...CONTINUED FROM PAGE 28 mate selection to avoid affected (aa) calves (i.e. embryonic mortalities) while optimizing genetic gain was more complicated, in this case a computer software program like MateSel would likely be required to optimally assign mate decisions to maximize profit. The results of our research show that avoiding carrier matings at the same essential gene locus is the more profitable mating strategy than avoiding carrier matings as a class. More genetic progress can be made in the first scenario while still avoiding the occurrence of homozygous affected (aa) calves (i.e. embryonic mortalities). As a result, females that become pregnant will be more likely to stay pregnant, having increased longevity within the herd. As bovine genome sequencing projects identify more essential genes and LOF alleles, breed associations will need to develop policies on the management of lethal recessive conditions. In the long run, there may be some benefit in having breed association policies that put some selection emphasis against the occurrence of LOF alleles. This would need to be balanced against the short-term costs associated with forgoing the beneficial genetics associated with carrier animals.
30 California Cattleman September 2017
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