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Providing Haematology Solutions Christophe Duroux

September, 25, 2009

Sales Area Manager

Sunny Beach, Bulgaria

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Hematology in One Step

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Contents Hematology Expertise Proven Technologies Hematology Results Easy Workflow Full Hematology Management Safety Report Quality Systems Explore The Future Š 2009 HORIBA Medical All rights reserved.


Hematology Expertise

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Hematology Market Leader

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International Activities

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Proven Technologies

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Reference Methods

+ Š 2009 HORIBA Medical All rights reserved.


Absorbance

The LMNE Matrix

Resistivity

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5 Differential 5 DIFF Eosinophil

Lymphocyte

Neutrophil

Monocyte

Basophil

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Double Diff Matrix

IMG % and #

Immature Granulocytes

IMM

Immature Monocytes

% and #

IML % and #

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Immature Lymphocytes


Fluorescence

Fluorescence RET

RBC

Volume

ERB

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WBC


Hematology Results

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Enhanced Parameters 8 Diff

+ CBF + RHCc

45

+ RETIC + NRBC

32 5 Diff + ALY + LIC + IMG + IML + IMM

26 19

5 Diff + ALY + LIC

18 3 Diff + CRP 3 Diff © 2009 HORIBA Medical All rights reserved.


The Gold Standard Quantity of cells

t1

L

Lymphocytes

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t2

G M

Monocytes

Granulocytes


The Exclusivity Unique and simultaneous determination of

CBC-3per DIFF (18P) + CRP

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The Compacity ABX Pentra 60 range The most compact revolutionary innovation Leukocyte formula using cytometry and cytochemistry in the smallest analyzer on the market 26 parameters On-board reagents Data management on stand-alone PC ABX Pentra 60 ABX Pentra 60 C+ ABX Pentra ES 60 New !

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5 Diff + 2 ! Abnormal population cells Large Immature Cells

Atypical Lymphocytes Š 2009 HORIBA Medical All rights reserved.


Full Automation ABX Pentra XL 80 A new way to manage your hematology workflow

Striking innovation: CDR (Customized Dilution Ratio) 26 parameters Integrated validation station with color touch screen

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Onboard reagents


Full Hematology Platform ABX Pentra DF 120 A flexible hematology platform Expert validation system Integrated slide-maker (option) 32 parameters Automatic reflex testing

LIC = Large Immatutre Cells Š 2009 HORIBA Medical All rights reserved.

IMG + IMM + IML


In the heart of Hematopoeisis ABX Pentra DX 120 Complete cytology platform 45 parameters Automatic reflex testing Integrated slide-maker (option) ABX Pentra DX 120 ABX Pentra DX 120 SPS Evolution The only instrument including Double DIFF Matrix in routine NRBC and Retic analysis in routine or reflex mode Š 2009 HORIBA Medical All rights reserved.


Anemia Diagnosis RET H

(RNA +++)

RET M RET L

(RNA ++)

3 maturation stages function to the RNA content

(RNA +)

IRF -> Immature Reticulocyte Fraction MFI -> Mean Fluorescence Index MRV -> Mean Reticulocyte Volume Monitoring the erythropoietic response CRC -> Corrected Reticulocyte Count Classifying anaemias (central/peripheral - generative or non-generative)

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Easy Workflow

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User Friendly Software

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Space Saving Competitors Solution

HORIBA MEDICAL Solution

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Space Saving

Easy to move ???

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Space Saving

Easy to move ???

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Space Saving Easy to move !!!

Easy to move ???

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Space Saving Easy to move !!!

Easy to move ???

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Space Saving Easy to move !!!

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Time Saving

Competitors Solution

HORIBA MEDICAL Solution

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Time Saving HORIBA ABX Solution

Other Solution

Primary Health Care Rapid Testing Š 2009 HORIBA Medical All rights reserved.


New Hematology Workflow Tubes & extension arrival

Extension Analyser Analyser 22

Put tubes into display

Analyser 1

Manual Operation

Archive Archivetubes tubes by day acc. and Day number No. Remove the cap of the tube

LIS Registry

Proceed with the extension

Emergency Routine Check results

HORIBA MEDICAL Solution

Close the tubes

Load Rack Bring Tubes to Laboratory

Search tubes to repeat

Print working list of RDL

Tubes Rerun Print Worklist

Waiting for Registry of samples in LIS

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Results Validation

Manual RDL at microscope

Manual entry Manual entry To LIS To LIS

Pos Neg

Bring Tubes to Analysers

Search positive samples

Identify the extension Put the rack for dye process Put the rack in place Take Rack off the dyer File the tube again Dyer extension

REPORT


No Maintenance Concept Double needle concept + Stepper motors concept + Liquid valve concept

=

Small sampling volume No noise No clogging No maintenance

User Maintenance

= 1 automatic start-up & shut-down per day

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Full Hematology Management

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Connecting Systems

LIS Competitors

Immunology, ESR,‌ Digital cell software Š 2009 HORIBA Medical All rights reserved.

Pre/post analytic robots


Connecting Systems

Reconfigurable ???

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Reconfigurable Reconfigurable !!!

One analyzer

Two analyzers

Three analyzers

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Reconfigurable Reconfigurable !!! 360 analysis/hour

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Reconfigurable

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Customized Solutions Collecting and data management

LIS Host Computer

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OPTIMUM OPTIMUMPROCESS PROCESS EFFICIENCY EFFICIENCY

Random Access

9 9 9 9 9 © 2009 HORIBA Medical All rights reserved.

Reflex Testing

9 9 8 9 9

Integrated SPS

Automatic Reruns

8 9 9 9 8

8 9 8 8 8

HORIBA MEDICAL - Pentra DX120 - SPS evolution - Pentra ML


Safety Report

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Flags & Alarms No: (Noise)

Rm: (Right-mono)

Nl: (Neutro-lympho)

Ln: (Left-neutro)

Rn: (Right-neutro)

Ne: (Neutro-eosino)

Ll, Ll1: (Left-lympho)

Mn: (Mono-neutro)

ALY: (Atypical Lymphocytes)

LIC: (Large Immature Cells)

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Automatic Rerun Final Report

Data Management

Sample Order

Re-run Order

Sample

Run Results

Order LIS

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Sample Run


Delta Check

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Reflex Testing

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Auto Validation

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Quality Systems

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Quality Standards „ISO Certifications : z9001 : Comapny Organization z13 485 : Medical Device z18 001 : Health & Safety z14 001 : Environmental

„WEEE Directive zWaste Electrical and Electronic Equipment Directive

„Cyanide-free reagents „Low Reagents Consumption © 2009 HORIBA Medical All rights reserved.


Products Validation

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Explore The Future

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New Hematology Range

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Clinical Chemistry Range

Pentra C200

Pentra 400 Š 2009 HORIBA Medical All rights reserved.


Thank you for your confidence

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Don’t forget to visit our booth !

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