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Mebendazole is an important medicine Mebendazole, guidechem, 31431-39-7 Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations, including roundworm, whipworm, threadworm, and hookworm. It is poorly absorbed and has no systemic effects. It is a kind of white to yellowish powders with Molecular Formula: C16H13N3O3 and Molecular Weight: 295.3. The CAS Registry Number is 31431-39-7. It is used to treat intestinal worm infections such as pinworm, roundworm, and hookworm. It may also be used for worm infections elsewhere in the body (e.g., trichinosis). In these cases, it is usually taken more often and for a longer time. Mebendazole(CAS NO:31431-39-7) is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells, thereby blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths. It comes as a chewable tablet. It usually is taken twice a day, in the morning and evening, for 3 days or as a single (one-time) dose. You may chew the tablets, swallow them whole, or crush and mix them with food. Treatment may have to be repeated in 2-3 weeks. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take mebendazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Oral dosage for treatment of pinworms is 100 mg taken once. (500 mg can also be taken instead) This regimen is repeated two weeks later if the infestation has not cleared up. Oral dosage for treatment of whipworm, common roundworm and hookworm is one 100-mg tablet in the morning for three consecutive days in children below 5yrs of age and below 18 kg weight. In adults it is 100 mg twice a day. It is very important to continue taking this medication exactly as prescribed by your doctor. Do not skip any doses. Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear. Stopping the medication too early may result in a return of the infection. In deciding to use Mebendazole, the risks of taking Mebendazole must be weighed against the good it will do. This is a decision you and your doctor will make. For mebendazole, the following should be considered: Allergies,Pediatric,Geriatric,Pregnancy,Breast Feeding. Mebendazole is relatively free of toxic side effects or adverse reactions, although patients may complain of transient abdominal pain, heart pain, diarrhea, slight headache, fever, dizziness, exanthema, urticaria, and angioedema.
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Published on Jan 25, 2014
Mebendazole(CAS NO:31431-39-7) is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroy...