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What diseases does Matrine cure Matrine, guidechem,519-02-8 Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and Âľ-receptor agonist. It is also have good function on Cardiac disease and Skin disease Cancer Matrineta(CAS NO: 519-02-8) has long been regarded an anticancer herb in China. According to cancer specialist Chang Minyi, "Matrineta works through stimulating the anticancer immune mechanism of the patient and reinforcing his resistance against the growth of the tumor." In 1998, Xu Xiangru and Jiang Jikai, working at the Congqing University of Medical Sciences, published a review of anticancer activity of Matrine. They relayed pharmacology studies indicating the alkaloids could inhibit growth of tumor cells directly, and could also affect immune functions. In clinical work, they described the use of Matrine for treating the side effect of leukopenia caused by cancer chemotherapy or radiation therapy and for treating certain cancers, notably uterine cervical cancer and leukemia. The herb is also considered an important ingredient in treatment of esophageal and laryngeal cancer. In a recent pharmacology study, it was reported that matrine could help leukemia cells differentiate into mature and normal white blood cells. Nonetheless, Matrine should not be relied upon as a sole treatment for cancer, but as an adjunct therapy, as there is no proof that the herb or these compounds are curative. Cardiac disease Matrine is commonly used in China for treatment of heart arrhythmias. A possible mechanism of action is to help block sodium and calcium channels, a mechanism relied on by several antiarrhythmic pharmaceuticals. In a review of Matrine effects on the heart, Li Yan and He Liren, at the Affiliated Yueyang Hospital of Shanghai University of TCM, reported that: Matrine could counteract arrhythmia induced by many causes; it could regulate heart contractility; the total alkaloids could dilate the coronary artery, increase blood flow, and improve oxygen delivery to cardiac cells; and Matrine could counteract the coxsackie virus that causes myocarditis. Li and He also relayed a clinical report from the Third Clinical Medical College of Beijing Medical University, about treatment of 167 patients with fast arrhythmia. The patients received each day 3-10 Matrine tablets (extract of 2 grams crude herb/tablet). The results indicated positive effects on various kinds of arrhythmia, such as premature systole, paroxysmal ventricular


tachycardia, atrial fibrillation, and sinus tachycardia; the efficacy for premature systole appeared to be the best. This Beijing study and others were described also by Niu Kuizhi in his review of clinical applications of Matrine. Skin disease Matrine is frequently used in treatment of skin diseases, applied topically and consumed orally. One of the primary uses for topical therapy is treatment of vaginitis, particularly that due to candida infection . Recently, a topical liniment was developed combining Matrine's matrine with the anti-inflammatory flavonoid baicalin from scute (huangqin) for treatment of eczema, neurodermatitis, and psoriasis. This treatment was reported to be highly effective, especially for eczema, though the number of cases was small, so that further research must be done. The use of Matrine for psoriasis is a promising new area. Zhang Junling and his colleagues at the Department of Dermatology, Tianjin Changzheng Hospital, studied the mechanism by which Matrine reduce psoriasis patches. They found that the alkaloids could inhibit keratinocytes, the cells that reproduce continuously to produce the characteristic scales.

What diseases does Matrine cure  

MatrineisanalkaloidfoundinplantsfromtheSophoragenus.Ithasavarietyofpharmacological effects,includinganti-cancereffects,andactionasakappaopio...

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