashi EY (2018). “What The Great Divide Over IVF Coverage Can Tell Us About Future Of Other High-Tech Care.” Health Aff https://www.healthaffairs.org/do/10.1377/hblog20180118.320672/full/. Allen RH, Cwaik C. Contraceptives for Women with Medical Conditions in Contraceptive Technology. 21st Edition. Ayer Company Publishers, New York. 2018. Anderson B, Cu-Uvin S. “Antiretroviral therapy for the pregnant HIV-infected patient in resource-rich settings.” UpToDate. 2018 Jun 27. www.uptodate.com. Pettker C, Werner EF. Memorials to Two Mothers. Contemporary Ob/Gyn 2018; 63(4). http://www.contemporaryobgyn.net/modern-medicine-feature-articles/memorials-two-mothers. Spelke MB, Hardy EJ, Phipps MG. “Vaccinations/Immunizations During Pregnancy. Medscape Drugs & Diseases.” Updated April 23, 2018. https://emedicine.medscape.com/article/2500098-overview. Spivak R, Cohen IG, Adashi EY.(2018) “Moratoria and Innovation in the Reproductive Sciences: Of Pretext, Permanence, Transparency, and Time-Limits.” J Health & Biomed Law. XIV (2018) 5-26. Stewart L, Hampton BS, “Perioperative Care: A Review of Guidelines and Recommendations—Part 1: Preoperative Evaluation,” Topics in Obstetrics and Gynecology, 38(11):1-6, July 31, 2018. Stewart L, Hampton BS, “Perioperative Care: A Review of Guidelines and Recommendations—Part 2: Peri and post-operative Care,” Topics in Obstetrics and Gynecology, 38(12):5-6, August 31, 2018. Vigliani MB, Cunha CB. “Case report: Multiple recurrent abscesses in a patient with undiagnosed IL-12 deficiency and infection by Burkholderia gladioli.” IDCases 12(2018) 80-83. White, E and Cronin B. “Let pregnant teens control their health,” Our Turn Commentary, Providence Journal, pp A15. (2018, May 24). Will JF, Cohen IG, Adashi EY (2018). “Personhood Seeking New Life with Republican Control.” Ind Law J. 93(2):499-512. 2018 Annual Report

Editorial Positions

PUBLICATION

POSITION

DATES OF SERVICE

FACULTY

American Journal of Clinical Oncology

Editorial Board

2008 – Present

Gass

American Journal of Epidemiology

Associate Editor

2012 – Present

Savitz

American Journal of Obstetrics and Gynecology

Associate Editor

2007 – Present

Phipps

Advisory Board

2002 – Present

Wenstrom

American Journal of Perinatology

Associate Editor

2018

Werner

American Journal of Reproductive Immunology

Editorial Board

2010 – Present

Cu-Uvin

Brown Medicine

Editorial Board

2016 – Present

Luks

Editorial Board

2014 – Present

Vrees

Contraception and Reproductive Medicine

Editorial Board

2014 – Present

Alvero

Environmental Health Perspectives

Editorial Board

2009 – Present

Savitz

Female Pelvic Medicine and Reconstructive Surgery

Assistant Editor

2017 – Present

Sung

Fertility and Sterility

Editorial Board

2013 – Present

Buster

Fetal Diagnosis and Therapy

Associate Editor

2015 – Present

Luks

Infectious Diseases in Obstetrics and Gynecology

Editorial Board

2008 – Present

Cu-Uvin

Journal of Midwifery and Women’s Health

Contributing Editor

2011 – Present

Hunter

Journal of Perinatal and Neonatal Nursing

Editorial Board

2016 – Present

Howard

Contributing Editor for Perinatal Expert Opinion Column

2016 – Present

Journal of Women’s Health

Editorial Board

1988 – Present

Cu-Uvin

Obstetrics and Gynecology

Associate Editor

2013 – Present

Rouse

Editorial Board

2018 – Present

Allen

Rhode Island Medical Journal

Guest Editor

2018

Vrees

Topics in Obstetrics and Gynecology

Associate Editor

2013 – Present

Hampton

The Journal of Minimally Invasive Gynecology

Deputy Editor

2012 – Present

Frishman

Editorial Board

2010 – Present

Rardin

Editorial Board

2017 – Present

Wohlrab

Department of Obstetrics & Gynecology | Women & Infants Hospital | The Warren Alpert Medical School of Brown University

Contact Information Women & Infants Hospital of Rhode Island 101 Dudley Street Providence, RI 02905 womenandinfants.org Maureen G. Phipps, MD, MPH Department of Obstetrics and Gynecology Chair and Chief of Obstetrics and Gynecology mphipps@wihri.org (401) 274-1122, ext. 41575 Rohit Majumdar, MBA Director, Administrative Operations rmajumdar@wihri.org (401) 274-1122, ext. 41577 Kathy Farnum Executive Secretary kfarnum@wihri.org (401) 274-1122, ext. 41575 Dayna Burrell, MD Medical Education Director, Residency Program dburrell@wihri.org Paul DiSilvestro, MD Program in Women’s Oncology Division Director pdisilvestro@wihri.org Renee Eger, MD Obstetrics & Gynecology Care Center (Ambulatory Care) Medical Director reger@wihri.org

Gary Frishman, MD Reproductive Endocrinology and Infertility Interim Division Director gfrishman@wihri.org

James O’Brien, MD Inpatient Obstetrics Medical Director jobrien@wihri.org

Jennifer Gass, MD Breast Health Center Co-Director jgass@wihri.org

Charles Rardin, MD Minimally-Invasive and Robotic Surgical Services Director crardin@wihri.org

B. Star Hampton, MD Department of Obstetrics and Gynecology Vice Chair for Education bhampton@wihri.org Elisabeth Howard, PhD, CNM Midwifery Director ehoward@wihri.org Robert Legare, MD Breast Health Center Co-Director rlegare@wihri.org Kristen A. Matteson, MD, MPH Clinical Research in Women’s Health Division Director kmatteson@wihri.org Deborah Myers, MD Urogynecology and Reconstructive Pelvic Surgery Division Director dmyers@wihri.org

Roxanne Vrees, MD Specialists in General Obstetrics and Gynecology Emergency Obstetrics and Gynecology Medical Director rvrees@wihri.org Erika Werner, MD Maternal-Fetal Medicine Division Director ewerner@wihri.org Gary Wharton, MD Surgical Services Medical Director gwharton@wihri.org Kyle Wohlrab, MD Simulation Center Co-Director kwohlrab@wihri.org

The department would like to extend our deep appreciation to Chris Fruggiero for her years of service to the Department of Obstetrics and Gynecology as the director of administrative operations (2003-2017) and then for returning on an interim basis while we searched for a new director this year. The department would also like to thank Denise Flinn, Amy Blustein, and Kristen O’Grady for their incredible work putting this annual report together for us each year. We are sincerely grateful. 2018 Annual Report

Department of Obstetrics & Gynecology 101 Dudley Street Providence, Rhode Island 02905 (401) 274-1100 womenandinfants.org/BrownObGyn