The next generation refrigerant market is associated with the major companies that are into refrigerant production. The companies use their innovations and strategies along with bearing the high risks involved in the industry. This chapter details the latest strategies & developments adopted by the key market players in the next generation refrigerant market. In order to lead the market as well as engage in the process of market growth, a company needs to work in collaboration with the top market leaders, acquire the relatively weaker companies, bring new products and services to the market, and improve the existing products.